http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
제2형 당뇨병 환자에서 적극적 환자 교육이 혈당조절에 미치는 효과
이윤욱,황원선,최선정,이동훈,김도현,이은희,홍은경,노혜림,정윤석,이관우,김현만 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.1
연구배경: 현재까지의 당뇨병 교육에 대한 노력은 제한되었으며, 연구 결과를 보면 식사 조절 교육과 체중 조절 프로그램을 수행한 환자들 중 적극적이고 기간이 긴 교육을 받은 경우, 성공적 결과가 나타남을 알 수 있었다. 자가관리나 체중감량 등의 당뇨병 치료의 중요한 목표는 적극적이고 긴 기간의 교육 없이는 시행되기 어렵다. 본 연구에서는 외래에서 당뇨병 환자를 대상으로 시행할 수 있는 행동 및 식사 교육 등의 적극적 교육 프로그램을 개발하여 제2형 당뇨병 환자들을 대상으로 이들에게 식사 조절 방법에 대한 목표설정과 문제에 직면하였을 때의 해결 방법 등을 교육해서 궁극적으로는 적극적 자아관리에 연결될 수 있도록 도와주는 것을 목적으로 기존의 통상적 교육과 보다 적극적인 교육이 당뇨병 환자의 혈당 조절에 어떠한 영향을 미치는지에 대해 알아보기 위해 다음과 같은 연구를 시행하였다. 방법: 본 연구는 아주대학교 병원 내분비 대사 내과를 처음으로 방문하여 치료받았던 58명의 제2형 당뇨병 환자를 대상으로 하였다. 내원 환자들을 무작위하게 추출하여 진찰권 번호 끝자리에 따라 홀수는 통상적 교육군(conventional education group, CE)과 짝수는 적극적 교육군(intensive education group, IE)으로 나누어 교육하고, 3개월후에 교육의 효과를 평가하였다. 결과: 1) 연구 대상자들의 교육 전과 후의 공복혈당, 식후2시간 혈당 및 HbA_lc 치는 IE군과 CE군 모두 각 그룹 내에서, 유의적으로 감소하였다(p<0.05). IE군에서는 공복혈당이 12.4nmol/L에서 7.7nmol/L로, 식후2시간 혈당이 20.3nmol/L에서 10.9nmol/L으로, HbA_lc치가 9.4%에서 7.0%로 모두 교육 전에 비하여, 교육 후에 감소(p<0.05)하였고, CE군도 공복혈당은 10.9nmol/L에서 9.4nmol/L로, 식후2시간 혈당은 17.1nmol/L에서 14.6nmol/L으로 HbA_lc가 8.5%에서 7.3%으로 모두 교육 후에 감소하였다(p<0.05). 또한, 교육 전에 비하여 교육 후에 공복 혈당 및 HbA_lc치가 감소하는 정도는 IE군에서의 감소가 CE군에 비해 더 현저하였다Op<0.05). 2) 식사에 대한 태도는 3부분으로 나누어 식사에 대한 규칙성, 식사 내용의 균형성, 식사에 대한 태도 등으로 나누어 각각의 점수 및 총점을 비교하였으며 교육 전에 비해 교육 후에 연구 대상자들의 식태도가 향상되었음을 알 수 있었다. 두 그룹간의 차이를 분석한 결과 식사의 균형성 항목에서와 총점에서 유의적으로 두 그룹의 차이를 보여서 IE군에 CE군에 비해 식사의 균형성 측면이 향상되었고, 전체적인 식태도가 좋아졌음을 알 수 있었다(p<0.05). 결론: 비교적 긴 기간은 아니지만 적극적 교육을 받은 당뇨병 환자들이 통상적 교육을 받은 군보다 혈당 및 HbA_lc, 식태도 점수등의 수치의 호전뿐만 아니라 당뇨병 환자의 삶에서 중요한 부분을 차지하는 식사요법 관리 부분에 있어 향상됨을 알 수 있었다. Background: To this date, efforts to develop effective methods for the education of diabetic patients have been limited. The important goal of self-management and weight control for diabetic treatment can not be attained without long and intensive period of education. This study was undertaken to assess the effectiveness of an intensive educational program, of behavior and diet control, which was carried out on subjects with type 2 diabetes, on and out-patient basis. we compared the effectiveness of an intensive education programme with that of a conventional education programme for the self-management of type 2 diabetic patients. Methods: Subjects with type 2 diabetes were randomly selected, and allocated to one of two groups. One group received a conventional education programme of self-management(the CE group), and the second group received an intensive education progammes for three months, after which the effectiveness of the programmes were evaluate. Results: 1) The levels of fasting blood sugar(FBS), postprandial 2 hour blood sugar(PP2h) and HbA1c were significantly lowered in both groups following the intervention(p<0.05). In the IE group, the FBS declined from 12.4nmol/L to 7.7nmol/L, PP2h declined from 20.3nmol/L to 10.9nmol/L, and the HbA_lc showed a similar decline from 9.4 to 7.0% after intervention(p<0.05). In the Ce group, the FBS declined from 10.9 to 9.4nmol/l, the PP2h decreased from 17.1 to 14.6nmol/l, and the HbA_lc also decreased from 8.5 to 7.3% after intervention(p<0.05). The decrease in the FBS and HbA_lc following the educational intervention was more pronounced in the IE group than the CE group(p<0.05). 2) The effectiveness of the education programmes in promoting appropriate dietary behavior in the diabetic subjects was assessed by a scoring system in three parts: a regularity score, a balance score and an attitude score. From a comparative study of the three scores, the patients attitudes were observed to be much improved in both the groups following the intervention compared to before the programmes, but the balance and total scores were significantly higher in the IE group than the CE group(p<0.05). Conclusion: We can conclude that the intensive diabetic education programme is more effective than a conventional programme, not only in improving the patients' levels of glucose, HbA_lc, and dietary score, but also the diabetic patients self-control abilities, promoting behavioral change, and prompting problem solving capabilities in respect to the everyday problems that they have to face throughout their lives(J Kor Soc Endocrinol 18:63∼72, 2003).
