노령의 대퇴 전자간 골절 치료에서 압박고 나사못의 안정성 및 유용성

김종오,노권재,윤여헌,고영도,유재두,정준모,방한천,정재학 대한골절학회 2003 대한골절학회지 Vol.16 No.2

목 적: 노령의 대퇴 전자간 골절에서 압박고 나사못의 안정성에 영향을 주는 인자들간의 상관 관계와 골절 양상에 따른 술후 고관절 기능을 평가 및 분석하였다. 대상 및 방법: 압박고 나사를 이용하여 수술적 치료를 시행한 231명의 환자 중 6개월 이상 추시가 가능하였던 60세 이상 84명의 환자들을 대상으로 했다. 방사선적 계측은 압박고 나사못의 활강 길이 및 내반각, 가압 나사 위치, 정복 상태, 원위 골편의 내측 전위를 측정하였으며 술후 기능은 Clawson의 기능 평가표로 하였고 골절 양상에 따라 방사선 계측과 기능 회복과의 상관 관계를 평가하였다. 결 과: 임상 결과는 불안정 골절에서 양호가 10례, 불량이 23례, 안정 골절에서는 양호 40례, 불량이 11례로 안정 골절에서 임상 결과가 좋았고(p<0.001), 압박고 나사 활강은 10 ㎜ 이상일 때 양호가 4례, 불량이 21례, 10 ㎜ 이하에서 양호가 46례, 불량이 13례로 10 ㎜ 이상 활강시에 술후 결과가 불량했다(p<0.001). 다르 방사선적 계측 요인은 결과에 의미있는 차이를 보이지 않았다. 또한, 불안정 골절 중에서 전위 양상 골절의 경우 10㎜ 이상 활강이 12례, 10㎜ 이하 활강이 8례, 분쇄 양상 골절의 경우는 10㎜ 이상이 11례, 10㎜ 이하가 2례로 분쇄 양상의 불안정 골절에서 10㎜ 이상 활강이 의미있게 많았다 (p<0.001). 결 론: 10㎜ 이상의 지연 나사 활강은 고관절 기능 회복 약화를 유발시킬 수 있으며 불안정 골절 분쇄 양상 골절은 이런 지연 나사의 활강이 과도하게 유발될 수 있으므로 불안정 분쇄 양상 골절에서 압박고 나사의 단독 사용은 재고해 보아야 할 것이다. Purpose: To evaluate the relationship between fracture stability and functional results, and analyze the correlation between stability factors and the outcome in intertrochanteric fracture of the elderly. Materials and Methods: Of the 231 patients, 84 patients with age above 60 were able to follow up for minimum 6 months. We measured the sliding length of the lag screw, varus degree, position of lag screw, reduction status and medialization of distal fragment radiologically. The functional outcome of the treatment was evaluated with the Clawson's result classification and we evaluated the correlation between the radiological results of measurement and the functional recovery depending on the Evans fracture classification. Results: There were good results in 40 cases out of 51 stable fractures, and in 10 cases out of 33 unstable fractures (p<0.001). In case of sliding of lag screw more than 10㎜, good results were obtained in 4 cases, and poor in 21. And in case of sliding less than 10㎜, good results were obtained in 46, and poor in 13. (p<0.001).But there was no relationship between other radiologic factors and clinical results. In unstable type, there were 12 cases with lag screw sliding more than 10㎜ and 10 cases with less than 10㎜. In comminuted type, there were 11 cases with lag screw sliding more than 10㎜ and 2 cases with less than 10㎜(p<0.001). Conclusion: The sliding of lag screw more than 10㎜ may result in poor outcome. As in comminuted unstable pattern, sliding of lag screw might be excessive, the use of compression hip screw alone is not good treatment option.

Efficient Control of Human G-CSF Gene Expression in the Primary Culture Cell using a Tet-On Inducible Lentiviral Vector

Kwon, Mo Sun,Koo, Bon Chul,Kim, Young Hye,Chae, Mi Hyun,Kim, Teoan 충남대학교 형질전환복제돼지연구센터 2007 논문집 Vol. No.10

Hyperspectral Imaging and Partial Least Square Discriminant Analysis for Geographical Origin Discrimination of White Rice

Mo, Changyeun,Lim, Jongguk,Kwon, Sung Won,Lim, Dong Kyu,Kim, Moon S.,Kim, Giyoung,Kang, Jungsook,Kwon, Kyung-Do,Cho, Byoung-Kwan Korean Society for Agricultural Machinery 2017 바이오시스템공학 Vol.42 No.4

Purpose: This study aims to propose a method for fast geographical origin discrimination between domestic and imported rice using a visible/near-infrared (VNIR) hyperspectral imaging technique. Methods: Hyperspectral reflectance images of South Korean and Chinese rice samples were obtained in the range of 400 nm to 1000 nm. Partial least square discriminant analysis (PLS-DA) models were developed and applied to the acquired images to determine the geographical origin of the rice samples. Results: The optimal pixel dimensions and spectral pretreatment conditions for the hyperspectral images were identified to improve the discrimination accuracy. The results revealed that the highest accuracy was achieved when the hyperspectral image's pixel dimension was $3.0mm{\times}3.0mm$. Furthermore, the geographical origin discrimination models achieved a discrimination accuracy of over 99.99% upon application of a first-order derivative, second-order derivative, maximum normalization, or baseline pretreatment. Conclusions: The results demonstrated that the VNIR hyperspectral imaging technique can be used to discriminate geographical origins of rice.

