유치와 영구치에서 치과용 접착제의 전단결합강도

최진영,최남기,박영준,최충호,양규호 大韓小兒齒科學會 2007 大韓小兒齒科學會誌 Vol.34 No.4

The objective of this study was to compare the shear bond strengths of five adhesive systems to the enamel and dentin of primary and permanent teeth. Fifty noncarious primary and fifty permanent teeth were collected and stored in an 0.1% thymol solution at room temperature after extraction. The tested adhesives were: Adper Scotchbond Multi-purpose Plus Adhesive (SM) Adper Single bond 2 (SB), Clearfil SE Bond (SE), Adper Prompt L-Pop (PL), G-Bond (GB). For the shear bonding test, the labial and lingual surfaces of primary and permanent teeth were used. To obtain a flat surface, the labial and lingual surfaces of the teeth were sanded on SiO₂with number 600 grit and then divided into 20 groups of 10 surfaces each. All samples were theromocycled in water 5℃ and 55℃ for 1000 cycles. The results were as follows: 1. For primary enamel, shear bond strengths of SM and SB were significantly higher than that of SE and also SM, SB, and PL were higher than GB(p<0.05). 2. For primary dentin, there were no significant differences among the shear bond strengths of any other bonding systems except differnece between SE and GB. 3. For permanent enamel, SB showed significantly higher mean shear bond strength than those of any other bonding systems(p<0.05). 4. For permanent dentin, SM showed significantly higher mean shear bond strength than that of PL and GB(p<0.05). 5. Between the primary enamel and dentin, there were significant differences in SM, SB, and GB, whereas there was statistically significant difference in PL between the permanent enamel and dentin(p<0.05). 6. Between the primary and permanent teeth on enamel, there were no significant differences among all bonding systems, whereas there were statistically significant differences in SM and SB between the primary and permanent teeth on dentin(p<0.05). 본 연구에서는 최근에 개발된 치과용 접착제를 대상으로 유치와 영구치의 법랑질과 상아질에 대한 결합력을 비교 평가하여 입상에서 상아질 접착제를 적절하게 선택하는데 도움을 주고자 시행하였다. 실험재료로 Adper Scotchbond Multi-purpose Plus Adhesive (SM; 3M ESPE,USA),Adper Single bond 2 (SB; 3M ESPE,USA),Clearfil SE Bond (SE; Kuraray Medical Inc.,Japan),Adper Prompt L-Pop (PL; 3M ESPE,USA),G-Bond (GB:GC Cooperation Toyko,Japan)를 이용하여 전단결합강도를 평가하여 다음과 같은 결과를 얻었다. 1. 유치 법랑질에서 전단결합강도는 SM이 28.47±7.93 MPa로 가장 높았고 SB (28.18±6.84),PL (24.02± 6.14),SE (21.70±6.56),GB (17.70±6.68) 순이었다. SM과 SB는 SE보다 통계적으로 유의하게 높은 결합 강도를 보였으며,SM,SB,PL은 GB보다 높았다(p<0.05). 2. 유치 상아질에서 전단결합강도는 SE가 28.72±14.44MPa로 가장 높았고,PL (20.10±6.13),SM 07.72± 10.65),SB (15.48±2.66),GB (10.10±5.45) 순이었으며 SE와 GB간 에는 유의한 차이가 있었으나,다른 군 들 간에는 유의한 차이가 없었다. 3. 영구치 법랑질에서의 전단결합강도는 SB가 28.36±5.68 MPa로 가장 높았고 SM (22.77±4.63), PL(22.05 士6.57),SE (21.74±4.62),GB (15.60±6.75)순이었다. SB는 다른 접착제보다 통계적으로 유의하게 높은 결합력을 나타냈으며,GB는 가장 낮은 결합력을 보였다(p(0.05). 4. 영구치 상아질에서의 전단결합강도는 SM이 28.22±5.56 MPa로 가장 높았고,SB (21.68±7.44),SE (20.13 ±9.88),GB (14.30±6.81),PL (14.18±5.88)순이었으며,SM은 PL,GB와 유의한 차이가 있었다(p<0.05). 5. 유치의 법랑질과 상아질 간에는 SM,SB,GB에서 유의한 차이가 있었고,영구치 법랑질과 상아질 간에는 PL에서 유의한 차이가 있었다(p<0.05). 6. 유치 법랑질과 영구치 법랑질 간에는 모든 접착제에서 유의한 차이가 없었으나,유치 상아질과 영구치 상아질 간에는 SM과 SB에서 유의한 차이가 있었다(p<0.05).

