http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
충남대학교 학술림 산책로 훼손실태 및 관리방안에 관한 연구
이준우,김명준,최윤호,전용준,오도교,김민호,이소연,이경형 충남대학교 농업과학연구소 2004 농업과학연구 Vol.31 No.2
This study concentrates an the trail of the CNU(Chungnam National University) forest. The amount of use and the pattern of damage are considered, as well as the extent of environmental damage. Finally, some managerial strategies are proposed in connection with sustainable maintenance. The trail of the university forest is composed of three sections; one is the neighborhood park and the Institute of Information Technology/Communications, the second is the Institute of Information Technology/Communications and the Dormitory, and the third section is the Dormitory and the Foreign prof's Apt. The total length of the trail is 2.6km. The daily amount of use is 1,269 visitors per day. The amount of using increased three times the amount of that in 1998. This study shows the pattern of damage of the trail in the order of root-exposure, widening, rock-exposure, deepening and the divergence in the frequency of occurrence of all these factors. Environmental damage is also graded thus: grade 3 is 27.4m, grade 4 is 0.8m, grade 5 is 1.5m, and grade 6 is 0.2m. Accordingly, some managerial strategies were proposed in connection with the sustainable trail maintenance.
도립 진자 시스템의 안정화를 위한 퍼지 제어기의 실현에 관한 연구
최우진,이준탁,소명옥 동아대학교 공과대학부설 생산기술연구소 1996 生産技術硏究所硏究論文集 Vol.1 No.-
In this paper, a hierarchical fuzzy controller for stabilization of the inverted pendulum system is proposed. The facility of this hierarchical fuzzy controller which has a swing-up control mode and a stabilization one, moves a pendulum in an initial natural stable equilibrium point and a cart in an arbitrary position, to an unstable equilibrium point and to a center of rail. Specially, the virtual equilibrium point(Φ_VEq) which describes functionally considers the interactive dynamics between a position of cart and a angle of inverted pendulum is introduced. And comparing with the conventional optimal controller, the proposed hierarchical fuzzy inference structure made substainally the inverted pendulum system robust and stable.
( So-myeong Lee ),( Ju-won Kang ),( Ji-yoon Lee ),( Jeonghwan Seo ),( Dongjin Shin ),( Jun-hyeon Cho ),( Sumin Jo ),( You-chun Song ),( Dong-soo Park ),( Jong-min Ko ),( Hee-jong Koh ),( Jong-hee Lee 한국육종학회 2020 Plant Breeding and Biotechnology Vol.8 No.1
Biofortification is a cost-effective method for increasing the availability of micronutrients. Rice breeding for high levels of micronutrients is one of the best approaches to solve the problem of malnutrition. In this study, we developed a doubled haploid (DH) population derived from a cross between the rice cultivars 93-11 and Milyang 352 and evaluated QTLs for grain micronutrients and grain shape. Two co-localized QTLs, qFe3-1 and qZn3-1, were identified in the interval between ah03002520 and cmb0336.5 on chromosome 3, which explained 17.6% and 10.5% of the phenotypic variation, respectively. Correlation analysis between agronomic and micronutrient traits showed positive correlations between grain Fe and Zn contents but a negative correlation between grain Fe content and length-to-width ratio. This indicated the possibility of simultaneously increasing both Fe and Zn content in rice grains for improving the micronutrient profile of rice. We selected some promising lines by recombinant selection using linked markers on chromosome 3. The co-localized QTLs qFe3-1 and qZn3-1 might be useful for the improvement of biofortified rice breeding by marker-assisted selection and gene pyramiding.
