정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Apoptosis and necroptosis‑inducing effects of arctigenin on nasal septum carcinoma RPMI‑2650 cells in 2D and 3D culture

Yoon‑Jin Lee,Kwan‑Sik Park,Byoung Joon Baek,Kyong‑Ae Lee,Sang‑Han Lee 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.1

Backgrounds Arctigenin derived from the seeds of Arctium lappa Linnaeus is known as an anticancer drug candidate by targeting various pathways involved in anticancer therapy. Methods Using 2D monolayer and 3D spheroid culture systems in nasal septum carcinoma RPMI-2650 cells, the effects of arctigenin and dexamethasone on cell viability, ROS levels, ATP level, mitochondrial function, apoptosis and necroptosis were examined. Results The combination treatment of both compounds induced strong cytotoxicity, accompanied by increases of sub-G0/ G1 peak, annexin V-PE-positive cells, and ROS levels, loss of mitochondrial membrane potential, and decrease of cellular ATP content. These changes were observed as simultaneous induction of DNA damage, apoptosis, and necroptosis. A series of changes by arctigenin and dexamethasone were efficiently restored by decreasing ROS levels or supplementing ATP. Treatment of 3D spheroids with arctigenin and dexamethasone decreased cell viability in the spheroids, but it was slightly resistant than cells under 2D conditions. In addition, this phenomenon was accompanied by an increase in mediators for both apoptosis and necroptosis. Conclusion Results of this study suggest that the apoptosis and necroptosis-inducing effects of arctigenin are associated with ATP depletion due to oxidative mitochondrial dysfunction.

AUTOMATION OF QUANTITATIVE SAFETY EVALUATION IN CHEMICAL PROCESSES

Lee,Byung-Woo,Kang,Byoung-Gwan,Suh,Jung-Chul,Yoon,En-Sup 한국화재소방학회 1997 한국화재소방학회 학술대회 논문집 Vol.1997 No.-

A method to automate hazard analysis of chemical plants is proposed in this paper. The proposed system is composed of three knowledge bases - unit knowledge base, organizational knowledge base and material knowledge base, and three hazard analysis algorithms - deviation, malfunction and accident analysis algorithm. Hazard analysis inference procedure is developed based on the actual hazard analysis procedures and accident development sequence. The proposed algorithm can perform hazard analysis in two methods and represent all conceivable types of accidents using accident analysis algorithm. In addition, it provides intermediate steps in the accident propagation, and enables the analysis result to give a useful information to hazard assessment. The proposed method is successfully demonstrated by being applied to diammonium phosphate manufacturing process. A system to automate hazard analysis is developed by using the suggested method. The developed system is expected to be useful in finding the propagation path of a fault or the cause of a malfunction as it is capable to approach causes of faults and malfunctions simultaneously.

광대역 고출력 공간 전력 증폭 소자에 관한 연구

이성호,권세웅,이병무,윤영중 연세대학교 산업기술연구소 2002 논문집 Vol.33 No.2

In this paper, spatial amplifier using wideband printed dipole antennas is proposed for spatial power combining. The input and output printed dipole antennas have wide bandwidth of 22 %(5.44 ㎓∼6.75 ㎓) and 26.3 %(5.2 ㎓∼6.78 ㎓), respectively. Gain of the designed amplifier is 9.5 ㏈ at 6 ㎓. As a result, the proposed spatial amplifier using wideband printed dipole antennas and amplifiers shows that the gain is 16.8 ㏈ at 6 ㎓ and 3-㏈ gain bandwidth is 1.04 ㎓.

증발량 자동관측 방법에 관한 연구

이부용,박병윤 대구효성가톨릭대학교 응용과학연구소 1997 응용과학연구논문집 Vol.6 No.1

A new method of automatic evaporation measurement was tested at laboratory for the purpose of field observation. The results were as follows. 1) The measured evaporation values of water level showed the resolution of 0.023mm, and there was no problem for field observation. 2) There is no need of water temperature correction according to change of water density. 3) The voltage output of straingage loadcell make possible automatic recording by datalogger.

