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- 저자 : 이경아,박태호,박성용,김도현,오문국,김민수,안태진,이상원,김영국,안영섭,박충범,차선우,송범헌 (검색결과 9,691 건)
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Development and Comparison of Warfarin Dosing Algorithms in Stroke Patients
이경아,조선미,이경열,최종락 연세대학교의과대학 2016 Yonsei medical journal Vol.57 No.3
Purpose: The genes for cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase complex subunit 1 (VKORC1) have been identified as important genetic determinants of warfarin dosing and have been studied. We developed warfarin algorithm for Korean patients with stroke and compared the accuracy of warfarin dose prediction algorithms based on the pharmacogenetics. Materials and Methods: A total of 101 patients on stable maintenance dose of warfarin were enrolled. Warfarin dosing algorithm was developed using multiple linear regression analysis. The performance of all the algorithms was characterized with coefficient of determination, determined by linear regression, and the mean of percent deviation was used to predict doses from the actual dose. In addition, we compared the performance of the algorithms using percentage of predicted dose falling within ±20% of clinicallyobserved doses and dividing the patients into a low-dose group (≤3 mg/day), an intermediate-dose group (3–7 mg/day), and high-dose group (≥7 mg/day). Results: A new developed algorithms including the variables of age, body weight, and CYP2C9 and VKORC1 genotype. Our algorithmaccounted for 51% of variation in the warfarin stable dose, and performed best in predicting dose within 20% of actual dose and intermediate-dose group. Conclusion: Our warfarin dosing algorithm may be useful for Korean patients with stroke. Further studies to elucidate clinical utilityof genotype-guided dosing and find the additional genetic association are necessary.
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이경아,윤호필,고민정,김춘영 영남고고학회 2011 嶺南考古學 Vol.- No.56
Through archaeobotanical analysis on the three Neolithic sites in the Nam River basin, this research investigates the Neolithic economy in the region, particularly focusing on the cultivation of plant resource. Flotation samples from the Oun 1,Sangchon B and Pyeonggeo-dong 3-1 sites revealed at least 21 species of seeds, fruits,nuts, and tuber fragments. All three sites share two taxa of domesticates, foxtail millet and broomcorn millet. One of the significance of plant data from the Nam River is presence of two edible legumes of genera Glycine and Vigna. The AMS dates on millet and legumes confirm their association to the Late Neolithic period, dating to 3,050 to 2,300 cal. BC. Th Specimens of Glycine found at Oun 1 and Pyeonggo-dong are smaller than domesticated soybean (G. max) from the Mumun sites in Oun 1 and Daun-dong. However, a sheer quantity and prevalence of legumes indicate soybean at the Neolithic Nam R ive r s it e s wa s on e o f t h e imp o r t a nt e c onomic p l a nt s, r e g a r d le s s t o it s domestication status. On the other hand, Vigna beans at Pyeonggeo-dong resemble domesticated azuki bean (Vigna angularis) at the Daun-dong in both shapes and sizes. Unlike millet and rice, recent genetic studies indicate soybean and azuki were probably domesticated in multiple occasions. Plant data in the Nam River valley, along with a recent data from Middle Jomon sites in Tokyo and Kyushu supports the multi-origins of these two legumes. Overall, as the Nam River data indicates, dry farming of domesticated millets and economically important legumes contributed to the Neolithic subsistence more significantly than it has been proposed previously. 본 연구는 남강유역의 진주 대평리 어은 1지구 유적, 진주 상촌리B 유적, 진주 평거 3-1지구유적에서 확인된 식물유체 분석을 토대로 신석기시대 남강유역의 생업경제상을 고찰한 것이다. 3개 유적에서 현재까지 확인된 식물유체는 종자, 구근, 견과류를 포함하여 약 21종이다. 식물유체중 조와 기장은 3개 유적 모두에서 확인되었으며, 일부 확인된 밀과 보리는 후대 유구 교란에 의한 것으로 확인되었다. 이번 연구에서 새롭게 확인된 것은 진주 평거 3-1지구 유적에서 다량의콩속(Glycine sp.) 종자와 팥(Vigna angluari )으로 추정되는 두류가 발견되었다는 점이다. 콩속종자는 작물화된 청동기시대의 콩(Glycine max )에 비해 그 크기가 작으나 팥은 거의 비슷한 크기로 주목된다. 하지만 작물화의 여부를 단순히 종자의 크기만으로 판단할 수는 없기 때문에 신석기시대의 콩과 팥이 완전히 작물화되었는지는 아직 알 수 없다. 일본 동경·구주 일대의 죠몽시대 중기의 식물유체 자료와 더불어 평거 3-1지구 유적의 식물유체 자료는 일본과 한반도에 자생하는 야생콩(Glycine soja )이 최소한 기원전 3천년대 말 또는 2천년대 후반기부터 이용되기 시작하였고, 이때부터 작물화도 진행되었음을 시사한다. 이는 콩과 팥의 작물화가 어느 한정된 지역에서 기원한 것이 아니라, 한반도를 포함한 여러 지역에서 독립적으로 이루어졌음을 의미한다 . 본 연구는 신석기시대 중기후반(또는 후기 전반)에 남강유역의 조 , 기장의 화본과 식물과 콩과 식물의 재배가 성행하였음을 입증하였으며, 또한 탐색적 통계분석법(exploratory statistics)을 적용하여 유구 간 식물유체 분포의 근사성을 파악하고 식물자원의 처리 및 폐기과정에서 보이는 문화적 특징에 대해 검토하였다.
