p-형 Si(100) 기판 위에 성장시킨 Bi_(3.25)La_(0.75)Ti₃O_(12) (BLT) 박막의 전기적 특성

최은경,박문흠,김현주,하태곤,강민주,김상수 昌原大學校 基礎科學硏究所 2003 基礎科學硏究所論文集 Vol.15 No.-

Bi₃zsLa(0.75)Ti₃0_(12) (BLT) thin film have been grown on p-type Si(l00) substrates by a sol-gel spin coating process. The structure and surface morphology of the film were analyzed by X-ray diffraction (XRD) and scanning electron microscopy (SEMI. Furthermore, the electrical properties were examined by capacitance-voltage ( C-V) characteristics by using a LF Impedance Analyzer(HP 4192A). XRD measurement show layered perovskite structure with a single phase in BLT thin film annealed at 700C for 30 min in oxygen. The measured grain size of BLT on Si is about 0.04 - 0.1 pn. From the cross-sectional SEM image, BLT film thickness is measured to be 0.4 pm. The C-V characteristic hysteresis curves show that the NIFS (metal-fexroelectric-semiconductor) structure has memory effect. The memory window decreases, with increasing frequency at MFS structure. And it is found that the memory window increases as the applied voltage to the ferroelectric capacitor is increased. These phenomena may be due to polarization reversals of the BLT ferroelectric film and because of the charge injection from Si substrate into the ferroelectric thin film. The results obtained indicate that the present BLT films are suitable for making ferroelectric field effect transistor(FeFET) memory.

주개 이온을 첨가한 강유전체 Bi₄Ti₃O_12(BIT) 박막의 특성

최은경,박문흠,김두회,구영건,김상수 昌原大學校 基礎科學硏究所 2001 基礎科學硏究所論文集 Vol.13 No.-

Bismuth layered structure ferroelectric thin films, BIT and donor (V, Nb and W) doped BIT, were prepared on the Pt/Ti/SiO2/Si substrates by sol-gel method. BIT film was characterized by strong c-axis prepared orientation. In the case of donor doped BIT thin films, the degree of c-axis prepared orientation decreased systematically V-BIT→W-BIT→Nb-BIT and Nb-BIT film was shown random orientation. Surface morphologies of BIT and V-BIT films had a plate-like and Nb-BIT and W-BIT had a mixture of plate-like and rod-like. In the results of ferroelectric hysteresis loops, the remanent polarization (2Pr) of random-oriented Nb-BIT capacitor was 26 μC/cm2, and this value was over two times higher than that of 12 μC/cm2 for BIT capacitor. The polarization fatigue up to 4.5×1010 read/write switching cycles of W-BIT capacitor was shown superior to the other capacitors. The polarization of the W-BIT capacitor decreased only 10% of the initial value after 4.5×1010 switching cycles.

