시와사람_이선미_선정소감

이선미 고요아침 2016 열린시학 Vol.21 No.3

[시와사람_이선미_선정작] 미운 꽃 외 1편

이선미 고요아침 2016 열린시학 Vol.21 No.3

[시와사람_이선미_신작] 물 소리를 듣다

이선미 고요아침 2016 열린시학 Vol.21 No.3

섬백리향과 백리향 70% 에탄올 추출물의 미백효과에 관한 연구

이선미 한국화장품미용학회 2021 한국화장품미용학회지 Vol.11 No.1

This study confirmed that the tyrosinase enzyme activity is inhibited in two extracts as a result of the experiment on the whitening of the 70% ethanol extract from Thymus mmagnus and Thymus quinquecostatus. In the test of cell viability using Melanoma cell-line B16F10, more than 80% of cell viability was identified in the concentration of 100 μg/ml of the 70% ethanol extract from Thymus mmagnus and Thymus quinquecostatus. In the measurement of the melanin biosynthesis inhibitory activity in B16F10 cell, the inhibitory effect on Melanogenesis with 11.09%, 17.16% was verified in the concentration of 100 μg/ml of two extracts. In the 70% ethanol extract from Thymus mmagnus and Thymus quinquecostatus, the inhibitory efficacy of melanin biosynthesis and secretion was inspected to be shown by the inhibition of tyrosinase expression through hindering MITF as well as directly impeding the tyrosinase enzyme activity. The aim is to suggest applicability as the cosmetic material through experimenting the whitening effect of the 70% ethanol extract from Thymus mmagnus and Thymus quinquecostatus. 섬백리향과 백리향 70% 에탄올 추출물의 미백에 관한 연구 결과 melanoma 세포주 B16F10를 이용한 세포 생존율 실험에서 섬백리향과 백리향 70% 에탄올 추출물 모두 멜라닌 형성 억제 효과가 있는 것으로 나타났다. 이러한 미백 효능은 melanin에 대한 tyrosinase의 활성을 직접적으로 저해하기 보다는 α-MSH에 의해서 자극되는 전사인자인 MITF의 발현을 억제함으로써, MITF에 의해 촉진되는 tyrosinase의 발현 자체를 저해함으로써 나타난다는 것을 실험을 통해 확인하였다. 이러한 결과로 보아 섬백리향과 백리향 70% 에탄올 추출물이 우수한 미백 화장품 활성 소재로의 가치가 높음을 보여준다.

Expression and Function of TLR2 on CD4 Versus CD8 T Cells

이선미,주영돈,서수길 대한면역학회 2009 Immune Network Vol.9 No.4

Background: Toll-like receptors (TLRs) play a fundamental role in innate immunity through their capacity to recognize pathogen-associated molecular patterns. Also, TLRs that are expressed in T cells are reported to function as co-stimulatory receptors. However, the functional capacity of TLRs on CD4 T and CD8 T cells has not been directly compared. Here we compared CD4 and CD8 T cell responses to TLR2 ligand plus TCR-mediated stimulation. Methods: TLR2 expression was analyzed on T cell subsets under naïve and alloantigen- primed conditions. We analyzed the effects of TLR2 co-stimulation on proliferation and survival of T cell subsets in vitro when stimulated with soluble anti-CD3 in the presence or absence of synthetic ligand Pam3CSK4. Results: TLR2 expression on CD8 T cells was induced following activation; this expression was much higher than on CD4 T cells. Thus, the molecule was constitutively expressed on Listeriaspecific memory CD8 T cells. Based on these expression levels, proliferation and survival were markedly elevated in CD8 T cells in response to the TLR2 co-stimulation by Pam3CSK4 compared with those in CD4 T cells. Conclusion: Our data show that TLR2 co-stimulation is more responsible for proliferation and survival of CD8 T cells than for that of CD4 T cells. Background: Toll-like receptors (TLRs) play a fundamental role in innate immunity through their capacity to recognize pathogen-associated molecular patterns. Also, TLRs that are expressed in T cells are reported to function as co-stimulatory receptors. However, the functional capacity of TLRs on CD4 T and CD8 T cells has not been directly compared. Here we compared CD4 and CD8 T cell responses to TLR2 ligand plus TCR-mediated stimulation. Methods: TLR2 expression was analyzed on T cell subsets under naïve and alloantigen- primed conditions. We analyzed the effects of TLR2 co-stimulation on proliferation and survival of T cell subsets in vitro when stimulated with soluble anti-CD3 in the presence or absence of synthetic ligand Pam3CSK4. Results: TLR2 expression on CD8 T cells was induced following activation; this expression was much higher than on CD4 T cells. Thus, the molecule was constitutively expressed on Listeriaspecific memory CD8 T cells. Based on these expression levels, proliferation and survival were markedly elevated in CD8 T cells in response to the TLR2 co-stimulation by Pam3CSK4 compared with those in CD4 T cells. Conclusion: Our data show that TLR2 co-stimulation is more responsible for proliferation and survival of CD8 T cells than for that of CD4 T cells.

