뇌하수체 종양 제거술 시행 후 뒤늦게 발생한 횡문근 융해증과 동반된 중추성 열

장제혁,최규남,김일환,노은지,김윤정,유충헌,고정해,박봉수,김태균,권민정,이순희,박정현 인제대학교 2008 仁濟醫學 Vol.29 No.-

Body temperature is controlled by thermoregulatory center of the hypothalamus. We report a case of 24 years old man with central fever. He was subjected to a partial excision of pituitary tumor compressing optic chiasm four years ago. He has received hormonal therapy for panhypothyroidism after removal of pituitary tumor. And He received gamma knife operation for partially contrast-enhancing masses in suprasellar and both hypothalamic areas that is probably postoperatively remnant or recurrent tumor of pituitary adenoma. One year after gamma knife operation, he presented with a febrile syndrome of unknown origin including rhabdomyolysis. All usual investigations proved negative. We diagnosed him as central fever with rhabdomyolysis. He received medical ICU care with cooling bed, ice pack. And his symptom improved. Postoperative hyperthermia may result following resection of the pituitary tumor. When central fever is suspected taking note of past history, a quick recognition of course of fever can help reduce the using of unnecessary antibiotics and hospital stay.

소수성 물질을 포함한 커들란 겔의 특성 및 식품으로의 활용 연구

최춘순,이기영,이창문,정제명,이인영 전남대학교 촉매연구소 2001 觸媒硏究 論文集 Vol.22 No.-

The thermal stability of curdlan suspension was investigated. Also curdlan gel containing hydrophobic materials (DHA(Docosa hexaenoic acid), olive oil and Dong-chunghacho (Militaris)) were prepared. Curdlan suspension prepared under 40℃ and 15000rpm was stable for 1 hour. Curdlan gel, including hydrophobic material were dried at 30℃ and swollen in the water. Curdlan gel including Dongchunghacho absorbed water of 980%.

FGF signaling이 연골 형성에 미치는 영향

박충제,이상원,남순현,김영진,류현모,김현정 大韓小兒齒科學會 2003 大韓小兒齒科學會誌 Vol.30 No.4

막내골화와 연골내골화 등의 정상적인 골격 성장은 섬유아세포 성장인자 (FGF) 와 이들 수용체들 (FGFR) 에 의한 신호전달체계에 의해 조절된다. 또한 전사조절인자인 Runx2 (Cbfa1/Pebp2αA/AML3) 는 골아세포분화 뿐만 아니라 골형성에도 필수적인 유전자로 알려져 있다. FGF signaling이 mouse의 두 개관과 하악에서의 연골 형성에 어떤 영향을 미치고 있으며, 이 과정에서 Runx2의 연관성을 알아보고자 in vivo 및 in vitro 실험을 시행하여 다음과 같은 결과를 얻었다. 두 개관의 하악을 Alcian blue 염색한 결과 시상두개봉합부 연골은 태생16일부터, Meckel's 연골은 태생11일부터 형성되기 시작하였다. 이들 연골세포들의 성사을 알아보기위한 in situ hybridization 결과 시상두개봉합부 연골 및 Meckel's 연골 모두에서 type Ⅱ collagen은 발현되었으나, Type X collagen은 발현되지 않았다. Runx2 mRNA는 시상두개봉합부 연골과 Meckel's 연골 모두에서 발현되지 않았지만, 이들 연골들의 가장자리를 둘러싸고 있는 독특한 발현양상을 나타내었다. 두개 봉합부에서의 FGF2 protein의 국소적 적용은 두개봉합부 하방의 연골형성을 억제하였다. 또한 하악의 Meckel's 연골 발생부위에 FGF2 protein의 국소적 적용 역시 Meckel's 연골의 형성을 억제하였다. FGF2 protein은 시상두개봉합부상의 bead 주위로 Runx2의 발현을 유도하였다. 이 결과들을 종합해볼 때, FGF signaling은 골아세포와 연골아세포가 공존하고 있는 조직에서의 연골 형성을 억제하고 있음을 시사해 주고 있으며, 이 과정에서 FGF signaling은 부분적으로 Runx2 유전자의 발현을 조절하므로써 연골세포의 증식과 분화에 관여할 것으로 사료된다. Figroblast growth factor (FGF) / FGF receptor (FGFR) mediated signaling is required for skeletogenesis including intramembranous and endochondral ossifications. Runx2 (Cbfa1/Pebp2αA/AML3) is an essential transcription factor for osteoblast differentiation and bone formation. Murine calvaria and mandible are concurrently undergoing both intramembranous bone and cartilage formations in the early development stage. However the mechanism by which these cartilage formations are regulated remains unclear. To elucidate the effect of FGF signaling on development of cranial sutural catilage and Meckel's cartilage and to understand the role of Runx2 in these processs, we have done both in vivo and in vitro experiments. Alcian blue staining showed that cartilage formation in sagittal suture beings from embryonic state 16 (E16), Meckel's cartilage formation in mandible from E12. We analyzed by in situ hybridization the characteristics of cartilage cells that type Ⅱ collagen, not type X collagen, was expressed in sagittal sutural cartilage and Meckel's cartilage. In addition, Runx2 was not expressed in Meckel's cartialge as well as sagittal sutural cartilage, except specific expression pattern only surrounding both cartilages. FGF signaling pathway was further examined in vitro. Beads soaked in FGF2 placed on the sagittal suture and mandible inhibited both sutural and Meckel's cartilage formations. We next examined whether Runx2 gene lies in FGF siganling pathway during regulation of catilage formation. These results suggest that FGF signaling inhibits formations of sagittal sutural and Meckel's cartilages, also propose that FGF siganling is involved in the proliferation and differentiation of chondroblasts through regulating the transcription factor Runx2.

