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양이온 교환수지 복합체 형성에 의한 파모티딘의 지속성 현탁체제화 연구
신동선,최영욱 중앙대학교 약학연구소 1996 약학 논총 Vol.10 No.-
Famotidine is poorly water-soluble and relatively susceptible to acid-catalyzed hydrolysis. Although famotidine undergoes minimal first-pass metabolism, its oral bioavailability has been reported to be relatively low. Ion exchange resin complexes of famotidine have been prepared by the reaction of famotidine solution with activated ion exchange resins. Drug release characteristics from the resin complexes were evaluated by the batch elution method. Famotidine release was dependent on the type of ion exchange resins. Strongly acidic resins revealed some advantages over weakly acidic resins for overcoming instability of famotidine in gastric juice. The stability of famotidine-resin complexes upon storage in distilled water and aqueous solutions containing flavors and sweeteners such as peppermint essence, lemon essence, stevioside, and sorbitol was evaluated for further development of a sustained-release suspension formulation. The cumulative famotidine release from strongly acidic resin complexes was about 10% after 60 days storage n water, but it was less than 2% after 60 days strorage in the above aqueous solution, due to the ion-masking effect of these excipients.
신동선,김효연 한국식공간학회 2019 식공간연구 Vol.14 No.3
This study is to look into the changes of quality properties such as appearance, moisture, specific volume, color value and texture of rice bread using six cultivars and different flour particle sizes. Rice flour was classified by particle size using a 150, 200, and 250 mesh sieve. The appearance of 150 mesh sieve flour bread showed the highest specific volume when baked. The moisture content decreased as the particle size of rice flour went down. In terms of color values, the L-, and the b-value of rice flour increased as the particle size of rice flours went up, while the a-value declined as the particle size decreased. In the texture, measurements using a texture analyzer, which included hardness, springiness, cohesiveness, gummiess and chewiness, were significantly higher with the increase in particle size. Rice bread prepared using flour from the Samkwang(SKR) cultivar showed the largest volume (133.00±1.00 mL) and a uniformly distributed pore structure in bread crumbs whose hardness value was 462.00±57.00 g. These results will be applied as a quality standard to aid in the selection of the most suitable particle size and cultivars for baking.
일부 농촌지역주민의 보건지소 이용에 관한 조사 -이화여자대학교 농촌지역사회 보건시범지역을 중심으로-
신동선,Shin, Dong-Sun 대한예방의학회 1984 Journal of Preventive Medicine and Public Health Vol.17 No.1
In order to know about the utilization of health subcenter in a Korean rural community, a study was carried out through analyzing the records on the outpatients in Su-Dong Health Subcenter during 5 years from 1978 to 1982, and the following results were obtained. 1. The annual utilization rate of health subcenter of Su-Dong Myun showed decreasing tendency such as 946.6 in 1978, 886.4 in 1979, 736.5 in 1980, 708.3 in 1981 and 609.1 in 1982 per 1,000 people. 2. In terms of annual utilization rate of health subcenter by sex, utilization rate of female was higher than that of male such as in 1978 (male 908.6, female 986.3), 1979 (male 819.2, female 956.7) and 1981 (male 686.0, female 731.5) except 1980(male 790.0, female 683.3) and 1982(male 632.7, female 585.0). 3. Every year the 5 major diseases of the new patients cared in health subcenter were the same as follows; Diseases of the Respiratory System, Diseases of the Digestive System, Diseases of the Skin and Subcutaneous Tissue, Accident Poisoning and Violence, and Diseases of the Nervous System and Sensory Organ. 4. In terms of annual utilization rate of health subcenter by age, utilization rate of $0{\sim}4$ year group was highest every year such as 3,666.0 in 1978, 3,232.5 in 1979, 2,819.0 in 1980, 2,361.4 in 1981 and 2408.7 in 1982 per 1,000 people. 5. The average visiting times per case to health subcenter were not much different every year such as 1.75 times in 1978, 1.79 times in 1979, 1.69 times in 1980, 1.79 times in 1981, and 1.80 times in 1982. 6. The monthly utilization rates per 1,000 people of health subcenter had two peaks in February(40.9 in 1980 and 86.4 in 1981) and July(84.6 in 1980 and 72.1 in 1981) except 1982. 7. The distribution of new patients by the source of medical fee payment was follows; community health organization member 86.9%, medicaid program 6.5%, and medical insurance 6.6% in 1980 and community health organization member 76.8%, medicaid program 11.4%, and medical insurance 11.8% in 1981 and community health organization member 78.2%, medicaid program 14.8% and medical insurance 13.2% in 1982.
신동선,권오상,이현옥,윤영철 대한신경과학회 2004 대한신경과학회지 Vol.22 No.5
An 18-year-woman was referred with seizure activity and global aphasia. Diagnosis of MELAS syndrome with left temporo-parieto-occipital infarction was confirmed by gene analysis. Global aphasia was improved completely. Right temporal infarction developed after 5 months. Diagnosis of pure word deafness was made in view of impaired verbal comprehension in presence of adequate reading, writing, spontaneous speaking, and well preserved environmental sound perception. MRI findings of the patient support the hypothesis of the pathway of non-verbal hearing in previous reports.
신동선,박장환,최인덕,이석기,박지영,김남걸,최혜선,Shin, Dong-Sun,Park, Chang Hwan,Choi, In Duck,Lee, Seuk Ki,Park, Ji Young,Kim, Nam Geol,Choi, Hye Sun 한국식품영양학회 2019 韓國食品營養學會誌 Vol.32 No.2
This study evaluates the quality properties of soy-paste soybean cultivar for fermented soybean products. The six soybean varieties that include Jinpung, Saedanbaek, Daepung 2, Pyeongwon, Cheonga and Saeolkong were used in the experiment. The range of water uptake ratio, hardness after soaking and hardness after steaming were 117.00~131.33%, 1.65~3.30 kg and 0.05~0.14 kg, respectively. The physicochemical analysis indicated the following: Moisture content, 63.27~68.72%; pH, 6.43~6.60; total acidity, 0.27~0.45%. Color values for L value (lightness), a value (redness), and b value (yellowness) ranged from 39.07~67.92, 7.64~11.79, and 7.48~20.67, respectively. The amylase and protease activities of the Saedanbaek samples were the highest among all cultivars. The amount of viscous substance in the fermented soybean products by cultivars ranged from 5.93 to 8.37%, and Saedanbaek was the highest. The total viable cells counts for soybean fermented products were 9.11~9.42 log CFU/g. The amino-type nitrogen contents of all samples were in the range of 401.07 to 524.47 mg% and Saedanbaek cultivars showed the highest content (524.47 mg%). Based on the results, Saedanbaek will be suitable as a soy-paste soybean cultivar and the quality standards for the fermentation process of the fermented soybean products.