Temporal trends of the prevalence and incidence of atrial fibrillation and stroke among Asian patients with hypertrophic cardiomyopathy: A nationwide population-based study

Choi, You-Jung,Choi, Eue-Keun,Han, Kyung-Do,Jung, Jin-Hyung,Park, Jiesuck,Lee, Euijae,Choe, Wonseok,Lee, So-Ryoung,Cha, Myung-Jin,Lim, Woo-Hyun,Oh, Seil Elsevier 2018 INTERNATIONAL JOURNAL OF CARDIOLOGY Vol.273 No.-

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Atrial fibrillation (AF) and stroke are common in hypertrophic cardiomyopathy (HCM). We aimed to determine the prevalence and incidence of AF and stroke in patients with HCM during a 10-year period.</P> <P><B>Methods</B></P> <P>Using the Korean National Health Insurance Services database, we identified patients diagnosed with HCM from the entire Korean population between 2005 and 2015. The annual prevalence and incidence of AF and stroke in HCM patients were estimated.</P> <P><B>Results</B></P> <P>The prevalence of AF in HCM patients has gradually increased to 1.6-fold from 13.4% in 2005 to 20.9% in 2015. The incidence of AF ranged from 4.1 to 5.5%, a similar trend was observed for each year in HCM patients. The prevalence of stroke in HCM patients was approximately 10%, while that in HCM patients with AF was about 20%. During 8741 person-years, AF-related stroke occurred in 257 subjects among 2309 HCM patients with new-onset AF. The overall incidence rate of AF-associated stroke was 2.94 per 100 person-years. In subgroup analysis, the incidence rate of AF-associated stroke was 1.49 per 100 person-years in the under 45 year-old group and 1.48 per 100 person-years in the group with CHA<SUB>2</SUB>DS<SUB>2</SUB>­VASc score of 0 or 1 point in HCM patients.</P> <P><B>Conclusions</B></P> <P>The prevalence of AF in HCM patients gradually increased over 10 years. The annual risk of AF-associated stroke in HCM was over 1% even in younger patients and those with CHA<SUB>2</SUB>DS<SUB>2</SUB>­VASc score of 0 or 1 point, which provide evidence to support the prevention of stroke in HCM patients with AF.</P> <P><B>Highlights</B></P> <P> <UL> <LI> This is the first largest nationwide study on hypertrophic cardiomyopathy (HCM), a rare myocardial disease in Korea. </LI> <LI> The prevalence of AF in HCM patients gradually increases to 1.6-fold from 13.4% in 2005 to 20.9% in 2015. </LI> <LI> The annual incidence of AF in HMC patients was about 5%, and higher in female and the elderly. </LI> <LI> The prevalence of stroke in HCM patients with AF was about 20%, which were more than twice that in overall HCM patients. </LI> <LI> The risk of AF-related stroke in HCM patients was >1% per person-year even in younger patients or low CHA<SUB>2</SUB>DS<SUB>2</SUB>­VAS<SUB>C</SUB> score. </LI> </UL> </P>

친환경농업 농가 컨설팅에 대한 반응 조사

오환중,차광홍,정우진,김길용,박노동 全南大學校 農業科學技術硏究所 2011 農業科學技術硏究 Vol.46 No.-

The interactions between Environment-Friendly Agriculture Research Center (EFARC) and farmers in Jeonnam Province area who have practiced environment-friendly agriculture (EFA) under guidances of EFARC were investigated through enquete. The enquete was conducted during July - September, 2010. One hundred and eighty nine farmers responded all inquiries among 200 farmers. The main results are summarized as follows: 1. Rice was the predominant crop grown by farmers (49%), and the next major was hot pepper (12%). Most farmers (95.3%) have practiced environment-friendly agriculture at the levels of no-pesticide (55.6%), lower pesticide (32.8%), and organic (6.9%). 2. Major motivations of practicing EFA are for the production of safe foodstuffs (52.6%) and for an increase of income (40.1%). 3. Around 3 quarters of the environment-friendly agriculture products are shipped through Nonghyup, the cooperative marketing. The price margin between ordinary agriculture products and EFA products was of 5~10% for 63.5% farmers, of 10~20% for 14.3% ones, and of 20~30% for 14.8% ones. 4. Bottlenecks for practicing EFA are in the order of the unstability of shipping price (34.9%), cultivation techniques (20.1%), excess labor input (19.6%), and control of disease and insect pest (18%). 5. It turned out that more than 90% farmers who have practiced EFA under guidance of EFARC recognized the consulting activities of EFARC as to be helpful for them. 6. Establishment of national organizations which are specialized in consultation for EFApracticing farmers has been suggested.

