Interventional Management of Esophagorespiratory Fistula

신지훈,김진형,송호영 대한영상의학회 2010 Korean Journal of Radiology Vol.11 No.2

An esophagorespiratory fistula (ERF) is an often fatal consequence of esophageal or bronchogenic carcinomas. The preferred treatment is placement of esophageal and/or airway stents. Stent placement must be performed as quickly as possible since patients with ERFs are at a high risk for aspiration pneumonia. In this review, choice of stents and stenting area, fistula reopening and its management, and the long-term outcome in the interventional management of malignant ERFs are considered. Lastly, a review of esophagopulmonary fistulas will also be provided.

공항 지상 근무자의 심폐소생술 수행능력

신지훈 한국응급구조학회 2009 한국응급구조학회지 Vol.13 No.3

미래 자동차 디자인 변화에 대한 고찰: 자동차 기술, 시장 환경, 사용자 변화 중심으로

신지훈 차세대컨버전스정보서비스학회 2021 디지털예술공학멀티미디어논문지 Vol.8 No.3

최근 자동차 산업은 4차 산업혁명 및 친환경 규제의 영향으로 시장 전체가 전기차로 재편성되고 있는 가운데 자동차의 등장 이래 유래 없는 변화를 겪고 있다. 이러한 시장의 변화는 내연기관장치를 중심으로 형성되고 발전한 전통적인 자동차 디자인에 또한 큰 변화를 요구하고 있으며 새 시대에 대응할 수 있는 미래 자동차 디자인에 대한 연구의 필요성 역시 대두되고 있다. 본 논문은 자동차에 가장 크게 영향을 미치는 세 가지 요소인 자동차의 기술, 시장 환경, 사용자를 중심으로 연구 방법을 고찰한다. 전기차는 미래 자동차 디자인의 물리적 구조를 혁신적으로 바꿀 것으로 기대되며, A.I.와 인터넷으로 연결된 시장 환경은 가전제품의 미니멀 디자인 트랜드를 따르는 한편 모빌리티 서비스 및 VR 시장과 같은 새로운 플랫폼은 다양한 MZ 세대의 취향을 수용할 것이다. 점점 모든 것이 연결되는 미래 시장은 사용자들의 이러한 다양성에 대한 니즈를 수용할 수 있게 성숙될 것이며 미래 자동차 디자인은 이러한 수요에 대응할 수 있도록 변화해야한다. The car industry is going through unprecedented changes with the 4th industrial revolution and new environmental legislations. Accordingly this new era of mobility is demanding for changes of traditional vehicle design that was mostly formed and developed around the platform of internal combustion engine system. This paper has been reviewed focused on three most influential elements of vehicle design; change of technology, market environment and user through literature review and industry case studies. Electric and autonomous vehicles are expected to change and innovate physical layouts of vehicle design while the market environment newly connected through Internet of Things will likely follow similar changes of minimal design trend observed in appliance design. New platforms like mobility services and VR will accommodate diverse taste of millennials. Technological progression will enable the market to mature towards diversified user tastes and combined with aforementioned changes vehicle design is expected to diversify providing a larger spectrum of design solutions and options for the users and market.

