천자서평 2 : 아빠를 젊고 건강하게 - 황성주 / 호도애 / 1990 -

황성주 한국상담선교연구원 ( 구 한국상담선교학회 ) 1997 상담과 선교 Vol.5 No.2

오메프라졸복합체 함유 직장좌제의 특성비교

황성주,박성배,이계주,Hwang, Sung-Joo,Park, Sung-Bae,Rhee, Gye-Ju 한국약제학회 1995 Journal of Pharmaceutical Investigation Vol.25 No.3

Omeprazole(OMP) complexes such as inclusion complexes of OMP with $hydroxypropyl-{\beta}-cyclodextrin$(HPCD) and ${\beta}-cyclodextrin({\beta}-CD)$, OMP-cholestyramine(CHL) and OMP-ethylenediamine(OMP-ED) were prepared, respectively. The partition coefficients in Witepsol H-15 /pH 7.4 phosphate buffer solution of OMP complexes$(OMP-HPCD;\;3.69{\pm}0.26,\;OMP-{\beta}-CD;\;4.08{\pm}0.21,\;OMP-CHL;\;4.36{\pm}0.25\;and\;omeprazole\;sodium(OMP-Na);\;3.64{\pm}0.37)$ were higher than that of OMP $(2.66{\pm}0.47)$. OMP was not completely dissolved until even 3 hrs, but all the OMP complexes studied were released about 100% in 20 min. The rectal suppositories containing OMP or each above OMP complex were prepared using Witepsol H-15 base, and their dissolution and stability were examined, and pharmacokinetic study were investigated after their rectal administrations to the rabbits. While the suppository containing OMP was released only less than 60% in 150 min, $OMP-{\beta}-CD$, OMP-CHL, OMP-Na and OMP-ED suppositories were all released about 65% in 20 min. Especially, OMP-HPCD suppository released OMP about 70% in 10 min. All the additives such as sodium laurylsulfate, eglumine, arginine and PVP increased drug release from OMP-HPCD suppository to some extent. The decomposition rate constants of OMP in the suppositories were $9.117{\times}10^{-3}\;day^{-l}$ for OMP suppository, $2.121{\times}10^{-2}$ for OMP-HPCD, $1.607{\times}10^{-2}$ for $OMP-{\beta}-CD$, $9.26{\times}10^{-3}$ for OMP-Na, $6.769{\times}10^{-3}$ for OMP-CHL and $5.58{\times}10^{-3}\;day^{-l}$ for OMP-ED suppository, respectively. Additives such as arginine, eglumine and ED had some stabilizing effect for OMP-HPCD, OMP-CHL and OMP-Na suppositories, respectively. After 6 month-storage at $30^{\circ}C$, 75% RH, OMP-CHL suppository was most stable. The values of Tmax for OMP-HPCD and OMP-Na suppositories were $11.7{\pm}2.36\;and\;11.4{\pm}2.56\;min$, respectively. The values of Cmax for OMP-HPCD and OMP-CHL suppository were $2.31\;{\mu}g/ml\;(p<0.01)\;and\;1.89\;{\mu}g/ml\;p<0.01)$, respectively. The values of AUC for OMP and $OMP-{\beta}-CD$ suppository were $61.9{\pm}25.79\;and\;68.6{\pm}29.48\;{\mu}g\;{\cdot}\;min/ml$, and the corresponding values for OMP-HPCD and OMP-CHL were $106.1{\pm}43.16\;(p<0.05)\;and\;127.3{\pm}42.52\;{\mu}g\;{\cdot}\;min/ml(p<0.01)$, respectively. The above results indicate the OMP-HPCD and OMP-CHL suppositories have the excellent bioavailabilties in vivo study.

일부도시지역 주민의 상병상태에 대한 조사연구

황성주,Hwang, Sung-Joo 대한예방의학회 1986 Journal of Preventive Medicine and Public Health Vol.19 No.2

A Health Interview Survey at Chuncheon city was conducted to assess level of illness by stratified random sampling method. Sample size was 6,007 and the prevalence of illness in period of 15 days was studied. 1) Prevalence rate of illness among Chuncheon citizen was 20.8 percent, and that of acute condition was 10.8 percent and chronic condition, 10.0 percent. 2) There was significant difference in prevalence rate by sex, especially the prevalence rate of chronic illness. 3) High positive correlation was noted between aging and prevalence rate of chronic illness. But negative correlation was noted in case of acute illness. 4) Multiple regression analysis on morbid state by socioeconomic variables was not seen to be appropriate for this survey, especially the analysis of acute illness. 5) Estimation of anual prevalence rate could not be possible because of seasonal variation of disease prevalence.