Bisthmus 제재와 항생제의 복합 투여가 Helicobactor pylori 박멸과 재발에 미치는 영향

김선주,황성규,박상흠,이문호 순천향대학교 1994 논문집 Vol.17 No.4

위점막내에 존재하는 Helicobacter pylori는 소화성 궤양의 발생과 재발에 중요한 인자로 인식되고 있으며, bisthmus, metronidazole, amoxicillin을 포함하는 3제 병합요법을 시행하면 H. pylori균의 박멸에 유효하고 소화성 궤양 재발 빈도를 낮출 수 있다고 한다. 그러나 3제 병합요법은 부작용 발생율이 높아 치료 실패의 주원인이 되고 있다. 이에 저자등은 H. pylori 양성인 소화성 궤양환자에서 H₂ 길항제 투여와 함께 3제 병합요법을 시행하였고, 또한 비교적 약제 부작용이 많은 metronidazole을 제외한 이제 병합 요법을 시행하여 H₂ 길항제 단독 투여한 대조군과 6개월간 추적하여 균의 박멸및 재발 여부를 비교 관찰하였다. 대조군은 Nizatidine을 8주간 투여하였으며 치료 1군은 nizatidine(150mg 하루 2회 복용)을 8주간 투여하고 첫 2주간은 TDB(240mg 하루 2회 복용), amoxicilline(500mg 하루 4회 복용) 투여하였다. 치료 2군은 nizatidine(150mg 하루 2회 복용)을 8주간 투여하고 첫 2주간은 TDB(240mg 하루 2회 복용)과 amoxicilline(500mg 하루 4회복용) metronidazole (250mg thrice a day)을 투여하였다. 치료 8주후 치료 1군은 53%에서, 치료 2군은 100%에서 균이 음전되었으나 대조군은 1예도 음전되지 않았다. 치료 2군의 13%에서 약물에 의한 부작용이 관찰되었다. 치료 6개월 추적 검사시 대조군은 모두 H. pylori 감염이 지속되었으며 치료 1군에서는 63%에서 재발하였으며, 치료 2군에서는 15%에서 재발하였다. 대조군에서는 소화성 궤양(위궤양 1명, 십이지장 궤양 4명)이 5명에서 재발하였으나 치료군에서는 재발이 없었다. H. pylori박멸된 환자에서의 항 H.pylori 항체(IgG)가는 치료 6개월에 치료전의 40%로 감소한 반면, 대조군의 항체가는 변화가 없었다. 이상의 결과로 H₂ 길항제(nizatidine)을 metronidazole 750mg/day, TDB 480mg/day, amoxicillin 2.0gm/day를 2주간 투여하면 약제에 의한 합병증이 비교적 적고, Helicobacter pylori 박멸과 재발 방지에 효과적이며 혈청 H. pylori 항체(IgG)의 추적 검사는 항 H. pylori 치료후 균박멸의 추적검사에 유용함을 알 수 있었다. It has recently been recognized that Helicobacter pylori is a important factor in the development and the recurrence of peptic ulcer diseases. Several studies has been shown that the eradication of Helicobacter pylori is associated with considerable reduction in the the rate of recurrence of peptic ulcer. Triple therapy including bisthmus, amoxicillin, metronidazole is known to be useful in the eradication of Helicobacter pylori, but relatively frequent side effects are a major problem. This study was performed to evaluate the clinical course and the efficacy of triple therapy with H₂ blocker and bisthmus plus amoxicillin therpy with H₂ blocker in the eradication and the recurrence of Helicobacter pylori at 8 weeks and 6 months of treatment. Forty five patients with peptic ulcer disease with a positive urease test of the gastric mucosa were enrolled and assigned to receive H₂ blocker (nizatidine 150mg twice a day) for 8 weeks(control group), tripottasium dicitrato bismuthate 240mg twice a day and amoxicillin 500mg four times a day for 2 weeks, nizatidine for 8 weeks (treatment group Ⅰ), tripottasium dicitrato bismuthate 240mg twice a day and amoxicillin 500mg four times a day, metronidazole 250mg thrice a day for 2 weeks, nizatidine for 8 weeks(treatment group Ⅱ). H. pylori was eradicated in 53% of treatment group Ⅰ, 100% of treatment group Ⅱ, none of control group after 8 weeks of treatment. Helicobacter pylori infection is recurred in 63% of of treatment group Ⅰ and 15% of treatment group Ⅱ. Side effects were recorded in 3 patients(2 patients on treatment group Ⅱ, 1 patient on treatment group Ⅰ), but it were minor side effects. No patients on treatment groups recurred peptic ulcer disease, while 5 patients on control group. Anti-H. pylori antibody IgG remained constant in bacteria positive control group, but in patients in whom H. pylori had been eradicated serum antibody titers fell significantly at 6 months of treatment. In conclusion, triple therapy including a low dose metronidazole with nizatidine is effective on the eradication of Helicobacter pylori infection and reduced the rate of side effects. Bisthmus and amoxicillin with nizatidine is not effective on the eradication and the recurrence of Helicobactor pylori infection. Serologic tests for H. pylori are reliable means of monitoring success of eradication of H. pylori.

