홍씨 앞방각측정법의 임상적 유용성

강신희,박기호,홍철,김동명,Shin Hee Kang,M,D,Ki Ho Park,M,D,Chul Hong,M,D,Dong Myoung Kim,M,D 대한안과학회 2007 대한안과학회지 Vol.48 No.3

Purpose: To compare the Hong`s grading method, utilized for slit-lamp grading of the mid-peripheral angle, with other conventional grading methods. Actual angle was measured by ultrasound biomicroscopy (UBM) for comparison. Methods: Fifteen eyes with narrow angles and eighteen eyes with wide angles were studied. The average age of thirty-three subjects was 46.8±19.2, and the male to female ratio was 1:3.7. The mid-peripheral angle was graded by Hong`s, van Herick`s and Spaeth`s grading system. The actual anterior chamber angle was evaluated by UBM and the correlation between each grading system and actual angle was investigated. Results: The results from the Hong`s grading (r=0.802, R2=0.643, p<0.01), Spaeth`s grading (r=0.728, R2=0.530, p<0.01) and van Herick`s grading (r=0.618, R2=0.382, p<0.01) methods correlated significantly with the actual angles. Conclusions: The Hong`s grading method was an easy and effective tool to evaluate anterior chamber angle. In addition, the results of the Hong`s grading method were closer to the actual angle than the other methods.

The Gospel Implied in the Passover

Hong,Sung-Chul 한국신학교육연구원 2006 Korea Journal of Theology Vol.5 No.-

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

4행정 SI엔진의 연소효율에 대한 준평형 모델

홍명석,안철봉 조선대학교 동력자원연구소 1996 動力資源硏究所誌 Vol.18 No.2

A simple but accurate model for the combustion efficiency of 4-stroke homogemeous charge spark ignition engines has been developed based upon thermochemical equilibrium arguments. This model assumes that the combustion efficiency is a function of only the fuel-air equivalence ratio for hydrocarbon fules with a hydrogen-to-carbon ratio similar to that of iso-octane. This model was shown to accurately predict experimental data for ranges of compression ratio, load, ignition timing, and speed typical of the normal engine design and operation. The model slightly overpredicts the data for high than typical engine speeds and is not applicable to engines operating near the partial burn, ignition, or lean misfire limits. An example of the potential usefulness of this model is also briefly discussed.

중ㆍ고등학생 응급처치 지식수준에 관한 실태 조사

홍경용,남철현,최상복,위광복,김기열 韓國保健敎育.健康增進學會 2001 보건교육건강증진학회지 Vol.18 No.3

This study was conducted to examine middle and high school students' knowledge level of first aid, health promotion, and safety. Data were collected from 1.165 students from March 6, 2000 to April 4, 2000. The results of this study are summarized as follows. 1.80.1% of the respondents felt the necessity of first aid. The sources of information about methods of first arid were school (43.9%), mass media (15.6%), and self-study (10.5%). 30.0% of them never leaned the methods of first aid. 2.In the case of obtaining information on first aid through mass media, 58.2% of them got it from TV. 7.3% of them obtained it from magazines, while 5.8% of them got it from newspapers. According to their viewpoints of adequate time to teach the methods of first aid, 38.6% of them thought that the methods had to be taught in the primary school and 25.2% of them thought that they had to be taught in the kindergarten. 24.9% of them replied that the methods had to be taught in the middle school, while 11.3% of them replied that they had to be taught in the high school. 3.The points for knowledge of first aid were 98.29±20.91 on the basis of 150 points (65.5 points on the basis of 100 points). The points showed significant differences in the variables of sex, education level, numbers of siblings, parents' education level, and guardian's occupation.

