Pharmacokinetic characteristics of cilostazol 200 mg controlled-release tablet compared with two cilostazol 100 mg immediate-release tablets (Pletal) after single oral dose in healthy Korean male volunteers

손진동,조상민,최연웅,김수환,권인선,진은희,김재우,홍장희 대한임상약리학회 2016 Translational and Clinical Pharmacology Vol.24 No.4

Cilostazol controlled-release (CR) tablets have recently been developed by Korea United Pharm (Seoul, Korea). The tablets use a patented double CR system, which improves drug compliance by allowing “once daily” administration and reduces adverse events by sustaining a more even plasma concentration for 24 h. We conducted an open, randomized, two-period, two-treatment, cross¬over study to compare the pharmacokinetic (PK) characteristics and tolerability of cilostazol when administered to healthy Korean male volunteers as CR or immediate release (IR) tablets (Pletal, Korea Otsuka Pharmaceutical Co., Gyeonggi-do, Korea). Each volunteer was randomly allocated to receive a single tablet of cilostazol CR (200 mg) or two tablets of cilostazol IR (100 mg) with a 7-day washout period between treatments. Plasma cilostazol, OPC-13015 (3,4-dehydrocilostazol), and OPC-13213 (4'-trans-hydroxycilostazol) were assayed using liquid chromatography-tandem mass spectrometry for PK analysis. Thirty participants completed the study with no clinically relevant safety issues. The peak concentrations (Cmax, mean ± SD) of cilostazol CR and cilostazol IR were 1414.6 ± 49.3 and 1413.1 ± 35.2 ng/mL, respectively, and the areas under the plasma concentration– time curve from 0 to the last concentration (AUClast) were 23928.7 ± 65.9 and 25312.0 ± 62.6 ng∙h/ mL, respectively. The geometric mean ratios (cilostazol CR/ cilostazol IR, GMR) of the Cmax and AUClast values were 1.001 (90% CI: 0.822, 1.220) and 0.945 (90% CI: 0.814, 1.098), respectively. The frequencies of adverse events were similar. The present study showed that cilostazol PK and toler¬ability were comparable when administered to healthy Korean men, regardless of whether adminis¬tered as cilostazol CR or IR.

한국 농촌교육농장 활성화 방안- IPA 기법을 활용하여 -

손진동,김선희 한국농촌계획학회 2015 농촌계획 Vol.21 No.3

The Purpose of this study is to analyze the importance and satisfaction on the items related to rural education farm management. The survey was carried out on the operators of rural education farm from October 6th, 2014 to April 30th, 2015, and 144 questionnaires were used for the final analysis. According to the analysis result, In the first quadrant, the environment of the farms(safety of the education farms, accessibility to the farms) and the existing customer management(dealing actively with the customer complaints, consulting with schools regarding the hands-on education and the feedbacks) were included. In the second quadrant, fourteen items were included. To mention these items in detail, the environment of the farms(lounge area for the guiding teachers), customer management(diversification of the publicity for the education farms, efforts to secure loyal customers, efforts to create new customers), campaigns of publicity and contents of publicity management(diversification of the publicity channels for education farms, off-line contents management, on-line contents management), ensuring professionalism(worksheet development and utilization, periodical supplemental education for operators), hands-on education programs(new program development, customized program development, distinguished program development), costs(efforts for cost reduction, fees for hands-on education) were included. In the third quadrant, the environment of the farms(size of the education farms), publicity activities and publicity contents management(enthusiastic publicity activities), strengthening professionalism(participation in the training programs related to rural education farm management) and in the fourth quadrant, the environment of the farms(environmentally-friendly and aesthetic natural landscape, convenient facilities such as powder rooms and washstands, parking lots) were included.

