痙攣性 腦-電氣衝擊에 의한 생쥐 視床下部 및 腦幹의 Monoamine 代謝의 變動에 관한 硏究

全普權,申炅浩,朴靑山,李明雅 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.4

Male ICR mice ranging from 15g to 20g were given a single ECS(1-ECS : 13mA, 1sec,100cps) daily or on alternate days for 10 days(5-ECS). The contents of monoamine metabolites in the hypothalamus and the brain stem(BS) were measured 10, 30. and 60 min after ECS-administration as well as before ECS. Contents of monoamine metabolites in the HT and the BS, such as 5-HIAA, MHPG, DOPAC and HVA increased rapidly after 1-ECS or 5ECS and then came down to the pre-ECS values. However, their increases induced by 5-ECS were significantly smaller than those by 1-ECS except the tedious increase of the hypothalamic HAV content. 5-HIAA and MHPG in the HT decrease significantly by the 4the administration of ECS in the course of the 5-ECS treatment. These results suggest that the repeated treatment of ECS may decrease the turnover rates of serotonin and noradrenaline in the hypothalamus.

림프종 환자에서의 갈륨, TI-201 그리고 Tc-99m MIBI 섭취의 비교

천경아,조인호,원규장,이경희,이형우,현명수,이재태,이규보 영남대학교 의과대학 2002 Yeungnam University Journal of Medicine Vol.19 No.2

Purpose; Ga-67 scintigraphy has been used for the evaluation of tumors, especially lymphoma. Recently, Tl-201 and Tc-99m MIBI were also used to tumor imaging. Tl-201 and Tc-99m MIBI had better physiologic characteristics than Ga-67, so we studied 32 biopsy proven lymphoma patients (male 24, female 8, mean age 46 years) with Ga-67, Tl-201 or Tc-99m MIBI and compared the scan findings. Materials and Methods: Twenty-three of 32 patients were injected 74-111 MBq (2-3 mCi) of Tl-201, before chemotherapy and imaged with dual-headed SPECT (Prism 2000, Picker, USA) at 30 minutes after injection. Delayed images were obtained after 3 hr in 8 patients. Twenty seven of 32 patients were injected 740 MBq (20 mCi) of Tc-99m MIBI and imaged at 30 minutes after injection. 111-185 MBq (3-5 mCi) of Ga-67 was injected in 12 patients and imaged at 48 and 72 hours after injection. Twenty eight patients were diagnosed as non-Hodgkin's lymphoma and others were Hodgkin's lymphoma. Results: Twenty patients were positive on Tl-201 scan and 3 patients showed negative findings. One of these 3 patients, Tc-99m MIBI and Ga-67 scan were positive. Twenty two patients were positive on Tc-99m MIBI scan and 5 patients showed negative findings. One of these 5 patients, Tl-201 was positive and 2 were positive on Ga-67 scan. Ten of 12 patients showed positive findings on Ga-67 scan. The sensitivity of these agents were 83.3%, 87.0% and 81.5% for Ga-67, Tl-201 and Tc-99m MIBI, respectively. The sensitivity was highest in Tl-201 scan, but there were no significant differences among three tests. In this study, there was no significant difference of uptake ratios between early and delayed images of Tl-201. Conclusion: Scintigraphy with Tl-201 and Tc-99m MIBI in lymphoma patients have similar sensitivity with Ga-67.

Interleukin-1β에 의한 사람 정상 코점막 상피세포의 분비기능 및 형태 변화

김경수,윤주헌,최진우,이정권,문형진,박준호,전희선 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.11