ORiginal Article : Gastroprotective Effects of PMK-S005 against Ethanol-Induced Acute Gastric Damage in Rats

( Yoon Jeong Choi ),( Nayoung Kim ),( Ju Yup Lee ),( Ryoung Hee Nam ),( Ji Hyung Seo ),( Seonmin Lee ),( Hee Jin Kim ),( Yoon Jin Choi ),( Hye Seung Lee ),( Dong Ho Lee ) 대한간학회 2016 Gut and Liver Vol.10 No.3

Background/Aims: This study aimed to examine the gastroprotective effects of PMK-S005, which is a synthetic S-allyl-Lcysteine (SAC; a sulfur-containing amino acid), against acute ethanol-induced gastric damage in rats. Methods: Sprague- Dawley rats were divided into six groups, including a nonethanol group, groups treated with absolute ethanol 1 hour after pretreatment with various doses of PMK-S005 (1, 5, and 10 mg/kg) or rebamipide (50 mg/kg), and an absolute ethanolonly group. Ethanol-induced gross ulcer and mucus levels were measured. Myeloperoxidase, tumor necrosis factor a, interleukin 1β, PGE2, LTB4, cPLA2, COX-1, and COX-2 levels were estimated by enzyme-linked immunosorbent assay or Western blot analysis. Furthermore, the protein expression levels of antioxidant enzymes, including heme oxygenase-1 (HO-1), NAD(P)H:quinine oxidoreductase 1 (NQO-1), GCLC, and GCLM, were assessed. Results: PMK-S005 significantly attenuated the ethanol-induced gastric damage; it reduced mucosal inflammatory cytokine production and increased mucus levels. The expression levels of cPLA2, COX-1, and COX-2 were decreased by PMK-S005. PMK-S005 did not affect PGE2 synthesis, but LTB4 production was significantly suppressed. In addition, long-term administration of PMKS005 significantly increased the expression of HO-1, NQO-1, GCLC, and GCLM. Conclusions: These results strongly suggest that PMK-S005 prevents gastric mucosal damage and that these gastroprotective activities are due to anti-inflammatory effects and enhancement of the gastric defense system, including antioxidant enzymes. (Gut Liver 2016;10:348- 355)

Sheehan 증후군 발생한 Torsades de Pointes

김승환,김남호,김용철,최준호,박은미,이상재,이은미,유남진,윤경호,오석규,정진원 圓光大學校 醫科學硏究所 2008 圓光醫科學 Vol.23 No.1

재발하는 심실 빈맥으로 내원한 환자에서 Sheehan 증후군을 진단하였고, 적절한 호르몬 보충 치료 후 심전도 이상이 정상으로 회복된 예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Torsades de Pointes is a form of polymorphic ventricular tachycardia that is associated with prolongation of QT intervals, characterized by QRS complexes of progressively changing ampulitude and cyclic length, giving the appearance of oscillations around the baseline. A 77 years-old woman was presented with hypotention and arrhythmia. Twenty four-hour ECG showed typical episodes of torsades de pointes with QT prolongation. This arrhythmia was controlled by isoproterenol and magnesium infusion, but it was not disappeared. She was diagnosed as Sheehan's syndrome by past history, anterior pituitary stimulation test and empty sella on CT scan. After hormone replacement treatment, Prolonged QT interval was normalized and polymorphic ventricular tachycardia has not recurred. We report a case of torsades de pointes associated with Sheehan's syndrome

백서 척수후근절로부터 슈반세포의 효과적인 체외 배양법

김성민,이종호,김남열,안강민,최원재,최시호,차미주,이주영,황순정,장정원,명훈,최진영,서병무,정필훈,김명진 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.4

Schwann cells(SCs), an important component of the peripheral nervous system, intract with nerous to mutually support growth and replication for the peripheral nerve regentation. Recently, ading SCs to the lumen of guidance channel is widely tried to improve regeneration or to make regeneration possible over otherwise irreparable gaps. however, it is not easy to isolate and multiplicate SCs as much as enough to help the axonal regeneration. For the allogeneic SCs source for tubular nerve guidance, we developed a little bit improved technique of harvesting and multiplicating SCs. by culturing dispersed dorsal root ganglia in specially designed medium with growth factors and serial processing, we repeatedlly generate relatively homogenous SC cultures. Our technique was compared with other methods of literature using immunostaining methods such as GFAP, S100, BDNF and the total SC count assessment at different time interval after primary culture.

