지하수 중 자연방사성물질의 위해성 관리에 대한 고찰

신동천,김예신,문지영,박화성,김진용,박선구 한국환경독성학회 2002 환경독성보건학회지 Vol.17 No.4

At present, the health risks associated with the natural radionuclides of ground water have become a concern as potential social problems. However, there are no regulatory actions or control strategies for such risks. Therefore, we have investigated and discussed the risks and associated management strategies for radionuclides in other countries. US EPA has proposed MCL (300 pCi/L) and AMCL (4,000 pCi/L) for radon, and 30 ppb for uranium, 15 pCi/L for gross-alpha and 5 pCi/L for radium as final MCLs. Also, Canada, WHO and European countries have their inherent management levels. Finally, we suggested several criteria for setting guidelines in our countries including exposure related criteria such as geological distribution, occurrence, exposure probability distribution, exposure population and multimedia exposure assessment, acceptable risk, and cost-benefit analysis. The national-scale exposure and risk assessment, and economic analysis should be conducted for producing and aggregating the representative information on these criteria.

LCA 기법을 적용할 제품의 우선순위 선정 방법론

신동희,권은선,문승식,김만영,정종연,허진호 한국전과정평가학회 2004 한국전과정평가학회지 Vol.5 No.1

본 연구의 목적은 일정한 논리적 절차를 거쳐서 객관적인 전과정평가의 우선순위를 선정하기 위한 일반적인 방법론의 개발이다. 우선 전과정평가 대상이 되는 제품(산업군)의 우선순위를 평가하기 위해서 제품의 환경성과 관련된 환경규제, 국내외 전과정평가 수행사례, 유해물질 등을 평가항목으로 설정하였다. 설정된 평가항목들에 대한 자료조사 및 분석을 통하여 세분화한 데이터베이스를 생성하였으며, 또한 학계 및 산업계의 의견을 반영하기 위해 전과정평가 전문가 및 산업계 관계자들을 대상으로 설문조사를 실시하였다. 설문조사결과를 바탕으로 각각의 평가항목 및 세부평가항목의 가중치를 부여하였고, 각 평가항목별로 점수를 설정하였다. 본 연구에서 개발한 방법론은 우선순위를 비교해야하는 제품(산업군)들이 각각의 평가항목에서 설정해놓은 해당 점수를 부여받게 된다. 부여받은 각 평가항목의 점수들을 모두 합산하면 평가대상이 되는 제품(산업군)에 대해 하나의 우선순위 평가 점수를 갖게 된다. 이와 같은 과정으로 방법론이 구축되었으며, 사례연구를 통하여 방법론의 타당성을 검증하였다. 이렇게 산출된 우선순위 평가점수를 평가하고자하는 제품(산업군)들과 비교하여 높은 점수를 갖는 제품(산업군)이 전과정평가를 먼저 실시하는 것이 바람직하다는 결론을 얻을 수 있다. The purpose of this study is to develop a general method to decide the priority of LCA application through a logical procedure. First of all, evaluation categories were developed to decide priority of subject products(industrial groups). The evaluation categories consist of environment regulations related to subject product, LCA case studies, hazardous substances, etc. The subdivided database was constructed through researching and analyzing information about the selected evaluation categories. In addition, a questionnaire was conducted to reflect the opinions from academic and industrial circles. Based on the result of the questionnaire, each evaluation category and sub-evaluation category were weighed differently, and certain points were assigned to them. According to the method developed in this study, comparing industrial groups or products for prioriting will have its total score that is a sum of points assigned to each evaluation category. This results that an industrial group or product having higher score than the others becomes the subject to apply LCA.