만성 간염과 간경변증의 고해상 초음파 소견

정덕환,구봉식,최종철,박병호,남경진 동아대학교의과대학 1997 동아의대학술지 Vol.9 No.2

저신장 소아에서 성장호르몬 치료가 두개안면필 성장에 미치는 영향

정성호,김진욱,박용훈,황충주,이희경 대한치과교정학회 2010 대한치과교정학회지 Vol.40 No.4

Objective: The purpose of this study was to analyze the effect of growth hormone treatment (GHT) on craniofacial growth in children of short stature. Methods: Nineteen untreated children of short stature were referred from the Pediatric Department, Yeungnam University Hospital as a subject group. All subjects had lateral cephalograms taken before, after 1 year and after 2 years of growth hormone treatment. As a reference group, we selected 19 normal children with paired sampling who matched the subjects' age and sex, from the Department of Orthodontics, Kyungpook National University Hospital. Results: Before GHT, anterior cranial base length and upper posterior facial height, posterior total facial height, mandibular ramus length, and mandibular corpus length were significantly smaller in the reference group. In angular craniofacial measurements, saddle angle and mandibular plane angle were larger. SNA and SNB were smaller in the reference group. After two years of GHT, growth hormone accelerated growth in several craniofacial components. The posterior total facial height, the anterior, posterior cranial base length, and the mandibular ramus length were increased. And the difference in mandibular plane angle and ANB values compared with the reference group was decreased. Conclusions: GHT over 2 years leads to a craniofacial catch-up growth tendency, which is pronounced in interstitial cartilage and condylar cartilage. 저신장이란 같은 연령 및 성별 소아들의 표준 신장 평균치에서 -2.0 SD 이하인 경우를 말한다. 본 연구의 목적은 저신장 소아의 두개안면골격의 특성을 분석하고, 성장호르몬 치료가 신장을 성장시킴과 동시에 두개안면골격에 어떤 영향을 주는지 알아보고자 함이다. 영남대학교 의과대학 부속병원 소아청소년과에서 저신장으로 진단받은 소아를 대상으로 성장 호르몬 치료 전 그리고 치료 후 1년, 2년 후 총 3회 측모 두부 방사선 규격 사진의 촬영을 시행하였다. 대조군은 경북대학교 치의학전문대학원 교정과에 소장된 한국인 평균 신장의 2 표준오차 내의 아동들을 대상으로 측모 두부 방사선 규격사진을 2년마다 10년간 촬영한 자료를 이용하여 저신장 소아의 연령과 성별을 기준으로 짝진 표집(paired sampling)을 하였다. 성장 호르몬 치료 전 저신장 소아는 작고 후퇴된 하악골과 편평한 두개저를 가지는 것으로 나타났다. 성장 호르몬 치료 후 anterior, posterior cranial base length, upper posterior facial height, lower anterior facial height, posterior total facial height, mandibular ramus length, mandibular corpus length와 overall mandibular length 성장량이 정상군에서의 2년 성장량과 비교했을 때 유의하게 큰 것으로 나타났으며 각도 계측에서는 saddle angle, mandibular plane angle과 ANB변화량이 정상군에서의 2년 성장량과 비교했을 때 큰 변화를 보이며 정상군의 평균치를 따라잡는 경향을 보였다. 성장 호르몬 치료는 불균형적인 성장의 징후 없이 정상화를 향한 성장(따라잡기 성장)을 나타내었으며 이는 특히 하악과두의 성장과 후안면고경의 성장을 촉진시켜 저신장 소아의 convex 한 profile을 완화하는 것으로 판단된다.

5-Fluorouracil로 유발된 백서후지의 선천성 기형

김천호,박성국,김선,박경란,김원식 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.1

To study the teratogenic mechanism of 5-fluorouracil on the developing rat hindlimbs and to reveal the congenital anomalies induced by 5-FU, 25mg/kg of 5-fluorouracil was injected intramuscularly into S-D rats on gestational day 10.5. The rats were sacrificed under ether anesthesia on gestational day 11.5, 12.5, 13.5, 14.5, 15.5, 16.5 and 17.5. The whole uterine horns were removed for observing the congenital anomalies of the hindlimbs with stereoscope. Some fetuses were fixed by the neutral buffered formalin solution for LM exmination and some hindlimbs were fixed by 2.5% glutaraldehyde solution for TEM and SEM examination. After routine processing, LM and TEM examination were performed. The results were as follows ; 1. The mean survival rate of 5-fluorouracil-treated rat fetuses was decreased sign ificantly(p<0.01) compared with that of the control group. 2. The mean body weight of the 5-fluorouracil-treated rat fetuses on gestaticnal day 17.5 was significantly lower (p<0.01) than that of the control group. 3. The congenital anomalies on the hindlimbs of the rat fetuses were 4 digit, short digit, 3 digit, and 2 digit anomalies in that order. These anomalies occured moreon the right limb about 2.6 times than on the left limb. 4. On LM and TEM examination, 5-fluorouracil injured the apical ectodermal ridge epithelial cells and mesenchymal cells of hindlimb bud initially, but, this recovered around gestational day 14.5. According to the above results, 5-fluorouracil-induced congenital anomalies of the hindlimbs of rat fetuses may be caused by injury to the apical ectodermal ridge epithelial cells of limb bud. Apical ectodermal ridge epithelial cells that have recovered from injury around gestational day 14.5 may elicit changed information of abnormal patterning and differentiation into the underlying mesenchymal cells in progress zone, and the various digital anomalies, such as oligodactyly and short digit anomalies will be resulted.

남녀 중학생의 체육학습 태도에 관한 연구 : 인천광역시 소재 중학생 대상

김경호,김형룡,천광호 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.3

This research is designed to provide basically necessary for the sake of promoting the normalization of physical- education classes and shedding light upon the actual conditions of operating physical- education at school by making an analysis of middle-school boys and girls at school. 1. The understanding of the objectives of physical education. In regard to the enhancement of sociality, improvement of physical strength, understanding of exercise, function of exercise, one's health brought about by their physical education, boy-girl combined classes are more excellent than the rest, and as for the understanding of the pursuit of life, boys are better than girls. Concerning the understanding of exercise, physical education is said to be of help in the sequence of boy-girl separated co-ed schools. 2. The attitude of taking part in physical education activities. The survey has it that warning up and finishing exercise are sincerely practiced, While students are little impressed by the safety of facilities and instruments in the physical-education classes, both boys and girls are highly satisfied with the explanations and demonstrations of physical education teachers. 3. The attitude of tolerating the evaluation of physical education, Students say that they are under a lot of notice in the beginning of each term, which is designed to let them enhance the justice and confidence of the evaluation of practical training, and that they are not satisfied with a variety of evaluation and the evaluation of practical training in the field of physical education.

