정상과 갑상선 종양조직에서 사람 IGF-I 유전자의 발현

김성운,장현하,박상미,김덕윤,우정택,양인명,김진우,김영설,김광원,고석환,홍성화,최영길 경희대학교 유전공학연구소 1993 遺傳工學論文集 Vol.5 No.-

Many of the growth-promoting properties of growth hormone(GH) are mediated by insulin-like growth factor-I(IGF-I), a highly conserved circulating 70-amino acid peptide. Recent studies have shown that multiple mechanisms influence IGF-I gene expression, including transcription from two promoters, alternative RNA splicing, and variable polyadenylation. In thyroid tissue, thyroid stimulating hormone(TSH) and IGF-I are the most possible candidates for follicular cell proliferation and hypertrophy. Actually IGF-I had autocrine and paracrine effect for tissue growing. We prepared thyroid tumor tissue mRNAs using single step method for detecting IGF-I levels according to different tissues, i.e., thyroid adenoma or papillary thyroid carcinoma. We used Northern blot analysis for IGF-I mRNA and RNase protection assay (RPA) for IGF-I transcription start sites. For Northern blot, we used whole human IGF-I cDNA as a DNA probe and for RPA, we used IGF-I exon 1 containing noncoding promoter 1 as a riboprobe. We got good RNA bands from Northern blot analysis around 1 kb (IGF-IA) and 7.5 kb (IGF-IB) region. To clarify the amount of both IGF-IA and IB mRNAs, we measured autoradiographied signal of IGF-I mRNAs bands using densitometer. In IGF-IA signals, there's no change among liver and thyroid tissues, but in case of IGF-IB mRNA bands, the signal was markedly increased in thyroid carcinoma tissues than that of normal thyroid tissue (85% vs 14%). In the study of RPA, all thyroid tissues used the same transcription start sites as those of liver's. We concluded that that this different regulation of IGF-I mRNA was originated from tissue specificity. That meant some tissue specific transcription factor/s were related to tissue IGF-I expression.

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1994)

김재홍,안진균,정성재,김영태,김중환,김시영,이석종,이홍렬,서호석,김경훈,권혁진,정우권,고우석,이용석,안필수,오준규,오용섭 대한화학요법학회 1996 대한화학요법학회지 Vol.14 No.1

Background : In recent years gonorrhoea has been panendemic and remains one of the most common Sexually Transmitted Diseases in the world, especially in developing countries. Objective & Method : For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria Gonorrhoeae(PPNG), Ive have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1994, 168 strains of N. gonorrhoeae were isolated, among which 109 (64,9% ) were PPNG. Conclustion : Our results suggests that the prevalence of PPNG in Seoul is still increasing.

심한 골병변으로 발현된 기능성 낭종성 부갑상선 선종

전숙,김영희,박지영,고관표,박철영,김덕윤,우정택,김성운,김진우,김영설,고석환 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.2

낭종성 부갑상선 선종과 심한 골병변을 동반한 부갑상선 기능항진증은 매우 드문 질환으로서, 저자들은 양측 고관절의 통증을 초기 주소로 내원한 환자에서 고칼슘혈증과 부갑상선 호르몬 증가, 골병변의 방사선적 소견을 통해 부갑상선 기능항진증을 진단하고, 경부 초음파와 컴퓨터 단층 촬영, 부갑상선 스캔검사 및 수술중 부갑상선 낭종액 검사 등을 통해 기능성 부갑상선 낭종의 한 종류인 낭종성 부갑상선 선종을 진단하고 수술적 제거를 통하여 정상화된 1예를 경험하였다. A cystic parathyroid adenoma is rare. A case of primary hyperparathyroidism, with the cystic formation of a parathyroid adenoma and a severe bony lesion, is reported. A 52-year-old male was admitted due to pain in both hips and for evaluation of hypercalcemia. The plasma level of the intact parathyroid hormone (iPTH) was elevated to 1424 pg/mL. Ultrasonography and the computed tomography revealed a parathyroid cyst on the left thyroid lower pole. Parathyroid scintigraphy detected a parathyroid adenoma. A radiograph showed a subperiosteal bone resorption on the phalanges, and a brown tumor (osteitis fibrosa cystica) on the femur shaft was noted. A surgical excision of the parathyroid adenoma was performed. The PTH level in the cystic fluid was increased. A histological examination confirmed a cystic parathyroid adenoma. The PTH level was normalized after the operation (J Kor SOC Endocrinol 18:214-220, 2003).

