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A549 폐암원형체의 침윤성 증가 및 독소루비신 내성 발현
윤지은 청주대학교 2018 産業科學硏究 Vol.35 No.2
Cancer stem cells are characterized by properties, such as self-renewal, differentiation, the capacity to drive tumorigenesis, and have been regarded as the mediators of metastasis, recurrence. and/or resistance to anticancer drug. In this study, sphere-forming cells were isolated from A549 cells, a non-small cell lung cancer cell line. The A549 spheres demonstrated increased invasion capacity as compared with A549 adherent cells. A549 spheres also appeared to be resistant to the anticancer drug doxorubicin. The mechanism involves in part through Notch signalling cascade. The protein expression of Notch ligands(Jagged1 and 2) and Notch target gene(c-Myc) was remarkably high in A549 spheres compared to that in A549 adherent cells. Therefore, the results suggest therapeutic targets for cancer stem cell directed lung cancer as a strategy for resolving metastasis, recurrence. and/or resistance to anticancer drugs.
대학무용교육에서 라반움직임이론 교육의 필요 -델파이 조사를 중심으로-
윤지은 한국무용예술학회 2018 무용예술학연구 Vol.71 No.4
This study examined the perception toward the Laban Movement Theory Education in Korean and American University. Delphi survey was carried out to investigate this research. The conclusion regarding the necessity of the Laban Movement Theory education in university dance education is as follows. First, it helps to improve overall movement ability as basic education of movement. Second, it helps to improve dance skill. Third, it can help developing creativity and imagination by providing materials of creation. Fourth, it can be used as dance literacy education. Fifth, it helps to train leaders in the process of dance education. This study suggests expanding classes related to Laban Movement Theory in university dance education in the future in order to provide a broader view of dance and to foster dance educators recognizing the possibility of applying it to various fields as well as helping graduates finding their careers.
수종(數種) 한약재의 콜라겐 생합성 효과에 대한 실험적 연구
윤지은,김남권,황충연,조은희,박민철,Yoon, Ji-Eun,Kim, Nam-Kwen,Hwang, Chung-Yeon,Jo, Eun-Hee,Park, Min-Cheol 대한한방안이비인후피부과학회 2010 한방안이비인후피부과학회지 Vol.23 No.3
Background & Objective : This study was performed to find a new anti-aging, anti-wrinkle agent. Ten kinds of hers were evaluated by proliferation, cytotoxicity, collagen synthesis tests in cultured human dermal fibroblast. Methods : MTT assay was carried out to check cell proliferation, cytotoxic effect of each herbal medicine. Collagen synthesis was investigated by the amount of propeptide using procollagen type-Ⅰ C peptide(PIP) ELISA kit(Takara). Results and Conclusions : There are no cytotoxicity in all group herbs by MTT assay. Collagen synthetic ability was greatest in LYCII FRUCTUS(LF) and was excellent in order of Rehmanniae Radix Preparat(RRP) > Nelumbinis Semen(NS) > Asparai Radix(AR) > Schizandrae Frucus(SF).
Lipid-Soluble Ginseng Extract Inhibits Invasion and Metastasis of B16F10 Melanoma Cells
윤지은,김보근,강종순,박성규,이기호,현동훈,김환묵,인만진,김동청 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.1
This study was performed to elucidate the effect of a lipid-soluble ginseng extract (LSGE) on cancer invasion and metastasis. The LSGE, even at noncytotoxic concentrations, potently inhibited invasion and migration of B16F10 mouse melanoma cells in a dose-dependent manner. In the presence of 3 lg/mL of LSGE, the invasion and migration of B16F10 cells were significantly inhibited by 98.1% and 71.4%, respectively. Furthermore, the LSGE decreased mRNA and protein levels of matrix metalloproteinase (MMP)-2 in B16F10 cells, leading to a decrease in MMP-2 activity. After B16F10 cells were intravenously injected in the tail vein of C57BL/6 mice, 1000 mg/kg/day of LSGE was orally administered for 13 days, after which lung metastasis of cancer cells was inhibited by 59.3%. These findings indicate that LSGE inhibits cancer cell invasion and migration in vitro and lung metastasis of melanoma cells in vivo by inhibiting MMP-2 expression.
교사-예술가 협력수업을 통한 효과적인 학교문화예술교육의 방향 탐색
윤지은,김은혜 상명대학교 글로벌문화예술교육연구소 2023 문화예술융합연구 Vol.4 No.2
본 연구는 2021년 한국문화예술교육진흥원에서 처음 시행하였던 주제중심 학교문화예술교육 지원사업 ‘예술로 탐구생활’의 사례를 바탕으로 교사와 예술가의 협력을 통한 효과적인 학교문화예술교육의 방향을 탐색하고자 하였다. 이를 위해 2021년과 2022년 사업에 참여했던 예술가와 교사 6명을 대상으로 인터뷰를 실시하였다. 인터뷰 내용을 종합한 결과, 교사-예술가 협력수업의 목적은 ① 동등한 입장에서 강점을 내세운 효율적 진행, ② 예술을 통해 세상을 바라보는 관점을 만들어 주는 것 ③ 예술을 통해 교과와 연계된 다양한 수업을 만드는것이다. 또한 교사의 역할은 ① 학교 교육과정을 토대로 예술가의 수업과 학생들을 연계, ② 수요자중심의 교육추구, ③ 문화예술교육의 지속성을 가질 수 있도록 참여로 도출되었으며, 예술가는 ① 예술적 전문성을 토대로예술의 가치를 발견하고 감수성을 풍부하게 하며 ② 교사가 하지 못하는 다양한 예술적 체험을 제공하여 풍부한 수업을 만드는 역할이 필요함을 알 수 있었다. 앞으로 협력수업을 통한 학교문화예술교육이 활성화 되기 위해서는 다음과 같은 결론을 도출하였다. 첫째, 교사와 예술가가 소통이 가능한 기회가 확대되어야 한다. 둘째, 교사들의 인식개선을 위한 노력이 필요하다. 셋째, 예술가들의 교육자적인 태도가 필요하다. 앞으로 교사와 예술가의 협력이 필수적인 부분으로 된 예술로 탐구생활 사업을 계기로 교사와 예술가가 함께 협력하는 학교문화예술교육의 개별사례를 통한 집중적인 연구를 통해 보편적으로 적용가능한 가이드라인을 만들 수 있기를 기대해본다.