심근경색의 위험인자로서 Thrombomodulin유전자변이의 의의

박현영,김영미,권혁문,지선하,조승연,정남식,심원흠,장양수 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.6

Comparison of Melanoma Subtypes among Korean Patients by Morphologic Features and Ultraviolet Exposure

( Hong Sun Jang ),( Jee Hung Kim ),( Kyu Hyun Park ),( Jae Seok Lee ),( Jung Min Bae ),( Byung Ho Oh ),( Sun Young Rha ),( Mi Ryung Roh ),( Kee Yang Chung ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.4

Background: Genetic alterations have been identified in melanomas according to different levels of sun exposure. Whereas the conventional morphology-based classification provides a clue for tumor growth and prognosis, the new classification by genetic alterations offers a basis for targeted therapy. Objective: The purpose of this study is to demonstrate the biological behavior of melanoma subtypes and compare the two classifications in the Korean population. Methods: A retrospective chart review was performed on patients found to have malignant melanoma in Severance Hospital from 2005 to 2012. Age, sex, location of the tumor, histologic subtype, tumor depth, ulceration, lymph node invasion, visceral organ metastasis, and overall survival were evaluated. Results: Of the 206 cases, the most common type was acral melanoma (n=94, 45.6%), followed by nonchronic sun damage-induced melanoma (n=43, 20.9%), and mucosal melanoma (n=40, 19.4%). Twenty-one patients (10.2%) had the chronic sun-damaged type, whereas eight patients (3.9%) had tumors of unknown primary origin. Lentigo maligna melanoma was newly classified as the chronic sun-damaged type, and acral lentiginous melanoma as the acral type. More than half of the superficial spreading melanomas were newly grouped as nonchronic sun-damaged melanomas, whereas nodular melanoma was rather evenly distributed. Conclusion: The distribution of melanomas was largely similar in both the morphology-based and sun exposure-based classifications, and in both classifications, mucosal melanoma had the worst 5-year survival owing to its tumor thickness and advanced stage at the time of diagnosis. (Ann Dermatol 26(4) 485~490, 2014)

Kainic Acid로 처리한 해마박편배양 마우스 간질모델에서 치아이랑 Parvalbumin 면역 반응성 사이신경세포의 형태학적 변화

정희선,신미영,김영훈,이인구,황경태,김명석 대한소아과학회 2002 小兒科 Vol.45 No.12

파종시기가 다른 일미찰의 등숙 중 호화 특성 비교

김미정, 박효진, 이유영, 김선림, 김정태, 우관식, 권영업, 정일민 忠北大學校 農業科學硏究所 2014 農業科學硏究 Vol.30 No.2

This study was conducted to investigate the pasting properties of waxy corn ‘Ilmichal’ during ripening with different sowing date. Starch content of Ilmichal was increased as matured (p<0.05). Analysis of pasting properties with waxy corn starch using a rapid visco analyser (RVA) showed linear changes in peak viscosity, trough viscosity, final viscosity, breakdown and consistency according to ripening. There were significantly positive correlation between starch content of Ilmichal and peak viscosity (0.39*), trough viscosity (0.58***), final viscosity (0.58***), and consistency (0.57**). Differential scanning calorimerty (DSC). The enthalpy of gelatinization was increased as ripening. But onset and peak temperature were decreased. There were significantly positive correlation between starch content of Ilmichal and onset temperature (0.44*), peak temperature (0.38*), and completion temperature (0.59***), on the other hand, crude protein content presented significantly negative correlation between completion temperature (-0.41*).

