톳 추출물에 의한 인체유방암세포의 세포주기 G1 Arrest 유발에 관한 연구

정선화,최영현 대한암예방학회 2009 Journal of cancer prevention Vol.14 No.2

Hizikia fusiforme is a kind of brown edible seaweed that mainly grows in the northwest pacific including Korea, Japan and China, and has been widely used as a healthy food for hundreds of years. Recently, H. fusiforme has been known to exert pharmacological activities including antioxidant, antimutagenic and anticoagulant activity. However, the molecular mechanisms of H. fusiforme in malignant cells have not been clearly elucidated yet. In this study, it was investigated the effects of ethyl alcohol extract of H. fusiforme (EAHF) on the anti-proliferative effects of MDA-MB-231 and MCF-7 human breast cancer cells. EAHF treatment resulted in a concentration-dependent growth inhibition by including G1 phase arrest of the cell cycle in MDA-MB-231 and MCF-7 cells as measured by flow cytometry analysis. The G1 arrest of EAHF was accompanied by an inhibition of cyclin D1 and cyclin-dependent kinase 2 (Cdk2) expression. EAHF treatment induced the level of Cdk inhibitor p27 without significant alteration of p53 and p21 expression. However, EAHF treatment resulted in a down-regulation of retinoblastoma protein (pRB) and E2F-1 and E2F-4 expression. In addition, the cell motility of both cell lines was markedly inhibited by EAHF treatment in a time- and concentration-dependent manner. The present results suggest that EAHF has divergent biological functions and additional studies will be needed to identify the active compounds that confer the anti-cancer activity of EAHF.

『한국사』 교과서 속의 고대 목간 자료의 활용 -『日本史B』 교과서와의 對較를 중심으로-

정선화 한국목간학회 2018 목간과 문자 Vol.0 No.21

Starting with the 2007 revision of the curriculum, middle school history (issued in 2011), the school considered the description of the ancient wooden tablets contained in the revised curriculum (issued in 2013) of high school year. In March this year, Japan’s history textbooks were published after reviewing descriptions of the wooden tablets of middle school history textbooks. In response, he examined the history textbook of Japan as a comparative example to examine whether the description of the wooden tablets in the high school history textbook reflects the latest achievements of the history studies in the right place. From the 1990s, which was earlier than Korea, Japan has included the ancient wooden tablets in its history textbooks. 『Korean history』 textbooks contain more wooden tablets than Japanese textbooks. However, there were considerable differences in the method of writing wooden tablets and the method of selecting them. While Japan clearly described the value of the wooden tablets as the primary historical materials in its history textbooks, it can be seen that Korean history textbooks contain many descriptions that are not limited to the achievements of history studies. The description of the wooden tablets should clearly describe the characteristics of the primary data and accurately reflect the achievements of the history studies. From a perspective, the descriptive features of the ancient wooden tablets in the 『Korean history』 textbook were reviewed to suggest problems and improvements. 본고는 2009년 개정 교육과정(2013 발행) 『한국사』 교과서에 수록되어 있는 고대 목간의 서술 현황을 검토하는데 목적이 있다. 올해 3월 역사교육연구회를 통해 중학교 역사교과서의 목간 관련 서술 내용을 검토한 글을 게재하게 된 것을 계기로 일본의 역사교과서에 관심을 가지게 되었다. 이에 『한국사』 교과서에 목간 관련 서술이 역사학계의 최신 연구 성과를 적재적소에 잘 반영하고 있는지를 검토하기 위한 비교 사례로 일본의 역사교과서를 살펴보았다. 일본은 우리보다 빠른 시기인 1990년대부터 고대 목간 자료를 역사교과서에 수록하였다. 山川出版社, 東京書籍, 実敎出版에 기재된 고대 목간은 「長屋王家」 관련 목간, 「郡·評論爭」 관련 목간, 「天皇」 호 관련 목간 등 3종류로 대별된다. 『한국사』 교과서는 고대 목간이 수록된 6종의 교과서에 6종류의 고대 목간이 등장한다. 일본에 비해 상대적으로 많은 목간이 수록되어 있다. 그러나 목간의 기재 방식이나 목간의 선정 방식에서부터 상당한 차이를 있음을 발견하였다. 일본은 역사교과서를 통해 1차 사료로서의 목간의 가치를 분명하게 나타나도록 서술한 반면, 한국의 역사교과서는 단순한 소개차원이거나 역사학계의 연구 성과에 반하는 서술이 많다는 것을 알 수 있었다. 목간 관련 서술은 1차 자료가 가지고 있는 특징이 잘 나타나도록 서술하면서 역사학계의 연구 성과가 정확히 반영되어야 한다. 그러면 측면에서 『한국사』 교과서 속의 고대 목간 관련 서술상의 특징을 검토하여 문제점과 개선방안을 제시하였다

해외 온라인 검색동향(검색전문가를 중심으로)