무균돼지 사육시설 계획을 위한 사례연구 : 공간구성 및 동선계획을 중심으로

권순정,성제경,염수청 한국의료복지시설학회 2006 의료·복지 건축 Vol.12 No.1

According to the increase of demand for human organs such as kidney, heart, pancreas, joint, and cornea for therapeutic transplantation, the production of alternative organs based on Gnotobiotic Pigs gains a lot of concerns all over the world. However, it is not common to design and build Gnotobiotic Pigs' facility, and there are only a few those facilities and planning principles for them. Considering the situation above, this paper tries to develop planning guidelines for space organization and circulation system of standardized Germ Free Pig's facility on the bases of case analysis. The results of this study are as follows. At first, four swine farms including a Gntobiotic Pig's facility has been analysed from the point of space organization and circulation system. Secondly, the space zoning of Gnotobiotic Pigs' facility has been proposed into 5 groups : pigs' area, adminstration area, operating room and laboratory, service area, and mechanical area. Space components of each group have been presented also. Finally, circulation system of Gnotobiotic Pigs' facility has been explored from a operational point of view. This, also, includes human circulation, pig's circulation, and goods' circulation. This study has some limitations because it does not consider the SOPs(standard operational policies) of that facility to the fullest measure and does not suggest space area of each part, either. Despite of some weaknesses, it is expected that this study can give some useful guidelines for the design and planning of Germ Free Pigs' facilities.

기능적 악정형 장치를 이용한 기능성 전치부 반대교협의 치료효과

박충제,남순현,김현정 大韓小兒齒科學會 1995 大韓小兒齒科學會誌 Vol.22 No.1

기능적 악정형 장치에 의한 가능성 전치부 반대교합의 치료효과를 평가하기 위하여 기능성 전치부 반대교합으로 진단된 환자들 중 Activator를 이용하여 치료하였던 35명과 FR-Ⅲ를 이용하여 치료하였던 17명의 치료전후 측모두부방사선 규격사진상에 계측항목을 설정하고 각 항목들의 변화량을 반대교합의 치료를 연기하고 관찰한 대조군의 성장량과 비교, 분석하여 다음과 같은 결론을 얻었다. ·두 치료군 모두 상악골의 전방 성장은 관찰되지 않았다. ·두 치료군 모두 하악골의 후하방 회전이동을 나타내었으며 그 회전량에 있어 Activator군이 다소 많은 경향을 보였다. ·두 치료군 모두 전방안면고는 다소 증가하였으나 유의성은 없었으며(p>0.05), 후방안면고는 대조군에 비해 상대적으로 증가가 미약하였다.(p<0.05). ·전, 후방안면고의 수직적 비율은 대조군에서 일정하게 유지되는데 비해 두 치료군은 감소되었다.(Ar-Go/ANS-Me : p<0.01, S-Go/N-ME : p<0.05). ·Activator군은 상악 전치의 순측 경사(p<0.01) 및 하악 전치의 설측 경사(p<0.05)에 있어 현저한 증가를 보였고, FR-Ⅲ군은 대조군에 비해 유의한 차이가 없었다.(p>0.05). ·두 치료군 모두 overjet이 증가하였고(p<0.01), overbite는 다소 감소하였으나 유의성은 없었다.(p>0.05). This study investigated the treatment effects produced by two types of functional orthopedic appliance, one primarily tooth-borne(Activator) and one primarily tissue-borne(FR-Ⅲ of Frankel). The pre- and post-treatment lateral skull radiographs from 35 patients who had been treated with the Activator and from 17 patients who had been treated with the FR-Ⅲ were compared with 15 untreated persons with functional anterior crossbite. The findings in this investigation were as follows : ·Insignificant maxillary changes were noted in both treatment groups. ·The mandible was rotated backward and downward in both treatment groups, but the distance of the Activator group was greater than that of the FR-Ⅲ group. ·The increase in the anterior facial height was found to be insignificant and the increment of the posterior facial height had a stagnant tendency in both treatment groups. ·Control group had a strong tendency to maintain the ratio of anteroposterior facial height through observed period. In contrast, the ratio of anteroposterior facial height was decreased in both treatment groups. ·The Activator group had a greater treatment effect in upper incisor proclination and lower incisor retroclination than did the FR-Ⅲ group. ·The negative overjet that was present at the beginning of the treatment has been converted into a positive overjet but the reduction in overbite was found to be insignificant in both treatment groups.

