Association between Lung Cancer Susceptibility Variants Identified by Genome-Wide Association Studies and Survival of Non-Small Cell Lung Cancer

이소연,( Mi Jeong Hong ),( Yi Young Choi ),( Hyo Sung Jeon ),( Seung Soo Yoo ),( Shin Yup Lee ),( Jaehee Lee ),( Seung Ick Cha ),( Chang Ho Kim ),( Eung Bae Lee ),( Jae Yong Park ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-

Introduction: A number of genome-wide association studies (GWASs) have identified chromosomal regions containing genes associated with the risk of lung cancer. Genetic polymorphisms influence not only the development of cancer, but also cancer progression and prognosis. Therefore, we investigated the impacts of genetic variants associated with susceptibility to lung cancer in GWASs on the prognosis of NSCLC. Materials and Methods: This study included patients (n=363) with stage I, II, or IIIA (micro-invasive N2) NSCLC who under-went curative surgical resection at the Kyungpook National University Hospital, Daegu, Korea between September 1998 and December 2007. Eight single nucleotide polymorphisms (SNPs) in the six chromosomal regions (CRP rs2808630, FAM13A rs7671167, HHIP rs1489759, GYPA rs2202507, TERT rs2736100, CLPTM1L rs402710, BAT3 rs1052486, and CHRNA5 rs16969968) were genotype by a PCR-RFLP analysis. Results: None of the eight SNPs were significantly associated with overall survival and disease-free survival. In addition, when the patients were categorized according to age, gender, smoking status, tumor histology and pathologic stage, there were no significant associations between the eight SNPs and survival outcomes. Conclusions: These results suggest that the genetic variants identified by GWASs for lung cancer susceptibility are not sig-nificantly associated with the prognosis of patients with early stage NSCLC.

정신분열병과 기분장애 환자의 언어적 기억능력과 기억과정의 특성에 대한 연구

이소연,이분희,이정애,김계현,김용구,박선화,Lee, So-Youn,Lee, Bun-Hee,Lee, Jung-Ae,Kim, Kye-Hyun,Kim, Yong-Ku,Park, Sun-Wha 대한생물정신의학회 2005 생물정신의학 Vol.12 No.2

Objectives:This study was to compare verbal memory ability among patients with schizophrenia, bipolar manic patients and unipolar depressive patients, and to understand their charicteristics of memory process. Methods:All subjects were hospitalized patients and had been interviewed by using the Structured Clinical Interview for DSM-IV(SCID). Schizophrenic patients(N=40), bipolar manic patients(N=17), and unipolar depressive patients(N=20) were assessed with K-AVLT for verbal memory and with K-WAIS for verbal IQ. Three groups were compared regarding total immediate recall, delayed recall, delayed recognition, learning curve, memory retention, and retrieval efficiency under controlled verbal IQ. Multiple regression analysis was performed to find which clinical factors have an influence on verbal memory ability. Results:In MANCOVA, differences of verbal memory test scores among the groups were statistically significant(F=1.800, p<.05). In post hoc analysis, Patients with schizophrenia and bipolar mania showed poorer performance in immediate recall, delayed recall, delayed recognition, retrieval efficiency than unipolar depres- sive patients. And schizophrenics performed poorly in delayed recall, delayed recognition, retrieval efficiency than nonpsychotic affective disorder group, but no difference in total immediate recall, delayed recall, delayed recognition, retrieval efficiency between the schizophrenic group and the psychotic affective group. Conclusions:These results partially confirm previous reports of verbal memory ability among major psychiatric disorders. Our results showed that psychotic symptoms were related with verbal memory, and longer duration of illness was related with poorer performance in schizophrenia and unipolar depression.

전자기록의 속성에 기반한 기록관리의 과제

이소연,Lee, So-Yeon 한국기록학회 2008 기록학연구 Vol.0 No.18

최근 18년간 한국 소아 Helicobacter pylori 유병률의 변화: 기능성 반복성 복통 소아에서 연도별 내시경 진단 양성률의 감소에 관한 연구

이소연,고재성,서정기,Lee, So-Yeon,Ko, Jae-Sung,Seo, Jeong-Kee 대한소아소화기영양학회 2009 Pediatric gastroenterology, hepatology & nutrition Vol.12 No.2