초등 신임교사의 직무역량 요구도 분석

정제영,윤홍주,김갑성,강태훈,류성창,선미숙 부산대학교 과학교육연구소 2016 교사교육연구 Vol.55 No.2

The purpose of this research was to analyze the needs assessment of beginning teacher’s job competence in elementary schools. For this purpose, an on-line questionnaire was created and sent to 14,398 teachers in 17 Local Education Provinces. The questionnaire composed of 10 areas related to job skills of beginning teachers. The result of survey indicated that the priority of job competencies required for beginning teachers are ‘student guidance and counseling’ and ‘conjunction with parents and the community’. For future the competence of elementary school teachers, ‘the actual problem solving skills’, ‘relationship skills’, ‘communication skills’, ‘patience’, and ‘conflict management skills’ appeared to be needed. Furthermore, programs to enhance job competences in the future should involve ‘mentoring’ and ‘school based peer supervision’. This research concludes with these practical suggestions; First, on-the-job training needs to be strengthened to develop the expertise of beginning teachers. Second, in order to improve the job competence of new teachers in newly appointed elementary teachers, a training program to identify the needs new teachers needs to be developed. Third, the teachers’ appointment and rotation policy are needed to be reconsidered.

지페프롤 과량복용에 의해 사망한 65사례에서의 혈액중 농도

정희선,김은미,김명덕,김미경 內務部 國立科學搜査硏究所 1996 國立 科學 搜査 硏究所 年報 Vol.28 No.-

연구기관의 인터넷 웹사이트 운영관리를 위한 웹사이트 평가 비교분석

김미선,정영수,정철호 충남대학교 경상대학 경영경제연구소 2003 경영경제연구 Vol.26 No.1

기존의 웹사이트의 구축목적은 조직의 홍보에 중점을 두었으나, IT기술 발전과 더불어 웹사이트의 목적은 단순한 정보제공기능을 능가하게 되었다. 연구기관의 웹사이트는 일반기업의 경우와는 달리 복합적인 성격을 가진다. 연구기관 웹사이트의 목적을 연구정보 제공, 교환 및 관리의 기능에 초점을 맞추어 보면, 웹사이트의 구축운영 과정에서 제공되어지는 다양한 정보는 효율적인 평가와 신뢰성있는 평가기준을 통해 정보의 질관리가 필요하다. 이에 본 연구는 현재 구축되어 운영중인 과학기술부/한국과학재단 지정 지역협력연구센터(RRC) 웹사이트 45개를 대상으로 한국웹사이트평가개발원의 3C-D-T 모형을 적용하여 내부사용자 관점과 외부전문가 관점으로 평가를 실시하였다. 내부사용자의 주관적 평가와 외부전문가의 객관적 평가 결과를 비교하는 것을 통해 도출된 요소를 분석함으로써 지역협력연구센터 웹사이트의 운영상 제기되고 있는 문제점들을 각 평가부문별로 제시하고 성공적인 웹사이트의 관리방안을 제시하고자 하였다.

일부 여대생의 스트레스와 철분 영양상태에 관한 연구

승정자,하보경,김미현,최선혜 숙명여자대학교 건강. 생활과학연구소 1999 生活科學硏究誌 Vol.14 No.1

The purpose of this study was to evaluate the iron status of 39 female adult who divided into five groups according to the stress condition. The iron status was evaluated based on dietary intake and blood analysis. The average age of the subjects was 23.10years, and the average score of BMI was 20.06kg/m2. The proportion of subjects in each stress condition was : 2.56%(1) in A1type(the group who easily get disease associated with stress), 64.10%(25) in A2type(condition susceptible to the disease associated with stress), 30.77%(12) in ABtype(middle type of A and B), 2.56%(1) in B2type(appropriate stressed condition) and 0%(0) in B1type(risk free to the disease associated with stress). The average daily intake of energy in study subjects was 2,399kcal, ti caloric ratio of carbohydrate, protein, fat was 59.90 : 14.39 : 25.71, respectively. There was no significant difference in anthropometric measurements, dietary intake status, hematologic indices of iron status between high stress group(A1type and A2type) and low stress group(ABtype and B2type). To compare the iron stores between high stress group and low stress group, subjects in each group were devided into iron 0 mg, 250 mg, 500 mg group. Stress level did not affect iron stores although in both groups, number of subjects in iron 0 mg group were higher than those of iron 250 mg and 500mg groups. Correlation coefficients between anthropometric measurements, nutrient intake status, hematologic indices of iron status and stress score of subjects did not reveal any significance. Therefore, the results suggest that psychological stress did not affect the iron status in normal female adult. However, be more systematic study on stress and the iron status is required in the future.

