Water-soluble Genistin Glycoside Isoflavones Upregulate Antioxidant Metallothionein Expression and Scavenge Free Radicals

Chung, Mi-Ja,Kang, Ah-Young,Jun, Hee-Jin,Kim Sang-Yeon,Moon, Tae-Hwa,Park, Kwan-Hwa,Lee, Sung-Joon 생명자원연구 2005 생명자원연구 Vol.13 No.-

한국비서자격시험의 개선점과 비교연구

남자현,이미정,이미영,이아영,정해금,최유정,이미숙,전인선,정혜림 이화여자대학교 법정대학 비서학과 1997 비서학연구 Vol.- No.17

Alkylhalide가 Mouse의 LDH isozyme 분포에 미치는 영향 : Cellulose Acetate Electrophoresis Method

권미경,김영옥,박은주,이동화,이명미,이문희,이양자 曉星女子大學校 藥學大學 學生會 1988 曉星藥誌 Vol.4 No.-

The effect of Carbontetrachloride administration on Lactatedehydrogenase isozyme patterns were analyzed by cellulose acetate electrophoresis for the brain, heart, kidney, lung, liver and mouse muscle. Each other tissue was found to have a characteristic distribution of these isozymes. At normal condition, aerobic tissue such as brain, heart, kidney, and lung were found to have all five isozymes from LDH_1 to LDH_5, while anaerobic tissues such as liver and muscle were found to have superiorly LDH_5 The toxicity of Carbontetrachloride administration was most prominence in the liver, and lung toxicity was occured also.

한국해안으로부터 Purple, Non-Sulfur Photosynthetic Bacterium, Rhodobacter sp. EGH-24의 분리 및 특성

차미선,김기한,조순자,이나은,이정은,이재동,이상준,박재림 한국환경과학회 2003 한국환경과학회지 Vol.12 No.12

A species of facultative photo-organotrophic, purple, non-sulfur bacterium was isolated from the 47 point at west and south coast of Korea in September 2001. Separated 13 samples of changes with red color under 28~32 ℃, 3000 lux, anaerobe conditions for 7 days cultivated in basal medium. For pure isolation from 13 samples, we used agar-shake tube method (0.4 % agar) and separated 5 strains through 13-repetition test. EGH-24 and EGH-30 was identified as the same strain through the RAPD(Random Amplified Polymorphic DNA)-PCR of strain EGH-9, EGH-13, EGH-23, EGH-24, EGH-30. Four isolates cultivated in synthesis wastewater for wastewater biodegradation test. EGH-24 was selected with efficient wastwater treating strain. Based on the results obtained from morphology, nutrient requirements, major bacteriochlorophyll content, 16S-rDNA phylogenetic analysis, EGH-24 strain may be identified as a new strain of the genus Rhodobacter and named Rhodobacter sp. EGH-24.

성인간호학회지 논문(1989-2000)의 내용과 경향 분석

서문자,김소선,송미순,이명선,오의금,신경림,김옥수,이숙자,이영자,오효숙,정재심,김철규 성인간호학회 2001 성인간호학회지 Vol.13 No.4

"Journal of Korean Academy of Adult Nursing" has been published since 1989 and more than 330 articles have been published up 2000. We reviewed all the articles published in this journal to analyze the contents and trend of published articles and to find out the way of improvement both in quantity and quality of studies in this area. The results are as follows : 1) Ninety percent of articles were quantitative studies. Experimental design was used in 16.1% and quasi-experimental design was adapted in 73.6% of articles. Qualitative research were 10.3% of total articles reviewed. 2) Only 5.1% of articles described theoretical framework and 73.6% of experimentally designed articles included research hypotheses. 3) Among experimental studies, only one was true experimental studie design. Eighty nine point three persent had descriptive survey method among non-experimental studies. Amog the thirty four qualitative studies, phenomenologic(73.5%), grounded theory(14.7%), and ethnographic (11.8%) design were used. 4) Most of research subject were patients and few healthy people, healthcare worker, and patient family. 5) Psychosocial data collection method which used questionnaire were 53.7% and interview. physical measurement, observation were used in 22.8%. 8.2% 5.4% of articles respectively. 6) Total number of keywords were 692, and average number of key words per article was 2.2. Health-related keyword was the most frequently used according to four metaparadigm of nursing (human, health, nursing, and environment). Environment related keyword was rarely appeared. The number and quality of nursing research in "Journal of Korean Academy of Adult Nursing" have been improved continuously. It is difficult to find out special trend or characteristics which is unique in this journal because of relatively short history of adult nursing studies. This review study was performed to analyze adult nursing studies only in the view of quantitative aspect, but it is needed to analyse qualitatively to find philosophical or theoretical trend in nursing.

