ABO 혈액형 기록 불일치로 적발된 신분 도용 사례

최수인,신희봉,조덕,최수인 대한수혈학회 2019 大韓輸血學會誌 Vol.30 No.1

アルバイトをした後

최수인 덕성여자대학교 일어일문학회 1986 語り合い Vol.3 No.-

The characteristics of pulmonary disease in North Korean articles published between 2006 and 2018

최수인,김병근,정원재,이상엽,인광호,이은주 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.-

Background: We supposed that past decades of division between South and North Korea made differences in medical environments. However, there are few studies about North Korea’s medical status and research field. In this study, we reviewed the status and characteristics of North Korea’s articles regarding pulmonary diseases. Methods: Among the eleven medical journals, articles published in Internal Medicine between 2006 and 2018 were reviewed. A total of 267 articles were associated with pulmonology. We analyzed these articles according to their features, disease categories and publishing year. Results: Experimental studies accounted for 45% (n=121), observational studies for 24% (n=63), reviews for 18% (n=49) and case reports for 13% (n=34). Experimental studies were all comparison studies but diagnostic criteria and randomization were not mentioned. Articles related to respiratory infection accounted for 36% (n=96). those to chronic obstructive pulmonary disease for 14% (n=36), those to asthma for 11% (n=29), those to CO poisoning for 9% (n=24), those to tumor for 13% (n=35) those to critical care medicine for 2% (n=6) and the others for 15% (n=41). Conclusion: Compared with South Korea, studies for infection and CO poisoning were actively conducted. There were many studies for pleural effusion and most of them were related to tuberculosis. Persistent studies have been carried out in North Korea with dedication despite the poor medical environment. We hope that this study will be the beginning of comprehension of North Korea’s medical status and research field.

Weak D Testing is not Required for D- Patients With C-E- Phenotype

최수인,천세종,이환태,유홍비,서지영,조덕 대한진단검사의학회 2018 Annals of Laboratory Medicine Vol.38 No.6

Background: Although testing to detect weak D antigens using the antihuman globulin reagent is not required for D- patients in many countries, it is routinely performed in Korea. However, weak D testing can be omitted in D- patients with a C-E- phenotype as this indicates complete deletion of the RHD gene, except in rare cases. We designed a new algorithm for weak D testing, which consisted of RhCE phenotyping followed by weak D testing in C+ or E+ samples, and compared it with the current algorithm with respect to time and cost-effectiveness. Methods: In this retrospective study, 74,889 test results from January to July 2017 in a tertiary hospital in Korea were analyzed. Agreement between the current and proposed algorithms was evaluated, and total number of tests, time required for testing, and test costs were compared. With both algorithms, RHD genotyping was conducted for samples that were C+ or E+ and negative for weak D testing. Results: The algorithms showed perfect agreement (agreement=100%; κ=1.00). By applying the proposed algorithm, 29.56% (115/389 tests/yr) of tests could be omitted, time required for testing could be reduced by 36% (8,672/24,084 min/yr), and the test cost could be reduced by 16.53% (536.11/3,241.08 USD/yr). Conclusions: Our algorithm omitting weak D testing in D- patients with C-E- phenotype may be a cost-effective testing strategy in Korea.

Population pharmacokinetic analysis of metformin administered as fixed-dose combination in Korean healthy adults

최수인,Sangil Jeon,한승훈 대한임상약리학회 2018 Translational and Clinical Pharmacology Vol.26 No.1

Metformin, an oral antihyperglycemic agent, is widely used as the first-line pharmacotherapyfor type 2 diabetes mellitus (T2DM). It has been in use for several decades as numerous differentformulations. However, despite its use, population pharmacokinetic (PK) modeling of metforminis not well developed. The aim of the present study was to evaluate the effect of formulation on PKparameters by developing a population PK model of metformin in Koreans and using this model toassess bioequivalence. We used a comparative PK study of a single agent and a fixed-dose combinationof metformin in 36 healthy volunteers. The population PK model of metformin was developedusing NONMEM (version 7.3). Visual predictive checks and bootstrap methods were performed todetermine the adequacy of the model. The plasma concentration.time profile was best describedby a two-compartment, first-order elimination model with first-order absorption followed by zeroorderabsorption with lag time. From the covariate analysis, formulation had significant effect (p <0.01) on relative bioavailability (F = 0.94) and first-order absorption constant (Ka = 0.83), but thedifference was within the range of bioequivalence criteria. No other covariate was shown to havesignificant effect on PK parameters. The PK profile of the disposition phase was consistent with thepublished literature. However, in the present study, the multiple peaks found during the absorptionphase implied the possible diversity of absorption PK profile depending on formulation or population. Unlike traditional bioequivalence analysis, the population PK model reflects formulation differenceson specific parameters and reflected simulation can be performed.

