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공터키안을 동반한 쉬한 증후군에서 그레이보스 병이 병발된 2예
최윤종,정춘희,박의련,김홍승,신영구 대한내분비학회 1996 Endocrinology and metabolism Vol.11 No.4
The empty sella syndrome is characterized by obesity, frequent pregnancy, headache and high blood pressure, but its exact cause remains unknown. Usually the incomplete diaphragmatic sella has been considered as the cause of the empty sella syndrome, but some authors recently have suggested that the antipituitary antibody way be related to development of pituitary atrophy and the pituitary empty sella syndrome, and thus it may be clinically useful as screening test for the empty sella syndrome. We experienced two empty sella syndromes associated Graves disease and applied the antipituitary antibody as the diagnostic tool of the empty sella syndrome. But none of this two patients had antipituitary antibody and we report these cases with reviews of literatures. (J Kor Soc Endoerinol 11:517~522, 1996)
G-protein coupled receptor 40 agonists as novel therapeutics for type 2 diabetes
최윤종,신동윤,이주연 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.4
With growing needs for new antidiabetic drugswhich are safe and effective alone or in combination withexisting drugs, G-protein coupled receptor 40 (GPR40) hasdrawn a considerable attention as a potential therapeutictarget for type 2 diabetes. As GPR40 agonist may offeradvantages to commonly used agents, by acting ambientglucose dependent manner which mechanistically leads toreduced risk of developing hypoglycemia. Since deorphanizationin 2003, development of small molecule GPR40agonists has been spurred by several research groups. There are a number of lead molecules targeting GPR40,and among these molecules TAK-875 (full agonist) andAMG 837 (partial agonist) advanced into clinical stage.
Fracture Analysis for Ceramic Disk with Semi-Elliptical Crack and Pore
최윤종,송문석,Yi-Jun Yoo,이준성 한국정밀공학회 2014 International Journal of Precision Engineering and Vol. No.
Crack resistance is important to exam the structures destroyed under static and dynamic load as well as to the ceramic products under extreme mechanical and thermal load. But in addition to the metallic material, ceramic and ceramic composite materials have been pointed out as low resistance referred to a brittle materials form thermal impact. As destroyed ceramics are impossible to be restored, so the development of high toughness ceramics is required. To get high strength material design variables while keeping light weight, this study derives the modulus of elasticity for ceramic disk with elliptical crack pore and performs fracture behaviors assessment by applying the modulus of elasticity derived and MSST(Maximum Shear Stress Theory) techniques to compare with test data. As a result of assessment of fracture behavior based on the MSST, if stress is greater than fracture strength of material, it showed high probability of occurring of the shear fracture when fracture strength is 38 kgf.
수술 후 잔위에서 Helicobacter pylori의 분포와 역할
최윤종 ( Yeun Jong Choi ),김현수 ( Hyun Soo Kim ),박동훈 ( Dong Hoon Park ),김문영 ( Moon Young Kim ),백순구 ( Soon Koo Baik ),이동기 ( Dong Ki Lee ),권상옥 ( Sang Ok Kwon ),박광화 ( Kwang Hwa Park ) 대한소화기학회 2003 대한소화기학회지 Vol.41 No.3
Background/Aims: The distribution of Helicobacter pylori (H. pylori) and its effect on postoperative remnant gastritis has not been clearly investigated. Thus, we carried out this study to examine H. pylori positive rate in the body and cardia and to assess the role of H. pylori on the pathogenesis of remnant gastritis. Methods: Eighty-two patients who had undergone gastric surgery (Billroth I, II) were studied. Four biopsy specimens were obtained from the cardia and oral side of anastomosis for histological analysis and CLO test. The histological grades of gastritis were determined by four parameters of visual analogue scales adopted by updated Sydney system. Results: The overall positive rate of H. pylori was 48.8%. Among the infected patients, H. pylori positive rate was significantly higher in the cardia than in the body (87.5% vs. 37.5%, p< 0.01). The H. pylori positivity was not associated with age, sex, primary disease, type of surgery, chemotherapy, and postopertive interval. The gastritis scores of inflammatory cell infiltration were higher in H. pylori positive patients. However, the scores of atrophy and intestinal metaplasia were not significantly different between the two groups. Conclusions: The H. pylori positive rate is higher in the cardia than in the body of postoperative remnant stomach. It suggests that H. pylori may play an important role in remnant gastritis through acute and chronic inflammatory cell infiltration. (Korean J Gastroenterol 2003;41:177-182)
A Path-level Smooth Transition Method with Curvature Bound between Non-smoothly Connected Paths
최윤종(Yun Jong Choi),박부견(Poo Gyeon Park) 대한전자공학회 2008 電子工學會論文誌-SC (System and control) Vol.45 No.4
연속적인 경로 사이를 부드러운 곡선으로 잇기 위해서 기존의 로봇 제어기들은 일반적으로 연속적인 경로를 시간 축에서 합성하는 방법을 사용해 왔다. 하지만 이런 방법은 다음과 같은 두 가지 단점을 내재하고 있다. 천이 경로의 형태가 연접하게 생성될 수 없다는 점과 천이하는 동안 속력을 제어할 수 없다는 점이 그것이다. 이러한 문제점들을 극복하기 위해서 본 논문은 매끄럽지 않게 연결된 두 경로들을 부드럽게 잇기 위해 곡률이 제한된 새로운 천이 궤적 생성 방법을 제시하고자 한다. 실험 결과는 기존의 방법들보다 천이 궤적이 더 부드럽게 생성되는 것을 보여주며, 또한 보장된 곡률의 제한 수준은 0.02 ~ 1임을 보여준다. For a smooth transition between consecutive paths, conventional robot controllers usually generate a transition trajectory by blending consecutive paths in a time coordinate. However, this has two inherent drawbacks: the shape of a transition path cannot be designed coherently and the speed during transition is uncontrollable. To overcome these problems, this paper provides a path-level, rather than trajectory-level, smooth transition method with the curvature bound between non-smoothly connected paths. The experiment results show that the resultant transition trajectory is more smoothly connected than the conventional methods and the curvature is closely limited to the desired bound within the guaranteed level (0.02∼1).
최윤종(Choi, Yoon-Jong),이준성(Lee, Joon-Seong) 한국산학기술학회 2011 한국산학기술학회논문지 Vol.12 No.1
본 논문은 기존의 스파크 점화 방식이 아닌 bulk combustion 방식을 도입하여 별도의 점화장치 없이 상용 단기통 디젤기관에 유입되는 흡입공기를 가열 및 제어하여 흡기관에 분사되는 가솔린연료의 압축착화성을 향상시킴 으로서 기관작동을 가능하게 하였다. 제동열효율의 최대값은 공기-연료비가 35부근에서 나타나며, 35이상의 영역에서 는 급격히 감소하고 흡입공기 가열온도가 올라갈수록 제동열효율은 증가한다. 따라서 공기-연료비를 감소시키면서 흡 입공기의 가열온도를 상승시키는 방식이 열효율 측면에서 효과적이라는 것을 알 수 있다. In this study, it made to run conventional single direct injection(DI) diesel engine, which adapted bulk combustion system not following spark ignition system without any ignition apparatus. It was heated and controlled inlet-air into conventional single DI diesel engine. The maximum value of brake thermal efficiency was at 35 region of air-fuel ratio. On the contrary, when the region of air-fuel ratio leaner than 35, brake thermal efficiency was decreased suddenly. And brake thermal efficiency was increased as much as inlet-air heating temperature increased. So, when air-fuel ratio was decreased and inlet-air heating temperature was higher, the engine was in optimal operation condition.