태백산국립공원 백두대간 생태축 연결을 위한 평가항목 및 가중치 설정

신지훈,김혜리,장수림,김학윤,노백호 한국환경생태학회 2019 한국환경생태학회지 Vol.33 No.3

본 연구는 태백산국립공원 백두대간 생태축 연결을 위한 평가항목 및 요인별 가중치 설정을 위해 공원관리와 생태계 조사, 생태환경계획과 관련된 분야별 전문가 대상의 설문조사를 토대로 계층화 분석을 실시하였다. 문헌연구와 담당자 면담조사로 생태축 연결을 위한 상위 평가지표 4개와 하위 평가지표 13개를 선정하였으며, 일관성 분석에 의한 유효 설문을 대상으로 항목별 가중치를 산정하였다. 분석결과, 상위평가 지표에서는 생태계 가치증진이 0.474로 가장 높고, 자연-인간 갈등완화(0.247), 지역주민의 참여(0.165), 경제적 측면(0.114) 순으로 나타났으며, 하위 평가지표에서는 생물이동경로(0.116), 경관생태적 패치 연결성(0.112), 기능적 서식지(0.099) 등이 중요 항목으로 추출되었다. 분야별 평가항목과 가중치 비교에 따르면 생태계조사 분야에서는 생물종 이동경로(0.116)을 가장 중시하는 반면, 공원관리 분야에서는 기능적 서식지가 0.110로 가장 중요한 항목으로 평가되었으며, 생태환경계획 분야에서는 지역의 보전 및 이용자원 분포현황이 0.123으로 가장 높게 나타났다. 본 연구결과는 태백산국립공원 일대의 생태축 연결에 필요한 조사항목의 선정이나 분야별 연결성 분석방향 설정에 기여할 것이다. This study conducted a hierarchy analysis based on a questionnaire survey of experts in park management, ecosystem survey, and ecological environment planning to establish evaluation items and a weighing value of each item to develop ecological connectivity in Baekdudaegan mountain range neighboring the Taebaeksan National Park using the AHP approach. We selected four high-level evaluation indexes and 13 low-level evaluation indexes through literature review and interview with the people in the field and calculated weights for each question through the consistency analysis. The analysis showed that increasing the ecological value was the most important item with the index of 0.474 among the high-level evaluation items, followed by the mitigation of human-nature conflict at 0.247, participation by local residents at 0.165, and the economic perspective at 0.114. Among the low-level evaluation indexes, the movement route of wildlife was the highest at 0.116, followed by the connectivity of landscape ecological patch at 0.112, and functional habitat at 0.099. The comparison of the evaluation items in each working group and the weight factors showed that the movement route of wildlife was the most important at 0.116 in ecosystem survey, the functional habitat was the most important at 0.110 in park management, and the regional preservation and distribution of resources was the most important at 0.123 in ecological environment planning. The results of this study is useful to identify evaluation items for developing ecological network with a diverse source of the actual environmental data in the Taebaeksan National Park.

Immune-triggering effect of the foodborne parasite Kudoa septempunctata through the C-type lectin Mincle in HT29 cells

신지훈,Jung-Pyo Yang,Seung-Hwan Seo,Sang-Gyun Kim,Eun-Min Kim,Do-Won Ham,Eun-Hee Shin 생화학분자생물학회 2020 BMB Reports Vol.53 No.9

Kudoa septempunctata is a myxozoan parasite that causes food poisoning in individuals consuming olive flounder. The present study aimed to investigate the currently insufficiently elucidated early molecular mechanisms of inflammatory responses in the intestine owing to parasite ingestion. After Kudoa spores were isolated from olive flounder, HT29 cells were exposed to spores identified to be alive using SYTO-9 and propidium iodide staining or to antigens of Kudoa spores (KsAg). IL-1, IL-8, TNF- and NFKB1 expression and NF-B activation were assessed using real-time PCR, cytokine array and western blotting. The immunofluorescence of FITC-conjugated lectins, results of ligand binding assays using Mincle-Fc and IgG-Fc, CLEC4E expressions in response to KsAg stimulation, and Mincle-dependent NF-B activation were assessed to clarify the early immunetriggering mechanism. Inflammatory cytokines (IL-1, GM-CSF and TNF-), chemokines (IL-8, CCL2, CCL5 and CXCL1) and NF-B activation (pNF-B/NF-B) in HT29 cells increased following stimulation by KsAg. The immunofluorescence results of spores and lectins (concanavalin A and wheat germ agglutinin) suggested the importance of Mincle in molecular recognition between Kudoa spores and intestinal cells. Practically, data for Mincle-Fc and KsAg binding affinity, CLEC4E mRNA expression, Mincle immunofluorescence staining and hMincledependent NF-B activation demonstrated the involvement of Mincle in the early immune-triggering mechanism. The present study newly elucidated that the molecular recognition and immune- triggering mechanism of K. septempunctata are associated with Mincle on human intestinal epithelial cells.