Comparison of Recurrence Rate Based on the Frequency of Preceding Symptoms in Patients With Neurocardiogenic Syncope or Presyncope

이선미,오혜림,김준수,박정왜,임혜란,신대희,온영근,이상훈 대한심장학회 2011 Korean Circulation Journal Vol.41 No.8

Background and Objectives: In patients with neurocardiogenic syncope or presyncope, symptoms developed unpredictably and intermittently. The purpose of this study was to determine whether there was any significant difference in the recurrence rate of symptoms during the follow-up period between patients with many episodes of symptoms and those with fewer episodes of symptoms before diagnosis, as well as to assess the clinical significance of previous episodes of symptoms during treatment. Subjects and Methods: A total of 100 patients with neurocardiogenic syncope or presyncope were divided in two groups (high episode group, n=54; low episode group, n=46) according to the frequency of symptoms before the head-up tilt test. We retrospectively analyzed the recurrence of symptoms using telephone interviews and medical record reviews. Results: The clinical characteristics were not significantly different between the two groups. However, the recurrence rate was significantly lower in the high episode group than in the low episode group (5.6% vs. 19.6%, p=0.001). In the high episode group, patients treated with medication showed higher recurrence of symptoms than those without medication. In the lower episode group, a similar result was observed. Conclusion: The frequency of previous symptoms at the diagnosis of neurocardiogenic syncope or presyncope did not predict the occurrence of symptoms during the follow-up period. Therefore, to continue drug treatment based on the frequency of symptoms in patients with neurocardiogenic syncope or presyncope may not be the best option.

Preparation of W/O/W Microcapsule Containing Hydrogel Hollow Particles and Their Properties

이선미,한주현,서경도 한국고분자학회 2008 한국고분자학회 학술대회 연구논문 초록집 Vol.33 No.2

치위생학교육평가·인증체계 정립을 위한 학습성과기반 치위생 핵심역량에 관한 조사

이선미,장경애,이정화,Lee, Sun-Mi,Jang, Kyeung-Ae,Lee, Jung-Hwa 한국융합학회 2020 한국융합학회논문지 Vol.11 No.9

치위생학교육평가·인증체계 정립을 위한 학습성과기반 치위생 핵심역량을 파악하고자 치위생(학)과 전임교수 207명을 대상으로 설문 조사를 실시하였다. 핵심역량별 세부영역에서 전문가적 행동 및 윤리적 의사결정 능력(1영역)과 과학적이고 전문적인 임상치위생과 임상치과업무의 지식과 기술을 적용할 수 있는 능력(2영역)의 전체 점수가 가장 높게 나타났고, 의사소통 능력 정도(3영역)는 4.48점, 근거중심의 통합적 사고와 문제해결 능력 정도(5영역)는 4.35점으로 나타났다. 핵심역량 세부영역들은 강한 상관관계가 있는 것을 확인하여 보건의료서비스 직종간의 핵심역량 파악과 임상 실무현장에 근무하고 있는 치과위생사들의 핵심역량에 대한 질적 연구가 필요하다고 사료된다. This study conducted to investigate the core competency of dental hygiene based on learning outcomes for establishing an educational evaluation and certification system for dental hygiene. The sub-categories of core competencies, the overall score of professional behavior and ethical decision-making ability (category 1) and the ability to apply scientific and professional clinical hygiene and knowledge and skills of clinical dental work (category 2) was highest. and the level of communication skills (category 3) was 4.48 points, and the level of evidence-based integrated thinking and problem solving skills (category 5) was 4.35 points. Furthermore, there was a strong correlation between the core competency sub-categories, and it is necessary to identify the core competency between health care service occupations and to qualitatively study the core competency of dental hygienists working in clinical practice.