대한간학회지 제8차 춘계학술대회 초록집 : 구연 ; 간경변 환자에서 Octreotide 정주가 문맥압에 미치는 영향
박동훈 ( Park Dong Hun ),백순구 ( Baeg Sun Gu ),김문영 ( Kim Mun Yeong ),최윤종 ( Choe Yun Jong ),김현수 ( Kim Hyeon Su ),이동기 ( Lee Dong Gi ),권상옥 ( Kwon Sang Og ),김영주 ( Kim Yeong Ju ) 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.2(S)
메모리 소자에의 응용을 위한 SrBi<sub>2</sub>Nb<sub>2</sub>O<sub>9</sub> 박막의 성장 및 전기적 특성
강동훈,최훈상,이종한,임근식,장유민,최인훈,Gang, Dong-Hun,Choe, Hun-Sang,Lee, Jong-Han,Im, Geun-Sik,Jang, Yu-Min,Choe, In-Hun 한국재료학회 2002 한국재료학회지 Vol.12 No.6
$SrBi_2Nb_2O_9(SBN)$ thin films were grown on Pt/Ti/Si and p-type Si(100) substrates by rf-magnetron co-sputtering method using two ceramic targets, $SrNb_2O_6\; and \;Bi_2O_3$. The structural and electrical characteristics have been investigated to confirm the possibility of the SBN thin films for the applications to destructive and nondestructive read out ferroelectric random access memory(FRAM). For the optimum growth condition X-ray diffraction patterns showed that SBN films had well crystallized Bi-layered perovskite structure after $700^{\circ}C$ heat-treatment in furnace. From this specimen we got remnant polarization $(2P_r)$ of about 6 uC/$\textrm{cm}^2$ and coercive voltage $(V_c)$ of about 1.5 V at an applied voltage of 5 V. The leakage current density was $7.6{\times}10^{-7}$/A/$\textrm{cm}^2$ at an applied voltage of 5V. And for the NDRO-FRAM application, properties of SBN films on Si substrate has been investigated. From transmission electron microscopy (TEM) analysis, we found the furnace treated sample had a native oxide about 2 times thicker than the RTA treated sample and this thick native oxide layer had a bad effect on C-V characteristics of SBN/Si thin film. After $650^{\circ}C$ RTA process, we got the improved memory window of 1.3 V at an applied voltage of 5 V.
상·하악 전치부의 근관치료에 사용되는 시술길이 (Working Length)에 관한 통계학적 연구
최동훈,박동수,이찬영,이정식 大韓齒科保存學會 1984 Restorative Dentistry & Endodontics Vol.10 No.1
This study was undertaken to obtain the average canal length of upper & lower anterior teeth which was important in canal length measuring procedure of endodontic treatment. It was based upon 827 out-patients who had endodontic treatment on their upper & lower anterior teeth at the Department of Operative Dentistry, Dental Infirmary, Yonsei Medical Center from February, 1978 to June, 1984. The 1249 teeth of these patients were devided into sex and age groups. The root canal length of these teeth were measured. The following results were obtained; 1. The mean root canal length of upper & lower anterior teeth were as follows; Upper central incisors : 21.8mm Upper lateral incisors : 21.0mm Upper canines : 24.1mm Lower central incisors : 18.6mm Lower lateral incisors : 19.9mm Lower canines : 22.6mm 2. There was no significant difference in root canal length between sex. (p>0.05) 3. There was no significant difference in toot canal length between age groups. (p>0.05) 4. The distribution of upper central incisors showed the highest distribution followed by upper lateral incisors and lower central incisors between 10 to 40 year old age groups, and there was no significant difference in the rest of the age groups. There was no significant difference in sex distribution, which was 49.5% for males and 50.4% for females. The number of the upper anterior teeth was 74.3% of all the specimens and the lower anterior 25.7%, and 40.6% of all the specimens were upper central incisors.
