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두경부암세포주에서 Cisplatin 및 5-FU 처리 후 Telomerase 발현에 대한 연구
왕수건,이진춘,김준영,이병주,노환중,고의경,전경명,김철민 대한이비인후과학회 2004 대한이비인후과학회지 두경부외과학 Vol.47 No.5
Background and Objectives:Telomerase activity appears to be associated with cell imortalisation and malignant progres-sion. Telomerase activity has been found in the majority of human tumours, but not in most somatic cells or tisues. We studied the change in the telomerase activity by cisplatin and 5-fluorouracil (5-FU) in head and neck cancer cel lines Subjects and Methods: (PNUH-12, SNU-899, HEp-2) were studied. Cell cytotoxi-city and change of telomerase activity by 5-FU and cisplatin treatment were assessed by MT and TRAP assays. Results:The telomerase activity was detected in the head and neck cancer cell lines. After the cisplatin treatment, the telomerase activity was decreased in a concentration-dependent manner. However, after 5-FU treatment, the telomerase activity showed a slight decrease or no change at the concentration similar to that of cisplatin in the inhibition of tumor growth. Conclusion:Our results can
식도협착으로 식도부분절제술과 위간치술 후 발생한 식도암에서 시행한 전인두후두식도위적출술 및 대장치환술 치험 1예
왕수건,손봉형,이병주,이형렬 대한기관식도과학회 2003 大韓氣管食道科學會誌 Vol.9 No.2
Various flaps are using for reconstruction of esophageal defect. The choice of reconstruction is depended to the oncologic needs of the situation. If the entire esophagus or significant part of the thoracic esophagus is involved by tumor, then total esophagectomy and gastric pull-up or colon transposition is indicated. But for most hypopharyngeal tumors, laryngopharyngeal tumors, and cervical esophageal tumors, segmental resection of these area and replacement with a jejunal fee or forearm free flap has become the standard technique. The authors have experienced a case of total pharyngo-laryngo-esophago-gastrectomy and colon transposition in a patient of esophageal cancer following partial esophagectomy and gastic pull-up due to corrosive esophageal stricture. We report this case with brief review of the literatures.
왕수건,장선미,Wang, Soo-Geun,Jang, Sun-Mi 대한후두음성언어의학회 2008 대한후두음성언어의학회지 Vol.19 No.1
Total laryngectomy is the most useful procedure tor advanced laryngopharyngeal cancer, but it remains the major problem such as loss of voice. Voice restoration is essential for every patients who undergo a total laryngectomy. Ideal voice rehabilitation methods can resolve three factors. First, every laryngectomee can produce voice sufficient for communication, second every patient should be allowed to use both hands freely during phonation, and last, the voice restoration methods should be easy and safe without complication during and after treatment. Among various voice rehabilitation procedures during or after total laryngectomy, it can be divided electronic and pneumatic methods. In pneumatic methods, there are also divided both pulmonary air and non-pulmonary air methods. The non-pulmonary air methods include esophageal speech, buccal speech, and pharyngeal speech. Pulmonary air methods are divided into surgical and non-surgical such as pneumatic speech aid. In the surgical methods, there are neoglottic operation, tracheopharyngeal shunt, and tracheopharyngeal shunt operations. Recently, tracheoesophageal shunt with or without prosthesis are being recognized the most effective method. Blom-Singer low pressure prosthesis, Panje button, and Provox are well known types of prosthesis in the tracheoesophageal shunt operation. Amatsu method is a kind of famous tracheoesophageal shunt method without using prosthesis. Authors tried to review the published articles for evaluation of effectiveness and problems of tracheoesophageal shunt operation with or without prosthesis. In conclusion, indwelling type of prosthesis and pharyngeal myotomy and plexus neurectomy are recommended for higher success rate during tracheoesophageal puncture procedure. More over, Amatsu method is also one of the recommended voice rehabilitation procedure during total laryngectomy. In this situation, pharyngeal myotomy and plexus neurectomy may be helpful for better fluent communication.
왕수건,Wang, Soo-Geun 대한후두음성언어의학회 2013 대한후두음성언어의학회지 Vol.24 No.1
Because the human voice is produced through vibration of the vocal cords during the exhalation of airflow, it is important to observe the vibration pattern of the vocal cords in patients complaining of voice changes. However, it is not easy to observe the actual vibration pattern of the vocal cord because it vibrates so fast that it cannot be observed by the naked eye and it is located deep in the throat. Recently, with advances in instruments, including laryngoscopes and video camera systems, the vibration pattern of the vocal cords can now be observed. However, considering that present video camera systems can detect 30-60 images per second and the vocal cord vibrates at 100-200 and 200-300 times per second in men and women, respectively, it is not possible to record the whole mucosal wave of the vocal cord in real time. To overcome this limitation, a stroboscope, which converts fast movements of the vocal cord into slower images, has been developed. Since then, several instruments were developed to examine vocal vibration pattern. However, each instruments have advantages and disadvantages. Therefore, we should know about these things to apply them in patients with voice problem.
왕수건,권순복,노환중,고의경,전경명 대한후두음성언어의학회 1999 대한후두음성언어의학회지 Vol.10 No.1
Vocal hyperfunction is considered to be the most significant characteristic in larynx disorders which is found among many patients presenting hoarseness Primarily as chief complaint. In Pusan National University Hospital, we executed the voice therapy to 28 patients being 17 female and 11 male patients who visited the Voice & Speech Therapy Clinic, due to the voice disorder, and then compared and analysed the voice before and after its therapy using acoustic and aerodynamic test. The obtained results were as follows. In the analysis by the local findings, it was improved to 88% in the patients of vocal nodule, 75% in mutational falsetto, 75% in the functional dysphonia, 75% in the vocal cord palsy, 50% in the vocal polyp and 50% in dysphonia plica ventricularis. For the acoustic analysis, Fo, litter, Shimmer and NHR were measured. In the patients of mutational falsetto, Fo, Jitter and NHR were shown to be improved significantly and in the patients of vocal nodule, Shimmer was shown to be improved significantly. In the patients of vocal polyp, Fo was significantly improved. In the patients of vocal cord palsy in litter and NHH were significantly improved. In the patients of dysphonia plica ventricularis, Shimmer and NHR were significantly improved and the patients of functional dysphonia were more improved in Fo, litter and Shimmer. For the aerodynamic analysis, MPT was measured. In particular, it was shown to be improved significantly in the patients of vocal nodule, improved in the vocal polyp, vocal cord palsy, functional dysphonia patients.