메추리알의 저장성 향상에 대한 세척 및 저장 조건의 효과

차보숙,김학현,엄권용,김우정 한국산업식품공학회 2003 산업 식품공학 Vol.7 No.4

메추리알의 저장성 향상을 위하여 세척수의 온도와 pH, 세척후의 mineral oil coating, 저장중 공기의 상대습도(RH)와 CO₂의 영향을 비교하였다. 메추리알의 품질특성은 난황계수, Haugh unit, 중량감소를 측정하였다. 그 결과 세척수 온도 50℃와 pH 11.0의 KOH 용액이 수돗물이나 pH 3.5의 lactic acid 용액으로 세척한 것보다 저장성 향상에 효과가 있었다. 환경기체조건을 상대습도 70%와 3.0% CO₂ 농도로 조절한 것은 상대습도 80%와 2.0% CO₂의 조건보다 저장 기간을 50% 이상 연장 시켰다. 또한 mineral oil로 coating 처리할 경우 50℃에서 알칼리 용액으로 세척한 후 상대습도 70% 및 3.0% CO₂ 조건에서 저장하는 것보다 54% 가량 저장성 향상에 효과가 있었다. 이러한 조건에서 저장온도를 4℃로 낮출 경우 3개월 이상의 저장이 가능하였으며 선정된 세척 및 환경기체 조건은 저장 중 메추리알의 무게의 감소도 크게 낮춰 주었으며, 특히 mineral oil coating은 무처리구와 비교할 때 2.5배 이상 무게감소를 억제하는데 효과적임을 알 수 있었다. Effects of pH and temperature of the washing water, mineral oil coating, and PH and CO₂consentration for storage were investigated to extend the shelf-life of quail eggs. The quality characteristics of quail eggs measured were yolk index(YI), Haugh unit(HU) and weight loss. The results showed that KOH-adjusted washing water of pH 11.0 at 50℃ were effective on the improvement of storage stability of the eggs. Comtrolled atmosphere of RH 70.0% and 3.0% CO₂resulted in prolonged shelf-life by 50% when it was compared to the condition RH 80.0% and 2.0% CO₂. Coating the eggs with mineral oil extended futher the shelf-life up to 54%. combined treatments of washing at 50℃ and pH 11.0, coating with mineral oil, and controlling the atmosphere at RH 70.0% and 3.0% CO₂ extended the shelf-life more than 4 monts during storage at 4℃. The wight loss of the eggs during storage was significantly reduced by the storage at above condition and treatment particularly storing at 4℃.

하악골에 발생한 골막 골육종

김태우,김승범,권혁찬,문선재,윤정훈,김형준,차인호,육종인,김진 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.1

Periosteal osteosarcoma is a distinct entity of malignant bone tumor with characteristic clinical, morphological, and histological features within the group of juxtacortical osteosarcoma. Periosteal osteosarcoma is predominantly located in the tubular long bones, and extremely rarely involving the jaws. A case of periosteal osteosarcoma of the right mandible is presented. A 27-year-old woman complained of the gingival swelling and bleeding tendency of the right posterior mandible. Clinical examination revealed a reddish brown strawberry-like swelling on the affected mucosa, which measured 1.5㎝×1.5㎝. The tumor was located on the lingual cortex of the mandible and extended into the surrounding soft tissues. Microscopically, the tumor consisted exclusively of atypical chondroblastic cells with a small osteoblastic area. A minimal bone marrow involvement was noted and the adjacent cortex was free of tumor. These findings suggested that the tumor originated from the periosteal cambium layer, which lies between the periosteal fibrous layer and the cortex of mandible.