Miliary cutaneous tuberculosis caused by multi-drug resistant M. tuberculosis in an AIDS patient
( Dae Hun Suh ),( Sang Duck Kim ),( Kwang Hyun Cho ),( Hee Chul Eun ),( Jai Il Youn ),( Woo Ho Kim ),( Dong Hyon Shin ),( Young Soo Shim ),( Myoung Don Oh ),( Kang Won Choe ) 대한피부과학회 1998 초록집 Vol.36 No.20
Lee, Dong-Eun,Na, Jin Hee,Lee, Sangmin,Kang, Choong Mo,Kim, Hun Nyun,Han, Seung Jin,Kim, Hyunjoon,Choe, Yearn Seong,Jung, Kyung-Ho,Lee, Kyo Chul,Choi, Kuiwon,Kwon, Ick Chan,Jeong, Seo Young,Lee, Kyung American Chemical Society 2013 MOLECULAR PHARMACEUTICS Vol.10 No.6
<P>An efficient and straightforward method for radiolabeling nanoparticles is urgently needed to understand the <I>in vivo</I> biodistribution of nanoparticles. Herein, we investigated a facile and highly efficient strategy to prepare radiolabeled glycol chitosan nanoparticles with <SUP>64</SUP>Cu via a strain-promoted azide–alkyne cycloaddition strategy, which is often referred to as click chemistry. First, the azide (N<SUB>3</SUB>) group, which allows for the preparation of radiolabeled nanoparticles by copper-free click chemistry, was incorporated to glycol chitosan nanoparticles (CNPs). Second, the strained cyclooctyne derivative, dibenzyl cyclooctyne (DBCO) conjugated with a 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) chelator, was synthesized for preparing the preradiolabeled alkyne complex with <SUP>64</SUP>Cu radionuclide. Following incubation with the <SUP>64</SUP>Cu-radiolabeled DBCO complex (DBCO-PEG<SUB>4</SUB>-Lys-DOTA-<SUP>64</SUP>Cu with high specific activity, 18.5 GBq/μmol), the azide-functionalized CNPs were radiolabeled successfully with <SUP>64</SUP>Cu, with a high radiolabeling efficiency and a high radiolabeling yield (>98%). Importantly, the radiolabeling of CNPs by copper-free click chemistry was accomplished within 30 min, with great efficiency in aqueous conditions. In addition, we found that the <SUP>64</SUP>Cu-radiolabeled CNPs (<SUP>64</SUP>Cu-CNPs) did not show any significant effect on the physicochemical properties, such as size, zeta potential, or spherical morphology. After <SUP>64</SUP>Cu-CNPs were intravenously administered to tumor-bearing mice, the real-time, <I>in vivo</I> biodistribution and tumor-targeting ability of <SUP>64</SUP>Cu-CNPs were quantitatively evaluated by microPET images of tumor-bearing mice. These results demonstrate the benefit of copper-free click chemistry as a facile, preradiolabeling approach to conveniently radiolabel nanoparticles for evaluating the real-time <I>in vivo</I> biodistribution of nanoparticles.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/mpohbp/2013/mpohbp.2013.10.issue-6/mp300601r/production/images/medium/mp-2012-00601r_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/mp300601r'>ACS Electronic Supporting Info</A></P>
Woo, Dong-Cheol,Kim, Goo-Young,Kim, Hyun-Ju,Bang, Eunjung,Rhim, Hyang-Shuk,Kim, Sang-Young,Lee, Do-Wan,Choi, Chi-Bong,Seoung, Youl-Hun,Choe, Bo-Young Hindawi Limited 2013 Journal of spectroscopy Vol.2013 No.-
<P>The purpose of this study is to investigate the metabolic alterations associated with acute alcohol treatment in zebrafish by<SUP>1</SUP>H nuclear magnetic resonance spectroscopy (NMRS). The brain metabolism of zebrafish was investigated after acute alcohol treatment (one-hour long exposure of adult fish to 0.00%, 0.25%, 0.50%, or 1.00% ethyl alcohol) with whole brain extraction. The results of this study showed that glutamate (Glu) was significantly decreased, scyllo-inositol (sIns) showed a small apparent increase only in the highest acute treatment dose group, and myoinositol (mIns) showed a significant decrease. [Glu]/[tCr] and [mIns]/[tCr] levels were significantly reduced regardless of the alcohol dose, and [sIns]/[tCr] was increased in the highest alcohol treatment dose group. The present NMR study revealed that specific metabolites, such as Glu and mIns, were substantially decreased in case of acute alcohol exposed zebrafish brain.</P>
초기 동맥혈 Carboxyhemoglobin 농도가 높았던 화상 환자들의 예후지표에 관한 연구
최창순 ( Choe Chang Sun ),김철홍 ( Kim Cheol Hong ),김근숙 ( Kim Geun Sug ),이태유 ( Lee Tae Yu ),정연손 ( Jeong Yeon Son ),엄광석 ( Eom Gwang Seog ),박용범 ( Park Yong Beom ),장승훈 ( Jang Seung Hun ),김동규 ( Kim Dong Gyu ),박 대한결핵 및 호흡기학회 2003 Tuberculosis and Respiratory Diseases Vol.55 No.2