위암 환자의 복강내 투여를 위한 Activated Charcoal-Alginate Bead 제형으로부터 Mitomycin C의 용출 거동

이진호,최선웅,서중기,김동민,정경수,오정연,김진향,노승무,민병무,김용백,김창식,박근성,강대영,송규상,양준묵,조준식,정현용,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherapy seems a logical choice for cancer chemotherapy. In this study, Mitomycin C (MMC)-activated charcoal (CH)-alginate (ALG) beads were prepared by the mixtures of CH particles adsorbed with MMC as an anti-cancer drug and aqueous alginate solution. The alginate is recognized as biodegradable, nontoxic, and biocompatible. The release of MMC from the beads in 0.1 M Tris buffer was stable and continuous until about 1 week. The MMC-CH-ALG beads can be applied in the peritoneal cavity for intraperitoneal chemotherapy since they provide a good adhesiveness on the tissue and controlled release pattern of the drugs.

인체 지방 및 간장조직 중 유기염소제류 및 PCB의 확인 및 정량기법 체계화 : 2차년도

이상기,양자열,김기욱,이수연,오승민,김대현,정규혁 內務部 國立科學搜査硏究所 2002 國立 科學 搜査 硏究所 年報 Vol.34 No.-

정상인과 정신지체인,다운증후군 환자에서 치주질환 원인균의 출현율

이해송,김선미,최남기,오종석,강미선,임희정,양규호 대한소아치과학회 2006 大韓小兒齒科學會誌 Vol.33 No.3

포도상구균의 약제 내성 및 β-lactamase의 생산에 관하여

양재윤,박상욱,이용진,조규봉,이연태 단국대학교 신소재기술연구소 1994 신소재 Vol.4 No.-

항균제의 오남용으로 내성균의 출혈빈도가 매우 높아져 임상가에서는 환자치료에 어려움이 적지 않다. 특히 많은 균종중에서 병원감염의 문제가 되고 있고 포도상구균에 대한 내성빈도는 환자치료에 중요하다고 판단된다. 따라서, 1992년 12월부터 1993년 2월 사이에 서울대 병원에 내원(來院)한 환자로부터 총 108주의 포도상구균을 분양 받아 항균제 내성검사를 실시하였고 황색포도상구균의 경우는 β-lactamase 생산유무 확인 및 methicillin에 대한 MIC 농도를 비교하였으며, methicillin에 대하여 각기 다른 MIC농도를 갖는 균종에 대한 substrate 분해능 검사를 실시하여 다음과 같은 결론을 얻었다 (1). 항균제 내성검사를 실시한 108주의 포도상구균은 penicillin에 가장 높은 내성을 나타냈다. 황색포도상 구균의 경우는 97%, 표피포도상 구균의 경우 100%, coagulase 음성포도상구균의 경우 95.7%로 나타났다 (2). vancomycin의 경우는 전 균주가 감수성을 나타냈다 (3). methicillin에 대한 내성율은 41.4%로 나타났다. 이 내성균주들은 10가지 검사 항생제중 최고 9가지에 대한 항균제 내성을 나타내어 다약제 내성임을 알 수 있었다 (4). β-lactamase 생산 실험에서는 58균주의 황색포도상 구균중 53주가 양성을 나타내어 91.4%의 결과를 얻었다. β-lactamase 생산균주와 methicillin에 대한 내성균주가 반드시 일치하지는 않았다 (5). Spectrophotometric assay에서는 내성이 높은 균주와 낮은 균주간에 β-lactamase에 의한 substrate 분해능이 서로 유사하게 나와 황색포도상 구균의 methicililin에 대한 내성 획득은 β-lactamase 뿐만이 아닌 penicillin binding protein(PBP)의 구조적 변화로 인한 내성획득도 시사함을 알 수 있다. One hundred and eight Staphylococcus aureus strains were isolated from patients of Seoul National University Hospital from December 1992 to Feburary 1993. All strains were tested for their sensitivities against antibiotics. β-lactamse producing test was also performed in order to know the relationship between the methicillin resistance and β-lactamase production. Its activity was determined by direct spectrophotometric method. Initial velocities of hydrolysis of the antibiotics were monitored at wavelength 323 nm which corresponded to maximal change in absorbance between the unhydrolyzed substrate and the hydrolyzed product. The results are summarized as follows: 1. In antibiotics sensitivity test of 108 isolated strains of Staphylococcus, they showed hightest resistance to penicillin but all of tested strains were susceptible to vancomycin. 2. 41.4% of them showed resistance to methicillin. 3. All methicillin resistant strains were found to be multi-drug resistant, from 3 to 9 antibiotics. 4. 91.4%(53 out of 58) produced β-lactamase, β-lactamase producing strains did not always coincide with the methicillin resistant strains. 5. β-lactamase activities were similar among staphylococus strains, irrespective of their methicillin resistance.

