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미세증가감수지수검사와 자기청력검사를 이용한 난청 유형의 감별 진단
김진동,전계록,왕수건,신범주,Kim, Jin-Dong,Jeon, Gye-Rok,Wang, Soo-Geon,Shin, Bum-Joo 한국전기전자재료학회 2009 전기전자재료학회논문지 Vol.22 No.8
As using recruitment phenomenon, SISI test and Bekesy audiometry are employed to differentially diagnose both the cochlear hearing loss and the retrocochlear hearing loss. The main purpose of this study is to find out the sensitivity and specificity of the SISI test within the scope of 1 KHz to 4 KHz in diagnosing various types of hearing losses. In this study, the Bekesy audiometry was conducted for Bekesy audiograms of certain groups according to Jerger's classification, which included persons with normal hearing and patients with hearing impairment. Subject persons of the SISI test were categorized into the several groups with normal hearing, mild hearing loss, moderate hearing loss, moderate-severe hearing loss and severe hearing loss, respectively. The sensitivity and specificity of certain groups were evaluated according to the SISI scores of 20 % below, 25 ${\sim}$ 65 %, and more than 70%. Also, the Bekesy audiometry is conducted on the several subject groups with normal hearing, mixed hearing loss, and sensori-neural hearing loss.
리눅스 실시간 스펙트럼 분석기를 이용한 컴퓨터 기반 순음청력검사 시스템의 자동 보정 지원
이승희,신범주,송복득,김진동,전계록,왕수건,Lee, Seung-Hee,Shin, Bum-Joo,Song, Bok-Deuk,Kim, Jin-Dong,Jeon, Gye-Rok,Wang, Soo-Geon 한국전기전자재료학회 2012 전기전자재료학회논문지 Vol.25 No.10
Compared to conventional pure-tone audiometer(PTA), the computerized one has several advantages such as relatively lower price, better flexibility, and easy operation. In addition, the computerized PTA can be easily extended to support automatic calibration. In this study, the support of automatic calibration in the computerized PTA has been addressed using the Linux realtime spectrum analyzer and network. In terms of accuracy, the new automatic calibration machine was compared to the existing manually operated one. According to the comparison, normal operation and high accuracy were observed within the scope of the international standard.
국소 진행성 두경부암 환자에서 docetaxel과 cisplatin을 이용한 유도 화학요법
최영진 ( Young Jin Choi ),신호진 ( Ho Jin Shin ),정주섭 ( Joo Seop Chung ),조군제 ( Goon Jae Cho ),이병주 ( Byung Joo Lee ),왕수건 ( Soo Geon Wang ) 대한내과학회 2007 대한내과학회지 Vol.73 No.4
목적: 본 연구는 국소 진행성 두경부 편평세포암에서 docetaxel과 cisplatin 유도 화학요법의 치료 효과와 부작용을 조사하였다. 방법: 2001년 10월부터 2003년 8월까지 부산대학교 병원에서 두경부 편평세포암으로 진단된 국소 진행성병기(AJCC stage III & IV) 환자 44명을 대상으로 하였다. Docetaxel은 제 1일에 70 mg/m2를 5% 포도당 용액에 농도가 0.9 mg/mL 미만으로 희석하여 1시간 동안 정맥 주사하고 cisplatin은 docetaxel 정주 2시간 후 75 mg/m2를 생리 식염수에 희석하여 1시간 동안 정맥 주사하였다. 결과: 대상 환자 44명에 대한 치료 효과는 완전 반응은 20명(45%), 부분 반응은 20명(45%)로 전체 반응율이 90%로 나타났다. 호중구 감소증은 23건에서 관찰되었고 grade 3이 8건, grade 4가 4건에서 관찰되었다. 오심 구토 등이 18건으로 다소 흔한 부작용이었으며 신기능 장애 2건, 설사 4건, 기면 5건, 구내염 6건 등이 있었다. 그리고 림프절 전이가 높을 수록 반응율이 유의한 감소를 보였다. 정중 추적 관찰기간은 15개월(2-51개월)이었고 4년 예측 치료실패시간은 56.3±10.2%이었다. 4년 예측전체 생존율은 87.4±6.9%였다. 결론: 이상의 결과로 docetaxel과 cisplatin의 유도화학요법은 국소 진행성 두경부암에서 높은 반응율과 낮은 부작용으로 유용한 치료법이었다. 환자의 생존율과의 관계를 알기 위해 향후 더 오랜 기간의 추적 조사가 필요하며 docetaxel과 cisplatin 유도 화학요법의 유효성을 검증하기 위해 대규모 무작위 대조군 연구가 필요할 것으로 생각된다. Background: This prospective study was conducted to assess the efficacy and toxicity of induction chemotherapy with docetaxel and cisplatin for patients with previously untreated, locally advanced squamous cell carcinoma of the head and neck (SCCHN). Methods: Forty four patients received 120 courses of treatment with docetaxel (70 mg/m2 in a 1-hour infusion) and cisplatin (75 mg/m2 in a 1-hour infusion), repeated every 3 weeks. Responsive patients (complete response: CR, or partial response: PR) received one more course of chemotherapy before undergoing local radiotherapy. Results: All 44 patients were assessable for response and toxicity analysis. The most common grade 3/4 adverse events were neutropenia, which occurred in 23 patients. Four cases of febrile neutropenia were noted. The overall response rate was 90% (CR 45% & PR 45%). The four year probability of time to treatment failure was 56.3±10.2%. The four year estimated overall survival rates were 87.4±6.9%. Conclusions: Docetaxel and cisplatin induction chemotherapy shows considerable CR, with an acceptable toxicity profile in patients with locally advanced head and neck squamous cell carcinoma.(Korean J Med 73:415-422, 2007)
조철우,양병곤,왕수건 한국음성과학회 1999 음성과학 Vol.5 No.1
This paper describes a series of researches to diagnose vocal diseases using the statistical method and the acoustic signal analysis method. Speech materials are collected at the hospital. Using the pathological database, the basic parameters for the diagnosis are obtained. Based on the statistical characteristics of the parameters, valid parameters are chosen and those anre used to diagnose the pathological speech signal. Cepstrum is used to extract parameters which represents characteristics of pathological speech. 3 layered neural network is used to train and classify pathological speech into normal, benign and malignant case. Keywords: diagnosis, disease, acoustic signal