中.長距離 달리기의 最適戰略에 關한 數理的 模型

洪盛杓,全鍾貴,崔哲圭 忠南大學校體育科學硏究所 1988 體育科學硏究誌 Vol.6 No.1

The mathematical theory of competitive running by Keller, which is based on the Newton's second law of motion, is applied to analyze the track records of the Asian and Korean athlets. In addition, the empirical formular proposed by Toots is used to represent the aver age speed of the runners for various races. The main conclusions arrived at are as follows. 1. According to the Keller theory, running at a constant speed is an optimum strategy throughout the races except the initial two seconds and the final 3 seconds, approximately, for distances greater than certain critical distances. But it is effective to run at a full speed with maximum propulsion, for the short distance sprints. 2. The critical distances obtained from the records are 291m for the World records, and 298 (320m for women) and 303m (330m for women) for Asian and Korean records, respectively. Thus the 400m race may be considered the reference item for the mid-range race. 3. Korean athletes show rather inferior physiological characteristics for the most cases analyzed, with the only exception for the oxygen supply rate of male athelets, which is somewhat greater than that of the Asian records. This may indicate a passilility of future development of superior mid and long distance runner from Korean athletes.

선삭가공에서 절삭조건에 따른 절삭력과 표면거칠기에 관한 연구

홍철기,이호용 동국대학교 산업기술연구원 1995 산업기술논문집 Vol.6 No.-

STS410 스텐레스 강과 STC3 탄소공구강을 피복초경합금공구를 이용하여 절삭속도, 이송량, 절삭깊이 등의 절삭조건을 바꾸며 선삭가공하여 주분력, 배분력, 이송분력의 절삭력의 변화와 표면거칠기의 변화를 측정하였다. 날끝반경 0.8mm의 공구보다 0.4mm의 공구를 사용하였을 때 절삭력이 작게 나타났으며 표면거칠기는 0.8mm의 공구를 사용할 때가 양호하였다. 절삭력만을 고려할 때의 적절한 절삭조건은 절삭속도 223m/min, 절삭깊이 0.15mm, 이송량 0.06mm/rev이다. 또한 절삭속도 111.6m/min, 절삭깊이 0.55mm, 이송량 0.015mm/rev에서 양호한 표면거칠기가 얻어졌다. Turning experiments are conducted to investigate the relationship between cutting conditions and cutting forces and surface roughness. The cutting conditions consists of the cutting speed, depth, and feed. The STC3 carbon tool steel and STS410 stainless steel are used as working materials, and the KT250 coated sintered carbide tools with nose radius of 0.4mm and 0.8mm are used as the machining tools. It was observed from experiments that cutting with nose radius of 0.4R results in low cutting forces and that of 0.8R results in better surface roughness. Proper cutting conditions are obtained when we use the combinations of the cutting speed of 223m/min, depth of 0.15mm, and feed of 0.06mm/rev to minimize cutting force. Cutting speed of 111.6m/min, depth of 0.55mm, and feed of 0.105mm/rev are recommended for good surface roughness.

운동선수의 임장불안에 대한 연구

홍관이,이광재,김두경,부기원,노성규,한상준,박기동,오수일,문병용,이철규,박장평,엄기진,박남환 江原大學校附設 體育科學硏究所 1984 江原大學校附設體育科學硏究所論文集 Vol.- No.9

This study is designed to grasp the elements and situations of stage fright in order to propose a part of ways to cope with it. We make 511 top-class high school players, male and female, in the central districts (Seoul, Inchon, Kyungki, Chungbuk, and Kangweon Province) on object of questionnaire, and get the following results. Through players generally have all-round characters they show weakness in the superiority and emotional stability while showing strength in the sonformity. This fact comes to be related to the elements which cause stage fright. Physiological changes also have many effects on the symptom of stage fright. Especially, stage fright increases when players show sensitive reaction to the self-consciousness of final consequence which comes from the tension or uneasiness of sympathetic nerve, Thus, it turns out that players make use of reducing psychological burden by physical exercise or adjusting the level of demanded result in order to release the stage fright.