F-163 Analyses on the clinical usefulness of natural killer cell activity in non small cell lung cancer patients

최수인,정상미,오지연,최종현,김병근,정원재,이승현,이영석,김영,이은주,민경훈,허규영,이승헌,이승룡,김제형,이상엽,신철,심재정,강경호,인광호 대한결핵 및 호흡기학회 2017 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.124 No.0

Background: Natural killer(NK) cells are one of the innate immunity cells and are involved in the elimination of malignancy cells. Low activity of NK cells has been associated with the various cancer. We evaluated the clinical implication of serum NK cell activity(NKA) in non-small cell lung cancer(NSCLC). Method: In this prospective, cross-sectional study, we enrolled 40 healthy controls, 40 benign lung disease patients and 67 NSCLC patients (stage I: 20, stage II: 10, stage III: 17, stage IV: 20). Serum NKA was measured by NK VueⓡGOLD assay detecting interferon-γ released from NK cells. NKA was compared by non-parametric Kruskal-Wallis test. Results: We found a significant decrease in NKA of NSCLC group compared to other groups but there was no significant difference between control and benign lung disease group. (control vs benign lung disease vs NSCLC; 1341±102.8 vs 1219±116.0 vs 744.8±86.21pg/mL)(p<0.0001) NKA of advanced stage NSCLC patients was lower than early stage NSCLC patients. (stage I, II vs stage III, IV; 1298±119.0 vs 295.9±54.41pg/mL)(p<0.0001) Conclusion: Impaired NKA was associated with NSCLC but not with other lung disease. NKA decreased further in advanced stage NSCLC than early stage NSCLC. NKA of early stage of NSCLC patients had no wide difference from control and benign lung disease subjects. It suggests that reduced NKA is involved in progression and metastasis of NSCLC. Clinically, we expect that NKA measurement might be helpful in assessing the stage of NSCLC but not in screening NSCLC.

전암성 병변인 위선종 자연 경과와 치료 전략

최수인,박준철 대한상부위장관ㆍ헬리코박터학회 2018 Korean Journal of Helicobacter Upper Gastrointesti Vol.18 No.2

The concept and pathological diagnostic criteria of gastric adenoma (dysplasia) differ between Western countries and Japan, and discrepancies between histopathological examinations before and after endoscopic resection may occur. Therefore, the natural history of adenoma should be interpreted and the treatment strategy of adenoma established. It is recommended that endoscopic resection be performed for high-grade dysplasia due to the potential higher risk of progression to carcinoma. For low-grade dysplasia, the risk of malignant transformation is relatively low. However, resection is considered the first approach for the purpose of diagnosis and treatment. If resection is not feasible, the alternative may be to use argon plasma coagulation for selected lesions that are less likely to be malignant. When Helicobacter pylori infection is detected, eradication therapy is recommended to reduce the risk of metachronous lesions. Post-resection follow-up should be performed within 1 year to detect synchronous lesions and then follow-up endoscopy at 1 or 2-year intervals may be considered for metachronous lesions. (Korean J Helicobacter Up Gastrointest Res 2018;18:103-109)