재배열된 GaAs(001)표면의 전자 구조

金玟機,吳榮基,朴辰鎬,趙和錫 嶺南大學校 基礎科學硏究所 1990 基礎科學硏究 Vol.10 No.-

We investigated the atomic structure and the density of state of the rearrangered GaAs(001) surface from the surface layer to the third layer. The geometry is calculated by the energy minimization by the described formula. The result is that displacement of the first layer is asymmetric with no twist, the dimer angle is about 7˚.

불소함유치약의 인공우식 법랑질에 대한 도포효과

김낙현,홍석진 전남대학교 치과대학 1990 전남치대논문집 Vol.2 No.1

The purpose of this study was to compare the anticarious effect by kinds of fluoride - containing dentifrices and kinds of fluorides contained in dentifrices. The author randomly selected 9 different fluoride containing dentifrices which were saled in Korea. Bovine enamel slabs involved early carious lesions were treated with flouride - containing dentifrices, NaF and SMFP solution by pH-cycling method. Surface hardness and fluoride contents of bovine enamel were measured for dentifrice treated groups in comparison with fluoride treated groups control group. A comparative study of the obtained results led to the following conclusions. 1. The fluoride contents of Perioe doctor^ⓡ and Amore ion^ⓡ groups were higher than that of the other fluoride - containing dentifrice groups. But that of Close up^ⓡ was lower than of others but Acacia^ⓡ group. 2. The dentifices containing sodium monofluorophosphate and sodium fluoride were higher on fluoride content than those containing NaF, SMFP, respectively. 3. Fluoride - containing dentifices were more effective on enhancing surface hardness than control gourp. 4. NaF solution was more effective on fluoride content than SMFP solution. Two fluoride solutions were the same effect on surface hardness, but they were more effective on surface hardness than control group.

寒中콘크리트施工에 대한 韓國의 地域條件에 관한 硏究 : 寒中콘크리트의 初期養生 및 施工條件의 比較分析 Comparative analysis of early curing conditions of winter concerting

金武漢,尹錫天,宋寅春,鄭秀永,韓辰錫 충남대학교 공업교육연구소 1981 論文集 Vol.4 No.1

In this study it is the aim to analize the climate conditions influencing to the early frost damage of concrete such as temperature, precipitation, wind, and snow in winter seasons, and this study provided the basical reasonable data as a guideline for preparation of Korean Architectural Standard Specifications for the building activities throughout the winter seasons in the future.

발전기 안정화 운전을 위한 PSS 파라미터 선정

김창석,황석영,서진연,정삼용 조선대학교 동력자원연구소 1995 動力資源硏究所誌 Vol.17 No.1

This paper describes the proper selection method of the power system stabilizer(PSS) parameter for stabilizing operation of a synchronous machine which connected to infinite bus by using pole assignment method. The purpose of PSS is to enhance the damping capability at small frequency oscillation (0.5∼2㎐). It can be achieved by moving the real part of critical eigenvalue (pole) on left side of s-plane. The PSS parameter was selected by using the proposed method to match with a pre-assigned pole associated with poorly damped swing mode. This method has been studied to synthesize the PSS on Yong-Gwang N/P. And the simulation results show that the selected parameter by using proposed method is effective for dynamic and transient stability of power system.