치유농장 창업 및 사례

손진동 인간식물환경학회 2020 인간식물환경학회 학술대회 Vol.2020 No.추계

한국 농촌교육농장 활성화 방안- IPA 기법을 활용하여 -

손진동,김선희 한국농촌계획학회 2015 농촌계획 Vol.21 No.3

The Purpose of this study is to analyze the importance and satisfaction on the items related to rural education farm management. The survey was carried out on the operators of rural education farm from October 6th, 2014 to April 30th, 2015, and 144 questionnaires were used for the final analysis. According to the analysis result, In the first quadrant, the environment of the farms(safety of the education farms, accessibility to the farms) and the existing customer management(dealing actively with the customer complaints, consulting with schools regarding the hands-on education and the feedbacks) were included. In the second quadrant, fourteen items were included. To mention these items in detail, the environment of the farms(lounge area for the guiding teachers), customer management(diversification of the publicity for the education farms, efforts to secure loyal customers, efforts to create new customers), campaigns of publicity and contents of publicity management(diversification of the publicity channels for education farms, off-line contents management, on-line contents management), ensuring professionalism(worksheet development and utilization, periodical supplemental education for operators), hands-on education programs(new program development, customized program development, distinguished program development), costs(efforts for cost reduction, fees for hands-on education) were included. In the third quadrant, the environment of the farms(size of the education farms), publicity activities and publicity contents management(enthusiastic publicity activities), strengthening professionalism(participation in the training programs related to rural education farm management) and in the fourth quadrant, the environment of the farms(environmentally-friendly and aesthetic natural landscape, convenient facilities such as powder rooms and washstands, parking lots) were included.

동아시아 사막 면적의 경년변화분석

한현경,이은경,손상훈,최성원,이경상,서민지,진동현,김홍희,권채영,이다래,한경수 대한원격탐사학회 2018 大韓遠隔探査學會誌 Vol.34 No.6

The area of desert in East Asia is increasing every year, and it cause a great cost of social damage. Because desert is widely distributed and it is difficult to approach people, remote sensing using satellites is commonly used. But the study of desert area comparison is insufficient which is calculated by satellite sensor. It is important to recognize the characteristics of the desert area data that are calculated for each sensor because the desert area calculated according to the selection of the sensor may be different and may affect the climate prediction and desertification prevention measures. In this study, the desert area of Northeast Asia in 2001-2013 was calculated and compared using Moderate Resolution Imaging Spectroradiometer (MODIS) and Vegetation. As a result of the comparison, the desert area of Vegetation increased by 3,020 km2/year, while in the case of MODIS, it decreased by 20,911 km2/year. We performed indirect validation because It is difficult to obtain actual data. We analyzed the correlation with the occurrence frequency of Asian dust affected by desert area change. As a result, MODIS showed a relatively low correlation with R = 0.2071 and Vegetation had a relatively high correlation with R = 0.4837. It is considered that Vegetation performed more accurate desert area calculation in Northeast Asian desert area. 사막면적은 매년 증가하는 추세이며, 이에 따라 막대한 사회적 피해 비용을 발생시키고 있다. 이러한 사막은 광범위하게 분포하고 사람의 접근이 어려워 인공위성을 이용한 모니터링이 많이 이루어지고 있지만 인공위성의 센서에 따라 산출되는 사막 면적 비교 연구는 미비한 편이다. 센서의 선택에 따라 산출되는 사막 면적은 상이할 수 있고 이에 따라 기후 예측이나 사막화 방지대책 등에 영향을 미칠 수 있어 센서별로 산출되는 사막면적 자료의 특성을 인지하는 것은 중요하다. 본 연구에서는Moderate Resolution Imaging Spectroradiometer (MODIS)와 Vegetation을 이용해 2001-2013년 동북아시아 지역의 사막 면적을 산출하고 비교 분석하였다. 분석 결과, MODIS에서 산출한 사막 면적은 비교적 과소 탐지하는 경향과 20,911 km2/year로 감소하는 추세를 보였고 Vegetation에서 산출한 사막 면적은 3,020 km2/year로 증가하는 추세를 보였다. 또한 실측자료 확보가 힘든 사막지역에서 인공위성을 이용해 산출된 사막 면적의 간접검증을 위해 사막 면적 변화에 영향을 받는 황사 발생빈도와 상관관계 분석을 실시하였다. 그 결과, MODIS는 R=0.2071로 비교적 낮은 상관관계가 나타났고 Vegetation은 R=0.4837로 비교적 높은 상관관계가 나타났다. 이는 Vegetation이 동북아시아 사막 영역에서 보다정확한 사막 면적 산출을 수행한 것으로 사료된다.