만성 B형 간염환자에서 인터페론 치료 후 간 조직검사 소견의 변화와 Tumor Necrosis Factor의 임상적 의의

김홍수,윤동진,김은주,정일권,박상흠,이문호,김선주 순천향의학연구소 2000 Journal of Soonchunhyang Medical Science Vol.6 No.2

Background: Interferon has been widely used in the treatment of chronic hepatitis B, but its effectiveness is debatable. The clinical indices as the loss of HBeAg, HBV DNA, and improvement of liver function are applicated to identify the effectiveness of interferon therapy, but the mechanism of hepatohistological change is not well known. We investigated the changes of histologic finding and plasma tumor necrosis factor(TNF) in the patients with chronic hepatitis B after treatment with interferon-alpha. Methods: 11 patients with chronic hepatitis B who had treated by interferon-alpha were enrolled for this study. Liver biopsy was done before and after treatment of interferon and plasma TNF was evaluated at the same time. A semiquantitative study using a histologic scoring system was applied on pre and post liver biopsy specimens and the changes of HBeAg and HBV DNA were also evaluated. Results: Among subjects, the response group, recurrence group, and non-response group based on serologic response with clearance of HbeAg were6, 3, and 2 patients, respectively. The changes of serum ALT level and HBV DNA titer on pre and post therapy decreased significantly in the response group. The change of mean plasma TNF level in the response group decreased insignificantly to 19.4 from 19.9. The histological improvements of grading and staging were shown 4 patients in the response group. Conclusions: Serologic response with clearance of HBeAg was associated with histolofical improvement. The loss of HBsAg in the serum was significant indicator of reduction in the amount of HBV core antigen and HBV surface antigen in the hepatocytes. Plasma TNF level was not associated with response of interferon-alpha therapy and histologic activity.

Lessons Learned from a Comparative Analysis of Surgical Outcomes of and Learning Curves for Laparoscopy-Assisted Distal Gastrectomy

Moon, Jun-Seok,Park, Man Sik,Kim, Jong-Han,Jang, You-Jin,Park, Sung-Soo,Mok, Young-Jae,Kim, Seung-Joo,Kim, Chong-Suk,Park, Seong-Heum The Korean Gastric Cancer Association 2015 Journal of gastric cancer Vol.15 No.1

Purpose: Before expanding our indications for laparoscopic gastrectomy to advanced gastric cancer and adopting reduced port laparoscopic gastrectomy, we analyzed and audited the outcomes of laparoscopy-assisted distal gastrectomy (LADG) for adenocarcinoma; this was done during the adoptive period at our institution through the comparative analysis of short-term surgical outcomes and learning curves (LCs) of two surgeons with different careers. Materials and Methods: A detailed comparative analysis of the LCs and surgical outcomes was done for the respective first 95 and 111 LADGs performed by two surgeons between July, 2006 and June, 2011. The LCs were fitted by using the non-linear ordinary least squares estimation method. Results: The postoperative morbidity and mortality rates were 14.6% and 0.0%, respectively, and there was no significant difference in the morbidity rates (12.6% vs. 16.2%, P=0.467). More than 25 lymph nodes were retrieved by each surgeon during LADG procedures. The LCs of both surgeons were distinct. In this study, a stable plateau of the LC was not achieved by both surgeons even after performing 90 LADGs. Conclusions: Regardless of the experience with gastrectomy or laparoscopic surgery for other organs, or the age of surgeon, the outcome was quite acceptable; the learning process differ according to the surgeon's experience and individual characteristics.

A case of confluent and reticulated papillomatosis concurrent with pityriasis versicolor successfully treated with oral minocycline

( Tae Heum Park ),( Eun Ji Hong ),( Jae Yun Kim ),( Jung Eun Kim ),( Young Lip Park ),( Moon Kyun Cho ) 대한피부과학회 2022 대한피부과학회 학술발표대회집 Vol.73 No.2

The effects of green tea on acne vulgaris: A systematic review and meta-analysis of randomized clinical trials

( Tae Heum Park ),( Woo Il Kim ),( Na Gyeong Yang ),( Kyu Rak Hong ),( Young Lip Park ),( Sung Yul Lee ),( Moon Kyun Cho ),( Sooyoung Kim ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1