소프트웨어 프로세스 모형

李良圭 西原大學校 經營科學硏究所 1998 經營硏究 Vol.7 No.1

유리 광배근피판을 이용한 하지의 재건

이규윤,김용배,이영만,양순재,박종섭 大韓成形外科學會 1991 Archives of Plastic Surgery Vol.18 No.1

Significant soft-tissue defects in the lower extremity including the tibia and the foot are best managed with free skin-muscle of skin-grafted free muscle transfers. While free flap donor sites useful for lower exremity reconstruction include the latissimus dorsi, the rectus abdominis, the gracilis, and the scapular flaps, the latissimus dorsi seems ideal. This muscle has a reliably long vascular pedicle of wide diameter, making microsurgical anastomosis of the thoracodorsal vessels straightforward. Because it is so large, it can cover virtually and size defect. Furthermore, its flat configuration makes it especially easy to fold on itself to that it can be used to closure wounds with complex three-dimensional geometry and dead space. Although the gracilis and rectus abdominis muscles have their roles, in most cases the latissimus dorsi should serve well. We described technical considerations in each case and the advantages of free latissimus dorsi myocutaneous flap on the reconstruction of the soft tissue defect in the lower extremity.

비협조적인 아동에 약물투여시 행동조절효과에 관한 임상적 연구

이가연,양규호 전남대학교 치과대학 1990 전남치대논문집 Vol.2 No.1

The author compared the effect of three kinds of medication for management of the uncooperative 45 children aged from 11 months to 5 year 5 months needing extensive treatment. Fifteen patients were given a dose of 75 ㎎/㎏ of chloral hydrate recatally(groupⅠ). Fifteen patients received the same dose of chloral hydrate rectally in combination with 20 mg of hydroxyzine orally(group Ⅱ). The remaining 15 patients were given the same dose of chloral hydrate rectally in combination with 3 ~ 4 mg of diazepam intramuscularly(group Ⅲ). According to rating scale, sleep, crying, movement and overall behavior were checked for evaluation of the clinical sedative effect. Vital signs were also measured for assessing the safety of the patients and early detection of respiratory difficulties. The results were as follows : 1. In the evaluation of sleep before and after dental treatment, rating scale of chloral hydrate and diazepam was superior to the other drugs. 2. In the evaluation of crying and movement during treatjment, rating scale of chloral hydrate and diazepam was superior to the other drugs and mean rating of each group was significantly different from the other group. 3. In the evaluation of overall behavior after dental treatment, 80% children of the chloral hydrate and diazepam were rated good or very good. With the chloral hydrate and hydroxuzine group and chloral hydrate group, 67% and 47% were rated good or very good respectively. 4. Heart rate, blood pressure and respiration rate remained unchanged during procedure. None of three groups monitored produced any significant respiratory depression or airway obstruction except statiscally oxygen saturation value depression only for subjects receiving chloral hydrate and diazepam compared with chloral hydrate. Combined drug regimen was superior to single regimen, and the clinical effect of diazepam 3 ~ 4 ㎎ intramuscularly was superior to hydroxyzine 20 ㎎ orally. But further researches with the modified dosage and route will be needed to guide the most effective result for sedation.