산소중독에 대한 MALTOL의 보호효과에 관한 실험적 연구

황성주,조수헌,윤덕로,Hwang, Sung-Joo,Cho, Soo-Hon,Yon, Dork-Ro 대한예방의학회 1993 Journal of Preventive Medicine and Public Health Vol.26 No.4

Since the widespread application of hyperbaric oxygenation in clinical medicine, the problems of oxygen toxicity have been attracting a deep interest from the researchers on hyperbaric medicine as a practical issue. Among extensive research trials, the study on the protective agents oxygen toxicity occupied one of the most challenging field. As the mechanisms of oxygen toxicity, the role of the oxygen free radicals produced by peroxidation process are strongly accepted by the leading researchers on oxygen toxicity, the probable protective effects of antioxidant against oxygen toxicity are sustaining a sufficient rational. Maltol ($2-methyl-3-hydroxy-{\gamma}-pyrone$) which is known to be a component of Korean red ginseng has been reporting to have an antioxidant action. But, further study is needed to provide definite evidence for this compound to be an antioxidant, since the action was based on the results which were obtained under in vitro experiment. In this study, the author attempted to evaluate the effect of maltol as protective agent against oxygen toxicity through the observation of death rate, convulsion rate, time to convulsion and microscopic pathological changes in some organs of experimental rats exposed to various conditions. The findings observed are as follows : 1) The death rate, convulsion rate, time to convulsion, lung/weight ratio and microscopic pathological finding of lung were identified as reliable objective and quantitative indices for oxygen toxicity. 2) Maltol showed excellent protective effect against pulmonary oxygen toxicity as an antioxidant.

메토트렉세이트가 표면수식된 알부민미립구의 표적성

황성주,조항범,이계주,김종국 충남대학교 약학대학 의약품개발연구소 1996 藥學論文集 Vol.12 No.-

The surface of albumin microspheres was modified with methotrexate(MTX) by using 1.3-dicyclohexylcarbodiimide (DCC). Surface-modified albumin microspheres entrapping no MTX (SAMS), free MTX (SAMSF) and MTX-bovine serum albumin(BSA) conjugates (SAMSC) were prepared. The organ-targeting ability of free [^3H]MTX, [^3H]MTX-BSA conjugate and the above microspheres was evaluated after i.v. administration of the preparations, equivalent to 150 nCi via the tail vein of mice. The total radioactivity in the lung increased immediately in a few minutes after i.v. injection of the microspheres, and then declined for the period of 3-4 weeks. However, the radioactivity in the liver, spleen and kidney increased slowly during the rapid decrease in radioactivity in the lung. This suggested that the microspheres could be entrapped rapidly in the lung through mechanical filtration because of their large size and slowly redistributed to the liver, spleen and kidney due to either the microspheres being degraded enough for the size to allow passage through the capillary beds of the lung and/or the release of [^3H]MTX or [^3H]MTX-BSA conjugates from the microspheres. The amount of 60~70% of the dose was targeted to the liver after the i.v. injection of SAMS. SAMSF and SAMSC, and the values of (R_e^*_e)_liver from the microspheres were 5~7 compared to free MTX. This suggested that the liver-targeting ability from surface-modified albumin microspheres could be 5~7 times as that of free MTX. The liver~targeted drug was accumulated in the Kupffer cells at the initial stage. thereafter the drug in the Kupffer cell was slowly transferred into the hepatocytes. The value of AUQ for liver from SAMS was higher than that from SAMSF, but much lower than that from SAMSC. This suggest that MTX bound to their surface could be eliminated slower than the entrapped free MTX, and faster than the entrapped MTX-BSA conjugates. This is consistent with the in vitro release rates order in the presence of a proteolytic enzyme. Also, surface-modified MTX was scarcely released in the absence of a proteolytic enzyme^11). Therefore, the surface-modified MTX may be released (or eliminated) rapidly from SAMSC at the target site, and thereafter MTX may be released (or eliminated) slowly from the entrapped MTX-BSA conjugates in SAMSC for a long period.

