딥러닝 기반의 최대응력과 위치 예측 기법: 로드 휠 충격 테스트 예시

진아현(Ah-hyeon Jin),이성희(Sunghee Lee),유소영(Soyoung Yoo),신승연(Seungyeon Shin),김창곤(ChangGon Kim),허성필(Sungpil Heo),강남우(Namwoo Kang) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.8

The impact test of road wheels is one of the important tests to ensure the safety of the wheels. Automakers use CAE simulation to analyze the location and magnitude of maximum stress, reducing prototype testing costs and time. However, the time required for modeling and analysis is still large, so it is difficult to quickly evaluate a large amount of conceptual design. In addition, it is difficult for general engineering designers to utilize because it requires high expertise in CAE. This study develops an AI-based wheel performance evaluation process that uses deep learning with CAE data to learn the location and magnitude of maximum stress. This deep learning model can predict the strength performance of road wheels in real time, allowing rapid evaluation at the conceptual design stage without domain knowledge.

대식세포의 화학주성과 세포내 칼슘과 Actin의 증가에 미치는 인삼사포닌 성분의 영향

신은경,김세창,Shin, Eun-Kyoung,Kim, Sei-Chang 배재대학교 자연과학연구소 1998 自然科學論文集 Vol.10 No.1

본 실험은 대식세포 화학주성과 세포내 칼슘과 F-actin 증가에 대한 인삼사포닌 분획의 영향을 알아보기 위하여 수행되었다. 여러 가지 인삼사포닌 분획을 처리한 복강 대식세포는 대조군에 비해 화학주성이 28.4-71% 증가하였다. 세포내에 유리된 칼슘의 양은 65%까지 증가하였으며, NBD- phallacidin을 처리한 세포에서 F-actin의 양은 10% 증가하였다. 칼슘이나 PMA로 활성화시키고 사포닌 분획을 처리하였을 때, F-actin의 양은 현저하게 증가하였으며 이러한 현상은 2분까지 지속되었다. 이러한 결과로 보아 인삼사포닌 분획이 chemoattractant로 작용할 수 있을 것으로 생각된다. In the present study, We have tested the potential effects of ginseng saponin fractions on macrophage chemotaxis and intracellular calcium and F-actin mobilization. Peritoneal macrophages treated with various ginseng saponin fractions showed 28.4% to 71% of increasement of chemotaxis as compared with untreated cells. The activity of intracelluar calcium mobilization was increased up to 65% by treatment with saponins, and F-actin content also increased 10% in the cells loaded with NBD-phallacidin. When the cells were activated with calcium of PMA and treated with saponin fractions, the intracelluar F-actin content increased significantly and prolonged for 2 minutes. These results suggest that ginseng saponin fractions might be a chemoattractants.

마우스에서 Capillary hepatica 감염에 의한 간섬유증의 병리학적 연구

신은경,한정희,Shin, Eun-kyung,Han, Jeong-hee 대한수의학회 1998 大韓獸醫學會誌 Vol.38 No.1

This study was performed to investigate the pathogenesis of hepatic granuloma and hepatic fibrosis induced in mice infected with Capillaria(C) hepatica and treated cyclophosphamide. The results were as grossly well-defined yellowish white spots and small nodules at the surface of the liver were scattered. Histopathologically, there were numerous granulomas composed of eggs and fragments of C hepatica surrounded by heavy infiltration of inflammatory cells. Severe fibrosis was observed around granulomas. Pathological lesions of group infected with C. hepatica and then injected with cyclophosphamide were most severe than those of other groups. Therefore this study suggested that hepatic fibrosis induced by C hepatica in mice would be useful for animal model of hepatic fibrosis in human.

