사무직 근로자들의 카드뮴에 대한 노출정도

이경재,김주자,황정호,허지회,김강윤 순천향의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.1

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Cisplatin 병용화학요법시 발생한 오심, 구토에 대한 Ondansetron과 Metoclopramide의 효과에 대한 비교

김미자,국기용,김태원,박유환,김완중,허경,정춘해,홍순표 朝鮮大學校 附設 醫學硏究所 1993 The Medical Journal of Chosun University Vol.18 No.1

Inspite of possible effects for emesis following chemotherapy including cisplatin, nausea and vomiting are the most unpleasant side effects of cancer chemotherapy. None of the currently available antiemetic agents is entirely effective preventing emesis. Ondansetron, a 5-HT(5-hydroxytryptamine)_(3) receptor antagonist, has been shown to be effective antiemetic agent in the control of cisplatin induced emesis. Twenty solid tumor patients who are scheduled to receive cisplatin containing combination chemotherapy participated in a prospectively randomized study to compare the antiemetic efficacy and safety of ondansetron and metoclopramide. Ondansetron was given in dose of 8mg intravenous 30min before cisplatin and then 4hours and 8hours after cisplatin on day 1, and Ⅰ.Ⅴ. every 8hours from day 2 to 5. In the metoclopramide group, metoclopramide was given in dose of 2 ㎎/㎏ intravenous every 8hours from day 1 to 5. The control of emesis was graded in the following way : complete response, no vomiting : major response, 1-2 emetic episodes : minor response, 3-5 emetic episodes : failure, above 5 emetic episodes. Complete or major response of emesis was achieved 10 of 12(83.2%) patients receiving ondansetron and in 5 of 8(62.5%) patients receiving metoclopramide, but effectiveness was not significantly different. Ondansetron was at least as effective as metoclopramide therapy in controlling cisplatin induced emesis. Side effects in ondansetron was less than in Metoclopramide.

성인간호학 교과과정 내용개선을 위한 한국인의 질병분포에 관한 연구 : 일개 대학병원을 중심으로

김조자,이원희,유지수,허혜경,진혜영,최혜경 중앙의학사 1988 中央醫學 Vol.53 No.8

This study was a survey of the distribution of diseases in the Korean people, done to establish a criteria for time alottement for the patient need based theory in the curriculum in Nursing Care of Adult Patients. The methodology used was a descriptive survey of the statistical reports of disease. Data was gathered from the yearly reports from Yonsei University Medical Center, years 1982 to 1987 and the 1986 curriculum for Nursing Care of Adult Patients. Analysis was done by examining the frequency and percentages of diseases in each need category. The results of the study are as follows: 1. In the category of nutrition and elimination need. patents with diseases of the gastrointestinal system made up 1490 % and lectures in this area, 19.18 %. In the category of oxygen need, patients with respiratory diseases made up 13.70 % of the total and patients with cardiovascular diseases, 10.46 % lecture time was 15.07 % of the total. 2. The ratio of the frequency of diseases involving neoplasms, chronicity, emergency, rehabilitation, contagious, parasitic problems when compared to the lecture time allotted for them directly showed that in comparison. the lecture time was short. However, in the present curriculum material related to neoplastic, chronic, emergency and rehabilitation problems is given each need category and so, although. it is difficult to determine the exact frequency distribution, it can be assumed that it is not inadequate. 3. For safety and security needs, that is needs related to diseases of the nervous system and patients with sensory loss, and activity and rest needs, that is patients with diseases of the musculoskeletal system and patients with diseases of the connective tissue, the ratio of lecture time to number of patients showed a higher rate for lecture time. The lecture time for acute trauma and poisoning was lower. The interrelationship between these concepts needs to be reconciled. From this study it can be seen that the ratio of the distribution of patients with diseases related to the need categories and the lecture time for each category are very similar.