내시경적 결찰요법으로 치유한 위 혈관이형성증 1 예

김영호,이연수,김규식,김영관,김재권,이영록,조성구,박상모,구소영 대한소화기내시경학회 1999 Clinical Endoscopy Vol.19 No.3

Gastric angiodysplasia may be responsible for up to 2% to 6% of upper gastrointestinal bleeding. Moreover, gastric angiodysplasia may be particularly difficult to treat and is usually associated with a high rebleeding rate. Bleeding due to gastric angiodypsplasia is usually treated by various endoscopic approaches, including argon and Nd:YAG laser photocoagulation, monopolar or biopolar electrocoagulation, heater probe, or injection. Associated complications of these methods, however, such as perforation, acute bleeding during the procedure, or delayed massive hemorrhage have been reported. Recently a few reports have been suggested that endoscopic ligation therapy is a safe, effective treatment for gastric angiodysplasia. A 70-year-old man, who had undergone subtotal gastrectomy for perforation of a duodenal ulcer for 20 years, was admitted due to melena and dizziness persisting for 1 week. A gastroscopy revealed a single angiodysplasia with active bleeding just above the anastomotic site of the remnant stoach. Endoscopic ligation therapy was performed successfully and the bleeding stopped immediately after endoscopic ligation. Since then, no recurrence of bleeding has been reported to date.

견인방법에 의한 PEG 제거 후에 발생한 대량 출혈 1예

김재권,김영관,이영록,박상모,조성구,구소영,이연수,최지용,김현승,김영호 大韓消化器內視鏡學會 1999 Clinical Endoscopy Vol.19 No.부록2

최근 국내 유입 Vibrio cholerae균 및 1995년도 국내 집단 발생 콜레라의 역학적 양상

김호훈,신영학,강연호,유천권,박미선,김동술,유재연,전정훈,이복권,박기덕,김동진,정태화,이종구,박기동,김상순,이동모,김문식,조병륜 대한감염학회 1996 감염 Vol.28 No.6

목적 : 1992년 이후 국내에 유입, 확인되는 V. cholerae 균은 현격한 증가 추세를 보이고 있으며, 1995년도 국내 집단 발생 콜레라의 역학적 양상이 종래의 경우와 상이한 바 있어 최근의 콜레라균 유입상황과 국내 역학적 특성을 정리하여 향후의 방역 대책에 참고로 하기 위하여 본 연구를 시행하였다. 방법 : 국내 유입 V. cholerae 균은 세균학적 방법에 의해 1986-1995년 사이에 확인된 균주를 대상으로 분석하였고, 국내 집단발생 콜레라는 1995년도에 내국인 거주자에게서 진성 콜레라 환자로 구명된 환자를 대상으로 역학적 양상을 살펴보았다. 결과 : 국내 유입 V. cholerae균은 1992년 이후 1995년 사이에 계절과 무관하게 뚜렷한 증가 추세를 보였다. 1995년도 콜레라 국내 집단 발생의 역학적 양상은 초발 환자가 인지되면서 단기간 사이에 지역적 연고가 없는 다양한 지역에서 콜레라 환자 발생이 확인되었다. 환자 발생 지역 내에서는 비교적 소규모 환자 발생에 그쳤고 진성 콜레라 환자로 확인된 환자 중 사망자는 없었으며 남성에서 여성보다 발병율이 높았다. 결론 : V.cholerae O1균의 국내 유입이 최근 현격히 증가되었고, 1994년에는 V. cholerae O139균의 국내유입이 처음으로 확인되었다. 콜레라 환자의 국내 집단 발생 위험은 1992년 이후 증가되었으며 1995년도의 집단 환자 발생은 지역적 연고가 없는 다양한 지역에서 비교적 단기간에 사망자 없이 소규모의 환자 발생양상을 보였다. Background: Imported Vibrio cholerae strains have increasingly been found since 1992 and the pattern of recent cholera epidemic outbreak in Korea showed a little difference from that of former epidemic outbreak. Methods: We had collected suspected V. cholerae isolates from Quarantine Stations or Public Health Laboratories, which were identified as V. cholerae O1 or O139. Epide miological analysis was made on the base of field surveys. Results: During the period from 1986 through 1995, 138 V. cholerae strains were imported. Nearly 85.5% of the strains (118 strains) were imported within recent 4 years from 1992 to 1995. One hundred and twenty-eight strains were E1 Tor-Ogawa type V. cholerae O1, 6 strains were V. cholerae O139 and 4 strains were E1 Tor-Inaba type V. cholerae O1. Of 138 strains, 71 strains were isolated from the airplane toilet swab and 67 strains from the passengers who entered into Korea after international travel. From 1993 to 1995, 101 strains were imported from the Southeast Asian countries; including Thailand(65), Indonesia(17), Philippines(10), Hongkong(6) Singapore(2) and Vietnam(1). During the cholera epidemic in 1995, 68 patients with V. cholerae O1 (E1 Tor-Ogawa) were found. Oneset of the index-case occurred on August 26th and the last on September 13th. Geographically it occurred in Incheon city(25), Chungcheongnam do(25), Kangwon do(6), Kyungsangbuck do(5), Kyunggi do(4), Daejeon city(2) and Pusan city(1). Of total 68 cases, 39 were male. Cases were found in all age groups, but it was more common in elderly groups. During the epidemic, E1 Tor-Ogawa type V. cholerae O1 strains were also isolated from the coastal sea water of Kanghwa kun where the epidemic outbreak occurred. Conclusions: In Korea, the imported V. cholerae O1 and V. cholerae O139 strains have increasingly been found without seasonal variation since 1992. Cholera epidemic outbreak in 1995, occurred simultaneously at many different local areas within a short period without mortality.

