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노인 인구에서 신경인지기능저하와 혈청 지질농도와의 상관성
유영선,최석주,정성수,김지은,윤성욱,전동욱,백준형,박성우,이정구,추일한,김영훈 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.6
Objectives : In this study, the authors evaluated the correlation between eurocognitive impairments and serum lipids levels among Korean elderly over the age of 65. Methods : A total of 609 elderly individuals participated in this study. Screening for cognitive impairments were carried out using the Mini-Mental Status Examination-Korean version (MMSE-KC). There were 197 subjects above 1.5SD Of MMSE- KC and they were evaluated using the Korean versions of the Consortium to Establish a Registry for Alzheimer's Disease (AD) (CERAD-KC) and Geriatric Depression Scale (GDS-K). Results : There was a correlation between old age/low levels of education and AD (p<0.05, P<0.01). There was an inverse correlation between the serum level of total cholesterol and the word list recognition test scores. The serum levels of LDL cholesterol were inversely correlated with the scores on the constructional praxis test, word list recall test and word list recognition test. Inverse correlations between the serum level of triglyceride and scores on the word list recall test and word list recognition test were also observed. Conclusion : There were inverse correlations between the serum levels of lipids and language/memory function in subjects with AD.
Ji Hyun Baek,Ji Sun Kim,Andrew A,Nierenberg,Hong Jin Jeon,Kyung Sue Hong 대한신경정신의학회 2020 PSYCHIATRY INVESTIGATION Vol.17 No.11
Objective In this study, we aimed to determine clinical correlates of false positive assignment (FPA) on commonly used bipolar screening questionnaires. Methods A retrospective chart review was conducted to a total of 3885 psychiatric outpatients. After excluding patients who have bipolar spectrum illnesses, patients who were assigned as having hypomania on the mood disorder questionnaire (MDQ) or the hypomania checklist-32 (HCL-32) were identified as patients who had FPA. Psychiatric diagnoses and severity of emotional symptoms were compared between patients with and without FPA. Results Patients with FPA on the MDQ showed significant associations with presence of major depressive disorder, generalized anxiety disorder, and alcohol-use disorder, while patients with FPA on the HCL-32 showed associations with presence of panic disorder and agoraphobia. FPA on the MDQ was also associated with greater emotional symptoms and lifetime history of suicide attempts. Logistic regression analysis showed that male sex, younger age, presence of alcohol-use disorder, and severity of depression and obsessive-compulsive symptoms were significantly associated with FPA on the MDQ. Conclusion The FPA for the MDQ was associated with clinical factors linked to trait impulsivity, and the FPA for both the MDQ and the HCL-32 could be related to increased anxiety.
Predictors of Silicone Tube Intubation Success in Patients with Lacrimal Drainage System Stenosis
Ji Sun Baek,Saem Lee,Jung Hye Lee,Hye Sun Choi,Jae Woo Jang,Sung Joo Kim 대한안과학회 2016 Korean Journal of Ophthalmology Vol.30 No.3
Purpose: To evaluate prognostic factors affecting silicone tube intubation outcomes in Asian patients with lacrimaldrainage system stenosis. Methods: A retrospective review was conducted on the medical records of 822 patients (1,118 eyes) who hadundergone silicone tube intubation to treat lacrimal drainage system stenosis between January 2011 andDecember 2012. Patients were divided into two groups: a success group and a failure group. Success wasdefined as the disappearance of epiphora symptoms, normalization of tear meniscus height, and the easypassage of fluid without resistance on the postoperative syringing test. Patient and ocular parameters werecompared between the success and failure groups. Results: A total of 994 eyes of 727 patients were included in analyses. Patients had a mean follow-up period of34.11 ± 18.70 weeks. Silicone tube intubation was successful in 67.2% of participants. Significant differencesbetween the success and failure groups were found for age (p < 0.001), history of ipsilateral facial palsy (p= 0.028), follow-up period (p < 0.001), and degree of passage on the preoperative syringing test (p = 0.001). Only age (p < 0.001) and degree of passage on the preoperative syringing test (p = 0.002) remained significantlyassociated with silicone tube intubation success in multivariate analysis. Conclusions: Age was negatively associated with silicone tube intubation success in patients with lacrimaldrainage system stenosis. The success rate was higher in patients who showed easy passage of fluid withoutresistance on the preoperative syringing test. These factors should be considered by surgeons planning siliconetube intubation in patients with lacrimal drainage system stenosis.
( Ji Sun Baek ),( Wan Ho Lee ),( Woo Dae Kang ),( Seok Mo Kim ) 대한산부인과학회 2016 Obstetrics & Gynecology Science Vol.59 No.1
Objective The aim of this study is to assess the effectiveness of oral progestin treatment in women diagnosed with complex atypical hyperplasia (CAH) or grade 1 endometrial cancer (G1EC), who desire to preserve their fertility, as alternative treatment to a hysterectomy. Methods We reviewed the medical records of women younger than 45 years old that had been diagnosed with CAH or G1EC, who expressed a desire to preserve their fertility using alternative treatment at our institution. Women without evidence of myometrial invasion on pelvic magnetic resonance imaging scans were included. The study period was between 2004 and 2014. Endometrial biopsies were taken at follow-up appointments. Results We identified 31 young women with CAH or G1EC. The median age was 33 years old (range, 20 to 41), and the median period of time undertaking the treatment was 5 months (range, 1 to 12). Twenty-three patients (74.2%) achieved complete remission (CR; median time to CR was 3 months; range, 1 to 22), 16 patients (88.9%) with CAH and 7 (53.8%) with G1EC achieved CR. 6 patients (26.1%) who had achieved CR, had recurrence of the disease (median time from CR to recurrence was 12.5 months; range, 4 to 18). Eight patients (25.8%) finally underwent a hysterectomy. Conclusion Oral progestin therapy is an alternative treatment for women with CAH or G1EC who desire fertility preservation. However, more prospective studies are needed for standard progestin regimen. Also, there still remains a risk of disease progression and recurrence. Therefore, close follow-up is important during treatment and after CR. In addition, a hysterectomy is recommended as a definitive treatment after completion of childbearing.