개발사업의 경관영향 검토를 위한 주요 조망점선정 방법에 관한 연구

신지훈,신민지,최원빈 한국조경학회 2018 韓國造景學會誌 Vol.46 No.1

The Natural Landscape Rating System was introduced in the amendment of the NATURAL ENVIRONMENTCONSERVATION ACT in 2006. For landscape preservation, the system aims to consider the effects of development projectsor plans implemented in a natural landscape on skylines, scenic resources, and view corridors. Currently, a lack of consistencyin standards for determining Landscape Control Points (LCP) to assess landscape impact lowers the accuracy and reliabilityof the assessment results. As the perception of and the impact on a landscape varies, depending on the location of theLCP, it is necessary to establish a reasonable set of criteria to select viewpoints and avoid unreliability in the assessmentdue to unclear criteria. The intent of this study is to propose an objective and reasonable set of criteria for LCP selectionto effectively measure the impact on the landscape from development projects that anticipate a change in the landscapeand, ultimately, to suggest basic analysis methods to assess the landscape impact of development projects and to monitorthe landscape in the future. Among the development projects affecting natural landscapes, as reported in the statementof the environmental impact assessment, cases of construction of a single building or other small-scale development projectswere studied. Four spot development projects were analyzed in depth for their landscape impacts, in order to makerecommendations for the LCP selection procedure, which aims to widen the scope of selection according to the directionof viewpoints from the target site. The existing results of analysis based on LCP have limitations because they failed tocover the viewshed of the target buildings when there are topographical changes in the surroundings. As a solution tothis problem, a new viewshed analysis method has been proposed, with a focus on the development site and target buildings,rather than viewpoints, as used in past analysis. 2006년 자연환경보전법 개정에 따라 자연경관심의 제도가 도입되었다. 자연경관심의제도는 자연경관 내 개발사업및 개발계획 시행 시 사업의 규모와 형태 배치로 인한 스카이라인과 경관보전, 경관자원, 조망축 등의 항목을 검토하는제도이다. 그러나 경관영향평가를 위한 조망점의 선정은 모든 평가마다 기준의 일관성이 미흡하여 영향 평가 결과의정확도와 신뢰도가 크게 저하되고 있는 실정이다. 이처럼 조망점의 위치에 따라 지각되는 경관의 모습이 현저하게 변화하게 되고, 불명확한 선정기준은 경관영향평가 결과에도 시각적 영향이 과소평가되므로 합리적인 선정기준이 필요하다. 본 연구는 개발사업 진행으로 인한 경관 변화가 예상될 때 경관영향을 평가하기 위한 객관적이고 합리적인 조망점 선정기준을 제시하고, 궁극적으로는 개발사업에 대한 경관영향 검토 및 향후 경관 모니터링을 위한 기초적인 분석방법을제시하는데 목적을 갖고 있다. 환경영향평가서의 자연경관 내 시행되는 개발사업 중 단일건축물 및 소규모 개발을 하는사례를 조사하고, 그 중 점적 개발사업 4곳을 대상으로 경관영향평가 부분을 분석하여 주요 조망점 선정과정에 대해제안하였다. 기존 가시지역 분석방법의 결과인 지형 변화에 따라 가시지역 범위를 반영하지 못하는 한계를 극복하기위해 조망 대상물 기준 가시지역 분석방법은 가시 범위를 확대하여 영향력이 높은 유효한 조망점을 선정할 수 있는가능성을 판단하였다.

딥러닝 기반의 조류농도지도를 활용한 금강유역 피코시아닌과 클로로필-a의 시공간적 분포 및 발생특성에 영향을 미치는 환경인자 조사

신지훈,임인혁,전형철,윤성현,차윤경 대한환경공학회 2017 대한환경공학회 학술발표논문집 Vol.2017 No.11

KRICT 나노셀룰로오스 연구현황: 셀룰로오스 나노 결정체 및 나노 섬유

신지훈 한국고분자학회 2017 한국고분자학회 학술대회 연구논문 초록집 Vol.42 No.2

‘비뇨기계 인터벤션’ 특별호 발간에 부쳐

신지훈 대한영상의학회 2019 대한영상의학회지 Vol.80 No.4

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조리방법을 달리한 쥐눈이콩의 항산화력 및 이소플라본 배당체·비배당체 함량 비교

신지훈,주나미,Shin, Jihun,Joo, Nami 한국식품조리과학회 2016 한국식품조리과학회지 Vol.32 No.2

Purpose: In this study, small black beans (Rhynchosia nulubilis) that were produced in the Jungsun province of South Korea were selected for use in various cooking recipes because they are known to contain higher isoflavones and excellent antioxidant effects, as compared to any other domestic soybeans. Methods: Physicochemical and antioxidant characteristics of small black beans were analyzed with uncooked beans and four other cooking methods of pan broiling, boiling, steaming, and pressure cooking. Results: Contents of ${\beta}$-glucosides (daidzin, glycitin, and genistin) and aglycone (daidzein, glycitein, and genistein) in small black beans were significantly different depending on the cooking methods (p<0.001). The results of the experiment indicated that the amount of total polyphenol in pressure cooked beans was highest, showing a value of 7.16 mg/g (p<0.001). Most contents of isoflavones (${\beta}$-glucoside, aglycone) in uncooked beans appeared to increase after cooking. In particular, the amount of glycitein was highest in pan broiled beans ($9.63{\mu}g/g$). The total isoflavone content differed among the different cooking methods, ranging from highest to lowest in the following order : pan broiled beans ($759.49{\mu}g/g$), pressure cooked beans ($725.12{\mu}g/g$), boiled beans ($591.05{\mu}g/g$), steamed beans ($511.61{\mu}g/g$), and uncooked beans ($180.80{\mu}g/g$) (p<0.001). Conclusion: Especially, the amount of isoflavones increased significantly in pan broiled beans and pressure cooked beans, suggestive of optimized cooking methods for increasing nutritional and functional contents in cooked food.