축제 참가자 참여동기, 매력성, 관여도, 만족도 연구 : 한ㆍ일 야간축제를 중심으로

류인평,정총화,손진동 관광경영학회 2018 관광경영연구 Vol.83 No.-

Although the development of local festivals has led to many scholarly studies on festivals but there are few studies on night festivals. The purpose of this study is to suggest the implications of improving the quality of Korean festival by participation on motivation, attractiveness and involvement of festival, focusing on Korea and Japan night festival. For the empirical analysis of the survey, the spatial range was limited to the venue where "Gamaek Festival" was held Jeonju in Korea and "Yosakoi Festival" was held Kochi in Japan. The time range was from Aug. 10 to 12, 2017, when the "Gamaek Festival" was held, and "Yosakoi Festival" was held from August 11 to 13, 2017. During this period, 105 copies were distributed for each festivals to visitors. The content scope is composed of 5 chapters. First, Participants in Korea and Japan will have different motives for participation. Second, the attractiveness of Korean and Japanese festival participants will be different. Third, the involvement of participants in Korea and Japan festival will be different. Fourth, the satisfaction level of participants in Korea and Japan festival will be different. The result of Analysis is First, motivation for participation was significant in significance and deviation. Second, only the convenience was significant in the analysis of attractiveness difference. Third, in the analysis of difference between involvement and satisfaction, all results were significant.

IPA분석을 활용한 농촌교육농장 품질인증에 관한 연구

류인평 ( Ryu In-pyong ),손진동 ( Son Jin-dong ),김선희 ( Kim Seon-hee ) 한국관광산업학회 2019 Tourism Research Vol.44 No.2

본 연구는 농촌교육농장 품질인증을 받은 농장을 대상으로 품질인증 관련 항목들 그리고 품질인증농가 사후관리에 대한 중요도와 만족도를 비교·분석하여 농촌교육농장 활성화를 위한 유용한 정보를 제공하고자 하는 목적으로 실시하였다. 이러한 연구목적을 달성하기 위해 농촌진흥청에서 실시하는 농촌교육농장 품질인증을 받은 농장을 대상으로121부의 설문지를 활용하였다. 연구결과를 IPA 매트릭스로 분석해 보면, 제1사분면 ‘지속유지’ 는 중요도와 수행도가 모두 높은 영역으로 실내외 교육환경 개선, 농장 안전관리능력 향상, 정리정돈상태, 차별화된 체험프로그램 개발, 농장주 역량강화 등으로 나타났다. 제2사분면 ‘집중관리’ 는 중요도가 높지만 수행도가 낮은 영역으로 고객확보, 고객관리활동, 품질인증농장 사후관리 등이 해당되었다. 제3사분면 ‘낮은 우선순위’ 는 중요도와 수행도가 모두 낮은 영역으로 품질인증을 통한 농장이미지 제고 항목이 해당되었으며, 제4사분면 ‘과잉노력 지양’ 은 중요도는 낮지만 수행도는 높은 영역으로 교육프로그램 개발능력 향상, 농장주의 체험교육 지도력 향상, 교육농장 운영 및 관리능력 향상, 체험교육수준 향상 등으로 나타났다. 그러므로 농촌교육농장 활성화를 위해서는 ‘지속 유지’ 영역에 대해서는 현재와 같은 지속적인 관심이 필요하며, ‘집중관리’ 영역에 대해서는 보다 근본적인 운영개선이 이루어져야 할 것이다 This study evaluated importance and performance using 121 copies of a questionnaire after distributing 130 copies to the farms that obtained quality certification conducted by the Rural Development Administration. The results analyzed by the IPA Matrix showed that the first quadrant ‘maintenance’, an area of high importance and high performance, was improvement in indoor and outdoor educational environment, improvement in safety management skills of farms, an orderly condition, developing differentiated experience programs and strengthening farmers' capabilities. The second quadrant ‘intensive management’,an area of high importance but low performance, was securing customers, customer management and follow-up management of quality certified farms. The third quadrant ‘low priority’, an area of low importance and low performance, was promoting the farm image, the fourth quadrant ‘avoiding excessive efforts’, an area of low importance but high performance, was improving educational program development capacity, improving farmers' leadership in hands-on education, improving capacity of operating an educational farm and management skills and improving hands-on education level. Therefore, continuous interest is required for the area of ‘maintenance’just as it is for activating educational farms in rural communities and a more fundamental improvement in the operation should be made for the area of ‘ intensive management’.