목 적: Helicobacter pylori (H. pylori) 감염 유병률은 사회 경제적 수준에 따라 다르게 나타난다. 최근 우리나라가 경제적 성장을 이루면서 H. pylori 유병률에 변화가 있을 것으로 생각되나 소아를 대상으로 한 보고가 없다. 이번 연구에서는 기능성 반복성 복통 환아를 대상으로 지난 18년간의 H. pylori 유병률 변화를 알아보고자 하였다. 방 법: 1991년 7월부터 2008년 12월까지 반복성 복통으로 서울대병원을 찾은 1,194명(남아 499명, 여아 695명)의 환아들을 대상으로 하였으며 평균나이는 9.2${\pm}$3.1세였다. 모든 환아들은 상부위장관 내시경 검사를 시행 받았으며 CLO test로 H. pylori 감염을 판단하였다. 지난 18년간 H. pylori 감염률의 변화와 성별, 연령에 따른 감염률의 변화를 분석하였다. 결 과: 반복성 복통 환아의 H. pylori 감염률은 1991~1993년 25.1%, 1994~1996년 23.1%, 1997~1999년 19.3%, 2000~2002년 16.1%, 2003~2005년 11.3%, 2006~2008년 10.8%로 지난 18년간 유의하게 감소하였으며(p<0.001) 성별, 연령과 상관없이 모두 감소하였다. 결 론: 반복성 복통 환아에서 지난 18년간 H. pylori 감염률은 유의하게 감소하였으며 이는 사회 경제적 발전에 의한 것으로 생각한다. Purpose: The aim of this study was to evaluate observed changes in the prevalence of biopsy-proven Helicobacter pylori infection in Korean children with functional recurrent abdominal pain during the past 18 years. Methods: Between July 1991 and December 2008, 1,194 children with functional recurrent abdominal pain (499 males and 695 females) 9.2${\pm}$3.1 years of age were included. Upper gastrointestinal endoscopies were performed in all patients. H. pylori infection was assessed by the CLO test. Changes in the prevalence of the endoscopic diagnosis of H. pylori infection during 18 years were analyzed. Results: The prevalence of H. pylori infection between 1991 and 1993, 1994 and 1996, 1997 and 1999, 2000 and 2002, 2003 and 2005, and 2006 and 2008 were 25.1% (56/223), 23.1% (45/195), 19.3% (28/145), 16.1% (39/242), 11.3% (24/213), and 10.8% (19/176), respectively; these serial decreases in the prevalence over 18 years were statistically significant (p<0.001). Regardless of gender and age, the prevalence of H. pylori infection decreased. This decrease was inversely related to socioeconomic improvement as represented by the per capita gross national income growth of Korea. Conclusion: The prevalence of H. pylori infection has decreased significantly for the past 18 years in Korean children. This decrease might be caused by an improvement in socioeconomic status.

한국 정상안 및 백내장안에서의 스트레이라이트의 연구

이소연,오중협,So Yeon Lee,Jung Hyub Oh 대한안과학회 2011 대한안과학회지 Vol.52 No.2

Purpose: To compare intraocular straylight in normal and cataractous eyes as the morphology and to compare straylight as the result of subjective symptoms in early cataract cases using the C-quant straylight meter, the only tool to measure light scattering in media. Methods: Straylight values were measured in 217 normal eyes and 138 cataractous eyes. Cataractous eyes were classified into posterior subcapsular opacity, anterior subcapsular opacity and nucleosclerosis. Straylight values of each group were measured. The 56 early cataractous eyes were categorized into two groups, depending on the presence of subjective symptoms, and each straylight value was measured. The preoperative and postoperative straylight values of early cataracts were also compared. Results: The mean straylight values of normal and cataractous eyes were 1.34 and 2.46, respectively. The value of posterior subcapsular opacity (2.81) was significantly higher than that of anterior subcapsular opacity (2.33) and nucleosclerosis (1.99). The straylight values of early cataracts were significantly higher in the group with subjective symptoms (2.02) than in the group without subjective symptoms (1.56). The postoperative straylight value decreased to 1.42. Conclusions: The posterior subcapsular cataract showed significantly high intraocular straylight, indicating that light scattering occurred to a greater extent in this group. Light scattering occurred more in early cataractous eyes with subjective symptoms than in eyes without symptoms, and light scattering was reduced after surgery. The C-quant straylight meter, which measures the light scattering in media, can be a useful tool to determine the time of cataract surgery and to evaluate the quality of vision. J Korean Ophthalmol Soc 2011;52(2):182-189

기록관리를 위한 업무분석 방법론 연구: 호주표준 AS 5090을 중심으로

이소연,오명진,Lee, Soo Yeon,Oh, Myung-Jin 한국기록학회 2005 기록학연구 Vol.0 No.12

There have been growing interests in work process analysis methodology, ever since ISO 15489 and DIRKS were introduced to the Korean archival and records management community. It is because the methodology has been expected to provide with much needed information, with which records management programs could be designed. The information encompass from those needed in developing macro-organizational framework such as business classification schemes, to those essential to identify exact points of time, at which records management systems should capture records during each phase of business process. The Korean community, however, currently possesses a surprisingly scanty understanding of the methodology. The present paper aims to promote its understanding among Korean archivists and records managers, by reviewing an Australian standard of Work Process Analysis for Recordkeeping(AS 5090). It begins with drawing attention to the fact that the work process analysis is utilized in diverse areas, encompassing systems development, organizational re-engineering, and human resources management in business settings. When the methodology is implemented in records management settings, therefore, focus should be lied in finding out ways of creating and capturing records from the routine business activities. The paper then reviews the relationship among the three standards, AS 5090, DIRKS, and ISO 15489. Most parts of the paper are dedicated to review AS 5090 in detail, with examples. The paper also provides with output forms to be used to organize and represent results from the analysis.

