Development and Validation of the Korean Version of the Female Sexual Function Index-6 (FSFI-6K)

이유미,임명철,주정남,박기병,이수지,서시정,이동옥,박상윤 연세대학교의과대학 2014 Yonsei medical journal Vol.55 No.5

Purpose: To evaluate the validity and reliability of the Korean version of the FemaleSexual Function Index-6 (FSFI-6K). Materials and Methods: Participants were recruited from February 2013 to July 2013. The primary survey was conductedfor 220 participants, and a follow-up was conducted 3 weeks (±1 week) afterthe primary survey. The FSFI-6K data were analyzed and compared to the referencevalues in the original FSFI. Results: Of the 220 participants, 199 (90.5%) returned to follow-up, 18 (8.2%) had no further contact, and 3 (1.4%) declined to respond. The internal consistency of the FSFI-6K as measured by Cronbach’s alphawas 0.888 and the reliability based on test-retest intraclass correlation was 0.606; these values were acceptable. The cutoff used for diagnosis of female sexualdysfunction by an receiver operating characteristics (ROC) curve was a score of 21; the sensitivity and specificity for this curve are 0.89 and 0.86, respectively. The area under the receiver operating curve was 0.948. Conclusion: The FSFI-6K has high internal consistency and acceptable reliability. This validated questionnaire can be used for the Korean population.

Factors associated with osteoporosis medication initiation and adherence

이유미 대한골다공증학회 2018 Osteoporosis and Sarcopenia Vol.4 No.1

The current crisis in the treatment of osteoporosis has been acknowledged widely in the field [1]. The evidence is emerging that the 30-year downward trend in hip fractures in the U.S. has hit a plateau in the last few years leading many patients with high risk of hip fracture in danger [2]. The crisis is probably due to the increasing number of patients being reluctant to take osteoporosis therapies, due to the fears of rare side effects, even though the number of fractures that are prevented with treatment far outweighs the risk of atypical femur fractures and osteonecrosis of the jaw (ONJ) [3]. However, the actual incidence of ONJ is quite low as 0.001%e0.01% [4]. Treatment of women with osteoporosis for up to 5 years would result in fewer than one atypical femur fracture caused per 100 osteoporotic fractures prevented [5]. Meanwhile, the cost that has to be paid for the hip fracture is enormous. Despite the availability of several effective drugs to prevent further progression of bone loss and occurrence of fractures, many patients are either not even starting the medication or just not taking it if prescribed. Although there are many reasons for this “gap” in the treatment of osteoporosis, a significant factor is a physician and patient concerns over the risk of side effects. Thus the article by Orimo et al. [6] entitled “Understanding the factors associated with initiation and adherence of osteoporosis medication in Japan: An analysis of patient perceptions” is timely. The power of this study lies in several ways; firstly, many studies have been published more in Caucasians, but this study was done in Japanese, secondly, authors well identified real-world factors associated with initiation and adherence of osteoporosis medication from a patient perspective, lastly they applied a wellvalidated method of structural equation modeling. Authors concluded that the patient knowledge of their disease and the perception of barriers were most influential. Educating and communicating with patients to better understand their conditions and to reduce barriers may be useful in improving patient outcomes. Authors also suggested that a patient-centered, coordinator-based osteoporosis-specific care system that provides a systematic assessment of fracture patients, similar to the Fracture Liaison Services established across the United Kingdom may be helpful [7]. The recent concept of Osteoporosis Liaison Service by the Japan Osteoporosis Society could be one of the models as to know how it worked in enhancing the initiation and adherence to osteoporosis treatment [8]. To overcome the crisis in the field, we all will have to find a more efficient way to educate the healthcare professionals to focus on recognizing, diagnosing and treating patients at high risk for fracture, thus conveying the explicit messages to inform patients and public.

Brain 확산 자기 공명 영상(DWI) : Tetrahedral과 Orthogonal DWI의 비교 분석

이유미,김혁,안치복,유민수,김세영,강성호,임재식 대한자기공명기술학회 2012 대한자기공명기술학회지 Vol.22 No.-

말기 신부전증에 의한 이차성 부갑상선 기능항진증 환자에서 부갑상선 조직의 세포자가사멸 연구

이유미,이재복<SUP>1<,SUP>,Yu Mi Lee,Ph,D and Jae Bok Lee,Ph,D,<SUP>1<,SUP> 대한갑상선-내분비외과학회 2008 The Koreran journal of Endocrine Surgery Vol.8 No.4