천리안위성 1·2A호 지표면 알베도 상호 오차 분석 및 비교검증

우종호 ( Jongho Woo ),최성원 ( Sungwon Choi ),진동현 ( Donghyun Jin ),성노훈 ( Noh-hun Seong ),정대성 ( Daeseong Jung ),심수영 ( Suyoung Sim ),변유경 ( Yugyeong Byeon ),전우진 ( Uujin Jeon ),손은하 ( Eunha Sohn ),한경수 ( Kyung-so 대한원격탐사학회 2021 大韓遠隔探査學會誌 Vol.37 No.6

장기간에 걸친 전 지구적인 위성관측 지표면 알베도 자료는 전 지구 기후 및 환경의 변화 감시에 활발히 이용되고 있으며 그 활용도와 중요성이 크다. 우리나라의 경우 정지궤도위성 천리안위성 1호(Communication, Ocean and Meteorological Satellite, COMS) MI(Meteorological Imager) 센서와 천리안위성 2A호(GEO-KOMPSAT-2A, GK-2A) AMI (Advanced Meteorological Imager) 센서의 세대교체를 통해 지속적인 지표면 알베도 산출물의 확보가 가능하다. 그러나 COMS/MI 및 GK-2A/AMI의 지표면 알베도 산출물은 센서 및 알고리즘의 차이로 인해 산출물 간의 차이가 존재한다. 따라서 COMS/MI와 GK-2A/AMI 지표면 알베도 산출 기간을 확장하고 지속적인 기후변화 감시 연계성 확보를 위해 두 위성 산출물 간의 오차 분석이 선행되어야 한다. 본 연구에서는 COMS/MI 및 GK-2A/AMI 지표면 알베도 자료의 중복기간을 대상으로 지상관측자료 AERONET (Aerosol Robotic Network)와 타 위성자료 GLASS (Global Land Surface Satellite)와 함께 비교 분석하였다. 오차 분석 결과 AERONET과의 검증에서 COMS/MI의 평균 제곱근 오차(Root Mean Square Error, RMSE)가 0.043로 GK-2A/AMI의 RMSE인 0.015보다 높게 나타났다. 또한GLASS와 비교하였을 때 COMS/MI의 RMSE는 0.029로GK-2A/AMI의 0.038보다 낮게 나타났다. 이러한 오차특성을 이해하고 COMS/MI 및 GK-2A/AMI의 지표면 알베도 자료를 사용할 때 장기간 기후변화 감시에 적극적으로 활용할 수 있을 것이다. Global satellite observation surface albedo data over a long period of time are actively used to monitor changes in the global climate and environment, and their utilization and importance are great. Through the generational shift of geostationary satellites COMS (Communication, Ocean and Meteorological Satellite)/MI (Meteorological Imager sensor) and GK-2A (GEO-KOMPSAT-2A)/AMI (Advanced Meteorological Imager sensor), it is possible to continuously secure surface albedo outputs. However, the surface albedo outputs of COMS/MI and GK-2A/AMI differ between outputs due to differences in retrieval algorithms. Therefore, in order to expand the retrieval period of the surface albedo of COMS/MI and GK-2A/AMI to secure continuous climate change monitoring linkage, the analysis of the two satellite outputs and errors should be preceded. In this study, error characteristics were analyzed by performing comparative analysis with ground observation data AERONET (Aerosol Robotic Network) and other satellite data GLASS (Global Land Surface Satellite) for the overlapping period of COMS/MI and GK-2A/AMI surface albedo data. As a result of error analysis, it was confirmed that the RMSE of COMS/MI was 0.043, higher than the RMSE of GK-2A/AMI, 0.015. In addition, compared to other satellite (GLASS) data, the RMSE of COMS/MI was 0.029, slightly lower than that of GK-2A/AMI 0.038. When understanding these error characteristics and using COMS/MI and GK-2A/AMI’s surface albedo data, it will be possible to actively utilize them for long-term climate change monitoring.

AlSb 화합물 반도체 유전함수의 온도의존성 연구

정용우,변준석,황순용,김태중,김영동,신상훈,손진동 한국진공학회 2011 한국진공학회 학술발표회초록집 Vol.41 No.-