Echocardiogarphic Epicardial Fat Thickness on Long-Term Clinical Outcomes in Patients with STEMI
( So-Hee Lee ),( Jin-Sun Park ),( You-Hong Lee ),( Byoung-Joo Choi ),( So-Yeon Choi ),( Myeong-Ho Yoon ),( Gyo-Seung-Hwang ),( Seung-Jea Tahk ),( Joon-Han Shin ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1
Background: Epicardial adipose tissue (EAT) quantification has been demonstrated to correlate with the severity of coronary artery disease (CAD) and the CAD activity. Our previous study demonstrated that EAT thickness was closely related with short term clinical outcomes in patients with significant coronary artery disease. The aim of this study is to assess the relationship of EAT and long term clinical outcomes after percutaneous coronary intervention (PCI) in patients with ST elevation myocardial infarction (STEMI). Methods: We analyzed the data and clinical outcomes of 764 patients (616 males, 57 ± 12 year-old) STEMIpatients who underwent successful primary PCI from 2003 to 2009. Clinical outcome data was obtained and analyzed according to EAT thickness by echocardiography. Clinical outcome was defined as major adverse cardiac event (MACE; all cause of death, recurrent MI, target vessel revascularization). Results: Median and mean EAT of 764 patients were (median 3.3 mm) and 3.5±1.8 mm, respectively. Mean follow up month was 55±28 month. MACE was occurred in 142 patients (19%). Mean EAT was significantly increased in patients with MACE than those without MACE (3.5 ±1.7 vs. 3.9±2.0 mm, p=0.01. For all cause of death, age, killip classification and cerebrovascular disease were predictive. For TVR, age and EAT thickness were predictive variables. For recurrent MI, there was no predictive value. The MACE free survival of patients with thick EAT was significantly worse than patients with thin EAT (log-rank p=0.025). Conclusions: This study demonstrates that the EAT thickness is related with long term clinical outcome in patients with STEMI. The EAT thickness might provide additional information for future clinical outcome, especially TVR.
Lee, Jae-Myeong,Lee, Joo Won,Jeong, Tae Seok,Bang, Eun Sook,Kim, So Hee American Society for Microbiology 2018 Antimicrobial Agents and Chemotherapy Vol.62 No.10
<P>Meropenem is an ultrabroad-spectrum antibiotic of the carbapenem family. In brain-dead organ donors, administration of standard meropenem dosages does not reach therapeutic levels. Our objectives were to determine the plasma concentration of meropenem after the administration of standard meropenem dose and to estimate an improved dosage regimen for these patients. One gram of meropenem was administered as a 1-h infusion every 8 h for 1 to 3 days, and blood samples were collected. The plasma concentration of meropenem was measured and subjected to pharmacokinetic analysis. Simcyp simulation was performed to predict the optimum plasma levels and dosage based on the patients' individual pharmacokinetic parameters. The maximum plasma concentration of meropenem was 3.29 mu g/ml, which was lower than four times the MIC of 8 mu g/ml. Although the mean creatinine clearance of patients was moderately low (67.5 ml/min), the apparent volume of distribution at steady state (V-ss) and time-averaged total body clearance (CL) of meropenem were markedly elevated (4.97 liters/kg and 2.06 liters/h/kg, respectively), owing to massive fluid loading to decrease the high sodium levels and to treat shock or dehydration. The simulation revealed that dose and infusion time of meropenem should be increased based on patients' V-ss and CL, and a loading dose is recommended to reach rapidly the target concentration. In conclusion, a standard meropenem regimen is insufficient to achieve optimal drug levels in brain-dead patients, and an increase in dose and extended or continuous infusion with intravenous bolus administration of a loading dose are recommended for these patients.</P>
Lee, Su-Chan,Min, Hye-Young,Choi, Hoon,Kim, Ho Shin,Kim, Kyong-Cheol,Park, So-Jung,Seong, Myeong A,Seo, Ji Hae,Park, Hyun-Ju,Suh, Young-Ger,Kim, Kyu-Won,Hong, Hyun-Seok,Kim, Hee,Lee, Min-Young,Lee, Je American Society for Pharmacology and Experimental 2015 Molecular pharmacology Vol.88 No.2