건강칼럼: 생식으로 못 다루는 병은 없다 '생식'이 혈당관리 핵심이다

황성주,홍성길,Hwang, Seong-Ju,Hong, Seong-Gil 사단법인 한국당뇨협회 2011 당뇨 Vol.257 No.-

미 의회에서 '미국 상원 영양문제 특별위원회'를 구성하여 2년 동안 미국 사람의 건강과 식사 관계를 조사한 뒤, "모든 성인병은 식사의 잘못에서 비롯된다"라고 결론을 내렸다. 보고서의 내용에 따르면 서구식 식사법을 탈피하면 당뇨병은 50%, 심장병은 25%, 암은 20%의 발생률을 줄일 수 있다고 한다. 그런데 사람들은 병에 걸리면 병원에서 치료하려고만 하지 병의 발생 원인을 고치려고 하지 않는다. 식이요법은 자연치유요법 가운데 가장 확실한 방법이다. 그 중 생식은 성인병 치료에 도움이 되는데 당뇨병, 고지혈증, 고혈압, 위장병 등은 생식 3개월이면 효과를 볼 수 있다. 또, 음식물이 지니는 고유성분을 파괴하지 않고 체내로 공급하기 때문에 식사의 균형을 잡아주는 건강 지킴이 식품으로 바쁜 현대인에게 적합한 식사방법이라 할 수 있다.

7XXX계 단조재의 피로 및 파괴인성 개선

황성주,임재규,이오연,손영일,은일상,신돈수 한국추진공학회 1995 한국추진공학회 학술대회논문집 Vol.1995 No.11

백호탕으로 소양인의 소갈병을 치료한 경험

황성주,Hwang, Seong-Ju 사상체질의학회 1994 사상체질의학회지 Vol.6 No.1

리튬 2차 전지용 양극활물질 LiMO2(M=Co,Ni)의 온도와 산소 분압에 따른 상전이 거동

황성주,정연욱,이준형,김정주,김호진 한국세라믹학회 2005 한국세라믹학회지 Vol.42 No.4

LiMO2(M=Co,Ni) samples were synthesized with Li2CO3, Co3O4 and NiO by the solid-state reaction method. In the case of LiCoO2, at low temperature(T=400℃) spinel structure was synthesized and the obtained spinel phase was transformed to layered phase at high temperature(T≥600℃). The phase transition behaviors of LiCoO2 were investigated with various heating temperature and time. The rate of transition was directly proportional to the concentrations of reactant, and activation energy of reaction was around 6.76kcal/mol. When CoO(rock salt structure) was used as a starting material instead of Co3O4(spinel structure), layered structure of LiCoO2 was obtained at low temperature. In the case of LiNiO2, ,the transition from layered structure to rock salt structure occurred easily by disordering/ ordering reaction, but did not occur in LiCoO2. The difference in metal ion radii in LiCoO2 and LiNiO2 results in different behaviors of phase transitions. 출발원료로 Li2CO3, Co3O4와 NiO를 사용하여 고상반응법으로 LiMO2(M=Co,Ni)를 합성하였다. LiCoO2는 저온(T=400℃)에서 스피넬구조를 형성하고 온도가 증가(T≥600℃)되면 층상구조로 상전이 한다. 우리는 열처리 온도와 시간을 변수로 LiCoO2의 스피넬구조에서 층상구조로의 상전이 거동을 관찰하였다. 스피넬구조에서 층상구조로의 상전이 속도는 스피넬상의 농도에 1차 비례하고 상전이하는 활성화 에너지는 약 6.76 kcal/mol이다. 출발원료로 스피넬구조인 Co3O4 대신 암염구조인 CoO를 사용하면 저온(T=500℃)에서부터 층상구조가 형성되고 스피넬구조는 관찰되지 않는다. LiNiO2는 온도가 증가함에 따라 층상구조에서 암염구조로 상전이 한다. LiNiO2의 고온상인 암염구조는 저온에서 disordering/ordering에 의해 쉽게 층상구조로 되돌아가는 상전이 거동을 보인다. 반면 LiCoO2에서는 층상구조에서 암염구조로의 상전이가 쉽게 일어나지 않는다. 이온반경비 Li+/Co3+가 Li+/Ni3+보다 큰 것이 LiCoO2의 층상구조가 고온에서 LiNiO2의 층상구조보다 더 안정할 수 있는 이유 중의 하나로 생각된다.

웨어러블 디바이스를 활용한 건설작업자의 건강보건관리

황성주,Hwang, Seong-Ju 한국건설관리학회 2016 건설관리 : 한국건설관리학회 학회지 Vol.17 No.6