대식세포의 식세포활동과 화학주성에 대한 인삼분획물의 영향

신은경,김세창,Shin, Eun-Kyoung,Kim, Sei-Chang 배재대학교 자연과학연구소 1996 自然科學論文集 Vol.8 No.2

쥐의 복강과 폐포 대식세포를 분리하고 배양하여 효모에 대한 식세포활동 및 화학주성을 관찰하였다. 식세포활동이 일어나는 양상을 wright-Giemsa로 염색하여 사진으로 확인하였다. 복강 대식세포의 경우 diol saponin 처리군에 의해 약 48%까지 식세포활동이 증가되었고 total saponin 처리군에 의해 약 35%까지 식세포활동이 감소되었다. 폐포 대식세포의 경우 모든 인삼분획물 처리군에 의해 최고 50%까지 섭식이 증가되었다. 화학주성은 복강 대식세포의 경우 인삼분획물 처리군 모두 약 17%까지, 폐포 대식세포에서는 diol saponin만 약 16%까지 이동되었다. actin의 증감을 SDS-PAGE로 확인해 보았으나 변화가 없었다. The phagocytosis and chemotaxis of murine macrophages after treated with saponin fractions are investigated. Phagocytic appearance against yeast was photographed by dying with Wright-Giemsa. Phagocytic activity of peritoneal macrophage was invreased in diol saponin treatment by 48% and was decreased in total saponin treatment by 35%. The ingestion of alveolar macrophage was increased by 50% maximally. Peritoneal chemotactic activity was shown in 17% increases and only diol saponin had effect in alveolar macrophage by 16%. According to SDS-PAGE method the contents of actin did not show any alterations.

KS 시설관리 표준규격을 바탕으로 한 대학시설 FM 서비스 발전방향

신은경,김유진,김준하,Shin, Eun-Young,Kim, Yu-Jin,Kim, Jun-Ha 한국교육시설학회 2015 敎育施設 Vol.22 No.1

Over the years, great attention has been shown to the function of the campus facilities that should be well-equipped, operated and maintained to better support university's two main goals: providing education and supporting research. Properly managing campus facilities is the initial step to be prepared to meet the rapidly changing global educational standard. However, so far, no definitive answer has been given to the question of what service level/scope is appropriate for the effective campus facility management (FM) in Korea. Therefore, at the outset, it is imperative to establish the framework for the standardized campus FM services. The main focus of this research is to provide comprehensive understanding on the campus FM by establishing the framework in the form of FM performance indicator (PI). As the first step, FM standards set by Korean Agency for Technology and Standards (KATS) has been thoroughly reviewed and analyzed to establish the framework for FM standards applicable to campus facility management. Secondly, extensive literature review on the development of performance indicator (PI) for the educational facilities has been conducted to classify PI types and complement FM_KS. Finally, specific guideline and PIs developed by APPA which is globally well-known association in the field of FM for higher education facilities has been added to the combined PI which is the mixed form of FM_KS and PIs from the previous literature. This research provides campus facility managers and FM outsourcing service providers with framework in the form of PI to support future directions of effective campus FM services.

초경전 여아에서 운동의 기계적 스트레인과 칼슘섭취량에 따른 발꿈치뼈 골밀도의 분포

신은경,김기숙,김희영,이인숙,정효지,조성일,Shin, Eun-Kyung,Kim, Ki-Suk,Kim, Hee-Young,Lee, In-Sook,Joung, Hyo-Jee,Cho, Sung-Il 대한예방의학회 2005 예방의학회지 Vol.38 No.3

Objectives : The effects of exercise on bone density have been found to be inconsistent in previous studies. We conducted a cross-sectional study in premenarcheal girls to test two hypotheses to explain these inconsistencies. Firstly,'the intensity of mechanical strain, in terms of the ground reaction force(GRF), has more important effects on the bone mass at a weight-bearing site', and secondly, 'calcium intake modifies the bone response to exercise'. Methods : The areal bone mineral density was measured at the Os calcis, using peripheral dual energy X-ray absorptiometry, in 91 premenarcheal girls aged between 9 and 12 years. The intensity of mechanical strain of exercise was assessed by a self-report questionnaire and scored by the GRF as multiples of body weight, irrespective of the frequency and duration of exercise. The energy and calcium intake were calculated from the 24-hour dietary recall. An analysis of covariance(ANCOVA) was used to determine the interaction and main effects of exercise and calcium on the bone density, after adjusting for age, weight, height and energy intake. Results : The difference in the bone density between moderate and low impact exercise was more pronounced in the high than low calcium intake group. The bone density for moderate impact exercise and high calcium intake was significantly higher than that for low impact exercise (p=0.046) and low calcium intake, after adjusting for age, weight, height and energy intake. Conclusions : Our study suggests that the bone density at a weight-bearing site is positively related to the intensity of mechanical loading exercise, and the calcium intake may modify the bone response to exercise at the loaded site in premenarcheal girls.