석청(Mad-honey) 복용 후 유발된 부정맥 1예

김용철,김남호,김승환,최준호,박은미,이상재,이은미,유남진,윤경호,오석규,정진원 圓光大學校 醫科學硏究所 2008 圓光醫科學 Vol.23 No.2

석청에 포함된 grayanotoxin에 의해 독성 작용이 나올 수 있으며, 이러한 독성 작용은 일반적으로 24시간 이내 저절로 회복된다. 최근에 본 저자들은 석청 복용 후 발생한 심실빈맥을 경험하였기에 보고하는 바이다. 49세 남자가 호흡곤란으로 내원하였으며, 내원당시 분당 40회 정도의 동성 서맥이 관찰되었고, 수액을 투여하던 중 심실 빈맥이 발생하였다. 항부정맥제를 투여 후 정상 동율동으로 전환되었으며, 특별한 이상 없이 4일 후 퇴원하였다. Mad-honey intoxication caused by the consumption of honey producted from the nectar of rhododendrons. The grayanotoxins cause the intoxication. The toxic effects of mad-honey poisoning are rarely fatal and generally last for no more than 24 hours. We experienced one case, a 49 years-old man who presented with dyspnea after ingestion of mad-honey. He showed marked sinus bradycardia with < 40 beats per minute on admission. The cardiac rhythm was changed to ventricular tachycardia immediately. These features resolved completely in 24 hours with continuous infusion of amiodarone(600 mg per day) and fluids. We report the case of intoxication of mad-honey as a presentation of fatal cardiac arrhythmia.

정신지체 학생의 구강실태 및 우식활성도에 관한 연구

한수경,김남순,조홍규,송호준,최충호,최남기 대한소아치과학회 2007 大韓小兒齒科學會誌 Vol.34 No.1

본 연구의 목적은 정신지체 학생의 구강건강 실태 및 치아우식 활성도를 평가하여, 학생들의 구강건강 증진을 위해 필요한 교육 방안을 모색하고, 실제적인 구강건강 관리 향상을 위한 기초 자료를 마련하고자 하는 것이었다. 광주광역시 소재 S 정신지체특수학교 유아부부터 고등부까지의 학생을 대상으로 조사를 실시하였다. 구강건강실태를 평가하기 위한 구강검사는 213명에 대해 시행하였으며, 치아우식활성도 검사는 197명에 대해 시행하였다. 치아우식활성도 평가를 시행한 197명의 정신지체 학생 중 우식활성이 고도인 학생은 33명(16.77%)으로 나타났으며, 13세 이하가 그 이상의 연령에 비해 치아우식활성도가 높았다. 치아우식활성도의 경중도와 치은염 유무와는 관련성이 없는 것으로 나타났다. 정신지체 장애학생의 치아우식활성도 경중과 치아우식경험지수와의 상관성을 평가한 결과, 치아우식활성도가 증가할수록 우식경험치율과 우식경험치지수가 높은 양상을 보였으며, 특히 유치의 경우 우식경험유치율 및 우식경험유치지수는 치아우식활성도와 높은 상관성을 보였다. The purpose of this study is to evaluate oral health status, caries-inducing bacterial activity of the mental retardation students, and developing motivation method for improving oral hygiene management by clarifying the relationship between caries- inducing bacterial activity and oral health status of mental retardation students. Caries experience indices, caries susceptibility test, gingival health evaluation, and oral hygiene management and oral health survey were performed. Results were as follows: 1. The DMFT index of disabled students(12 years) was 2.07. 2. The gingival inflammation was occurred more frequently in older ages. 3. There also was a high positive correlation between caries incidences and the results of caries-inducing bacterial activity test especially in deciduous teeth. This result suggested that the Dentocult SM mutans test as a caries activity test is a reliable method for measuring the status of dental caries in mental retardation students. Because it would motivate the mental retardation students to care more actively for their oral hygiene if they learn how much dental caries-inducing bacteria are living in their mouth by observing the bacterial colony on the cultured test strip, it can become a possibly efficient educational tool for the mental retardation students.