노인의 특성을 반영한 단위세대 리모델링 제안 : 장애정도가 낮고 일상생활이 가능한 임대아파트 거주 독거노인 2인을 대상으로

홍유석,제해성,권순정 한국의료복지시설학회 2007 의료·복지 건축 Vol.13 No.2

As a result of rapid aging speed in our society, it is necessary to supply a lot of housing for older people in near future. When we think that high portion of residence in rental housing complex composed of small units is the elderly, the housing units in those apartments have to be designed for the physical, mental, social, and economical conditions of elderly people who lives in such a residential complex. Considering these living conditions of the elderly, this study proposes a remodeling prototype of a living unit for older people in rental housing complex. For the research of this topic, various characteristics of the elderly and the environmental requirements for them firstly have been analysed from the literature survey and the interviews with two residents living in a rental apartment. And the design considerations for each space of the housing unit such as entrance, living room, bed room, bath room, and so forth have been explored. Based on the design guidelines above, the remodeling plan of a housing unit for older people has been propose as a result of this study.

수지상세포의 방사선 저항성에 대한 연구

김은실,김종순,이명호,범희승,민정준,정환정,김성민,허영준,송호천,이제중 대한핵의학회 2003 핵의학 분자영상 Vol.37 No.3

목적 : 림프구와 비교되는 수지상 세포의 방사선 민감성을 보기 위하여 본 연구를 시행하였다. 대상 및 방법 : 말초혈액에서 분리한 T 림프구에 0 Gy, 10 Gy, 30 Gy의 방사선을 조사하고 4시간 후에 유세포 분석기를 이용하여 선량별 세포고사 빈도를 관찰하였다. 또한 조혈모세포에서 미성숙 및 성숙 수지상 세포를 단계적으로 분리 배양하여 각각 0 Gy, 10 Gy, 30 Gy, 100 Gy의 방사선을 조사하고 4시간, 24시간 그리고 48 시간 후에 선량별 세포고사 빈도를 관찰하였다. 사이토스핀(cytospin)슬라이드에 림프구와 미성숙 및 성숙 수지상세포를 3×104개 씩 분주하고 May Grunwald-Giemsa 염색한 후, 광학 현미경 하에서 각각의 세포군 당 100개의 세포에서 세포 면적당 핵의 면적 비를 측정하였다. 결과 : 림프구에서는 방사선조사 선량별로 세포고사 빈도가 유의하게 증가하였으나, 수지상 세포에서는 그 분화정도나 방사선조사 선량에 따른 세포고사의 빈도차이가 없었다. 또한 수지상 세포는 방사선선량과 관계없이 용량에 의존적으로 강력한 T-세포 자극능을 보였다. 림프구의 세포에 대한 핵의 면적 비는 미성숙 및 성숙 수지상세포의 세포에 대한 핵의 면적 비보다 현저히 큰 반면, 두 가지 수지상세포간에 유의한 차이는 없었다. 결론 : 수지상세포는 그 분화도와 상관없이 림프구에 비하여 방사선 저항성을 나타내었고, 이는 세포의 형태적 차이에 따른 표적의 크기와 관련이 있을 것으로 생각되며, 향후 분자 생물학적인 연구의 기초 자료로 활용할 수 있을 것으로 생각된다. Purpose : To evaluate radiation sensitivity of dendritic cells in comparison with lymphocytes. Materials and methods : T lymphocytes captured from peripheral blood were irradiated by 0 Gy, 10 Gy, 30Gy. Apoptosis was measured by flowcytometry for staining of Annexin V 4 hours after irradiation. Immature and mature dendritic cells processed from blood hematopoietic stern cell were irradiated by 0 Gy, 10 Gy, 30 Gy, 100 Gy respectively and apoptosis was measured by flowcytometry with time difference as 4h, 24h and 48h after irradiation. Morphometric analysis by percent nucleus was measured in three cell groups, also. Results : Lymphocytes showed radiation sensitivity by increasing apoptotic fraction according to radiation dose. However, both mature and immature dendritic cells showed consistent fraction of apoptosis in spite of increasing radiation dose. Percent nucleus ratio is significantly higher in lymphocytes than that of mature or immature dendritic cells. Stimulation of T-cell by dendritic cells was not changed after irradiation. Conclusion : Dendritic cells showed radioresistance which was associated with small size of nucleus in comparison with lymphocytes and this result would be used as a basal data of radio-labelling for the cellular trafficking studies in nuclear medicine fields.

