http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
신진우,조우승,조성빈,김재훈,정지은,사예지,백경동,박동규 순천향대학교 부설 산업기술연구소 2021 순천향 산업기술연구소논문집 Vol.27 No.2
As modern people's interest in health grows, wearable healthcare-related technologies that can collect biometric information and receive health-related services regardless of time and place are developing. This paper proposes the healthcare system based on voice recognition function. Unlike conventional wearable healthcare systems, the proposed system provides real-time telemedicine and diagnosis and the direct connection with doctors is possible through it. And almost all functions of the application in it are operated with voice commands to lower user access barriers. Because it deals with personal information including medical information, encryption algorithms have been applied between all data movements. Finally, the healthcare system proposed in this paper is expected to increase convenience in health care and reduce the medical gap.
뇌하수체 종양 제거술 시행 후 뒤늦게 발생한 횡문근 융해증과 동반된 중추성 열
장제혁,최규남,김일환,노은지,김윤정,유충헌,고정해,박봉수,김태균,권민정,이순희,박정현 인제대학교 2008 仁濟醫學 Vol.29 No.-
Body temperature is controlled by thermoregulatory center of the hypothalamus. We report a case of 24 years old man with central fever. He was subjected to a partial excision of pituitary tumor compressing optic chiasm four years ago. He has received hormonal therapy for panhypothyroidism after removal of pituitary tumor. And He received gamma knife operation for partially contrast-enhancing masses in suprasellar and both hypothalamic areas that is probably postoperatively remnant or recurrent tumor of pituitary adenoma. One year after gamma knife operation, he presented with a febrile syndrome of unknown origin including rhabdomyolysis. All usual investigations proved negative. We diagnosed him as central fever with rhabdomyolysis. He received medical ICU care with cooling bed, ice pack. And his symptom improved. Postoperative hyperthermia may result following resection of the pituitary tumor. When central fever is suspected taking note of past history, a quick recognition of course of fever can help reduce the using of unnecessary antibiotics and hospital stay.
Metabolomics approach to serum biomarker for loperamide-induced constipation in SD rats
Ji-Eun Kim,Young-Ju Lee,Moon-Hwa Kwak,Go Jun,Eun-Kyoung Koh,Sung-Hwa Song,Ji-Eun Seong,Ji Won Kim,Kyu-Bong Kim,Suhkmann Kim,Dae-Youn Hwang 한국실험동물학회 2014 Laboratory Animal Research Vol.30 No.1
Loperamide has long been known as an opioid-receptor agonist useful as a drug for treatment of diarrhea resulting from gastroenteritis or inflammatory bowel disease as well as to induce constipation. To determine and characterize putative biomarkers that can predict constipation induced by loperamide treatment, alteration of endogenous metabolites was measured in the serum of Sprague Dawley (SD) rats treated with loperamide for 3 days using ¹H nuclear magnetic resonance (¹H NMR) spectral data. The amounts and weights of stool and urine excretion were significantly lower in the loperamide-treated group than the Notreated group, while the thickness of the villus, crypt layer, and muscle layer was decreased in the transverse colon of the same group. The concentrations of aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and creatinine (Cr) were also slightly changed in the loperamide-treated group, although most of the serum components were maintained at a constant level. Furthermore, pattern recognition of endogenous metabolites showed completely separate clustering of the serum analysis parameters between the Notreated group and loperamide-treated group. Among 35 endogenous metabolites, four amino acids (alanine, glutamate, glutamine and glycine) and six endogenous metabolites (acetate, glucose, glycerol, lactate, succinate and taurine) were dramatically decreased in loperamide-treated SD rats. These results provide the first data pertaining to metabolic changes in SD rats with loperamide-induced constipation. Additionally, these findings correlate the changes in 10 metabolites with constipation.