암환자의 건강문제 분류를 위한 횡단적 조사연구 : 서울시내 일개 종합병원 중심으로

김조자,이원희,유지수,허혜경,진혜영,최혜경 연세대학교 간호학연구소 1989 간호학 논집 Vol.12 No.1

The impact of cancer on human life has been recognized and the demand for care for the patient with cancer is ever increasing. Yet very little study around these concerns has been reported. The subjects of this study were 388 patients with cancer who were receiving treatment .in the outpatient department of Yonsei University Cancer Center. The study dealt with the health problems experienced while receiving this treatment. The research method used in this study was the structured interview technique using a questionnaire. Data collection was done between Dec. 1. l986 and June 30. 1987. The questionnaire used in this study was a revision of three questionnaires, one developed by D.W. McCaffrey(coping with cancer), one developed by C.A. Morris(self concept as altered by the diagnosis) and one developed by M.J. Yasko(management of symptoms associated with chemotherapy). Content validity was treated with oncologists and oneology nurses & nursing faculty members. The results and recommendation of the study areas follows: 1. Results. 1) Characteristics of the Sample The diagnoses of the subjects were as follow: The most frequent diagnosis was cancer of the stomach(26.5%), followed by breast cancer, lymphoma, rectal / colon cancer and lung cancer. The average age was 48.6 years. There were an equal number of men and women. There were 116(30.4%) subjects who received chemotherapy and surgery for the treatment of their disease of the total number of subjects. 264(69.5%) were treated for less than 1 year, and 116(30.5%) were treated for more than 1 year. The average Length of treatment was 12.7 months. 2) In Summary Health problems were categorized under four areas: physical. emotional, social and economical. The patients with lymphoma and stomach cancer experienced more health problems than any others in this study. According to the age of the patients, those in their 20's complained of physical and emotional problems most frequently and of those in their 30's social-economical concerns were most evident. In female gender. physical and emotional problems were identified more frequently than male patients. And yet male patients indicated greater concern with economic problems than female patients. Regardless of the treatment method or length of treatment health problems in different areas were similar and statistically not significant. However, economic concern was statistically significant(F = 2.52. p< 0.5) in those with receiving a combination of chemotherapy and radiation Marital status and health problems were also statistically significant. That is patients who were divorced, separated or widowed had more physical, psychological and economical problems than those who were married. 2. Recommendations. 1) Since the physical symptoms of nausea / muscle weakness and malnutrition were major health problems, the patient's diet and activity need to be carefully detailed and included in the care plan and further research is needed in order to implement physical, psychological. economical & spiritual interventions. 2) A follow up study should be done using a larger number of subjects and indifferent settings to further validate the health problem checklist for cancer patients.

Ethyl benzoate 合成에 미치는 觸媒의 影響에 對한 小考

김인숙,오세종,유경희,허순자 梨花女子大學校 藥學硏究所 1967 梨花藥學硏究 Vol.- No.8

The concentrated sulfuric acid and hydrogen chloride gas which are strong acid by the Bronsted concepts, have been between benzoic acid and ethyl alcohol. In this paper we have studied about comparing with the yield and rate of the catalytic reactions on above two catalysers.

간호학생이 내린 간호진단의 분류에 관한 일 연구

이원희,김조자,유지수,허혜경,진혜영,최혜경 연세대학교 간호학연구소 1987 간호학 논집 Vol.10 No.1

Nursing diagnosis can improve nurses` efficiency, accuracy, provide an efficient standard for communication among nurses, improve the quality of nursing care, purpose and direction of nursing, and provide a unique dimension to nursing care. But in Korea we are using a nursing diagnosis system, which was developed in the American culture without evaluating vocabulary use or clinical application in the Korean culature. Actually many problems have appeared. Therefore. this research is to review and compare the North American Nursing Diagnosis Association‘s (NANDA) 5th conference on the etiology of nursing diagnosis and nursing diagnosis used in students` clinical practice in relation to how it fits into our culture and educational background. In order for nursing to be more scientfic. we must try to provide more basic data and develop nursing diagnosis. The subject of this research was 127 third year students in Y university for 1 year (1985). After tyey completed adult nursing clinical practice I and II tyey submitted case studies. In these case reports only nusing diagnosis was considered. There were a total of 1,019 nursing diagnoses used by the nursing students. In the data analysis we took the 813 nursing students' nursing diagnoses and fit them into 51 NANDA nursing diagnoses. Five professors from the College of Nursing met together and agreed on the selected the 813 after discussion The selected the 813 nursing diagnoses in the categories of: safety and secruity. nutrition and elimination, activity and rest, oxygen, sex, and' other'. These students' nursing diagnoses were compared with NANDA's etiology of nursing diagnosis by frequency. The research research were as follow ; 1. Among the 813 nursing diagnoses, the nursing diagnosis of 'Comfort, alteration in' was used 155 times (19.1%). This was the nursing diagnosis most frequently used by the students in the case reported. And 23 out of the 51 diagnoses (45%) was found 1 or 2 times and did't use nursing diagnosis in the case studies. 2. Among safety and security needs. many students used the etiology of 'Comfore alteration in : pain', pain and diverse etiology vocabulary. In 'Anxity'. the etiology of threat to or change in health status and knowledge deficit were listed. Among them, knowledge deficit was used 30 times as the etiology of nursing diagnosis. In the category of nutrition and elimination needs most students usually used nursing diagnosis accurately. In the category of activity and rest needs, the nursing diagnoses of activity intolerance, mobility, impaired physical' were confused the etiology of nursing diagnosis by the students. The students did't use many nursing diagnoses in the category of oxygen needs, and did't use the nursing diagnosis of sexual dysfunction. In the category of 'other' nursing diagnoses, "Knowledge deficit' was used many, and the etiology of 51 nursing diagnoses was generally used knowledge deficit. Until now in the nursing diagnosis used by the students, the vocabulary of the etiology of nursing diagosis is diverse. Although all students experience the 5 categor of human need in clinical practice, some of nursing diagnosis was used many but the other wasn't used. One reason is that only the definition of nursing diagnosis was taught in the classroom. No course content related to nursing diagnosis was covered. The nursing diagnosis concept was not taught in depth. second. the NANDA vocabulary is board and the English in interpretation is influenced by cultural factors. Third, among the students' clinical instructors there was difference knowledge and experience in nursing diagnosis. Therefore we believe the situation needs to be evaluated and revise to develop a unified vocabulary. And so that the etiology of nursing diagnosis would be fited into the cultural and educational background in Korea.