Background: Green tea extract (GTE) has been studied for the treatment of acne based on its anti-inflammatory/ antioxidant properties. Objectives: This systematic review and meta-analysis aimed to examine the effects of GTE on acne. Methods: Electronic databases, including PubMed, Embase, and the Cochrane Library were systematically searched up to August 2019. Results: The effect size of acne lesion counts is presented as mean differences and 95% confidence intervals (CIs). Five randomized-controlled studies were included in the meta-analysis (N; experimental=125, control=122). GTE significantly reduced the number of inflammatory lesions (-9.38; 95% CI: -14.13 to -4.63). In subgroup analysis, topical GTE application significantly reduced the inflammatory lesion counts (-11.39; 95% CI: -15.91 to -6.86) whereas oral GTE intake showed minimal effect (-1.40; 95% CI: -2.50 to -0.30). Although GTE did not significantly reduce the number of non-inflammatory lesions (-21.65; 95% CI: -47.52 to 4.22), when stratified by the route of admission, non-inflammatory acne lesions were significantly reduced by topical GTE application (-32.44; 95% CI: -39.27 to -25.62) but not with oral GTE administration (0.20; 95% CI: 0.00 to 0.40). Conclusion: This systematic review and meta-analysis suggest that topical GTE application is beneficial for the treatment of acne without causing significant adverse events while oral GTE intake has limited effects. Further high-quality clinical trials are warranted.

고속 비상체 충돌에 대한 고성능 섬유보강 시멘트 복합체의 방호성능 평가

문재흠(Moon, Jae-Heum),박정준(Park, Jung-Jun),박기준(Park, Gi-Joon),조현우(Jo, Hyun-Woo),김성욱(Kim, Sung-Wook),이장화(Lee, Jang-Hwa) 한국산학기술학회 2015 한국산학기술학회논문지 Vol.16 No.7

공공시설물의 대형화 및 도심지로의 인구 밀집화에 따라 충돌 또는 폭발과 같은 하중조건 하에서의 구조물 방호성능 의 중요성이 대두되고 있다. 그러나, 구조물의 방호설계 및 시공에 있어서 필수적이라 할 수 있는 구조재료 또는 자재에 대한 기술개발은 제대로 이루어지고 있지 않은 실정이다. 이에, 본 연구에서는 고성능 섬유보강 시멘트 복합재로의 기본적인 방호 성능 및 방호용 자재로서의 적용 가능성을 파악하고자 40 mm 가스건을 사용한 충격 파괴시험을 수행하였다. 실험 수행 결과, 고성능 섬유보강 시멘트 복합재료에 있어서 시멘트 매트릭스의 강도 및 보강섬유가 방호성능 향상에 도움이 됨을 확인할 수 있었다. The importance of public infrastructures’ protection against crash or blast loads has been emerging issue as structures are becoming bigger and population densities in downtown cities are growing up. However, there exists no sufficient study which considers the developments of protective building materials, that are essential for protective design and construction. To assess the protection performance and the applicability as protective materials of high performance fiber reinforced cementitious composites(HPFRCC), this study performed the impact tests with 40 mm gas-gun propelled projectile crash machine. From this study, it has observed that both high compressive strength of cement matrix and fiber reinforcement are beneficial for the improvement of impact resistance.

파도와 부유물의 충격에 의한 해양콘크리트의 침식저항성 평가

문재흠 ( Moon Jae Heum ),김성욱 ( Kim Sung Wook ),박정준 ( Park Jung Jun ),박준형 ( Park Jun Hyoung ) 한국구조물진단유지관리공학회 2013 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.17 No.1

해양 콘크리트 물리적 침식 저항성 평가 기술

문재흠(Moon, Jae Heum),김성욱(Kim, Sung Wook),박정준(Park Jung Jun),박준형(Park, Jun Hyung) 한국콘크리트학회 2013 한국콘크리트학회 학술대회 논문집 Vol.2013 No.10