일 도농복합지역 저소득층 노인의 건강문제 분석 : 보건소 방문간호사업 대상자 중심으로

고일선,,이태화,이경자,이정렬,임미혜,천의영,주윤미,이계철 노인간호학회 2005 노인간호학회지 Vol.7 No.2

Purpose: The purpose of this study was to analyze the health problems of low-income aged with chronic illness living in urban-rural composite area. Method: The sample consisted of 440 aged who were receiving home care services from a public health center. MDS-HC was applied to analyze the health problems of the aged. Data were collected through a face- to-face interview by six trained interviewers from June 28 to July 15, 2004. Result: Subjects had average number of 8 health problems in both urban and rural area. Lack of preventive health care measure, pain, and visual function were the most frequent health problem. The rural aged had more pain, bowel management problems, compared to the urban aged having more urinary incontinence and indwelling catheter. There were many health problems related to falls and pressure ulcers with middle-old aged in urban, and old-old aged in rural area. Conclusion: The results of this study showed strategies for care intervention of low-income elderly to put in practice. Therefore, tailored-service for each subject should be provided.

Southern Blot Hybridization법을 이용한 악성 림프종의 면역유전형에 관한 연구

전호종,기근홍,김윤신,이미숙,이미자,장원재,장숙진,박영진,정춘해,정종훈,양성훈,이광민 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.2

Immunogenotyping using gene rearrangement analysis has emerged as a precise laboratory aid in the diagnosis and classification of malignant Iymphoid neoplasms. The lineage and clonality of the malignant Iymphoid neoplasms can be identified by the demonstration of rearrangements of antigen receptor genes of the immunoglobulin and T-cell receptor genes. The analysis of the gene rearrangements on the malignant Iymphoid neoplasms are also useful as a sensitive unique clonal markers to detect early recurrence in patients with malignant Iymphoid neoplasms after treatment. To analyze the sensitivity and specificity of gene rearrangements in the diagnosis of malignant Iymphoid neoplasms. 24 cases of malignat Iymphoma were examined by Southern blot hybridization using CTβ-T cell receptor β chain gene-DNA probe and JH-immunoglobulin heavy chain gene-DNA probe. The results of the immunogenotypings using Southern blot hybridization disclosed high correlation between the immunophenotyping using immunohistochemical stain with monoclonal antibodies (B-cell Iymphoma 84.2%. T-cell Iymphoma 75% ). The analysis of the gene rearrangement of the angioimmunoblastic lymphadenopathy(AILD) and unclassifiable Iymphoma using immunohistochemical stain could resolve the monoclonality and lineage . Rearranged bands to the CTβDNA probe were observed in one case out of 2 cases of AILD. One case of unclassifiable Iymphoma showed rearranged bands to the CTβ DNA probe. There were no rearrangements in reactive follicular Iymphoid hyperplasia and paracortical Iymphoid hyperplasia. In conclusion, DNA gene rearrangement study should be applied to differentiate the clonality and cell lineage in the malignant Iymphoma with indistinctive immunophenotype.

항결핵 치료과정에서 호전되었다가 악화된 뇌 결핵종 1예 보고

이대훈,유진홍,강미자,김홍기,김선화,고동훈,천지성,유원종 대한화학요법학회 1997 대한화학요법학회지 Vol.15 No.3

In spite of nationmide tuberculosis control program, tuberculosis is still prevalent in Korea. Accordingly, tuberculous meningitis also poses one of the main trouble some problems. Recently, We experienced a perplexing case of tuberculous menin-gitis and tubercdoma in a 24-year old female patient. She was admitted to our hospital owing to meningeal irritation sign, aphasia, VI nerve palsy, and ,fever. CSF analysis showed a finding consistent with that of presumptive tuberculous meningitis.. Initial MRI of the brain revealed a large mass(tuhercu1oma) on left parieto-temporal area. Antitubeculous regimen(1soniazid (INH), rifampin(RMP), ethambutol(EMB), pyrazinamide(PZA)} of meningeal dose was given immediately, and her symptoms and signs were dramatically disappeared with a few days after treatment. She was discharged with improved condition and under maintenance treatment of tuberculosis. Follow-up one year after treatment. revealed that the previous lesion was nearly diminished. She showed no symptom at all until she recognized a total blindness of sudden onset on her left eye a t the 18th month of treatment. Brain MRI checked at that time showed multiple masses of tuberculoma scattered over the brain base and one of them invaded left optic nerve. In our opinion, the cause of relapse in this patient might he explained by the selection and ultimate replication of a minor population of resistant strain. Although such relapse is an extremely rare event, we think that we should always pay attention to this possible resistance problem every time we meet patients with tuberculous meningitis.