The rates in developmental dysplasia of the hip in breech presentation in twins and triplets
( Eun Ji Oh ),( Seong Been Kim ),( Ye Hyon Park ),( Young Eun Lee ),( Su Been Hong ),( Jee Yoon Park ),( Kyung Jun Oh ),( Joon-seok Hong ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-
Objective: To determine the incidence of developmental dysplasia of the hip (DDH) in breech presentation among multifetal pregnancies. Methods: This retrospective cohort study included 1256 consecutive live births who were born through cesarean section with at least one baby had been presented as non-cephalic presentation in each pregnancy from April 2013 to October 2018. Only births after 23+0 weeks of gestation were included. During analysis, neonates who had been presented as transverse lie in twins and triplets were excluded (n=39). In out institution, every baby is physically examined to assess the possibility of DDH by pediatricians and for the babies confirmed to be breech presentation during antenatal period, consultation to the orthopedists is routinely performed. The primary outcome was the diagnosis of DDH through ultrasonography. Results: The incidences of DDH diagnosed in neonates who had been presented as breech presentation antenatally were 5.1% (19/371) in singletons, 4.3% (20/463) in twins, and 8.1% (3/37) in triplets. In those three groups, the incidence of DDH was not significantly different. In twin pregnancy, the rate of DDH was significantly higher in breech presentations than cephalic presentations (4.3% vs. 0.3%, p<0.001). In the multivariate logistic regression analysis for the association between the incidence of DDH and various factors, breech presentation was the strongest and independent risk factor for the diagnosis of DDH (Odds ratio (OR) 8.9, 95% Confidence interval (CI) 2.1-38.3, p=0.003). Oligohydramnios and twin pregnancy were not statistically significant risk factors. however triplet pregnancy was found to be associated with DDH (OR 6.7, 95% CI 1.7-26.5, p=0.007). Conclusion: Pos Breech presentation is the strongest risk factor for the diagnosis of DDH even in the multifetal pregnancies.
Lipopolysaccharide로 활성화된 RAW264.7세포에서 염증반응사이토카인 발현에 대한 Epigallocatechin gallate의 억제효능연구
서은지(Eun Ji Seo),고준(Jun Go),김지은(Ji Eun Kim),고은경(Eun Kyoung Koh),송성화(Sung Hwa Song),성지은(Ji Eun Sung),박찬규(Chan Kyu Park),이현아(Hyun Ah Lee),김동섭(Dong Seob Kim),손홍주(Hong Joo Son),이충열(Cung Yeoul Lee),이희섭(Hee 한국생명과학회 2015 생명과학회지 Vol.25 No.9
Epigallocatechin gallate (EGCG)는 녹차(Camellia sinensis, green tea)에 포함되어 있는 대표적인 카테킨(Catechin)으로, 당뇨(diabetes), 신경퇴행성 질환(neurodegenerative disorders), 암(cancer), 심혈관계 질환(cardiovascular disease), 비만(obesity) 등의 다양한 임상질환에 우수한 치료효과를 나타내는 것으로 알려왔다. 본 연구에서는 EGCG가 LPS (Lipopolysaccaride)로 자극된 RAW264.7 세포의 염증억제과정에서 Nitric oxide (NO)관련인자와 사이토카인 발현에 미치는 영향을 분석하기 위해, NO농도, inducible NO synthase (iNOS) 발현량, TNF-α, IL-1β, IL-6, IL-10 사이토카인의 발현량을 분석하였다. 먼저, EGCG (100-400 μM)를 처리한 Raw264.7 세포에서 특이적인 독성이 나타나지 않음을 확인하였으며, 이후 Raw264.7 세포에 4가지 다른 농도(0.1, 0.5, 1.0, 5.0 ㎍/ml)의 LPS를 처리한 후 MTT분석, NO농도분석, IL-6농도분석을 실시하여, 염증을 유발할 수 있는 최적 LPS 농도를 1 ㎍/ml로 설정하였다. NO농도를 분석한 결과, LPS를 처리한 그룹이 No그룹에 비하여 급속히 증가하여 63 μ㏖/l까지 증가하였으나 400 μM EGCG를 처리한 그룹에서만 68.2% 정도 감소하였으며, 동시에 iNOS 발현 양상은 200, 400 μM EGCG/LPS 처리 그룹에서 각각 12.3%, 17.4% 감소하였다. 