http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
구역성 다주파수 생체전기 임피던스법을 이용한 유지혈액투석 환자의 한외여과 적절도 평가
최규복 대한신장학회 1999 Kidney Research and Clinical Practice Vol.18 No.2
Objective:Many patients has suffered from intradialytic hypo- or hypertension. These unsatisfactory control of blood pressure(BP) may be due to inadequate ultrafiltration during HD. In this study, segmental multifrequency BIA was used to estimate dry weight(DW). Then, ultrafiltration adequacy was evaluated according to the estimated DW. Methods:Total body water resistance(RTBW) and extracellular fluid resistance(RECF) were measured on the right lower extremity in 36 maintenance HD patients(22 men and 14 women) and in 234 control subjects(171 men, 63 women). BP was measured every 30 minutes during HD. Patients with RTBW/ RECF ratio higher and lower than the mean?2SD of control subjects were considered to be over-and underhydrated, respectively. Results: 1)RTBW/RECF ratio of control subjects was 0.3402±0.0062. 2)RTBW/RECF ratio of HD patients was 0.3650±0.0190 before and 0.3445±0.0150 after dialysis(P$lt; 0.01). After dialysis, 28 out of 36(77.8%) patients were normovolemic(NV group), 7(19.4%) patients woverhydrated(OV group), and 1 patient(2.8%) was underhydrated. 3)BP changes during HD; In NV group, BP were increased significantly(P$lt;0.05). But there was no change in OV group. In one underhydrated patient, a decrease in BP, albeit not significant, was noticed. 4)Body weight reduction rate(kg/hr) was higher in NV group(0.48?0.15) than in OV group(0.25±0.14)(P$lt;0.01). Conclusion:Segmental multifrequency BIA may be useful as a method for estimating DW and evaluating ultrafiltration adequacy in maintenance HD patients.
최규복,한경숙,김미경,배윤주,이순남,경난호 梨花女子大學校 醫科大學 醫科學硏究所 1985 EMJ (Ewha medical journal) Vol.8 No.1
Gilbert's Syndrome is the name most frequently used to describe a condition which has been called constitutional heptic dysfunction, familial nonhemolytic jaundice of icterus intermittens juvenilis. It is characterized by a benign, persistent, but vari-able elevation of the plasma unconjugated bilirubin. A 27-year-old man was admitted because of general malaise, anorexia, sore throat and slight icteric sclera. On physical examination, there were mild icteric sclera and slightly injected pharynx. The liver was palpable 1 finger breath BRCM and the spleen was also palpable I finger breadth BLCM. Hematologic studies reve-aled slight anemia with slightly elevated corrected reticulocyte count. Liver func-tion tests were normal except for slightly elevated serum total bilirbin. Histolog-ic findings of the liver showed nonspecific findings of mild cholestasis. Reduction in caloric intake to 300 calrory a day for 72 hours resulted in a significant increase in the plasma bilirubin concentration(especially unconjugated form) in this patient. Now he has no subjective symptoms and leads a normal activity without specific treatment.
최규복,류정화,유민아,이신아,류동열,김승정,강덕희 연세대학교의과대학 2016 Yonsei medical journal Vol.57 No.4
Purpose: Endothelial dysfunction (ED) is a pivotal phenomenon in the development of cardiovascular disease (CVD) in patients receiving hemodialysis (HD). Indoxyl sulfate (IS) is a known uremic toxin that induces ED in patients with chronic kidney disease. The aim of this study was to investigate whether AST-120, an absorbent of IS, improves microvascular or macrovascular ED in HD patients. Materials and Methods: We conducted a prospective, case-controlled trial. Fourteen patients each were enrolled in respective AST-120 and control groups. The subjects in the AST-120 group were treated with AST-120 (6 g/day) for 6 months. Microvascular function was assessed by laser Doppler flowmetry using iontophoresis of acetylcholine (Ach) and sodium nitroprusside (SNP) at baseline and again at 3 and 6 months. Carotid arterial intima-media thickness (cIMT) and flow-mediated vasodilation were measuredat baseline and 6 months. The Wilcoxon rank test was used to compare values before and after AST-120 treatment. Results: Ach-induced iontophoresis (endothelium-dependent response) was dramatically ameliorated at 3 months and 6 months in the AST-120 group. SNP-induced response showed delayed improvement only at 6 months in the AST-120 group. The IS level was decreased at 3 months in the AST-120 group, but remained stable thereafter. cIMT was significantly reduced after AST-120 treatment. No significant complications in patients taking AST-120 were reported. Conclusion: AST-120 ameliorated microvascular ED and cIMT in HD patients. A randomized study including a larger population will be required to establish a definitive role of AST-120 as a preventive medication for CVD in HD patients.