컴퓨터 시스템 설치를 위한 위치-할본-규모결정 모형

최수인,Choe, Su-In 한국전자통신연구원 1983 전자통신 Vol.5 No.3

복수 설비입지 문제의 한 유형인 컴퓨터 시스템 설치문제는 설치위치의 결정, 서비스 지역의 할본, 각 시스템의 규모 결정 등 복합적인 의사결정 과제를 안고 있다. 이 세가지 의사결정 문제는 상호 밀접하게 연결되어 있으므로 세 문제를 동시에 고려하여 전체적으로 최적화할 수 있는 해를 구하도록 해야하는 데 이는 매우 어려운 일이다. 그러므로 지금까지는 각각의 최적해를 독립적으로 구한 후 이를 적당히 결합한다거나 또는 아예 최적해를 구하기 보다는 만족할 만한 적정해를 구함으로써 만족할 수 밖에 없었다. 본 연구에서는 이러한 한계를 극복하기 위해 컴퓨터 시스템 설치에 있어서의 location-Size결정모형을 구축함으로써 이러한 의사결정 문제의 수리적 최적해를 구하고자 했다. 이 모형은 선형 및 비선형의 제약조건을 갖는 non-linear programming 문제로 수식화 되었으며, penalty function method, feasible conjugate, direction methods, branch & bound technique등의 algorithm들을 단계적으로 사용함으로써 최적해의 도출이 가능하게 되었다. 실제 문제에 적용한 결과 유용성은 충분한 것으로 보여졌으나 해법상의 개선을 통해 계산노력을 줄이도록 함이 요구 되었다. In the area of computer network planning, a location-allocation-size problem is involved. Since multi-facility location-allocation-size problems are very complex in formulating a mathematical model, it is a usual practise to adopt alternative approaches, which give no optimal results, instead of the optimal solution by mathematical approach. In this article, however, an attempt is made to formulate a mathematical model for the decision making problem of computer network design.

Electrophysiologic Investigation During Facial Motor Neuron Suppression in Patients With Hemifacial Spasm: Possible Pathophysiology of Hemifacial Spasm: A Pilot Study

최수인,김민욱,박동윤,허륭,장대현 대한재활의학회 2013 Annals of Rehabilitation Medicine Vol.37 No.6

Objective To evaluate the pathophysiological mechanism of hemifacial spasm (HFS), we performed electrophysiological examinations, such as supraorbital nerve stimulation with orbicularis oris muscle recording and lateral spread tests, after suppressing the patient’s central nervous system by administering intravenous diazepam.Methods Six patients with HFS were recruited. Supraorbital nerve stimulation with orbicularis oris muscle recording and the lateral spread test were performed, followed by intravenous application of 10 mg diazepam to achieve facial motor neuron suppression. Subsequently, we repeated the two electrophysiological experiments mentioned above at 10 and 20 minutes after the patients had received the diazepam intravenously.Results Orbicularis oris muscle responses were observed in all patients after supraorbital nerve stimulation and lateral spread tests. After the diazepam injection, no orbicularis oris muscle response to supraorbital nerve stimulation was observed in one patient, and the latencies of this response were evident as a slowing tendency with time in the remaining five patients. However, the latencies of the orbicularis oris muscle responses were observed consistently in all patients in the lateral spread test.Conclusion Our results suggest that ectopic excitation/ephaptic transmission contributes to the pathophysiological mechanisms of HFS. This is because the latencies of the orbicularis oris muscle responses in the lateral spread test were observed consistently in the suppressed motor neuron in our patients.

백혈구제거필터 및 수혈세트의 이상사례: 단일기관 보고 경험 및 한국과 미국의 보고현황

최수인,최수정,김진국,이진형,이유경 대한수혈학회 2022 大韓輸血學會誌 Vol.33 No.3

Background: Leukocyte reduction filters (LRF) and blood transfusion sets (BTS) are frequently used medical devices to prevent blood transfusion-related adverse reactions. This study attempted to analyze these medical devices related adverse events reported by an institution for 10 years and to understand the status of such reports in Korea and the United States (U.S.). Methods: From January 2013 to October 2022, adverse events reported at Soonchunhyang university Bucheon hospital (SCHBC) were analyzed. From 2016 to 2022, adverse events registered in the Korean Medical Device Information Portal and the Total Product Life Cycle (TPLC) database of the U.S. were collected and evaluated using the International Medical Device Regulators Forum (IMDRF) code for medical device problems, clinical signs, and symptoms or conditions. Results: A total of 12, 47, and 1,422 events were identified in SCHBC, Korea, and the U.S., respectively. The medical device problems reported in BTS included fluid leakage, breakage, disconnection, and no flow. In LRF, device or reagent problems, coagulation of device or device components, and filtration problems were reported. Most of the clinical signs and symptoms or conditions were not applicable (98.1%, 1,453/1,481), but hypotension and hemolysis were reported in LRF. Conclusion: To improve the safety of transfusion-related medical devices such as LRF and BTS, proper attention needs to be paid to adverse events and all medical institutions should participate in the reporting of such events. The various adverse events and associated IMDRF codes included in this study would help enable reporting of adverse events and improve patient safety. (Korean J Blood Transfus 2022;33:161-170)