뇌혈관(腦血管) 기형(奇形)이 없이 발병(發病)한 소아(小兒) 뇌경색(腦硬塞) 환자(患者) 1례(例) 경과(經過) 보고(報告)

이소연,신오철,박치상,윤현덕,Lee, So-Yeon,Shin, Wo-Cheol,Park, Chi-Sang,Yoon, Hyeon-Deok 대한한방내과학회 2005 大韓韓方內科學會誌 Vol.26 No.2

Cerebral infarction without cerebravascular malformation in childhood is very uncommon. One case of cerebral infarction without cerebravascular malformation in childhood, with symptoms similar to those of an adult, was encountered. This female patient had no cerebravascular malformation and was just ten years-old. She was treated with herb medicine, acupunture treatment and physical treatment. After treatment she recovered from stroke symptoms but the primary cause of stroke was not revealed. Follow-up research is needed to determine the cause of stroke. Results suggest that oriental medical treatment had beneficial effects in treatment of cerebral infarction in this child.

중풍증상(中風症狀)과 함께 나타난 Marchiafava-Bignami 병 1예 보고

이소연,윤현덕,박치상,박창국,장우석,Lee, So-Yeon,Yoon, Hyeon-Deok,Park, Chi-Sang,Park, Chang-Gook,Jang, Woo-Seok 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.3

Marchiafava-Bignami Disease(MBD) is a rate disease caused by chronic alcohol abuse and involves the degeneration of corpus callosum pathological in character. Until recently there was no method to diagnose MBD except postmortem examination, but nowadays rodiology has advanced increasingly, so MBD can be diagnosed correftly and easily. A case of MBD with stroke symptoms is reported. A 56-year-old man who has been a heavy alcoholic for several years was admitted with stroke symptoms such as stuporous mental, hemi-extremities weakness, dysphasia and dysphagia. After treatment these symptoms were improved.

뇌출혈 후 발생한 파리노드증후군 1예

이소연,윤상원,강성모,So Yeon Lee,MD,Sang Won Yoon,MD,Sung Mo Kang,MD 대한안과학회 2009 대한안과학회지 Vol.50 No.1

Purpose: To report one case of Parinaud syndrome after intracranial hemorrhage. Case summary: A 45-year-old man visited our emergency department complaining of right-sided weakness and right-sided hypoesthesia. Intracranial hemorrhage in the left thalamus and intraventricular hemorrhage were noted upon brain computed tomography, and the patient was admitted to the department of neurosurgery. He complained of diplopia and upgaze palsy, and he was referred to the department of ophthalmology. The patient exhibited convergence-retraction nystagmus, light-near dissociation and vertical gaze limitation within 15 degrees. The best-corrected visual acuity of both eyes was 20/20, but convergence-retraction nystagmus and light-near dissociation still remained. Upgaze palsy was also not improved. Conclusions: Once symptoms manifest, Parinaud syndrome does not resolve except in patients with hydrocephalus. If the findings persist for more than 6 months, the likelihood of complete resolution is very small. We reported a case of typical Parinaud syndrome with upgaze palsy, convergence-retraction nystagmus and light-near dissociation after thalamic and intraventricular hemorrhage.

디지털 아카이빙의 표준화와 OAIS 참조모형

이소연,Lee, So-Yeon 한국과학기술정보연구원 과학기술정보센터 2002 Journal of Information Science Theory and Practice Vol.33 No.3

OAIS Reference Model has become a basis for exchanging ideas and cooperating among institutions and various sectors concerned with digital archiving. It has been also recently approved as a new ISO standard. This paper reviews major concepts and issues that the reference addresses. It also introduces current activities of institutions and projects that have contributed to the development process of the model. Conclusion is devoted to address the importance of cooperation among cultural institutions. These institutions are taking the responsibility of preserving digital information for the long-term as authentic as possible and delivering it to the next generation. 디지털 정보보존 관련 분야와 기관간 의견교환과 협력의 기반이 되는 OAIS 참조모형이 최근 ISO 표준으로 인증 발표되었다. 이 논문은 OAIS 참조모형이 정의하고 있는 주요 모형들과 디지털 아카이빙에 관련된 문제들을 논의하고 이 모형의 개발에 참여한 주요 기관 및 프로젝트의 활동을 소개하였다. 귀중한 문화유산인 디지털정보를 진본 상태로 유지하면서 장기적으로 보존하여 현재와 후대의 인류에게 전승하는 책무를 맡고 있는 문화기관들의 협력 필요성에 대해서도 논의하였다.