알코올 의존 환자의 Tryptophan Hydroxylase 유전자 다형성

홍주봉,이상익,신철진,김헌,지경환,정인원 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.4

연구목적 : 알코올 의존 환자에서 세로토닌 합성 조절 효소인 tryptophan hydroxylase(TPH) 유전자 다형성 빈도를 정상 대조군과 비교함으로써 알코올 의존의 유전적 요인을 추적하고, 임상변인과 이 유전자 다형성과의 관련성을 알아보고자 하였다. 방 법 : DSM-IV진단기준에 부합되는 알코올 의존 환자 100명과 정상 대조군 100명을 대상으로 TPH유전자 다형성을 증합효소 연쇄반응과 제한효소 처리법을 이용하여 동정하였다. 여기서 분리된 대립 유전자와 유전자형에 따른 빈도의 차이를 서로 비교하였으며, 알코올 의존 환자군의 여러 임상 변인에 따른 차이를 비교하였다. 결 과 : 알코올 의존 환자군과 대조군 간에 TPH의 A216C 유전자형 및 대립유전자 빈도에서의 통계적으로 유의한 차이는 관찰되지 않았으나, 조기 발병한 환자의 경우는 유전자형의 빈도가 AA,AC,CC형이 0.57, 0.39, 0.04, 후기 발병한 환자의 경우 0.34, 0.45, -.21로, 조기 발병한 환자군에서 대조군과 비교하여 통계적으로 유의하게 A 대립 유전자의 빈도가 높은 것이 관찰되었다.(by chi-square test, p<0.05). 결 론 : 이는 조기 발병형 알코올 의존의 경우 TPH유전자 다형성과 관련이 있으며, 일부 알코올 의존 환자에서 유전적으로 세로토닌계의 이상이 있다는 사실을 시사한다. Objectives : This study was performed to explore the association of tryptophan hydroxylase (TPH) gene with diagnosis of alcohol dependence and/or clinical characteristics such as age of onset, family history, and severity of symptoms in Korean alcoholics. Methods : The genotype and allele frequencies of TPH in 100 male hospitalized patients who met DSM-IV criteria for alcohol dependence were investigated using polymerase chain reaction and restriction fragment length plymorphism and were compared with 100 age-matched healthy male control subjects. And the associations between gene polymorphisms and clinical characteristics in alcoholic patients were explored. Results : The distributions of TPH genotype and allele in alcohol dependent patients were not different from control subjects. However, the frequencies of TPH genotype in early-onset alcoholic patients, which were 0.57, 0.39, and 0.04(AA, AC and CC, respectively), were significantly different from those of late-onset alcoholics(0.34, 0.45, and 0.21, respectively). "A" allele was found more frequent in early-onset alcoholics. Conclusion : The result suggests that TPH gene polymorphism is associated with early-onset alcioholic patients possibly related with inherited abnormalities of serotonin system.

Lyapunov 제2방법에 의한 로보트 머니플레이터의 적응제어

홍철호,이택종 成均館大學校 科學技術硏究所 1989 論文集 Vol.40 No.1

본 논문에서는 머니플레이터의 nominal제이에 근거를 둔 기준 모델 추종 적응제어기법(Adaptive model following control)을 제안한다. 기준 모델은 머니플레이터의 Nominal 값들을 사용하여 머니플레이터의 모델과 유사한 비선형커플링 시스템으로 표현하며 로봇 머니플레이터가 미리 계획된 궤적을 최대한 근접하게 추종하도록 비선형 보상과 Lyapunov 제 2방법에 의해 대국적으로 점근안정하도록 구현된다. 제안된 제어칙(Control law)은 컴퓨터모사를 통해 그 성능의 효용성을 입증된다. This paper proposed AMFC based on nominal control scheme of a robot manipulator. Reference model is represented by a nonlinear coupled robot manipulator using its nominal values. Control lane is developed for the manipulator to track a preplanned trajectory as closely as possible and is designed to assure globally asymptotic suability via the second method of Lyapunov. The performance validity of the proposed control law is verified by computer simulation.