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최규성,고종영,조대호,Choi, Kyu-Sung,Koh, Jong-Young,Cho, Tae-Ho 한국정보처리학회 2000 정보처리논문지 Vol.7 No.1
본 논문은 제조 공정의 생산관리 시스템을 개발함에 있어서, 생산 공정상의 스케쥴링 문제를 해결할 경우 시스템내의 여러 하위 모듈간의 협동을 통해서 처리하게 되는데, 이런 경우 각 모듈간의 원활한 협동을 위한 연동 방법을 정의하여야 한다. 이러한 연동 문제를 해결하기 위해서 분산 인공지능의 분산문제 해결 방법 중의 하나인 블랙보드 구조(Blackboard Architecture)를 사용하였다. 시스템의 문제 해결 과정을 여러 단계로 나뉘어진 공유 작업 공간(Shared Work Space)인 블랙보드에 나타내었으며, 구성 모듈간의 통신은 블랙보드를 통해서 이루어진다. 문제 해결의 처리 절차는 블랙보드의 구성요소중의 하나인 제어기에 지식의 형태로 정의되어 있고, 제어기는 이 지식을 바탕으로 모듈간의 실행 순서를 제어한다. 이와 같이 블랙보드 구조를 적용하여 하위 모듈간의 협동시에 발생하는 연동 문제를 해결하였으며 또한 시스템의 수정 및 확장에 대처 가능한 환경을 구성하였다. In the development of a production process scheduling system a collaboration method must be defined for the cooperation among submodules within the system. The blackboard architecture is exploited for solving the collaboration problem, which is one of the problem solving architecture that belongs to the distributed artificial intelligence. The dynamic states of the problem solving processes are presented in the hierarchically constructed shared working memory called as a blackboard. The communication for the collaboration is done through the blackboard. The problem solving steps are contained in the global controller, one of a component that consists the blackboard architecture, as knowledge. The global controller activates proper submodules based on the knowledge. By applying the blackboard architecture the collaboration problem among submodules in the grating production process scheduling system (GPSS) has been solved as well as the system became adaptable to the future modifications and expansions.
Clinical Immune Tolerance in Liver Transplantation: Present and Future
최규성 한양대학교 의과대학 2014 Hanyang Medical Reviews Vol.34 No.4
Liver transplantation is the most effective treatment for end-stage liver diseases (ESLD) with satisfactory clinical results and so is considered as the treatment of choice for ESLD and early hepatocellular carcinoma with cirrhotic liver. Unfortunately, adverse effects of life-long immunosuppression prevent the development of alternative strategies to achieve better long-term outcome. Achieving clinical operational tolerance is one of the ultimate goals in the clinical transplantation field. Around 15% of liver transplantation recipients develop spontaneous operational tolerance after immunosuppression withdrawal, and the percentage may be even higher in pediatric living donor liver transplantation recipients. One of the possible explainable mechanisms is a T cell fatigue from large amount of antigen loaded. Despite continuing progress, clinical operational tolerance is still rare in liver transplantation. Reprogramming the recipient immune system by creating chimerism and utilizing regulatory cell therapies are among the newer promising means to achieve clinical liver transplantation tolerance in the future. In animal studies, administration of donor specific regulatory T cells allows a prolonged survival without immunosuppressive agents. In this review, proposed mechanisms for clinical tolerance will be offered and current experimental trial will be introduced.
최규성,김지대,김효철,민상일,민승기,제환준,정진욱 대한영상의학회 2015 Korean Journal of Radiology Vol.16 No.4
To evaluate the technical feasibility and clinical outcome of percutaneous aspiration embolectomy for embolic occlusion of the superior mesenteric artery (SMA). Between January 2010 and December 2013, 9 patients with embolic occlusion of the SMA were treated by percutaneous aspiration embolectomy in 2 academic teaching hospitals. The aspiration embolectomy procedure was performed with the 6-Fr and 7-Fr guiding catheter. Thrombolysis was performed with urokinase using a multiple-sidehole infusion catheter. The clinical outcome was investigated retrospectively. Superior mesenteric artery occlusion was initially diagnosed by computed tomography (CT) in all patients, and all patients had no obvious evidence of bowel infarction on CT scan. Percutaneous aspiration embolectomy was primarily performed in 6 patients, and thrombolysis was initially performed in 3 patients. In 3 patients who received primary thrombolysis, percutaneous aspiration was undertaken because the emboli were resistant to urokinase. Complete angiographic success was achieved in 6 patients and partial angiographic success was accomplished in 3 patients. One patient underwent bowel resection. One patient died of whole bowel necrosis and sepsis, and 8 patients survived without complications. Percutaneous aspiration embolectomy is a useful tool in recanalization of embolic occlusion of the SMA in select patients.
최규성,고정환,심형석,노웅래,박정주,조광래 한국항공우주학회 2013 한국항공우주학회 학술발표회 논문집 Vol.2013 No.4
나로호(KSLV-I)의 3차 비행시험이 2013년 1월 30일 나로우주센터에서 수행되었다. 레이다를 비롯한 추적시스템으로부터의 비행데이터 및 발사체 내부 데이터를 이용한 비행상황 감시는 정상적으로 이루어졌으며, 실시간으로 동작하는 비행안전 알고리듬 계산도 정상적으로 수행되었다. 본 논문은 비행안전시스템 및 비행안전영역 설정을 설명하고 비행중 실시간으로 처리된 데이터 및 수행된 알고리듬의 분석결과를 제시하였다. The third flight test of KSLV-I was performed on January 30th, 2013 at Naro space center. Utilizing flight data obtained by tracking system such as radar and onboard telemetry data, monitoring of flight status is normally performed and the algorithms for flight safety calculations including the one for instantaneous impact point computations are also executed normally. This paper describes flight safety hazard areas and flight safety information system and presents algorithm"s analysis results and data processed in real-time during KSLV-I 3rd flight test.
Hydrazide Schiff Base 리간드와 Cd(II) 이온과의 착물 형성에 관한 연구
최규성,김용규,김용남,Kyu-Seong Choi,Yong-Kyu Kim,Yong-Nam Kim 대한화학회 1991 대한화학회지 Vol.35 No.2
N,N'-oxalylbis(salicylaldehyde hydrazone), N,N'-malonylbis(salicylaldehyde hydrazone), 그리고 N,N'-succinylbis(salicylaldehyde hydrazone)과 Cd(II) 이온과의 착물형성에 따르는 안정도상수를 DMSO 용액에서 폴라로그래피법으로 측정하였다. 안정도상수의 크기는 OBSH < MBSH < SBSH의 순서로 증가하였으며, Cd(II) 이언은 이들 리간드와 매우 안정한 착물을 형성하였다. 안정도 상수를 여러 온도에서 측정하여 엔탈피 및 엔트로피 변화를 측정한 결과, 착물형성에 기여를 하고 있음을 알았다. The complexation of hydrazide schiff base ligands such as N,N'-oxalylbis(salicylaldehyde hydrazone), N,N'-malonylbis(salicylaldehyde hydrazone), and N,N'-succinylbis(salicylaldehyde hydrazone) with Cd(II) ion was studied by polarographic method in DMSO solution. The order of stability constants was OBSH < MBSH < SBSH, and these ligands formed stable complexes with Cd(II) ion. The stability constants of complexation were measured at various temperatures. As the results, ${\Delta}$H and ${\Delta}$S of the complexation were distributed on the complex stabilities.