우태아혈청 및 성인뇨중 β-에스트라디올, 에스트론, 에스트리올의 역상 HPLC

신희수,이동선 서울여자대학교 자연과학연구소 1997 자연과학연구논문집 Vol.8 No.-

A method for reversed phase high performance liquid chromatographic separation of estriol, estradiol, and estrone in biological samples such as human urine, fetal bovine serum is described. Estrogens were determined by HPLC following solid phase extraction using Sepak C18 cartridge for sample clean up. Chromatographic separation is completed in 10 min using mobile phase of 60v/v% acetonitrile in water and Spheri-5 RP-18 column (4.6mm*22cm, 5micron) at flowarte of 0.5ml/min. UV-detection of eluted compounds was accomplshed at 280nm. Retention time of triol was shorter than those of diol and monool. These result suggests than triol is polar than diol and monool.

LabView를 이용한 휴대형 브레이크 저더 측정 소프트웨어 구현

신동욱,김선형 순천향대학교 산업기술연구소 2007 순천향 산업기술연구소논문집 Vol.13 No.2

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사립체 DNA 돌연변이가 확인된 MELAS 증후군 1례

신동선 외 중앙대학교 의과대학 의학연구소 2004 中央醫大誌 Vol.29 No.1·2

The term mitochondrial encephalomyopathy is reserved for disorders that usually cause multisystem diseases by mitochondrial dysfunction. The major organs affected are brain and skeletal muscle, but other tissues that require intact oxidative metabolism are affected frequently. MELAS appears to be the single most common mitochondrial disorder. Most cases result from a point mutation in the tRNA^(leu(UUR)) gene at position 3243 when adenine is replaced by guanine. We report a case of MELAS syndrome confirmed by typical clinical presentation and molecular gentetic diagnosis.

자율신경계의 활성도 측정을 위한 Data Acquisition System의 개발 및 임상응용

신동구,박종선,김영조,심봉섭,이상학,이준하 영남대학교 기초/임상의학연구소 2001 Yeungnam University Journal of Medicine Vol.18 No.1

Background: Power spectrum analysis method is a powerful noninvasive tool for quantifying autonomic nervous system activity. In this paper, we developed a data acquistion system for estimating the activity of the autonomic nervous system by the analysis of heart rate and respiratory rate variability using power spectrum analysis. Materials and methods: For the detection of QRS peak and measurement of respiratory rate from patient's ECG, we used low-pass filter and impedance method respectively. This system adopt an isolated power for patient's safety. In this system, two output signals can be obtained: R-R interval(heart rate) and respiration rate time series. Experimental ranges are 30∼240 BPM for ECG and 15∼80 BPM for respiration. Regults: The system can acquire two signals accurately both in the experimental test using simulator and in real clinical setting. Conclusion: The system developed in this paper is efficient for the acquisition of heart rate and respiration signals. This system will play a role in research area for improving our understanding of the pathophysiologic involvement of the autonomic nervous system in various disease states.

American Medical Association 5판을 근거로 한 한국형 말초신경계 장애 평가기준 개발

박동식,김병조,황선철,송인욱,손병철,장성호,정두신 순천향대학교 의학연구소 2009 Journal of Soonchunhyang Medical Science Vol.14 No.3

