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단일클론성 감마병증과 함께 발현된 Helicobacter Pylori 음성 위장 MALT림프종 1예
황의경,정성현,이현우,강석윤,최진혁,한재호,김장희,김명욱,유병무,박준성,장은정,김선미 대한혈액학회 2009 Blood Research Vol.44 No.4
Lymphomas of mucosa-associated lymphoid tissue (MALT) comprise 7% of all newly diagnosed non-Hodgkin’s lymphomas. Helicobacter pylori (H. pylori) negative gastric MALT lymphomas account for 28 to 45% of gastric MALT lymphomas. H. pylori infection has a close relationship with most gastric low-grade B cell lymphomas of the MALT type. Monoclonal gammopathy can be seen in 36% of the patients and negatively associated with responses to eradication of H. pylori in gastric MALT lymphoma. Here, we describe a case of H. pylori negative MALT lymphoma that arose from the stomach with massive plasmacytic differentiation mimicking an extramedullary plasmacytoma with monoclonal gammopathy, and that was cured by total gastrectomy, chemotherapy and radiotherapy.
Clinical Features of Immediate Hypersensitivity to Isopropylantipyrine
황의경,남영희,진현정,신유섭,예영민,박해심 대한천식알레르기학회 2013 Allergy, Asthma & Immunology Research Vol.5 No.1
Hypersensitivities induced by isopropylantipyrine (IPA), a pyrazolone derivative within the wider family of non-steroidal anti-inflammatory drugs(NSAIDs), are rarely reported. We characterized the clinical features of 12 patients with IPA-induced hypersensitivity. Twelve patients with immediatehypersensitivity to IPA were enrolled and classified into two groups: group I, consisting of eight patients (66.7%) with selective hypersensitivity;and group II, consisting of four patients (33.3%) showing cross-intolerance to other NSAIDs. Skin prick and intradermal and oral provocation testswith IPA were performed. To confirm selective hypersensitivity, an aspirin oral provocation test was also conducted. The most common manifestationswere cutaneous reactions (91.7%), followed by anaphylaxis (66.7%), respiratory (41.7%), ocular (16.7%), and gastrointestinal reactions (16.7%). The median age and the median age at onset were 34.5 (range, 23-55) years and 28.0 (range, 7-47) years, respectively. In both groups I and II, all patientsshowed negative responses to skin prick testing, whereas only two patients in group I were positive in response to intradermal IPA tests. Theresponse time after drug exposure was shorter in group I than in group II. Here, we report on two types of IPA hypersensitivity: selective and crossintolerantNSAID hypersensitivity. An immediate IgE-mediated reaction may be involved in patients with selective hypersensitivity, whereas a cyclooxygenase-1-related inhibition mechanism may be a responsible mechanism for the patients with cross-intolerance to multiple NSAIDs.
황의경,권영방,정운익,강승원,Hwang Eui-kyung,Kwon Young-bang,Chung Un-ik,Kang Seung-won 대한수의사회 1984 대한수의사회지 Vol.20 No.11
Severe ulcerative colitis and cecitis by Balantidium coli was studied pathologically in a 40 day old male pig. Grossly, many variable-sized ulcers were diffusely scattered on the mucosa of the cecum and the colon. Microscopically, numerous balantidia pene