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Adjuvant Radiotherapy Outcome of Stage I Testicular Seminoma: A Single Institution Study
이하윤,조재호,김준원,홍성준,양승철,최영득,나군호 연세대학교의과대학 2015 Yonsei medical journal Vol.56 No.1
Purpose: To analyze treatment outcome and side effects of adjuvant radiotherapy using radiotherapy fields and doses which have evolved over the last two decades in a single institution. Materials and Methods: Forty-one patients received radiotherapyafter orchiectomy from 1996 to 2007. At our institution, the treatment field for stage I seminoma has changed from dog-leg (DL) field prior to 2003 to paraaortic (PA) field after 2003. Fifteen patients were treated with the classic fractionation scheme of 25.5 Gy at 1.5 Gy per fraction. Other patients had been treated with modifiedschedules of 25.05 Gy at 1.67 Gy per fraction (n=15) and 25.2 Gy at 1.8 Gy per fraction (n=11). Results: With a median follow-up of 112 months, the 5-year and 10-year survival rates were 100% and 96%, respectively, and 5-year and 10-year relapse-free survival rates were both 97.1%. No in-field recurrence occurred. Contralateral seminoma occurred in one patient 5 years after treatment. No grade III‒IV acute toxicity occurred. An increased rate of grade 1‒2 acute hematologic toxicity was found in patients with longer overall treatment times due to 1.5 Gy per fraction. The rate of grade 2 acute gastrointestinal toxicity was significantly higher with DL field than with PA field and also higher in the 1.8-Gy group than in the 1.5-Gy and 1.67-Gy groups. Conclusion: Patients with stage I seminoma were safely treated with PA-only radiotherapy with no pelvic failure. Optimal fractionation schedule needs to be explored further in order to minimize treatment-related toxicity.
이하윤,제갈영순,진성호,임권택,박종욱 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.1
The non-catalyst polymerization of 2-ethynylpyridine using 1,3-propandiol cyclic sulfate yielded a new ionic conjugated polymer in high yield. The chemical structure of this betaine polymer was characterized by various instrumental methods to have conjugated polymer backbone with the designed substituents. The cyclovoltammograms of polymer exhibited the irreversible electrochemical behaviors between the oxidation and reduction peaks. The oxidation current density of polymer versus the scan rates is approximately linear relationship in the range of 30-120 mV/s. It was found that the kinetics of the redox process of polymer is almost controlled by the reactant diffusion process from the oxidation current density of polymer versus the scan rates.