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사람 난소조직의 초자화 냉동보존과 면역결핍 동물에의 이식
이경아,윤세진,이숙현,신창숙,최안나,조용선,윤태기,차광렬,Lee, Kyung-Ah,Yoon, Se-Jin,Lee, Sook-Hyun,Shin, Chang-Sook,Choi, An-Na,Cho, Yong-Seon,Yoon, Tae-Ki,Cha, Kwang-Yul 대한생식의학회 2000 Clinical and Experimental Reproductive Medicine Vol.27 No.2
Objective: The present study was conducted to evaluate the viability of germ cells from the adult and fetal ovarian tissues after vitrification followed by xenografting. Method: The human adult ovarian tissues were obtained from 33 years old patient, and the fetal ovarian tissues were obtained from 22 weeks and 25 weeks in gestation. Ovarian tissues were cryopreserved by vitrification with 5.5 M ethylene glycol (EG 5.5) and 1.0 M sucrose as cryoprotectants. Adult and fetal ovarian tissues were pre-equilibrated with EG 5.5 at room temperature for 10 and 5 minutes, respectively and plunged into liquid nitrogen immediately. Frozen-thawed tissues were xenografted into NOD-SCID mice to evaluate the viability and capacity for further growth of the primordial follicles. Grafts were recovered from the recipients 4 weeks after transplantation and histological analysis was accomplished. Result and Conclusion: Grafts recovered 4 weeks after transplantation contained less number of oocytes and primordial follicles compared to that of the fresh tissues. Survived follicles were mainly primordial and intermediary with larger diameter and more granulosa cells. It is confirmed that 1) the ovarian tissues were healthy and the germ cells were survived after vitrification, and 2) the survived fetal primordial follicles after vitrification resumed the growth in the xenografts.
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이경아,이숙현,하상덕,윤세진,고정재,이우식,윤태기,차광열,Lee, K.A.,Lee, S.H.,Ha, S.D.,Yoon, S.J.,Ko, J.J.,Lee, W.S.,Yoon, T.K.,Cha, K.Y. 대한생식의학회 1999 Clinical and Experimental Reproductive Medicine Vol.26 No.2
The present study was conducted to evaluate whether vitrification could be used for ovarian tissue preservation. The important issue here is that the vitrification is very simple, easy, and economical compared to the conventional cryopreserving method that using automatic freezing instrument. Human ovarian cortical tissues were cryopreserved by vitrification with 5.5 M ethylene glycol and 1.0 M sucrose as cryoprotectant. Three points of temperature ($4^{\circ}C$, room temperature, and $37^{\circ}C$) and two points of duration (5 or 10 minutes) for cryoprotectant treatment were examined to determine the best condition for vitrification of the human ovarian cortical tissues. After thawing, viability of the isolated primordial follicles was examined by dye-exclusion method. Histological appearance of tissues before and after the cryopreservation was evaluated. There was no toxic effect of the 5.5 M ethylene glycol on the primordial follicles. However, when the tissues were treated with cryoprotectant at $37^{\circ}C$ for 10 minutes and exposed to liquid nitrogen, it seems likely that there is certain deleterious effects on the viability of the primordial follicles. The highest viability of the primordial follicles was obtained with the treatment of cryoprotectant at room temperature for 10 minutes. Follicles and oocytes survived after freezing and thawing had the similar normal shapes as was seen in the specimens before cryopreservation. It would be useful to apply vitrification in establishing ovarian tissue banking for clinical purposes.
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