Analysis of current drift on p-channel pH-Sensitive SiNW ISFET by capacitance measurement

Kim, Sihyun,Kwon, Dae Woong,Kim, Sangwan,Lee, Ryoongbin,Kim, Tae-Hyeon,Mo, Hyun-Sun,Kim, Dae Hwan,Park, Byung-Gook ELSEVIER 2018 CURRENT APPLIED PHYSICS Vol.18 No.supp

<P>The mechanism of drift effect in pH-sensitive silicon nanowire (SiNW) ion sensitive field effect transistor (ISFET) is comprehensively studied by measuring the time-dependent drain current (I-D) and the gate capacitance (C-G) under different liquid-gate biases (V(LG)s) and pH levels. It was revealed that the origin of the current drift can be divided into three different mechanisms; the bulk ionic diffusion in sensing insulator, the chemical modification of insulator surface, and the oxide etch process induced by hydroxide (OH-) ion. Based on the V-LG/pH dependency of current drift and the transient C-G variation, it is clearly recognized that the drift of n-type SiNW (n-SiNW) ISFET results from H+ thorn diffusion in the insulator, whereas that of p-type SiNW (p-SiNW) ISFET is caused by temporal chemical modification (hydration) of the insulator, along with the oxide thickness (t(ox)) reduction by OH- ions. (C) 2017 Elsevier B.V. All rights reserved.</P>

Zonal Responsiveness of the Human Intervertebral Disc to Bone Morphogenetic Protein-2

Kim, Hyang,Lee, Jeong-Uk,Moon, Seong-Hwan,Kim, Hyung-Chan,Kwon, Un-Hae,Seol, Nam-Hun,Kim, Ho-Joong,Park, Jin-Oh,Chun, Heoung-Jae,Kwon, Il-Keun,Lee, Hwan-Mo Lippincott Williams Wilkins, Inc. 2009 1528-1159) Vol.34 No.17

STUDY DESIGN.: In vitro experiment using bone morphogenetic protein-2 (BMP-2) and cells from the nucleus pulposus (NP), transitional zone (TZ), and anulus fibrosus (AF) of the human intervertebral disc (IVD). OBJECTIVE.: To demonstrate the differential effect of BMP-2 on DNA synthesis, proteoglycan synthesis, and osteocalcin mRNA expression in human IVD cells from the NP, TZ, and AF, respectively. SUMMARY OF BACKGROUND DATA.: BMP-2 has been proven to be effective in stimulating proteoglycan synthesis in articular chondrocytes and IVD cells from the NP. Nevertheless, the effect of BMP-2 on cells from different regions of the IVD has not yet been thoroughly elucidated. METHODS.: Human IVDs were harvested from surgical disc procedures and tissue from the NP, TZ, and AF was obtained. Disc tissue was enzymatically digested, and IVD cells were cultured three-dimensionally in alginate beads. Then IVD cell cultures from the NP, TZ, and AF were exposed to BMP-2. DNA synthesis and newly synthesized proteoglycan were measured. Reverse transcription-polymerase chain reaction for mRNA expression of bone sialoprotein, DLX5, osteocalcin, and collagen type I, was performed. RESULTS.: Cells from the AF responded to BMP-2 with mitogenesis. There was no significant increase in DNA synthesis in cultures from the NP and TZ treated with BMP-2. Only cells from the NP showed a significant increase in newly synthesized proteoglycan in response to BMP-2. IVD cells from all zones demonstrated no significant expression of bone sialoprotein, DLX5, osteocalcin mRNA after treatment with BMP-2. CONCLUSION.: BMP-2 clearly exerted a mitogenic effect on AF cells, and stimulated proteoglycan synthesis in NP cells. However, BMP-2 did not have an osteogenic effect in any IVD region. Taken together, these results confirm that BMP-2 can be used as an anabolic agent for mitogenesis in AF cells and NP cell matrix regeneration without the possibility of osteogenesis.