정선화,Jeong, Seon-Hwa 한국데이터베이스진흥원 1995 디지털콘텐츠 Vol.8 No.-

[그림검사] 다리 그림검사

정선화 계간 미술치료 2020 계간 미술치료 Vol.- No.20

포스터 발표논문 초록 ( 식품공학 / 물성 분야 Poster 초록 ) : 항냉동제 첨가에 의한 냉동저장 두부의 조직감 변화에 관한 연구

정선화,최원석,손혜숙,이철호 한국응용생명화학회(구 한국농화학회) 1997 한국응용생명화학회 학술발표회 Vol.1997 No.1

조현병 환자에서 항정신약물이 대사지표에 미치는 영향 조사 - 1년 추적연구

정선화,임선진,윤해주,박은경,이종일 대한조현병학회 2015 대한조현병학회지 Vol.18 No.2

Objectives : Schizophrenia patients are known to be more prone to metabolic disease than normal people. This study aimed to identifythe changes in metabolic parameters of schizophrenia patients using atypical antipsychotic drugs for 1 year. Methods : A total of 200 schizophrenia patients were recruited and categorized into the aripiprazole-treatment group and controlgroup taking 5 atypical antipsychotic drugs. Comparative analysis were between groups. The prescriptions of psychotropic drugswere collected by a review of medical records. Blood was collected after fasting for 12 hours at the starting point of treatment andthe 12th month, and patient medical records were evaluated for basici nformation and treatment history. Physical measurement,the prevalence of metabolic syndrome and metabolic parameters were studied using ATP-III diagnostic criteria. Results : From the study, the aripiprazole-treatment group had a mean weight increase of 0.6 kg and the control group had amean weight increase of 6.5 kg at the 1 year follow-up, showing a significant difference between the two groups. There were alsosignificant differences between the two groups in waist size, systolic and diastolic blood pressure, fasting blood sugar, total cholesterol,triglyceride, HDL-choleseterol and prolactin level. Along with meaningful improvement of the symptoms, aripiprazoletreatmentgroup showed less effect on in abdominal obesity, diabetes, blood pressure, cholesterol and prolactin than other atypicalantipsychotic drugs. Conclusion : Therapeutic intervention such as diagnosis, treatment, weight management and diet improvement is necessary forschizophrenia patients. Psychiatric symptoms as well as internal meicine-related problems such as metabolic disease need to beaddressed in case management.

자폐스펙트럼 장애 아동의 특별한 관심 및 비디오 모델 중재를 이용한 게임기술의 교수 효과

정선화 한국유아특수교육학회 2015 한국유아특수교육학회 학술대회 논문집 Vol.2015 No.3

소형화를 위한 패치형 Yagi-Uda 안테나 설계

정선화,황희용 강원대학교 정보통신연구소 2012 정보통신논문지 Vol.16 No.-

본 논문에서는 YagiᅳUda안테나를 소형화시키기 위해 비유전율이 4.4, Loss tangent(tanS)이 0.025, 금속의 두께는 0.762mm를 갖는 FR4기판에 인쇄하는 방식을 택하였으며 한 개의 도파기와 다이폴 공진기,접지면을 사용한 반사기로 지향성을 가지는 Yagi-Uda 안테 나를 제안하였다. 안테나의 공진 주파수는 접지면의 길이와 공진소자와 접지면 간의 간격을 조절하여 ISM대역 내로 설계하였다. 안테 나의 특성해석에는 상용 시뮬레이션 툴인 Ansoft사의 HFSS™을 사용하였으며,제작 및 측정을 통해 안테나의 성능을 확인하였다. 제 작된 안테나는 2.44GHz-2.49GHz 대역에서 10dB이하의 반사계수를 가지며 최대이득 4.316dBi를 가진다. 이는 면적의 제약을 받으나 지향성을 요구하는 공간이나 장소에 설치되어 사용될 수 있을 것이다. In order to miniaturize a Yagi-Uda antenna with one director we use a planar printing method on a PCB substrate which has 4.4 relative dielectric constant, 0.025 loss tangent(tanS) and 0.762 mm thickness. The structure is composed of a open \/2 line for director, two open 入/4 lines for driver and a ground-plane for re幻ector. The resonant frequency of the proposed antenna is optimized by changing the lengths of the ground-plane and the gap between resonant element and ground-plane in 2.4GHz ISM band. The tool for the optimizing is a commercial electromagnetic software HFSS1 x, by Ansoft. The performance is verified through fabrication and measurement. The fabricated antenna has a reflection coefficient less than -10dB and a gain of 4.316dBi at 2.44GHz-2.49GHz. This is expected to be installed and used in a small region with the restric仕on of area and directivity.

2008년도 덕성여자대학교 신입생의 특성

정선화,김남재 덕성여자대학 학생생활지도연구소 2008 學生生活硏究 Vol.24 No.-

Examined the characteristics of the students who entered Duksung Women's University in 2008. The total number of 1054(out of 1445) undergraduates completed an autobiographical questionnaire which inquires about demographic variables, family environment, satisfaction with the university, expectancies of a campus life, value system, self-concept, and lecture subject. Results show that a majority of the students were graduated from high schools located in Seoul. Both of their parents are alive, in the middle or higher socioeconomic groups and of high educational accomplishment(at the lowest, high school graduates). One of the replicated findings is that students are highly interested in career development. A great proportion of career preparation. The result also indicate that many students have chosen our university solely based on their grades. And many students report that they are satisfied with their choice, which is very encouraging. Other result such as the characteristics unique to each college are also summarized and several suggestions are presented in the discussion section.

지방금융에 있어서 농협의 역할

정선화 慶尙大學校 經營行政大學院 1996 最高管理者課程論文集 Vol.9 No.-