9-12세 정상 아동에서 종골 골밀도와 체성분의 연관성

신은경,김기숙,김희영,이인숙,정효지,조성일,Shin, Eun-Kyung,Kim, Ki-Suk,Kim, Hee-Young,Lee, In-Sook,Joung, Hyo-Jee,Cho, Sung-Il 대한예방의학회 2004 예방의학회지 Vol.37 No.1

Objectives : This cross-sectional study aimed to quantify the relationship between the bone mineral density at the os calcis and the body mass composition in healthy children. Methods : The areal bone mineral density was measured at the os calcis with peripheral dual energy X-ray absorptiometry. The fat free mass, fat mass and percentage fat mass were measured using bioelectric impedance, in 237 Korean children, aged 9 to 12 years. The sexual maturity was determined by self assessment, using standardized series of the 5 Tanner stage drawings, accompanied by explanatory text. Results : From multiple linear regression models, adjusted for age, sexual maturity and height, the fat free mass was found to be the best predictor of the calcaneal bone mineral density in both sexes. About 15 and 20% variabilities were found in the calcaneal bone mineral densities of the boys and girls, respectively, which can be explained by the fat free mass. After weight adjustment, the percentage fat mass was negatively associated with the calcaneal bone mineral density in both sexes. Conclusions : The findings of this study suggest that the fat free mass, among the body compositions, is the major determinant of bone mineral density at the os calcis in Korean children aged 9 to 12 years. Obesity, defined as the percentage fat mass, is assumed to have a negative effect on the calcaneal bone density in children of the same weight.

Escherichia coli 리보핵산 내부분해효소 RNase E의 돌연변이체 선별 및 특성분석

신은경,고하영,김영민,주세진,이강석,Shin, Eun-Kyoung,Go, Ha-Young,Kim, Young-Min,Ju, Se-Jin,Lee, Kang-Seok 한국미생물학회 2007 미생물학회지 Vol.43 No.4

대장균의 필수적인 리보핵산 내부분해효소인 RNase E는세포내에서 여러 RNA의 분해와 가공과정에서 중요한 역할을 하며, 이 단백질의 효소활성부위를 포함하는 N-말단부위의 498 아미노산(N-Rne)만의 발현으로도 세포의 생장을 가능하게 한다. 이러한 RNase E의 특성을 활용하여 다양한 표현형을 가지는 N-Rne 돌연변이체들을 분리, 동정할 수 있는 효율적인 유전학적 시스템을 개발하였다. 이 시스템을 이용하여 얻어진 효소활성부위 돌연변이체들을 표현형으로 분류하여 분석한 결과, S1 도메인의 6번째 아미노산의 치환(I6T)을 가진 변이체는 야생형 N-Rne의 기능을 대체하지 못하였고, Small 도메인의 488번째 아미노산의 치환(R488C)을 가진 변이체는 야생형 N-Rne의 발현양보다 현저히 작게 발현시켜도 세포의 생장을 정상적으로 가능하게 하였다. 또한 DNase I 도메 인의 305번째 아미노산의 치환(N305D)을 가진 변이체는 야생형 N-Rne의 발현양보다 과발현시켰을 때만 세포의 생장을 가능하게 하였다. 각각의 아미노산 치환을 포함하는 N-Rne를 한정적으로 과발현시켰을 때의 ColEl-타입 플라스미드의 복제 수에 대한 영향을 측정한 결과, 돌연변이체 N-Rne의 세포생장에 대한 영향은 이 변이체들의 세포 내 효소활성 정도에 기인하는 것으로 밝혀졌다. 이러한 실험결과는 이 연구에서 개발한 유전학적 시스템을 이용하여 다양한 표현형을 가진 RNase E 변이체를 선별할 수 있으며, 이 변이체들의 특성을 분석함으로써 RNase E가 RNA의 안정성을 조절하는데 있어서 각각의 세부 도메인의 역할을 규명할 수 있으리라는 것을 시사한다. RNase E is an essential Escherichia coli endoribonuclease that plays a major role in the decay and processing of a large fraction of RNAs in the cell and expression of N-terminal domain consisted of 1-498 amino acids (N-Rne) is sufficient to support normal cellular growth. By utilizing these properties of RNase E, we developed a genetic system to screen for amino acid substitutions in the catalytic domain of the protein (N-Rne) that lead to various phenotypes. Using this system, we identified three kinds of mutants. A mutant N-Rne containing amino acid substitution in the S1 domain (I6T) of the protein was not able to support survival of E. coli cells, and another mutant N-Rne with amino acid substitution at the position 488 (R488C) in the small domain enabled N-Rne to have an elevated ribonucleolytic activity, while amino acid substitution in the DNase I domain (N305D) only enabled N-Rne to support survival of E. roli cells when the mutant N-Rne was over-expressed. Analysis of copy number of ColEl-type plasmid revealed that effects of amino acid substitution on the ability of N-Rne to support cellular growth stemmed from their differential effects on the ribonucleolytic activity of N-Rne in the cell. These results imply that the genetic system developed in this study can be used to isolate mutant RNase E with various phenotypes, which would help to unveil a functional role of each subdomain of the protein in the regulation of RNA stability in E. coli.