<P>The clinical benefit of current anticancer regimens for lung cancer therapy is still limited due to moderate efficacy, drug resistance, and recurrence. Therefore, the development of effective anticancer drugs for first-line therapy and for optimal second-line treatment is necessary. Because the 90-kDa molecular chaperone heat shock protein (Hsp90) contributes to the maturation of numerous mutated or overexpressed oncogenic proteins, targeting Hsp90 may offer an effective anticancer therapy. Here, we investigated antitumor activities and toxicity of a novel deguelin-derived C-terminal Hsp90 inhibitor, designated L80. L80 displayed significant inhibitory effects on the viability, colony formation, angiogenesis-stimulating activity, migration, and invasion of a panel of non–small cell lung cancer cell lines and their sublines with acquired resistance to paclitaxel with minimal toxicity to normal lung epithelial cells, hippocampal cells, vascular endothelial cells, and ocular cells. Biochemical analyses and molecular docking simulation revealed that L80 disrupted Hsp90 function by binding to the C-terminal ATP-binding pocket of Hsp90, leading to the disruption of the interaction between hypoxia-inducible factor (HIF)-1<I>α</I> and Hsp90, downregulation of HIF-1<I>α</I> and its target genes, including vascular endothelial growth factor (VEGF) and insulin-like growth factor 2 (IGF2), and decreased the expression of various Hsp90 client proteins. Consistent with these in vitro findings, L80 exhibited significant antitumor and antiangiogenic activities in H1299 xenograft tumors. These results suggest that L80 represents a novel C-terminal Hsp90 inhibitor with effective anticancer activities with minimal toxicities.</P>
이명주 ( Myeong Ju Lee ),김영남 ( Young Nam Kim ),이소영 ( So Young Lee ) 한국치위생과학회 2015 치위생과학회지 Vol.15 No.2
This study was conducted to develop a plan for emotional labor of clinical dental hygienists by understanding the factors affecting their emotional labor. Self-administered questionnaires were distributed to 293 dental hygienists who worked in dental hospitals and clinics located in Busan and Gyeongsangnam-do from June to September in 2013. The questionnaire items used in this study consisted of 5 items of general characteristics, 2 items of characteristics related to turnover, and 9 items of emotional labor. t-test, ANOVA, and multiple regression analysis were performed using the SPSS Statistics ver. 17.0 for Windows program for data analysis. The average level of the study subjects was 69.85±12.82. With regard to the emotional labor according to the general characteristics, the frequency of emotional expressions (p<0.037) showed significant differences in the marital status. The workplace showed significant differences in the frequency of emotional expressions (p<0.001), attentiveness of emotional expressions (p<0.002), emotional dissonance (p<0.032), and total (p<0.001). The turnover intentions showed significant differences in the frequency of emotional expressions (p<0.001), attentiveness of emotional expressions (p<0.001), emotional dissonance (p<0.001), and total (p< 0.001). As a factor affecting emotional labor, turnover intention (p<0.001) and workplace (p<0001) had an effect on emotional labor. The results showed that turnover intention and workplace were associated with the emotional labor of dental hygienists. There is a need to develop an emotional education program to make it possible to effectively manage emotional labor of dental hygienists for providing high-quality medical services of dental institutions.
( Seul Lee ),( Dong Hyun Kim ),( Sung Yong Oh ),( So Yeon Kim ),( Myeong Seok Koh ),( Ji Hyun Lee ),( Suee Lee ),( Sung-hyun Kim ),( Jong-young Kwak ),( Min Gyoung Pak ),( Mi Ha Ju ),( Hyo-jin Kim ),( 대한내과학회 2017 The Korean Journal of Internal Medicine Vol.32 No.2
Background/Aims: CD11c is a dendritic cell marker in humans, which potentially induces a cytotoxic effect on lymphoma cells. Forkhead boxP<sub>3</sub> (FOXP<sub>3</sub>) is a regulator of T lymphocyte in the microenvironment of the lymphoma. The principal objective of this study was to determine whether the tumors` microenvironment expressions of CD11c and FOXP<sub>3</sub> are predictive of clinical outcomes in diffuse large B-cell lymphoma (DLBCL) patients receiving treatment with rituximab, cyclophosphamide, anthracycline, vincristine, and prednisone (R-CHOP) combination chemotherapy. Methods: The study population consisted of 100 patients with DLBCL. The CD11c and FOXP<sub>3</sub> expression in primary tumors` microenvironment were evaluated using an immunohistochemistry (IHC). Results: CD11c and FOXP<sub>3</sub> expression positivity in microenvironment were 25% and 35%, respectively. Each one counted for 1 point. In CD11c and FOXP<sub>3</sub> stain, positive was counted as 0 and negative was 1. The points were separated into low risk (0 to 1) and high risk (2) groups. Only the extranodal DLBCL patient group analysis conveyed significant differences of progression-free survival (p = 0.019) and overall survival (p = 0.039) between the two groups. Conclusions: We can achieve possible clinical significance of lymphoma tumor microenvironments through CD11c and FOXP<sub>3</sub> IHC stains in extranodal DLBCL patients receiving R-CHOP therapy.