Purpose: The cause of renal hyperparathyroidism is unclear and the role of hyperphosphatamia is the only well established cause of renal osteodystrophy. The long life span of the parathyroid cells and the absence of a definite tissue marker for nodular parathyroid gland prohibit the timing of surgical intervention. The discrepancy between proliferation and apoptosis has been proposed as one possible cause of nodular development of the parathyroid gland in patients suffering with renal osteodystrophy. In the present study, we investigated the apoptotic labeling index of the parathyroid tissue in patients with renal hyperparathyroidism. Methods: The parathyroid tissues of 76 patients with renal hyperparathyroidism and those of 33 normal glands were used for determining the level of apoptosis by performing a Tdt-mediated dUTP nick end labeling (TUNEL) assay. The patients' information was collected by a review of the clinical charts. Statistical comparison was done via two tailed t-tests. Results: The averages of the TUNEL indices were 0.19 in the normal parathyroid glands and 1.84 in the hyperplastic parathyroid glands (P=0.00). The TUNEL index was higher in the oxyphil type of cells than in the chief cells and the water clear cell types (P=0.01). There was statistically significant correlation of the TUNEL index with the duration of the dialysis and less than 10 years dialysis showed a 2.23 index, which was higher than that of the longer term dialysis patients (P=0.00). The preoperative PTH level, recurrence, the Ki-67 labeling index and the pathologic type didn't show any statistical correlation with the TUNEL index (P>0.05). Conclusion: Our findings showed that the TUNEL index is useful for separating the cases of advanced renal hyperparathyroidism from the early ones and the TUNEL index is well correlated with hyperplastic types of cells. A decrease of apoptosis could be a probable cause of the progression of parathyroid hyperplasia in renal patients who are on dialysis support. (Korean J Endocrine Surg 2008; 8:250-255)

프레임을 이용한 意思疏通 過程 硏究

이유미 한국어문교육연구회 2009 어문연구(語文硏究) Vol.37 No.2

The purpose of this study is to research the factors in a communi- cation process by Frame Theory. This study is different from existing studies in that it tries to give shape to communication processes using Frame Theory. Our research shows that ‘frames’ are applied to the speaker, the listener, and the message while communication takes place. All communications have purposes. When people communicate with someone, they try to convey their purpose to others. Consequently, speaker’s frames are applied to messages, which specify the purpose of the communication. Also, listener’s frames are used in the listener’s interpretation process. Understanding this framing process will be the foundation for studying the strategy for communication in detail. By incorporating various aspects of framing, we can clarify the process of strategic communication. 이 硏究의 目的은 意思疏通 過程에서 表現하고 解釋하는 데 작용하는 요소를 프레임 이론을 통해 살펴보고자 하는 데 있다. 즉 의사소통에 작용하는 요소의양상에 대한 연구가 부족한 점을 프레임 이론을 통해 補完하고자 하며 이 연구는 화자와 청자 그리고 메시지 각각의 프레임이 적용되어 의사소통 과정에 작용함을 보이고자 한 것이다. 화자의 발화는 언제나 有目的的인데, 目的性을 발현해 내는 메시지를 구성하는 방식에도, 화자가 發話를 실현하고자 하는 의도에도 프레임은 작용하게 된다. 또한 이렇게 發話된 메시지를 해석하는 청자의 해석 과정에 있어서 화자의 것을 그대로 받아들이지 않고 청자의 프레임에 맞추어 해석하게 되는 것이다. 이러한 과정을 이해하는 것은 意思疏通의 策略性을 면밀히 연구하는 데 있어 기초적인 작업이 될 것이며 이를 통해 각 프레임의 양상을 구체화함으로써 戰略的 意思疏通의 과정을 밝혀 낼 수 있을 것이다.

1930년대 후반 시단과 이상(李箱) -시 전문지를 중심으로

이유미 구보학회 2019 구보학보 Vol.0 No.23

In this article, I tried to examine the relationship between Lee Sang and the new generation of poets, which appeared in the poem magazine in the late1930s. Starting in November 1936, a large number of poetry magazines are published. Among them, Siinburak is regarded as the gathering place of the new generation of poets, and the members of the Siinburak form the same consciousness through the contact with Lee Sang .In this regard, this article examined whether Lee Sung-bum’s LeeSangaedo and 「Pa-Cheop(破帖)」 in the Jaosun , where members of the Siinburak , participated, revealed the point of contact with the Lee Sang. In particular, Cain, who appeared in the 「Pa-Cheop(破帖)」, appeared in the works of the new generation poets Oh Jang-hwan and Seo Jeong-ju and tried to clarify the intersection of generations by using Cain as a contact point .If Cain appeared in the 「Pa-Cheop(破帖)」 is depicted as a rebellious child of the times, Oh Jang-hwan and Seo Jeong-ju’s Cain are the wanderers living in modern times and the objects showing the renewal and uplift of vitality. In this process, Siinburak , Jaosun In the flow of poetry magazines consisting of Mack , Lee Sang is positioned as a new generation poet and a same generation poet. It can be seen that Lee Sang not only emphasizes life not captured by intelligence but also creates newness by drawing invisible realms. In addition, the poetic position of the poetical circles in the late 1930s could be recognized by illuminating the current position at the point of contact with the new generation of poets. 본고에서는 1930년대 후반 시 전문지에 나타난 이상(李箱)과 신세대 시인의 연관성을 고찰하고자 했다. 1936년 11월을 기점으로 많은 양의 시 전문지가 발행된다. 그 중 시인부락 은 신세대 시인의 집결 장으로 평가받는데, 시인부락 일원들은 이상과의 만남을 통해 동류의식을 형성한다. 이 글은 이 점에서 시인부락 일원들이 참여한 자오선 에 이성범의 「이상애도」와 이상의 유고 「파첩」이 게재됨으로써 1930년대 후반 시단과 이상의 접점이 지속적으로 드러나는지 살펴보았다. 특히 이상의 「파첩」에 등장한 카인은 신세대 시인인 오장환과 서정주의 작품에도 등장함으로써, 카인을 접점으로 세대의 교차가 발견되는 것을 구명하고자 했다. 이상의 「파첩」에 등장한 카인이 시대의 반항아로 그려졌다면, 오장환과 서정주의 카인은 현대를 살아가는 방랑자이자, 생명력의 재생과 고양을 보여주는 대상으로 나타난다. 이 과정에서 시인부락 , 자오선 . 맥 으로 이루어지는 시 전문지의 흐름 속에서 이상은 신세대 시인들과 동세대 시인으로 자리한다. 그들에게 이상은 가치 있는 타자로서 자리할 뿐 아니라 새로움의 추구에 위치한다. 그들에게 이상의 시는 지성으로 포착되지 않은 생명을 강조할 뿐 아니라 보이지 않는 영역을 그려냄으로써 새로움을 창출함을 알 수 있었다. 이와 더불어 이상의 시사적 위치를 신세대 시인들과 접점에서 조명함으로써 1930년대 후반 시단의 역동성을 인식할 수 있었다.