쭈쭈가무시병 17예에 대한 임상적 고찰

이요한,김흥식,한욱상,이경숙,허인자,서종호 대한가정의학회 1992 Korean Journal of Family Medicine Vol.13 No.8

Green Community ‘the International Green Island Forum Corporation’ and Birth of Carbon Free Island ‘Gapado’

Kyung-ja Hur 세계환경사회거버넌스학회 2014 World Environment and Island Studies Vol.4 No.2

A Case of Paraneoplastic Limbic Encephalitis Associated with Small Cell Lung Cancer

Ja Young Ryu,Seung Hyeun Lee,Eun Joo Lee,Kyung Hoon Min,Gyu Young Hur,Sung Yong Lee,Je Hyeong Kim,Sang Yeub Lee,Chol Shin,Jae Jeong Shim,Kwang Ho In,Kyung Ho Kang,Se Hwa Yoo 대한결핵 및 호흡기학회 2012 Tuberculosis and Respiratory Diseases Vol.73 No.5

Paraneoplastic limbic encephalitis (PLE) is a rare syndrome characterized by memory impairment, affective and behavioral disturbances and seizures. Among many different neoplasms known to cause PLE, small cell lung cancer (SCLC) is the most frequently reported. The pathogenesis is not fully understood but is believed to be autoimmune-related. We experienced a patient with typical clinical features of PLE. A 67-year-old man presented with seizure and disorientation. Brain magnetic resonance imaging demonstrated high signal intensity in the bilateral amygdala and hippocampus in flair and T2-weighted images suggestive of limbic encephalitis. Cerebrospinal fluid tapping revealed no evidence of malignant cells or infection. Positron emission tomography/computed tomography showed a lung mass with pleural effusion and a consequent biopsy confirmed the diagnosis of PLE associated with SCLC. The patient was subsequently treated with chemotherapy and neurologic symptoms gradually improved.

The protective efficacy of the enterotoxigenic Escherichia coli vaccine candidate by GI24 against neonatal piglet colibacillosis

( Ja Young Moon ),( Won Il Kim ),( Jin Hur ),( Won Kyung Kim ),( Min Su Choi ),( Jae Sam Lim ),( Sung Bok Kim ),( Jeong Sang Cho ),( Yeong Hwan Choi ),( Byoung Joo Seo ) 한국동물위생학회(구 한국가축위생학회) 2017 韓國家畜衛生學會誌 Vol.40 No.4

Enterotoxigenic Escherichia coli (ETEC) strains producing each F4, F5, F6 and F41 fimbriae were lysed by GI24 peptide. The lysate cells were used as ETEC vaccine candidate. This study was carried out to examine whether intramuscular (im) immunization of pregnant sows with the novel vaccine candidate could effectively protect their neonatal piglets against ETEC colibacillosis. All pregnant sows were primed at 11 weeks and were boosted at 14 weeks of pregnancy. Group A sows were im inoculated with PBS. Group B sows were im immunized with 2×10⁹ the mixture. Seral IgG, colostral IgA and IgG titers from group B sows, and seral IgG and IgA levels in group B piglets were significantly higher than those of group A sows and piglets, respectively. After challenge with wild-type ETEC, diarrhea and mortality was not observed in group B piglets. However, diarrhea was observed in 66.7% of group A piglets, and 33.3% mortality was observed. These findings indicate that im immunization of sows with the mixture of the novel vaccine candidate can effectively protect their offspring from ETEC colibacillosis.