수직적 안모유형에 따른 치료 후 교합평면 안정성에 관한 연구

박정은,차경석,이진우,정동화 대한치과교정학회 2006 대한치과교정학회지 Vol.36 No.5

본 연구는 수직적 안모유형에 따른 치료 후 교합평면 변화양상을 조사하여 향후 적절한 치료계획과 기전의 설정에 도움이 되고자 시행하였다. 골격성 1급 부정교합으로 진단되어 비발치로 치료받은 성인 60명(남자 28명, 여자 32명)을 대상으로 하였으며, Ricketts법의 facial axis, facial depth, mandibular plane angle, lower face height, mandibular arc의 5개 항목을 이용하여 한국 성인의 정상교합자 통계치의 기준에 따라 short face type (1군), average face type (2군), long face type (3군)으로 분류하였다. 각 군의 치료 전, 치료 종료, 종료 후 1년의 측모두부 방사선사진 계측치를 비교 분석하였다. 1군은 치료 종료 시와 비교하여 유지기간에 일반적 교합평면각, 기능적 교합평면각, L6/L1, MP-L6 항목이 유의하게 감소하였고 (p<0.01) L1-FOP 항목은 유의하게 증가하였다(p<0.001). 2군은 유지기간에 유의한 변화를 보이지 않았으며 3군은 유지기간에 기능적 교합평면각이 유의하게 증가하였다(p<0.05). 기능적 교합평면각의 치료 후 변화량은 각 군 간에 유의한 차이를 보였으며 특히, 1군과 3군 간에 매우 큰 유의성을 보였다. 따라서 치아의 압하, 정출 및 치료 후 전치부 피개 등에 있어 유지기간 중 교합평면각 변화의 고려가 필요하다고 생각된다. Objective: The purpose of this study was to find changes in the occlusal plane related to different vertical facial patterns and suggest treatment goals and conduct possible treatment mechanisms. Methods: 60 adult patients (28 males, 32 females) who had been diagnosed as Class I skeletal malocclusion and treated without extraction were selected. Patients were divided into three groups; short face type (group 1), average face type (group 2) and long face type (group 3), using the data on normal occlusion of Korean adults. Results: The results were achieved by analyzing cephalometric tracings of each group at pre-treatment, end-treatment and post-treatment (about 1 year recall check). The inclination of the occlusion plane tends to gradually increase as the face becomes longer. In group 1, COP-X, FOP-X, L6/L1, MP-L6 were significantly decreased, and L1-FOP was significantly increased during the retention period (T3-T2). Group 2 showed no significant change. In group 3, FOP-X was significantly increased during the retention period (T3-T2). During the retention period, FOP-X showed significant change among each group, especially between group 1 and group 3. Conclusion: These results suggest that changes of occlusal plane inclination according to facial vertical pattern need to be considered during the retention period for intrusion, extrusion, and incisor overbite.

고등어 및 정어리 선어의 휘발성성분

조우진,김훈,정연정,이영미,정은정,차용준 창원대학교 생활과학연구소 2002 생활과학연구 Vol.- No.6

This study was conducted to identify volatile compounds, associating with quality deterioration, which may play roles as indicators for quality assessment in fresh mackerel and sardine. Volatile compounds were analyzed by liquid liquid continuous extraction(LLCE)/GC/MSD methods. A total of 83 and 81 volatile compounds were detected in fresh mackerel and sardine, respectively, and these compounds were mainly composed of aldehydes(12 in raw mackerel, 11 in raw sardine), ketones(7, 4), alcohols(15, 14), esters(1, 3), aromatic compounds(13, 15), terpenes(5, 7), S-containing compounds(2, 2), hydrocarbons(13, 11) and miscellaneous compounds(2, 1). Most of compounds including carbonyls, alcohols, aromatic compounds and hydrocarbons were derived from lipid oxidation, and some compounds were detected from microbial degradation. It was supposed that LLCE method was proper to seek indicators for quality assessment in fresh mackerel and sardine, because of various volatile compounds derived from nonthermal lipid oxidation.