교정용 광중합형 및 화학중합형 레진접착제의 전단결합강도와 파절양상에 대한 연구

이민하,양규호 전남대학교 치과대학 1995 전남치대논문집 Vol.7 No.1

Light-cured orthodontic composite resin has been widely advertised recently for use in bonding brackets. However, the curability of light-cured resin when light waves are diffused through metal brackets is questionable. The purposes of this study were to evaluate shear bond strength and failure patterns of visible light-cured resin (Lightbond) and chemically cured-resin (Mono-Lok2), and to determine the relative value of light-cured resin as an alternative to conventional chemically-cured resin. Each of the two resins was tested on twenty extracted human first premolars. Standard edgewise metal brackets were bonded to the teeth in accordance with the manufacturers' recommendation. After bonding, the teeth were stored for 24 hours at 37℃, 100% humidity. The shear bond strength was tested with a universal testing machine (Instron 4302), at 0.5㎜/min crosshead speed. After debonding, brackets and enamel surfaces were examined with a scanning electron microscope and a stereoscopic microscope. The results were as follows : 1. Metal brackets bonded with Lightbond showed statistically higher shear bond strength than metal brackets bonded with Mono-Lok2. 2. The predominant failure site in Lightbond was the enamel-resin interface, and in Mono-Lok 2 it was the resin itself. 3. Enamel cracks were not found in any specimen. The above results suggest that direct bonding of metal brackets to enamel with light-cured resin bonding agent can be used effectively in clinics.

인터넷 메타데이타 검색 및 관리 시스템의 설계 및 구현

이원석,박경용,양영종,정효택,김순용,이규철 한국문헌정보학회 1997 한국문헌정보학회지 Vol.31 No.2

인터넷은 디지탈 형태의 다양한 정보를 신속하게 전달한다는 점에서 매우 각광을 받고 있다. 그러나, 대량의 인터넷 정보 중에서 자신이 원하는 정보 자원을 정확하게 많이 얻어 낼 수 있는 방법의 제공은 매우 어려운 문제이다. 본 논문에서는 인터넷 정보 자원의 메타데이타를 관리하기 위해 SeriCore라는 SGML 형식의 메타데이타 DTD(Document Type Definition)를 정의하고, 이들 메타데이타를 효율적으로 저장하고 검색, 관리할 수 있는 시스템을 설계, 구현하였다 The Internet has gained popularity because ot provides various information in digital format. However, it is very difficult to provide methods which make it possible to search adequate information resource from bulk of Internet information. In this paper, we define a SGML metadata DTD, named SeriCore, and design and implement a metadata retrieval and management system which can store, retrieve and manage the Internet metadata efficiently

Anodontia 소견을 보이는 외배엽 이형성증 환자에서 교합기능, 심미기능 회복에 관한 치험증례

양규호,이민하 大韓小兒齒科學會 1994 大韓小兒齒科學會誌 Vol.21 No.2

Ectodermal dysplasia is characterized by a partial or complete lack of primary and permanent teeth, other ectodermal structures that may be affected include the skin, hair, and sweat glands. The patient with the so-called anhidrotic type of ectodermal dysplasia exhibits dry skin, lack of sweat glands, sparse eyebrows, body hair, saddle nose, and everted lips. Genetic basis of anhidrotic ectodermal dysplasia is recessive and sex-linked, being manifested chiefly in males, but this is debatable. A 6-year-old boy, with typical signs of anhidrotic ectodermal dysplasia, was presented. Prosthetic restoratoins are of great value to these patients, both from the standpoint of function and for psychologic reasons. The need for complete denture is critical during preschool periods and continues into adulthood. The following case report is an approach to the management of a patient with anhidrotic ectodermal dysplasia.