STI571 (Glivec^(�))에 의하여 빠른 치료 반응을 보인 불응성 Gastrointestinal stromal tumor

윤경원,이제중,김여경,황호인,이병환,조상희,정익주,김형준 全南大醫大 2001 전남의대학술지 Vol.37 No.4

비정규 노동의 개념정의와 유형화에 관한 연구

이병훈,윤정향 한국산업노동학회 2001 산업노동연구 Vol.7 No.2

이 글에서는 노동의 비정규화에 대한 이론적인 고찰을 제시하고, 비정규 노동에 대한 개념정의와 유형화를 시도하고 있다. 근대 자본주의 기업들에 의한 관료제적인 노동통제체계의 성립을 통해서 자본-노동간의 내부화되었던 포드주의적 고용관계가 1990년대에 들어 전세계적으로 자본축적 환경의 재편과 경제활동주체-자본과 노동 그리고 국가-들에 의한 대응방식의 변화에 기반하여 시장매개적인(market-mediated) 방식으로 다양한 비정규 노동의 활용증대를 추구하는 "탈포드주의적 고용구조"로 전환되는 변화 경향이 두드러지는 것으로 분석된다. 또한, 형식적이고 법해석적이며, 잔여적인 접근 방식에 따른 기존의 개념정의가 자본의 외부화된 노동수취방식에서 비롯되는 비정규 노동의 본원적 특성을 밝히지 못하는 문제점을 비판하며, 비정규 노동에 대해 "자본의 시장의존적(market-dependent) 노동수취 전략에 따라 기업의 내부노동시장 또는 관료적 포섭-관리체계로부터 배제 또는 외부화되어 있는 노동자집단" 이라는 새로운 개념정의를 제시하고 있다. 아울러, 현실 직업세계에 있어 실로 다양한 고용형태들을 포괄하고 있는 비정규 노동에 대해 탐색적인 방식으로 직무특성, 보장체계, 고용관계 형성의 자발성과 공식성, 고용형태의 시대성, 직업위세, 고용의 이동가능성, 성별 편중성 등을 기준삼아 다측면적인 유형화를 논의하고 있다. This paper presents a theoretical analysis regarding the non-regularization of labor and attempts to define and categorize non-regular labor. The Fordistic employment relations, was established along with the implementation of the bureaucratic labor control system, has been transformed toward the post-Fordistic model in the 1990s. The post-Fordistic employment relations, which pursues the increasing utilization of various non-regular labor in the market-mediated way, has come to fore against a background of changing environment of capital accumulation and newly evolving strategic interactions between industrial actors - employers, labor unions, and the state. It is criticized that the existing definition, which is based on the formalistic, legally-interpretative, and residualistic approach, dismiss the essential attribute of non-regular labor, derived from the externalized labor appropriation strategy of capital. In this paper, non-regular labor is conceptualized as "the worker group excluded or externalized from the corporate hierarchy of bureaucratic incorporation and control (or internal labor market) in accordance with employers' market-dependent employment relations strategies". Moreover, multi-dimensional categorization regarding non-regular labor is explored, particularly by offering various criteria, such as job attributes, provision of welfare, patterns of employment relations(whether voluntary, formal, and non-traditional), occupational prestige, job upgradability, and gender orientation.

무균성 수막염 환자에서 분리한 enterovirus의 혈청형 및 계통발생학적 분석

이정희,안병윤,반성환,김상현,김의종 대한임상미샐물학회 2000 Annals of clinical microbiology Vol.3 No.2

선천성 슬개골 탈구 및 치료 1례 보고

이호승,배병권,윤희석 충북대학교 의학연구소 2001 忠北醫大學術誌 Vol.11 No.1

선천성 슬개골 탈구는 드문 질환으로 수술적 치료 없이는 정복이 불가능하며 다른 선천성 원인에 의한 재발성 슬개골 탈구와 구별되어야 한다. 본 증례는 생후 5개월 된 남아로 좌측 슬관절 신전 장애를 주소로 내원하였으며 이학적 검사상 좌측 슬부의 20도 굴곡구축, 좌측 경골의 외전 및 좌측 족부 모든 족지의 외측편위 등의 소견이 동반되어 있었다.단순 방사선 사진상 특이 소견은 보이지 않았으며 양측 슬부의 초음파검사에서 좌측 슬개골이 대퇴골 외과(lateral condyle)의 외측으로 탈구된 소견을 관찰할 수 있었다. 수술 소견상 슬개골은 슬부 외측으로 탈구되어 있었고 대퇴골 외과는 저형성되었으며 슬개골 외측 지대와 외측 광근의 심한 구축으로 인하여 도수정복이 불가능하였다. 저자들은 선천성 슬개골 탈구 1례에 관하여 슬부의 광범위 외측 유리(release), 대퇴 사두근 중 내측 광근의 전진, 슬개 건 종지부의 내측전이를 이용하여 좋은 수술적 치료 결과를 얻었기에 문헌 고찰과 함께 보고하는 바이다. Congenital dislocation of the patella is a rare condition that can not be reduced without operative treatment.It should be differentiated from recurrent or habitual patella dislocation. We experienced a case of congenital patella dislocation.Five months old male admitted for the extension lag of the knee.Physical examination revealed flexion contracture of the knee, external rotation of the tibia and lateral deviation of the all toes of the ipsilateral foot.Plain knee radiographs revealed no abnormal findings.An ultrasonographic image demonstrated that the patella was dislocated laterally to the lateral femoral condyle.On the operative field, the dislocated cartilaginous patella and lateral femoral condyle seemed to be hypoplastic, and the lateral retinaculum and the vastus lateralis were contracted.Because of tightness of the lateral retinaculum and the vastus lateralis, the dislocated patella failed to be reduced in any efforts of closed manipulation.After the extensive lateral release, the advancement of the vastus medialis and the medial transfer of entire patella tendon, the patella could be relocated within patella groove of the femur. We report a case of congenital patella dislocation that treated by the operative procedure with brief review of literatures

0.1mm 급 우량계 개발에 관한 연구 : LOAD CELL 특성에 관하여 Characterictics of Load Cell

이부용,박병윤 대구효성가톨릭대학교 응용과학연구소 1997 응용과학연구논문집 Vol.5 No.-

The load cell was tested for development of 0.1mm raingage at room temperature for 13 days. Two kinds of load cell was tested. One has a capacity of 120gram with no load, the other has a capacity of 3000gram with 500gram loaded. The results are as follows. 1) The out put of load cell was effected mainly by temperature. 2) The load cell had good ability in measuring the amount of 0.1mm rainfall. 3) The load cell with a capacity of 3000gram didn't show the creep under 500gram loaded during 13 days.