좌측 관동맥에서 시작된 관동정맥루에 동반된 거대 동맥류 1예

신미승,맹선희,이혜진,조홍근,정의모,신길자 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.7

3교대 근로자에서 교대근무기간과 혈압 및 심박수 변동성

하미나,김재용,박정선,정호근 대한산업의학회 2001 대한직업환경의학회지 Vol.13 No.2

목적 : 교대근무가 심혈관계에 미치는 만성적인 영향을 살펴보기 위하여 본 연구를 수행하였다. 방법 : 4조 3교대의 빠른 순환주기의 교대근무를 하는 1개 제조업체 남성근로자 134명을 대상으로 교대근무마다 혈압 및 심박수 변동성을 측정하였다. 교란변수로서 Karasek의 직무긴장도 모델에 의거한 49항목의 직무스트레스설문지를 이용하여 직무스트레스를 측정하였고, 수면유형과 흡연, 음주력 및 과거병력 등의 사항에 관한 설문조사를 실시하였다. 반복측정 자료의 분석을 위해 mixed model을 이용한 다변량 회귀분석을 수행하여, 교대근무기간과 혈압 및 심박수 변동성과의 관련성을 살펴보았다. 결과 : 대상 근로자의 평균연령은 29 세였다(범위 25∼44). 이들 중 77.9 % 는 현재도 흡연을 하고 있었고, 50 % 는 직무긴장도 모형에서 수동형이었다. 평균 총 교대근무기간은 5.21 년(범위 5.4 개월∼10년)이었다. 수면유형검사에서는, 극단적인 아침형이나 극단적인 저녁형은 없었다. 연령, 직무스트레스, 수면유형 및 흡연을 보정한 다변량 분석에서, 혈압은 총 교대근무기간이 증가함에 따라 통계학적으로 유의하게 증가하는 소견을 보였다(p(0.05). 심박수 변동성은 저주파 및 고주파 영역 모두에서 총 교대근무기간이 증가함에 따라 유의한 감소양상을 나타냈다(p<0.05) . 결론 : 본 연구의 결과는 교대근무가 혈압을 상승시키고 심박수 변동성을 감소시키는 것으로써 심혈관계 기능에 영향을 미침을 보여주었다. Objectives : This study was performed to investigate the chronic health effect of shift-work on cardiovascular system. Methods : We checked blood pressure(BP) and heart rate variability (HRV) at every shift on 134 male workers whose shift type was 8-hour and short rotating of 3 days shift interval. As confoundings, job stress was measured by Karasek's JCQ 49 items questionnaire and circardian type was assessed by morningness-eveningness questionnaire. Smoking and alcohol drinking habit, marital status and past medical history were also acquired. We used the method of repeated measured data analysis with mixed model to show the association between shiftwork duration and BP or HRV. Results : Average age of workers was 29 years olds(range 25∼44). Among them, 77.9 % were current smokers, 50 % were the passive type of job strain in Karasek's model. Mean shiftwork duration was 5.21 years(range 5.4 months∼10 years). In circadian type, no one was definitely morning type or definitely evening type. In multivariate analyses adjusted by age, job strain, shift, circadian rhythm and smoking, blood pressure were showed significantly increasing trends according to shiftwork duration in both systolic and diastolic (p(0.05) . Heart rate variability were also showed significantly decreasing trends according to shiftwork duration in both parasympathetic and sympathetic functions (p(0.05) . Conclusions : The results of this studs suggests the chronic negative health effect of shiftwork on cardiovascular system.