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간호사의 아동 통증 중재에 대한 지식 및 태도

신희선,김동희 대한간호학회 아동간호학회 2003 Child Health Nursing Research Vol.9 No.2

콘택트렌즈 소독제 및 PHMB의 3종 가시아메바 포낭에 대한 살충능력 평가

신종원,유학선,공현희,정동일 慶北大學校 醫科大學 1996 慶北醫大誌 Vol.37 No.3

목적 : 국내에 시판되고 있는 콘택트렌즈 보존 및 소독액, 그리고 아메바성 각막염의 치료제로서 인정받고 있는 polyhexamethylene biguanide (PHMB)의 가시아메바 포낭에 대한 살충효과를 평가하고자 한다. 대상 및 방법 : 카스텔라니가시아메바 Ma주, 대식가시아메바 Nagington주 및 담수가시아메바 KA/LI주에 대한 소독액의 살충효과의 평가는 한천 plate위에서 수행하였고, 최저살충농도(minimal cysticidal concentration : MCC)의 결정은 microplate를 이용하였다. 7일간 관찰 후, 탈낭하지 않는 가시아메바 포낭은 사멸한 것으로 판정하였다. Chlorhexidine 및 PHMB의 MCC를 결정하기 위해 8시간 및 48시간 처리 실험을 분리하여 시행하였다. 결과 : 시판 소독액 중 chlorhexidine과 thimerosal를 함유하는 용액 C만이 가시아메바 포낭에 대한 살충효과가 있었고, 나머지 3종의 소독액은 살충효과가 없었다. 0.02% PHMB로 4시간 이상 처리한 가시아메바 포낭은 충주에 관계없이 사멸되었다. Chlorhexidine 과 PHMB, 두 약제 모두 8시간 처리 MCC가 48시간 처리 MCC보다 다소 높았다. PHMB에 대한 감수성은 가시아메바 충주에 따라 차이가 격심하였다. 결론 : 3종 가시아메바 포낭에 대한 PHMB의 MCC (0.29∼9.38㎍/㎖)가 chlorhexidine의 그것(2.73∼18.75㎍/㎖)보다 낮아 PHMB는 아메바성 각막염의 치료제 및 콘택트렌즈 소독제로 사용 될 수 있을 것으로 사료되며 화학소독액에 PHMB를 10㎍/㎖ 첨가하는 것이 요망된다. In order to evaluate the cysticidal effects of contact lens disinfectants and polyhexamethylene biguanide(PHMB) against 3 clinical isolates of Acanthamoeba. in vitro cysticidal assay was performed on agar plates covered with heat-inactivated Escherichia coli. Three clinical isolates of Acanthamoeba were A. castellanii Ma strain. A. polyphaga Nagington strain, and A. lugdunensis KA/LI strain. After treatment of Acanthamoeba cysts with the disinfectants or PHMB, the cysts were cultivated for 7 or more days. Cysts which were not excysted in 7 days after treatment were recognized killed. Among commercial disinfectants, the solution C. which contains chlorhexidine and thimerosal. was the only one with cysticidal effects on Acanthamoeba cysts. PHMB of 0.02% concentration was also cysticidal. Sensitivity to PHMB varied profoundly from isolate to isolate. Minimal cysticidal concentration (MCC) of chorhexidine and PHMB were determined by cultivation of cysts treated for 8 or 48 hours with serially diluted chlorhexidine and PHMB in wells of a 96-well microplate containing axenic culture media for amoebae. MCC of 48-hour treatment with both chemicals was lower than that of 8-hour treatment. MCC of PHMB against amoebic cysts was lower than that of chlorhexidine. In the light of these results. PHMB could be a contact lens disinfectant as well as a chemotherapeutic agent of amoebic keratitis.

에피소드 구성력과 수험자의 스토리텔링 과업수행능력 분석

신동일,김금선,김나희 새한영어영문학회 2007 새한영어영문학 Vol.49 No.4

The purpose of this study is to investigate how Korean learners of English construct their linear story grammar (Stein & Glenn 1979) in oral proficiency testing situations. A total number of 31 storytelling samples from two oral proficiency tests were analyzed: MATE (Multimedia-Assisted Test of English) and OPIc(Oral Proficiency Interview computer). The 15 excerpts came from MATE and 16 from OPIc. This study explored which components of story grammar(setting, initiating events, internal responses, attempts, direct consequences, reactions) appeared in each of three categorized proficiency levels (advanced, intermediate high and low, intermediate low). It was found that the performance difference of episode completeness was explicit between each level of oral proficiency. The higher their speaking proficiency was, the more complete episodes were found in their storytelling samples. It was also found that the test-takers of English speaking lacked the competence in describing characters' feeling and emotion in their narratives regardless of their proficiency levels. Issues for further research are discussed.