교정선의 종류, 결찰방법, 타액의 유무에 따른 마찰력의 비교연구

한정숙,이진우,차경석 대한치과교정학회 2001 대한치과교정학회지 Vol.31 No.2

치아에 부착된 bracket이 교정선을 따라 이동할때 필연적으로 bracket과 교정선, 결찰재 사이에 마찰력이 발생된다. 이에 저자는 동일한 bracket내에서 교정선의 종류, 결찰방법, 건조와 타액상태에 따른 마찰력 차이, 타액의 윤활제로서의 기능을 살펴보기 위해 본 연구를 시행하게 되었다. 본 실험에 사용된 bracket은 .018"× .025" slot의 상악 견치용 standard edgewise bracket(RMO. USA)이며, 교정선은 .016" , .016" × .022" 크기의 Cobalt-chromium(Elgiloy . RMO. USA), Nickel-titanium(Ni-Ti) (ORTHOLLOY : Goldstar Cable Co. KOREA), Beta- titanium(TMA : ORMCO Co., USA)의 2가지형태의 3종을 이용하여 활주할때의 마찰력을 만능시험기(Instron, M 1000 EC)를 사용하여 계측하여 다음과 같은 결론을 얻었다. 1.각각의 동일조건하에서 교정전의 재질에 따른 마찰력은 Co-Cr, Ni-Ti, β-Ti순으로 증가하였다. 단, 타액상태에서 elastomeric으로 결찰한 .016" 군에서는 예외이다. 2.각 조건하(건조/타액상태, .016" /.016" × .022" ) 에서 결찰방법에 따른 마찰력은 elastomeric보다 stainless steel 결찰에서 더 크게 나타났다(p<0.05). 3.각각의 교정선과 결찰방법에서 타액 유무에 따른 마찰력은 stainless steel로 결찰한 .016" Co-Cr, Ni-Ti, β-Ti는 타액상태에서 감소하나, stainless steel로 결찰한 .016" × .022" Co-Cr, Ni-Ti, β-Ti는 타액상태에서 증가하였다(p<0.05). 4.각 조건하(건조/타액상태, elastomeric/stainless steel결찰) .016" 과 .016" × .O22" 교정선 사이의 마찰력은 .016" × .022" 교정선에서 증가하였다(p<0.05). The purpose of this study was fourfold - to evaluate the general laws of friction applied to orthodontic conditions, to compare archwire materials under these controlled conditions, to compare ligation method, and to measure the effect of the artificial saliva on friction with these materials Three wire alloys (Cobalt-chromium, Nickel-titanium, Beta-titanium) in two size wires (.016" ,.016" × .022" ) were examined respect to the bracket (0.18 × .025" standard), and two ligature material (stainless steel, elastomeric) in dry and wer conditions The result were as follows, 1.The order of frictional force against alloy materials was Co-Cr (lowest), Ni-Ti, and β -Ti(highest) - with the exception of elastomeric ligation under wet conditions. 2.S.S. ligation gave rise to significantly greater friction than elastomeric ligation did. 3.Testing in the presence of saliva, rather than in dry conditions, decreased the frictional force for S.S. ligation with .016" Co-Cr, Ni-Ti, β -Ti. but, increased the frictional force for 5.5. ligation with .016" × .022" Co-Cr, Ni-Ti, β-Ti. 4.016" ×.022 " wire generated more friction than .016" wire.

Preangulated TMA T-loop spring의 적용 위치 변화에 따른 견치의 초기 응력 분포에 대한 유한 요소법적 연구

김정민,차경석,이진우 대한치과교정학회 1999 대한치과교정학회지 Vol.29 No.5

본 연구는 상악 견치, 상악 제 2 소구치, 상악 제 1 대구치의 유한요소 모델을 제작하였고 0.018×0.025인치 Stainless steel wire를 고정원 강화를 위해 상악 제 2소구치와 제 1대구치에 위치시켰다. 0.017×0.025인치 T-loop spring의 전후방적 위치에 따른 응력 분포를 알아보기 위해 T-loop spring의 중간이 견치와 제 1대구치 거리의 중간에 위치하는 것과, 2mm전방에 위치하는 것, 2mm후방에 위치하는 것의 3가지 유한 요소모델을 제작하였다. 이 T-loop spring을 6mm 강제변위시켜 발생하는 힘을 각 치아에 적용시켰으며, 견치에서 발생하는 힘과 응력에 대하여 다음과 같은 결론을 얻었다. 1. 3가지 형태 모두에서 유사한 크기의 후방견인력을 보였다. 2. 3가지 형태 모두에서 유사한 크기와 비슷한 형태의 응력 분포를 보였다. 3. 3가지 형태 모두에서 회전 중심은 치근단 2/3부분에 보였다. 4. 2mm 전방 위치된 T-loop spring과 2mm 후방 위치된 T-loop spring에 각각 함입력과 정출력을 보이지만 그 크기가 작아서 응력 양상에 영향을 주지 못한다. The purpose of this study was to find the difference of stress distribution on canine altered by the application point of preangulated T-loop spring. For this study, the finite element models of upper left canine, upper left second premolar and upper left first molar were made. Also, the finite element models of 0.017×0.025 inch preangulated, preactivated T-loop spring and 0.018×0.025 inch stainless steel wire were made. Three types of T-loop spring were made : the middle of activated T-loop is positioned in accordance with the middle position of instance of bracket position of both the canine and first molar, 2mm anterior, 2mm posterior. We compared the forces and the distribution of stress that were generated by difference of position of T-loop spring. The results were as follows. 1. All of the 3 types of T-loop spring showed the similar retraction forces. 2. All showed the similar amount & pattern of stress distribution. 3. The centers of rotation of canine in 3 types of T-loop spring were same and were positioned between C and D plane. 4. The canine showed the intrusive force by 2mm anterior positioned T-loop spring, but the extrusive force by 2mm posterior positioned T-loop spring. Neverthless, because of the small amount of the forces, the effect of vertical force was not significant.