자외선 소독과 소독설비

염철민,조순행,정해웅,윤제용 대한상하수도학회 2002 상하수도학회지 Vol.16 No.2

유구치 조기상실로 인한 기능성 전치부 반대교합의 치료 증례

김영진,김현정,박충제,남순현 大韓小兒齒科學會 1994 大韓小兒齒科學會誌 Vol.21 No.2

The authors treated three patients who chiefly complained functional anterior crossbite due to premature loss of primary molars by using removable space maintainer and functional appliances. In orthodontic practice, the mandibular rest position and the possibility of taking construction bite have been as the criteria for evaluation of functional factors involved in anterior crossbite. Functional anterior crossbites, if left untreated, may have deleterious effects on the development and function of craniofacial complex and TMJ. Objectives of the treatment were as follows : 1) to recover vertical dimension 2) to eliminate functional disharmony 3) to correct anterior reversed occlusion 4) to attain good facial esthetics 5) to prevent unfavorable growth of jaw & dentition Characterized craniofacial morphology resulting from the premature loss of deciduous molars could be recovered following the correction of crossbite. Therefore, it is recommended that in orthodontic diagnosis of functional anterior crossbite due to premature loss of deciduous molars, the craniofacial abnormality affected by that should be considered.

초음파 펄스에코 신호의 3차원 처리

송문호,손상락,조정호,성제중,안형근,장순재 한국비파괴검사학회 2003 한국비파괴검사학회지 Vol.23 No.5

비파괴 시험을 위한 3차원 구조의 초음파 영상에는 다양한 결함을 명백하게 보여줄 수 있을 만큼 상세하고 쉽게 알아볼 수 있는 정보가 제공되어야 한다. 수년 동안 원자력 발전소에서 사용된 금속관에 발견되는 소규모의 균열은 전형적인 결함들인데, 이러한 밀리미터 이하의 균열이나 결함은 최종 3차원 영상에서 묘사되어야만 의미있는 검사가 될 것이다. 향상된 선명도와 그에 따른 결함의 발견 과정의 한 단계로써, 펄스에코(pulse-echo) 초음파를 사용한 3차원 영상제작 기술을 제안한다. 이 기술은 필요한 스캐닝과 펄스에코 데이터의 처리과정을 통한 검사로 3차원 물체의 3차원 영상을 생성하는데, 2차원 위너필터(Wiener filter)에 의해 초음파 빔을 선명하게 하는 기술을 포함한다. 제안하는 위너필터는 빔의 전달에서 펄스에코 데이터를 초음파 빔 방향의 수직방향에 따라 필터링한다. 이 3차윈 처리과정은 결함의 선명성을 증진시키고 사용자에게 3차윈 구조물의 좌우 회전 및 축 회전과 같은 조작 능력을 제공한다. 이러한 조작 능력은 3차원에서 다양한 결함들의 크기와 위치의 분명한 묘사를 가능하게 한다. Infrasonic imaging of 3-D structures for nondestructive evaluation must provide readily recognizable images with enough details to clearly show various flaws that may or may not be present. Typical flaws that need to be detected are miniature cracks, for instance, in metal pipes having aged over years of operation in nuclear power plants; and these sub-millimeter cracks or flaws must be depicted in the final 3-D image for a meaningful evaluation. As a step towards improving conspicuity and thus detection of flaws, we propose a pulse-echo ultrasonic imaging technique to generate various 3-D views of the 3-D object under evaluation through strategic scanning and processing of the pulse-echo data. We employ a 2-D Wiener filter that filters the pulse-echo data along the plane orthogonal to the beam propagation so that ultrasonic beams can be sharpened. This three-dimensional processing and display coupled with 3-D manipulation capabilities by which users are able to pan and rotate the 3-D structure improve conspicuity of flaws. Providing such manipulation operations allow a clear depiction of the size and the location of various flaws in 3-D.