[한반도 Plus] “북한 2인자는 김여정”

이유미 연합뉴스 동북아센터 2020 마이더스 Vol.2020 No.9

Localization of Oncogenic Osteomalacia by Systemic Venous Sampling of Fibroblast Growth Factor 23

이유미,이지연,박혜선,한승희,Jiyu Kelly Lim,홍남기,박성일 연세대학교의과대학 2017 Yonsei medical journal Vol.58 No.5

Purpose: Tumor-induced osteomalacia (TIO) is characterized by hypophosphatemia caused by a phosphaturic mesenchymal tumor. While surgical resection of the tumor leads to a cure, identification of the responsible tumor is challenging. Recently, several studies showed that systemic sampling of fibroblast growth factor 23 (FGF23) is helpful for localization of tumors. The present study aimed to evaluate the clinical utility of this method in Korean patients. Materials and Methods: Six patients compatible with TIO who were admitted to our hospital between 2006 and 2015 were analyzed. Systemic venous sampling of FGF23 was performed to detect blind lesions or to confirm a suspicious lesion identified in previous imaging studies. Results: Venous sampling helped confirming the tumor in five of the six patients. Three patients underwent surgery after sampling,and in two patients, the lesions were detected after 3 years by means of 68Ga-DOTATOC positron emission tomography with computed tomography. In one patient, there was a local elevation of serum FGF23 without any related lesion on additional imaging. Conclusion: Our data strengthened the value of venous sampling of FGF23 in predicting the location of tumors and suggested that it can be more effective in the presence of the relevant lesion in subsequent imaging analyses.

‘가족(家族)’ 단어(單語)의 연상의미(聯想意味) 연구(硏究)

李兪美,李燦揆 국어학회 2007 국어학 Vol.0 No.50

이 연구의 목적은 ‘가족’에 대한 네티즌의 단어 연상 결과를 바탕으로 ‘가족’의 연상 의미망을 구축하는 데 있다. 또한 이를 통해 가족에 대한 사회 언어학적 의미를 고찰해 보고자 한다. 이 실험은 이전의 단어 연상 실험과 달리 ‘가족’이라는 제시어를 주고 그 반응을 문장으로까지 확대하여 그 연상 내용을 조사하였다. 반응문에 나타난 어휘의 양상을 살펴 ‘가족’에 대한 연상 의미망을 구축하고, 사회언어학적 관점에서 하나의 ‘개념’에 대한 반응 범주의 다양성을 살펴보고자 한 것이다. 실제로 자극어에 대한 반응은 단어로만 이루어지는 것이 아니기 때문에 반응의 범위를 문장으로까지 확장하여 그 문장에 사용된 반응어를 분석하는 방식을 시도하였다. 이를 통해 반응자들의 의도를 좀 더 정확하게 파악할 수 있고, 관련 어휘를 더 다양하게 수집할 수 있다는 점에서 의의가 있다. 이 조사를 통해 9만 여개의 유효 반응어를 추출해 내었고 이 가운데 30개 이상의 빈도를 가진 8만여 어휘만을 대상으로 연상 의미망을 구축하고, 이를 통해 성별·연령별 반응의 차이를 살펴 전체적인 ‘가족’에 대한 인식의 양상을 구조화해보고자 하였다. 가족에 대한 반응 문장에 나타난 단어로는 ‘나’ ‘사랑’ ‘행복’ ‘사람’ 등의 순서로 많은 빈도를 차지하였으며, 성별, 연령별로도 차이가 많은 것으로 나타났다. 가족이라는 대상에 대한 가치 평가에서는 대부분 긍정적인 단어들이 많이 사용되었다.

새로운 날개가 된 전기자전거 ‘뚜뚜’

이유미,김희현(그림) 샘터사 2020 월간 샘터 Vol.609 No.-