파트너십에 의한 지하철 입구 공간의 쌈지공원 설계 및 시공

김승환,강현우,손용욱,박승범,남정칠,이기철,차민준 東亞大學校 建設技術硏究所 2009 硏究論文集 Vol.32 No.2

A pocket park is valued in securing green space in downtown and improving urban view in the aspect of natural and environmental values, and it signifies a lot as the center of local residents’ community and harmony as well. Since subway exits and surroundings that have high portions in taking up street space due to lack of green space in downtown aren't made full use of, valuable pocket park place. Dangni Pocket Park of subway exits is a park completed with cooperative works and partnership by students, specialists, administrative organizations, businesses and civilian organizations, etc. without support of special budget. The study site was finally chosen to the space between exit No.1 of Dangni subway station, after analyzing the surrounding circumstances, availability and accessibility of the space among the several subway station exits of Saha, Dangni, and Hadan Station in Busan Metropolitan city. For the designing process, The Citizens organization for Million Amenity Park performed the planning and project proceeding, and 19 design drafts were proposed during the class of landscape architecture in Dong-a University. Design review panel members discussed to select the best draft in practical and authentical, and the related experts reviewed and revised to present the final design plan. The construction was conducted was performed under the cooperation between the civil, authorities, and industrial organizations, among which Saha District office managed for the waste treatment and maintenance matters. The graduates of landscape architecture department of Dong-a University and related industrial enterprises supplied landscape materials and related labors, were supported by 20 members of GPM, one of clubs of Dong-a University volunteered durig the most of construction progress, completing the Pocket Park of subway exits through partnership.

신부전이 동반된 당뇨병 환자에서 발생된 침습성 모균증 : 수술과 Liposomal amphotericin B 및 GM-CSF 병합 요법에 의한 성공적인 치험 1예

이원영,오기원,임국희,장재혁,이동건,최정현,강무일,신완식,차봉연,이광우,손호영,강성구 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.4

저자들은 신부전이 동반된 당뇨병 환자에서 발생된 부비동형 모균증에 대하여 수술과 함께 liposomal amphotericin B 및 GM-CSF의 복합치료를 하여 성공적으로 치료한 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Mucormycosis (zygomycosis) primarily affects diabetic or immunocompromised patients and typically progresses rapidly, necessitating surgical excision and antifungal therapy with amphotericin B. Large doses of amphotericin B are needed for cure, but it has the risk of causing significant renal toxicity. The recent development of liposomal amphotericin B allows antifungal therapy to be administered with potentially improved efficacy and reduced nephrotoxicity. We have experienced a case of paranasal mucormycosis successfully treated with surgery, liposomal amphotericin B and GM-CSF. A 59-year-old male suffering from diabetes mellitus for 6 years was admitted with pain at left maxillary area. He was diagnosed as mucormycosis after cytologic exam on the necrotic nasal mucosa, which showed typical hyphae. He have had diabetic nephropathy with macroproteinuria and had rapidly rising serum creatinine levels with the amphotericin B treatment: creatinine levels reverted to basal level with the use of liposomal amphotericin B. Despite surgical excision and continued antifungal therapy, his infection was not effectively controlled. Therefore, GM-CSF was administered additionally to improve phagocytic activity of leukocytes. He was finally cured after receiving a combination of aggressive surgery, liposomal amphotericin B and GM-CSF. To our knowledge, this is the first detailed clinical description of the treatment of mucormycosis with liposomal amphotericin B in Korea.