자궁경부 편평세포의 종양화에 따른 종양단백의 변화

이미자,김권영,기근홍 朝鮮大學校 附設 醫學硏究所 2002 The Medical Journal of Chosun University Vol.27 No.2

자궁 경부의 정상 편평세포가 종양으로 전환되는 과정에 세포의 형태가 바뀌고, 세포의 분자생물학적 변화를 이해하는 것이 자궁 경부 편평세포암종에 대한 치료의 시작이라 할 것이다. 이에 본 연구는 자궁 경부의 편평세포가 종양으로 변화되는 과정에서 c-erbB2, c-lms, c-fos, c-myc과 같은 각종 종양 유전단백의 발현 양상을 파악하고 발현 양상을 비교하고자 하였다. 그 결과 c-erbB2의 양성세포율이 저등급 상피내 병변 또는 고등급 상피내 병변에 비해 각화성 편평세포암, 비각화성 편평세포암에서 의의 있게 높았다. c-fos는 저등급 상피내 병변과 고등급 상피내 병변이 비각화성 편평세포암 사이에 통계학적으로 차이가 있었다. c-fms는 저등급 상피내 병변이 고등급 상피내 병변과 비각화성 편평세포암 사이에 의의 있는 차이가 발견되었다. c-myc은 일부 암종에서 양성을 보였으나 양성세포율도 낮고, 각 병변간에 의의 있는 차이도 없었다. 이상의 결과를 종합하면 저등급 상피내 병변이 고등급 상피내 병변과 c-fms가 의의 있는 차이를 보여 주었다. 저등급 상피내 병변과 고등급 상피내 병변은 비각화성 편평세포암과 비각화성편평세포암 사이에 c-erbB2, c-fos, c-fms가 의의 있는 차이를 보였다. 그러므로 c-erbB2, c-fos, c-fms가 자궁 경부의 상피세포의 종양화와 관련이 있으며, 이들에 대한 양성세포율을 측정함으로써 종양의 진행 정도를 파악하여, 환자의 예후 판정에 도움을 줄 수 있으리라 여겨진다. Background and objectives: Most carcinomas of the uterine cervix arise from intraepitheliallesions that develop within a transformation zone. The clinical significance of intraepitheliallesions of the uterine cervix is widely accepted. However. their biologic characteristics are not fully understood. The purpose of this study was to evaluate cellular changes in the levels of various oncoproteins in low- and high-grade squamous intraepithelial lesions, and invasive squamous cell carcinomas. Materials and Methods : The author analyzed conized or resected uterus specimens diagnosed as low-grade squamous intraepitheliallesion (LSIL, 10 cases), high-grade squamous intraepitheliallesion (HSIL, 28 cases), keratinizing squamous cell carcinoma (KSCC, 12 cases), and nonkeratinizing squamous cell carcinoma (NKSCC, 12 cases). The evaluation of c-erbB2, c-fos, c-fms, and c-myc immunohistochemical staining was based on the percentages of positive neoplastic cells. Results: The average proportion of cells positive for c-erbB2 was 38.0, 45.4, 82.5, and 79.2% in LSIL, HSIL, KSCC, and NKSCC, respectively. The average proportion of cells positive for c-fos was 18.5, 25.9, 61. 7, and 45.8% in LSIL, HSlL, KSCC, and NKSCC, respectively. The average proportion of cells positive for c-fms was 8.0, 19.8,49.1, and 35.0% in LSIL, HSIL, KSCC, and NKSCC, respectively. The oncoprotein c-rnyc was negative in all LSIL and HSIL, except in one case of HSIL, and positive in 5 and 4 cases of KSCC and NKSCC, respectively. There were statistically significant differences between the amounts of c-fos and c-frns in intraopitheliallesions and in invasive carcinoma. Conclusion : These results suggest that expressions of c-erbB2, c-fos and c-fims changes in the tumorous progression of cervical squamous epithelium, The rate of positive cells gradually increased and became statistically significant, The opposite was true for the c-myc on coprotein.

직장여성의 직무태도 및 성과 : 직종별 비교연구

이도화,이미자,강인중 인제대학교 1998 仁濟論叢 Vol.14 No.1

This study aims to examine whether there is gender differences in job attitudes(i.e. job satisfaction, organizational commitment, work role centrality) and job performance, and whether those differences, if any, may be related to sex discrimination in personnel management practices and personal experiences of sex discrimination. In order to pursue above research questions, questionnaire survey was conducted for 600 workers in several different industries including manufacturing firms, banks, and high schools. The main results of One-way ANOVA are as follows: (1) For administrative worker group, job satisfaction of female was found to be lower than that of male. (2) For production worker group, organizational commitment of female was higher than that of male. (3) For professional worker group, overall job attitudes including job satisfaction, organizational commitment, and work role centrality were found to be higher than those of male workers. (4) Sex discriminations in personnel management and personal experiences of sex discrimination were highest for administrative worker group and lowest for the professional worker group. The above results suggest that females' poor job attitudes may be related to sex discrimination practices in the workplace. The implications of the these results and future research directions are discussed in the conclusion.