사용자 중심 일반병실계획 기준에 관한 연구

신은경(Shin, Eun-Gyeong),박수빈(Park, Soo-Been) 한국실내디자인학회 2015 한국실내디자인학회논문집 Vol.24 No.4

The goals of healthcare design based on the human rights to manage physically, psychologically, and emotionally healthy life. The healthcare design, however, have been criticized not to reflect their primary users, patients` and families` needs, under the management strategy centered by the functional efficiency. The study focused on the patients` room design on the users` perspective. The design criteria for the patients` room in Japan, Germany, Australia, U.S. and Korea were examined and compared. The subjects of analysis are the floor plans of general hospital recently planned and built in Korea and Japan and the standard floor plan models proposed by prior studies in Korea and AusHFG in Australia. Results and conclusions are as follows: (1) the patients room has developed as a place where the users manage their living during inpatient period and has become a private room. (2) The guidelines for patients` room size in Korea and Japan are not enough considering the users` diverse activities compare those in U.S. and Australia. (3) The guidelines of Korea should be reconsidered for the users` comfortable lives. It must include the specific criteria of the enough space between beds, the storages, and other assistant tools and facilities. (4) The desirable types of patients` rooms by the numbers of users in Korea are proposed as a one-bed room type and a four-bed room type.

장애인의 건강상태 분석 및 사회참여에 관한 사회적 지지 조절효과 검증

신은경(Eun Kyoung Shin),이한나(Han na Lee),신형익(Hyung ik Shin. M.D.) 연세대학교 사회복지연구소 2014 한국사회복지조사연구 Vol.39 No.-

본 연구의 목적은 WHODAS 2.0을 통해 국내 장애인의 건강상태를 평가하고, 사회참여에 영향을 주는 개인요인과 환경요인이라는 맥락에서 개인의 기능과 사회적 지지와의 상호작용을 고찰하는 것이다. 이를 위해 장애인복지법상 15개 유형의 장애인 993명(미등록 장애인 포함)으로부터 자료를 수집하여 WHODAS 2.0의 매뉴얼에 입각한 기술통계분석과 조절회귀분석을 실시하였다. 분석 결과, 4개 집단으로 재범주화한 장애인의 건강상태는 영역별로 차이가 있으나 전반적으로 지체-정신적-내부-감 각 순으로 건강상태가 열악한 것으로 나타났다. 지체장애는 전 영역에서 고르게 건강상태가 좋지 않았으며, 정신적 장애집단은 ‘이해와 의사소통’, ‘주위 사람과 어울리기’에서, 내부 장애인은 주위 돌아다니기 와 사회참여 의 건강상태가 나빴다. 다음으로 ‘사회참여’에는 통제변인으로 성별과 연령, 학력, 직업과 지역사회환경, 기능에 해당하는 ‘이해와 의사소통’, ‘주위 돌아다니기’, ‘자기관리’가, 환경요인에서는 ‘사회적 지지’가 영향을 주는 것으로 나타났다. 마지막으로 사회참여에 영향을 미치는 사 회적 지지의 조절효과 분석에서는 세 개의 상호작용 항이 모두 유의미하게 나타났다. 본 연구에서는 이를 바탕으로 ‘실제 일상생활에의 적용과 본인 주도’를 중심으로 하는 신체기능에 대한 접근과 이동지원과 신변처리를 넘어서는, ‘사회적 영역의 다양한 활동’을 아우르는 사회적 지원의 확대를 제언하였다. The purpose of this study is to evaluate health status of disabled people in Korea and to consider interaction effect of individual functions and social support through WHODAS 2.0. To do this, we collected data from 993 disabled people including non-registered and carried out descriptive analysis and moderated multiple regression. The key results are as follows: the health status of disabled people re-categorized into four groups varied according to domains, but it generally got better physical-mental-internal-sensory group order. The physically disabled group had poor health in all domains, while mentally disabled in cognition , ‘getting along , and internally disabled in mobility and participation . The factors affected social participation as control variables were gender, age, education, community environment. The independent variables, functions including cognition , mobility , ‘getting along , self-care , and social support as moderating variable also affected social participation. The interaction effects of functions and social support are significant in all three interaction terms. Based on these results, this study suggested approach to functions that focused on application to real situation and self-direction and expansion of social support which includes various activities in society beyond support to mobility and personal care.