또한, 감소비율에는 차이가 있었으나, anti-inflammatory 사이토카인(IL-1β, TNF-α)과 pro-inflammatory 사이토카인(IL-10)의 발현은 EGCG/LPS 처리에 따라 유의적으로 감소하였다. 그러나, IL-6단백질과 mRNA 농도는 Vehicle/LPS 처리 그룹과 EGCG/LPS 처리 그룹에서 유의적인 차이를 나타내지 않았다. 따라서, 본 연구의 결과는 EGCG가 LPS의 자극에 의해 활성화된 Raw264.7 세포를 효과적으로 억제하는 효능을 나타냄을 제시하고 있으며, 이러한 과정에 사이토카인들이 서로 다르게 특이적 반응을 중계함을 제시하고 있다. Epigallocatechin gallate (EGCG), the main catechin in green tea, has been shown to have some beneficial effects against various human diseases, including diabetes, neurodegenerative disorders, cancer, cardiovascular disease and obesity. To investigate the mechanism of the suppressive effects of EGCG on inflammatory response in macrophages, alterations on the levels of nitric oxide (NO) regulatory factors and inflammatory cytokines were measured in lipopolysaccharide (LPS)-activated RAW264.7 cells. No significant toxicity was detected in RAW264.7 cells treated with 100?400 μM EGCG. Moreover, the optimal concentration of LPS was determined to be 1 ㎍/ml based on the results of cell viability assay, NO assay and IL-6 enzyme-linked immunsorbent assay (ELISA). Furthermore, NO levels decreased significantly by 68.2% in the 400 μM EGCG/LPS treated group, while the level of inducible nitric oxide synthase (iNOS) expression decreased by 12-17% in the 200 and 400 μM EGCG/LPS treated group. A significant decrease in transcription of pro-inflammatory cytokines (TNF-α and IL-1β) and anti-inflammatory cytokine (IL-10) was also detected in the EGCG/LPS treated group. However, IL-6 transcript and protein was maintained at a constant level when in the LPS treated group relative to the EGCG/LPS treated group. Overall, these results suggest that the differential regulation of inflammatory cytokines is an important factor influencing the suppressive effects of EGCG against LPS-activated inflammatory response in RAW264.7 cells.
울증(鬱證)환자에게 용서프로그램을 활용한 오지상승요법(五志相勝療法)을 시행하여 호전된 1례
이상언 ( Sang Eon Lee ),노동진 ( Dong Jin No ),박장호 ( Jang Ho Park ),이고은 ( Go Eun Lee ),박인숙 ( In Sook Park ),류영수 ( Yeong Su Lyu ),안민섭 ( Min Seob Ahn ),정지호 ( Ji Ho Jung ) 대한한방신경정신과학회 2010 동의신경정신과학회지 Vol.21 No.2
Yuzheng(鬱證) comes from obstruction of qi by stress. The patient has depressed mood, irritable sign, chest discomfort, costal pain, angry state or some strange feeling on the throat. Oh-Ji-Sang-Seung(五志相勝) therapy is base on the theory of interrelation in five elements in oriental medicine. The contents of Oh-Ji-Sang-Seung(五志相勝) therapy include five subjugations of five emotions. Anxiety subjugates fear(思勝恐), fear subjugates joy(恐勝喜), joy subjugates pity(喜勝悲), pity subjugates anger(悲勝怒), and anger subjugates anxiety(怒勝思). Forgiveness program is a kind of psychological therapies to decrease the degree of anger and it is included in Oh-Ji-Sang-Seung(五志相勝) therapy. In this case, a female patient, 50 years old, who suffered from Yuzheng(鬱證) with chest discomfort, irritable sign, easily angry state, depressed mood, hot flush, insomnia. We used Oh-Ji-Sang-Seung(五志相勝) therapy besides herbal medication, acupuncture to her condition got improved. Therefore we reported it for the treatment.