관상동맥 스텐트 삽입술을 시행한 환자에서 안지오텐신 전환효소 억제제와 안지오텐신 수용체 차단제가 재협착에 미치는 영향

김연경,정진원,윤경호,박은미,송미진,최준호,이은미,유남진,김남호,오석규 圓光大學校 醫科學硏究所 2006 圓光醫科學 Vol.21 No.1

심근 허혈-재관류 백서 모델에서 mitogen-activated protein kinase 활성화에 대한 α-lipoic acid의 효과

김연경,박은미,최준호,윤경호,유남진,이은미,김남호,정진원,김민선,박병림,오석규 圓光大學校 醫科學硏究所 2006 圓光醫科學 Vol.21 No.1

급성 관동맥증후군 환자의 신기능 이상과 주요 심장사건과의 관계

이상재,윤경호,최준호,송미진,김연경,박은미,김현정,이은미,유남진,김남호,오석규,정진원 圓光大學校 醫科學硏究所 2006 圓光醫科學 Vol.21 No.1

Er:YAG 레이저를 이용한 치아삭제 효과

최남기,양규호,박상원,김옥준 大韓小兒齒科學會 2001 大韓小兒齒科學會誌 Vol.28 No.4

Er:YAG 레이저는 파장이 물의 주흡수 정점과 일치하는 2.94㎛의 방출파장을 가지기 때문에, 물분사를 하면서 사용했을 때, 다른 레이저보다 열손상은 더 작으면서 치아경조직을 보다 효과적으로 삭제한다고 알려져 있다. Er:YAG 레이저의 상아질 삭제 효과를 평가하고자 발거된 소구치와 대구치를 대상으로 상아질 시편을 제작하고 2.94㎛의 pulsed Er:YAG 레이저 (SDL-300EN, 삼성전자, 한국)를 handpiece형의 전달계를 이용한 비접촉식 방법으로, 물에 담궈진 시간과 레이저 조사시간에 따른 삭제량과 형태를 조사, 분석하여 다음과 같은 결과를 얻었다. 1. 건전 상아질에 대한 조사 결과 물에 담군 시간이 증가할수록 삭제율이 증가 하였다. 2. 건전 상아질과 우식 상아질에 150mJ, 10Hz의 조건으로, 30초간 레이저를 조사했을 때, 우식상아질에 비해 건전 상아질에서 surface irregularity가 증가하고 상아세관이 열리는 경향이 있었으며 crack이 관찰되었다. 또한 우식 상아질에 비해 많은 탄조각(ash flecks), crack이 관찰되었고 상아세관의 불연속성(inconsistency)이 관찰 되었다. 3. 우식 상아질에서 30초로 조사한 경우에서는 dark zone이 와동에 국한되어 나타났으며 작은 fleck들이 관찰되었고, 1분간 조사한 경우에서는 30초의 경우보다도 와동이 더 넓었으며, crack이 상아세관 주행방향과 직각으로 형성된 것을 관찰 할 수 있었다. 2분간 조사한 경우는 와동이 가장 넓었으며 crack이 더 많이 형성된 것을 볼 수 있었다. The purpose of this study was to evaluate the effects of Er:YAG laser on cutting efficacy and its histologic findings. Dentin specimens of human premolars and molars were used and irradiated by Er:YAG laser with noncontact handpiece type delivery system under different treatment condition of irradiation tiem. Cavity pattern and volume were evaluated to determine the cutting efficacy and following results were obtained. 1. Cutting volume of sound dentin was getting larger with time immersed in water increase 2. With the condition of irradiation (150mJ, 10Hz, 30sec), surface irregularity was more increased in sound dentin comparing to carious dentin. For the light microscopic examination, dentinal tubules were opened and ash flecks and cracks were noted with inconsistence of dentinal tubules. 3. In case of 30 sec, irradiation in carious dentin, dark zone was limited to small focus whereas 1 min, irradiation, more wider, and cracks were noted in the perpendicular to direction of dentinal tubules. For the 2 min, irradiation, cavity was the widest and more cracks were found.