http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
김영생(Young Saeng Kim),이종원(Jong Won Lee),임병천(Byung Chun Yim) 한국유럽학회 2000 유럽연구 Vol.11 No.1
The social system and it`s dynamics bring the structural process changes enormously. They acquire competence to survive and remain competitive under the market economic conditions. One of the main problems during the recent development of financial institutions in Europe and Korea is that the organizational structure is not able to grow simultaneously and organizational forms are not adequate to the changed new environments. As results there are lags in the handing over informations and missing clear definition of areas of competence. Beside many technical changes by the implementation of new technologies the dynamic system theory especially self-organization was improved as successfiil also in financial institutions.
최윤지,최정윤,김주원,임아름,이영우,장원진,이수현,성재숙,정희준,이종원,강은주,김정선,임태규,김혜숙,김유정,안미선,김영생,박지현,임승택,조성심,조장호,신상원,박경화,김열홍 대한암학회 2022 Cancer Research and Treatment Vol.54 No.1
Purpose K-MASTER project is a Korean national precision medicine platform that screened actionable mutations by analyzing next-generation sequencing (NGS) of solid tumor patients. We compared gene analyses between NGS panel from the K-MASTER project and orthogonal methods. Materials and Methods Colorectal, breast, non–small cell lung, and gastric cancer patients were included. We compared NGS results from K-MASTER projects with those of non-NGS orthogonal methods (KRAS, NRAS, and BRAF mutations in colorectal cancer [CRC]; epidermal growth factor receptor [EGFR], anaplastic lymphoma kinase [ALK] fusion, and reactive oxygen species 1 [ROS1] fusion in non–small cell lung cancer [NSCLC], and Erb-B2 receptor tyrosine kinase 2 (ERBB2) positivity in breast and gastric cancers). Results In the CRC cohort (n=225), the sensitivity and specificity of NGS were 87.4% and 79.3% (KRAS); 88.9% and 98.9% (NRAS); and 77.8% and 100.0% (BRAF), respectively. In the NSCLC cohort (n=109), the sensitivity and specificity of NGS for EGFR were 86.2% and 97.5%, respectively. The concordance rate for ALK fusion was 100%, but ROS1 fusion was positive in only one of three cases that were positive in orthogonal tests. In the breast cancer cohort (n=260), ERBB2 amplification was detected in 45 by NGS. Compared with orthogonal methods that integrated immunohistochemistry and in situ hybridization, sensitivity and specificity were 53.7% and 99.4%, respectively. In the gastric cancer cohort (n=64), ERBB2 amplification was detected in six by NGS. Compared with orthogonal methods, sensitivity and specificity were 62.5% and 98.2%, respectively. Conclusion The results of the K-MASTER NGS panel and orthogonal methods showed a different degree of agreement for each genetic alteration, but generally showed a high agreement rate.