우리나라 논 관개용 지하수 수질 특성

김진호,조광래,임수정,이경자,경기천,엄미정,김희권,김찬용,이영한,이신찬,윤순강 한국환경농학회 2003 한국환경농학회지 Vol.22 No.4

This study was carried out to evaluate the status of the groundwater quality for paddy fields irrigation in Korea. Water samples were collected at 130 sites throughout the country. Samples were collected at three seasons-April, July and October-in 2000. According to our survey, the groundwater was found to be suitable for irrigation purpose. Average EC was shown 0.286 dS/m. Nitrate-nitrogen and Cl^(-) concentration was 5.6 ㎎/L, 32.95 ㎎/L which satisfied the Korean Standards for Irrigation Water. Nitrate-nitrogen concentration in each province was shown as following orders: Jeju (11.17 ㎎/L) > Chungnam (8.16 ㎎/L) > Gyeongbuk (6.64 ㎎/L) > Gyounggi (5.91 ㎎/L) > Chungnam (4.95 ㎎/L) > Gyeongnam (3.91 mgk) > Jeonbuk (3.50 ㎎/L) > Jeonnam (3.27 ㎎/L) > Gangwon (2.91 ㎎/L). The concentration by sampling seasons were October (6.62 ㎎/L) > July (5.88 mg&) > April (4.78㎎/L). As the soil of Jeju Province is usually derived from volcanic ash soils mainly used for upland drops, it may influence the nitrate-nitrogen concentration of groundwater. The amount of rainfall also influence the water quality. But the COD_(Cr), were shown April (3.17㎎/L) > July (2.91 ㎎/L) > October (2.40 ㎎/L), it is highly related in the basal dose of organic matter fertilizers. This study demonstrated that groundwater quality was suitable for irrigation, but continuous monitoring is recommended for agricultural policy and developing OECD agricultural environment indicators.

대장직장종양에 있어서 Hand-Assisted Laparoscopic Surgery (HALS)의 초기 경험

조호영,최선근,구지회,허윤석,이건영,김세중,조영업,안승익,홍기천,신석환,김경래,우제홍 대한내시경복강경외과학회 2003 대한내시경복강경외과학회지 Vol.6 No.-

일부 소방공무원의 음주와 직무스트레스와의 관련성

강경화,이강숙,김석일,맹광호,홍현숙,정춘화 大韓産業醫學會 2001 대한직업환경의학회지 Vol.13 No.4

목적 : 소방공무원의 음주량과 직종별 직무 스트레스에 대해 알아보고 보다 나은 스트레스 관리방안과 문제성 음주예방을 위한 프로그램을 모색하기 위해 시도되었다. 대상 : 2000년 7월부터 8월까지 소방공무원 중 구조대원 97명, 구급대원 97명, 화재진압대원 179명,행정대원 116명, 기타대원 49명을 대상으로 설문지를 이용하여 수집된 자료를 분석하였다. 결과 : 소방공무원은 모든 직종에서 승진 및 임금제도의 스트레스 요인 점수가 가장 높았다. 직종별로 직무 내적 요인, 조직에서의 역할, 대인관계, 조직과 풍토, 직장환경과 스트레스 결과 점수에 있어 유의한 차이를 보였다 과음 주자인 경우 직무 내적요인, 직무 스트레스 수준, 개인적 특성, 대처방식의 점수가 높았으나 유의하지 알았다. 음주량은 직무내적 요인 중 업무 피드백과 음의 관련성을, 직무 스트레스 요인 중 역할 갈등은 음주량을 증가시키는 것으로 나타났다. 결론 소방공무원의 가장 높은 직무 스트레스 요인으로는 승진 및 임금제도인 것으로 나타났다. 음주량은 역할 갈등과 같은 직무 스트레스 요인과 관련이 있었으며, 향후 전향적인 음주행태조사를 통해 직무 스트레스 요인이 음주에 미치는 영향을 파악하기 위한 연구가 필요하다고 생각된다. 따라서 본 연구결과를 기초로 소방공무원의 직무 스트레스 요인에 대한 적절한 관리와 정책이 필요한 것으로 사료된다. Objectives : To establish the relationship between alcohol use and job stress among firemen, and to develop a comprehensive health promotion program including stress management and the prevention of problem drinking. Methods : Data was collected from July to August, 2000. Study subjects included 97 rescue workers, 97 emergency medical personnel, 179 fire extinguishers, 116 administrators and 49 others. Results : The firemen displayed higher scores of stress due to promotion-related pres-sures and salary. We found significant differences in job internal factors, job role, inter-personal relationship, organizational norm, work environment and stress outcome among the various jobs. Job internal factors, job stress factors, personal characteristics, coping skills, and stress outcome were higher in heavy drinkers compared with the light and moderate drinkers. Job internal factors and smoking habit showed a positive correlation with the amount of drinking, although coping skill, exercise frequency and monthly income showed a negative relation with the amount consumed. Conclusion : This study suggested that alcohol drinking is associated with job stress. This suggests that a comprehensive health promotion program including stress management and problem drinking prevention and control should be developed.