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장영 대한내과학회 2024 대한내과학회지 Vol.99 No.3
Hepatitis B virus (HBV) reactivation associated with various therapeutic interventions is a significant cause of morbidity and mortality among patients with current or resolved HBV infection. Since no curative treatment for HBV infection is currently available, a large number of individuals in the general population are at risk for HBV reactivation. Populations vulnerable to HBV reactivation include those currently infected with HBV or those who have had past exposure to the virus. The potential consequences of HBV reactivation are particularly concerning when these populations undergo anti-cancer chemotherapy, immunosuppressive or immunomodulatory therapies for managing various malignancies, rheumatologic diseases, inflammatory bowel disease, or undergo solid-organ or hematologic stem cell transplantation. This article aims to increase awareness of HBV reactivation and to elucidate the mechanisms and risks associated with HBV reactivation in various clinical settings.
장영,정승원,장재영,은혁수,이영선,송도선,유수종,이세환,김원,이현웅,김상균,류성호,박수연 대한간암학회 2022 대한간암학회지 Vol.22 No.2
Background/Aim: New biomarkers are urgently needed to aid in the diagnosis of early stage hepatocellular carcinoma (HCC). We performed a meta-analysis on the diagnostic utility of circulating tumor DNA (ctDNA) levels in patients with hepatitis B virus-induced HCC. Methods: We retrieved relevant articles from PubMed, Embase, and the Cochrane Library up to February 8, 2022. Two subgroups were defined; one subset of studies analyzed the ctDNA methylation status, and the other subset combined tumor markers and ctDNA assays. Pooled sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the summary receiver operating characteristic curve (AUC) were analyzed. Results: Nine articles including 2,161 participants were included. The overall SEN and SPE were 0.705 (95% confidence interval [CI], 0.629-0.771) and 0.833 (95% CI, 0.769-0.882), respectively. The DOR, PLR, and NLR were 11.759 (95% CI, 7.982-17.322), 4.285 (95% CI, 3.098- 5.925), and 0.336 (0.301-0.366), respectively. The ctDNA assay subset exhibited an AUC of 0.835. The AUC of the combined tumor marker and ctDNA assay was 0.848, with an SEN of 0.761 (95% CI, 0.659-0.839) and an SPE of 0.828 (95% CI, 0.692-0.911). Conclusions: Circulating tumor DNA has promising diagnostic potential for HCC. It can serve as an auxiliary tool for HCC screening and detection, especially when combined with tumor markers.
장영,요준문,곽묘묘,우단,리려 한국피부과학연구원 2023 아시안뷰티화장품학술지 Vol.21 No.3
Sanguis Draconis , the prepared resin of the fruit of Daemonorops draco Bl., is a precious traditional medicine from Southeast Asia. It has the effects of activating blood circulation and calming pain, removing blood stasis and hemostasis, generating muscle and astringeting sores. It is used for traumatic injury, abdominal stasis and pain, traumatic bleeding, etc. The chemical composition of Sanguis Draconis is complex, mainly including flavonoids, diterpenoid acids and other effective components. Modern pharmacological studies show that Sanguis Draconis has excellent pharmacological activities such as anti-inflammatory, antibacterial, anti-oxidant, anti-tumor, promoting wound healing and so on. This paper comprehensively arranges and summarizes the research status of the variety sources, chemical components and pharmacological effects of Sanguis Draconis , so as to provide scientific basis and new ideas for future research of Sanguis Draconis.
영화 <혐오스런 마츠코의 일생>의 여성 히스테리 신경증 분석
장영,차승재 동국대학교 영상미디어센터 2019 씨네포럼 Vol.0 No.34
Memories of Matsuko, directed by Tetsuya Nakashima (Japanese), has won the audience's great sympathy and love as it deeply reflects a woman’s living under the oppression of an androcentric society in a musical movie style with gorgeous colour-using. Matsuko, the heroine of the movie, moulded by the director as a character with hysterical neurosis, has ingeniously combined with the message conveyed beneath the film, telling a sweet and pleasant tragedy. The hysterical neuroticism people strive to meet the desire of the others, so we can find out the social problems which are persecuting them underlying that desire. Memories of Matsuko is about the desperate life of a woman persecuted by the paternalistic system. Based on the characteristics of hysterical neuroticism, Matsuko is a subject derived from her father and cannot finish her own subjectivation. In the movie, Matsuko was badly influenced by his father when she was young, then was oppressed and lost her independence in an androcentric society. The film criticizes the androcentric society by depicting the ashamed life of a poor women who exhausted her life in pleasing the man. 일본의 나카시마 테츠야 감독의 영화 <혐오스런 마츠코의 일생> 은 뮤지컬적인 스타일과 화려한 색채뿐만 아니라 남성중심주의 사회의 억압에서 살아간 한 여성의 삶을 보여주어 관객의 공감과 큰 사랑을 받았다. 특히 히스테리 신경증자로 연출된 주인공 마츠코의 캐릭터가 영화가 전달하는 메시지에 절묘하게 융합되어 달콤하고 유쾌한비극을 반영하였다. 히스테리 신경증자는 타자가 상실한 대상과의 관계 속에서 타자의욕망을 지배하기 위해 자신이 타자의 특정한 대상이 되려고 한다. 히스테리 신경증자는 타자의 욕망을 지속시키기 위한 특정한 대상이 되려고 하며 욕망이 불만족스러운 상태로 유지된다. 이것은 충족되지못한 욕망에 대한 욕망이다. 히스테리는 대타자와의 동일시를 통해주체를 찾아간다. 히스테리 신경증 여성은 자신의 무의식적 욕망과심리적 갈등을 자신이 속한 문화에서 타자가 인정하는 증상이나 행위로 치환하여 표현한다. 신경증자는 억압에 의해 자신의 존재를 상실하며 타자의 욕망에 의존하며 타자로부터 분리될 수 없다. 대타자가억압하여 신경증자는 타자의 욕망에 의해 자신의 욕망을 구성한다. 히스테리 신경증은 타자의 욕망이 되려고 노력하는 주체이기 때문에 타자의 욕망을 살펴보면서 주체에게 억압을 가한 대상을 찾아내어사회의 문제점을 발견할 수 있다. <혐오스런 마츠코의 일생>은 가부장체제의 피해를 받은 한 여성의 절망적인 삶을 연출하였다. 히스테리 신경증자의 특성에 따라 마츠코는 아버지의 분리된 주체로 존재하고 아버지라는 타자로부터 분리되어 주체화된 인생을 살 수 없게 된다. 영화 속 마츠코는 어린 시절 아버지의 영향으로 시작하여 남성중심주의 세상에서 억압을 받으며 주체성을 잃었다. 마츠코는 타자인