Effect of probiotic mix (<i>Bifidobacterium bifidum, Bifidobacterium lactis, Lactobacillus acidophilus</i>) in the primary prevention of eczema: a double-blind, randomized, placebo-controlled trial

Kim, Ji Yeun,Kwon, Jung Hyun,Ahn, So Hyun,Lee, Sang Il,Han, Young Shin,Choi, Young Ok,Lee, Soo Young,Ahn, Kang Mo,Ji, Geun Eog Blackwell Publishing Ltd 2010 Pediatric allergy and immunology Vol.21 No.2

<P>Kim JY, Kwon JH, Ahn SH, Lee SI, Han YS, Choi YO, Lee SY, Ahn KM, Ji GE. Effect of probiotic mix (<I>Bifidobacterium bifidum, Bifidobacterium lactis, Lactobacillus acidophilus</I>) in the primary prevention of eczema: a double-blind, randomized, placebo-controlled trial.Pediatr Allergy Immunol 2010: 21: e386–e393.© 2009 John Wiley & Sons A/S</P><P>Controversy exists regarding the preventive effect of probiotics on the development of eczema or atopic dermatitis. We investigated whether supplementation of probiotics prevents the development of eczema in infants at high risk. In a randomized, double-blind, placebo-controlled trial, 112 pregnant women with a family history of allergic diseases received a once-daily supplement, either a mixture of <I>Bifidobacterium bifidum</I> BGN4, <I>B. lactis</I> AD011, and <I>Lactobacillus acidophilus</I> AD031, or placebo, starting at 4–8 wks before delivery and continuing until 6 months after delivery. Infants were exclusively breast-fed during the first 3 months, and were subsequently fed with breastmilk or cow’s milk formula from 4 to 6 months of age. Clinical symptoms of the infants were monitored until 1 yr of age, when the total and specific IgE against common food allergens were measured. A total of 68 infants completed the study. The prevalence of eczema at 1 yr in the probiotic group was significantly lower than in the placebo group (18.2% vs. 40.0%, p = 0.048). The cumulative incidence of eczema during the first 12 months was reduced significantly in probiotic group (36.4% vs. 62.9%, p = 0.029); however, there was no difference in serum total IgE level or the sensitization against food allergens between the two groups. Prenatal and postnatal supplementation with a mixture of <I>B. bifidum</I> BGN4, <I>B. lactis</I> AD011, and <I>L. acidophilus</I> AD031 is an effective approach in preventing the development of eczema in infants at high risk of allergy during the first year of life.</P>

The treatment of coolant wastewater of rolling plate process by High Gradient Magnetic Separation

Kim, Tae-Hyung,Ha, Dong-Woo,Kwon, Jun-Mo,Sohn, Myung-Hwan,Baik, Seung-Kyu,Oh, Sang-Soo,Ko, Rock-Kil,Kim, Ho-Sup,Kim, Young-Hun,Park, Seong-Kuk The Korean Society of Superconductivity and Cryoge 2009 한국초전도저온공학회논문지 Vol.11 No.4

This study introduced wastewater treatment method by High Gradient Magnetic Separation (HGMS). HGMS treatment was high efficient method for various industrial wastewaters. The system is currently research state, but we have surveyed commercialize the technology for industry. In rolling plate process, coolant wastewater was recycled by sedimentation and sand filter system. It needs several large reservoirs and long time to remove suspended solid (SS) like metal fines and iron oxide in hot rolling plate making process. If removing rate of suspended solid in rolling coolant wastewater is improved by using HGMS system, the productivity of working process can be increased and the area of reservoir can be reduced. We manufactured high temperature superconducting HGMS system that had a purpose to treatment of coolant wastewater in rolling plate process. We fabricated the prototypes of magnetic matrix filter consisting of stainless steel 430 mesh, which is a core component in the magnetic separation system, In our basic preliminary experiment using HGMS system, it has been clear that the fine paramagnetic particles in the coolant wastewater obtained from rolling plate process of POSCO can be separated with high efficiency.