천연 산호와 모조 산호의 보석학적 특성

김경진,최석원 公州大學校 基礎科學硏究所 1998 自然科學硏究 Vol.7 No.-

본 연구에서는 천연산호와 모조산호의 광물학적 보석학적 특징을 비교 분석하여 천연산호와 모조산호를 구별할 수 있는 기초자료를 얻는데 그 목적이 있다. 천연산호와 모조산호의 광물학적, 보석학적 특징을 알아보기 위해 색, 광택, 투명도, 조흔색, 굴절률, 경도, 염산반응, 형광반응, 비중, 편광현미경 관찰, 전자현미경 관찰, 화학분석 및 X선회절 분석 등의 실험을 하였다. 그 결과, 천연산호의 주성분은 CaCO3이고, 방해석 결정구조를 가지고 있으며, 모조산호들은 탄산염 또는 기타 물질에 색소를 넣어 제조하였음을 알 수 있다. 그리고 천연 산호와 모조 산호는 X선 회절 분석에 의해서도 구별되지만 조흔색, 비중, 굴절률, 염산반응, 형광반응 등과 같은 몇몇 간단한 일반적인 실험을 통해서도 서로 비교되어 감정이 가능하다. It is significant to get the base data for the purpose of distinguishing natural coral from imitation coral by comparing about gemmological and mineralogical characters in this study. Color, luster, transparency, streak color, refractive index, hardness, chemical reaction, ultraviolet fluorescence, specific gravity, observation of microscope and XRD analysis were conducted for identification of natural and imitation coral. As a result, natural coral has usually CaCO3 composition and calcite structure. But, it is known that imitation coral impregnate calcic material with pigment. And they were distinguished also from not only XRD analysis but also a few simple experiments like streak color, specific gravity, refractive index, chemical reaction and ultraviolet fluorescence.

자외선 A-1으로 치료한 사마귀양 균상 식육종 1예

서기석,이진우,김상태 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.1

Verrucous mycosis fungoides is very rare variant of cutaneous T cell lymphoma that manifests verrucous crusted lesion and may be clinically misdiagnosed as a wart, deep fungal infection or atypical mycobacterial infection. If it is located acrally, it might then be better classified as mycosis fungoides palmaris et plantaris or pagetoid reticulosis. We report a case of solitary verrucous mycosis fungoides on the left knee in 25-year-old woman successfully treated ultraviolet A-1 phototherapy.

춘천산 연옥을 이용한 옥(玉)광물의 특성에 관한 연구

김경진,최석원 공주대학교 기초과학연구소 2000 自然科學硏究 Vol.9 No.-

우리나라에서 옥은 아름답고 귀한 모든 돌을 의미한다. 그러나 전통적인 옥광물로는 주로 경옥, 연옥, 사문석옥만을 지칭한다. 옥광물들은 외관 특징은 유사하지만 서로 다른 화학성분과 물리적 성질을 가지고 있다. 경옥, 연옥, 사문석 옥은 비중, 굴절율, 경도 등의 몇몇 간단한 실험을 통해 감정할 수 있다. 춘천산 연옥의 보석학적 및 광물학적 특성을 알아보기 위해 색, 광택, 투명도, 조흔색, 굴절률, 경도, 비중을 측정하였으며, 편광현미경 관찰, 주사전자현미경 관찰 및 화학분석 등의 실험을 하였다. 춘천산 연옥은 화학성분이 Ca₂Mg□(Si₄O□)₂인 tremolite이며, 보석학적 및 광물학적 특성은 일반적인 연옥에 비해 경도가 높아 내구성이 뛰어나다. Ok means beautiful and precious gemstone in Korea. There are jadeite, nephrite and serpentine in traditional Ok. These three kinds are nearly the same in appearance such as color, luster, transparency though they are different in chemical composition and physical character. They can be distinguished by a few simple experiments like specific gravity, refractive index, hardness. To find out gemological and mineralogical character of Chuncheon nephrite, color, luster, transparency, streak color, refractive index, hardness, specific gravity, observation of polarizing microscope, SEM and EDS analysis are examined. As a result of it, Chuncheon nephrite is tremolite composed of Ca₂Mg□(Si₄O□)₂. Compared with gemological and mineralogical character of general nephrite, Chuncheon nephrite is harder and durable than general nephrite.