춘향전의 자기실현화 과정에 대한 분석심리학적 접근

이선미,이영순,천성문 한국상담학회 2010 상담학연구 Vol.11 No.1

The purpose of this study is to show the process of Choon-Hyang's self-actualization in Choon-Hyang Jeon, one of the Korea's best-known classics, and to reflect on the significance to study the literature in the analytical-psychological point of view. Choon-Hyang Jeon can be valued as a novel which symbolically represented the unconsciousness of its contemporaries as it had been handed down orally from generation to generation. There appeared a number of stories that were slightly differentiated when they were recorded in a written formf sowever, the structures of those stories have some similarities in common to those of the heroic myths. First, Choon-Hyang and Mong-Ryong both are born with a heroic ego. Choon-Hyang's remarkable birth particularly tells her predisposition to be a heroine. In the dream of her mother, Wal-M's, it is revealed that Choon-Hyang and Mong-Ryong are celestial beings, which symbolizes the dignity of human being's innate ego. Second, Choon-Hang mentally takes on a re sona of the noble class, yangblassalthough she was of humble birth. It is displayed in the course of her growth and in her behavior. Third, Choon-Hyang and Mong-Ryong represent the collective anima and animus of the masses in Chosun Dynasty. These are also indignied in the sense that Choon-Hyang has manly courage as a typical woman and Mong-Ryong showcolllignie fellings like a woman doshe Nsxt, as forng-eriff Byoen, he is an sxample of being ruined by his own negative animus and ego inferiority complex which is a s-Ryongof a human being. Then, the mltn point of Choon-Hyang Jeon is that she finally conquers all the trials and obtltns her dignity as a human being, which is a set of self-actualizationense taffligity o that she gosh through can be re ceived as a go.ditionalestd obtltn, a rite of passageense trite of passage can be divided into isolbtltn, pch fignity ,ollath and reschrectionenChoon-Hyang is fatally lashed and sent to a prison. It is the time for her to struggle with fear of being isolated from the world. She reflects on herself in prison and confronts death by way of purification. It is the acme of the rite. After the death she returns to life and becomes a different being from the past, a daughter of a gisaeng. She possesses qualifications for being free and becomes a wife of yangban in the end. The marriage with Mong-Ryog means reconciliation of two conflicting elements and their being the whole one, that is, she reaches the final goal of the rite of passage, self-actualization. Accordingly, the old stories dealing with the psychological state of human beings help us realize that we are under an obsession of the conscious world and also have an insight into the unconscious. An old story like Choon-Hyang Jeon is a symbol of unconsciousness and its psychological theme is a person's self-actualization. Therefore, a reader can make gradual progress in attaining his or her own self-actualization by having an empathy with Choon-Hyang who becomes aware of her unconsciousness. 본 연구의 목적은 우리 고전 춘향전이 춘향이 삶의 궁극적 목표인 자기실현을 이루는 과정을 다룬 이야기라는 점을 밝히고, 분석심리학적 입장에서 춘향전을 보는 것이 어떤 의의가 있는지 살펴보고자 한다. 연구의 결과는 다음과 같다. 첫째, 춘향과 이몽룡은 본래 고귀한 영웅의 자아상을 가졌다. 춘향은 월매가 오랜 불임으로 고민하던 중 천지신명께 기도하여 선녀의 태몽을 꾸고 얻은 자식이다. 월매의 꿈 속에서 춘향과 이몽룡이 적강한 천상의 존재라는 것이 밝혀지는데, 이것은 인간의 본래적 자아는 고귀하다는 것을 상징하고 있다. 둘째, 춘향은 현실적으로는 비천한 신분이지만 정신적으로는 양반의 페르조나를 가졌다. 이몽룡도 전형적인 양반의 페르조나를 지녔으나 두 사람은 때로 이런 페르조나에서 벗어나 인간적인 모습을 보여 주기도 한다. 셋째, 춘향과 이몽룡은 조선 시대 민중들의 집단적 아니마, 아니무스를 나타낸다. 개인적으로도 춘향의 아니무스가 투사된 대상이 이몽룡이고, 이몽룡의 아니마가 투사된 대상이 춘향이로, 그러기 때문에 둘은 첫 눈에 반하게 된다. 또한 전형적인 여성인 춘향에게 남성다운 강인함이, 이몽룡에게는 여성다운 감정이 나타나는 부분도 이들의 아니무스, 아니마를 보여주는 것이다. 넷째, 자아의 열등하고 부정적인 모습이 그림자라면 변사또에서 그런 모습을 찾을 수 있다. 변사또는 부정적인 아니무스와 그림자가 합쳐져 자아를 파멸로 이끈 예라고 볼 수 있다. 다섯째, 춘향전의 중심 기둥은 춘향이 고난을 극복하고 자신의 본래 고귀한 모습을 찾아가는 자기실현화 과정이라고 볼 수 있었다. 마지막으로 죽음 이후 춘향은 새로운 존재로 재생된다. 이전의 비천한 기생의 딸에서 양반의 부녀, 진정한 자유인이 되는 자격을 갖춘 것이다. 그리고 암행어사가 된 이몽룡이 춘향을 구원하고 둘은 결혼한다. 결혼이란 대립되는 두 요소의 결합이며 완전한 전체가 되는 것을 상징한다. 즉, 통과의례를 거쳐 마지막 도달점인 자기실현의 경지에 이른 것이다. 춘향은 힘든 제의 과정을 겪어 내고 완전한 자기실현을 이루었다. 이상에서 춘향전은 무의식을 의식화해가는 과정, 즉 자기실현화 과정을 분석심리학적 접근으로 조망이 가능하였으며, 그리고 연구의 의의를 언급하였다.

금성 뇌졸중 환자에서 24시간 활동혈압 측정의 의의에 대한 연구

이선미,강흥선,송정상,강경의,조정휘,김권삼,배종화 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.11