http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
변건우,최영주,이혜진,오지영,홍영선,성연아,정혜원 대한내분비학회 2007 Endocrinology and metabolism Vol.22 No.5
Background: Polycystic ovary syndrome (PCOS) is a common disorder in premenopausal women, but there has been little agreement on its diagnostic criteria due to its uncertain pathogenesis and the heterogeneity of symptoms. This study was performed in order to assess the differences in clinical, metabolic, and hormonal characteristics of women in the PCOS subgroups defined by ESHRE criteria. Methods: Subjects were divided into four PCOS subgroups based on ESHRE criteria. The grouping groupings included: 1) hyperandrogenism, oligomenorrhea, and polycystic ovary morphology (HA + OM + PCO); 2) hyperandrogenism and oligomenorrhea (HA + OM); 3) hyperandrogenism and polycystic ovary morphology (HA + PCO); and 4) oligomenorrhea and polycystic ovary morphology (OM + PCO). Reproductive hormones and metabolic profiles were measured. Results: Of the total number of subjects, 60 (40%) fulfilled the criteria for HA + OM + PCO, 50 (33%) for HA + OM, 11 (7%) for HA + PCO, and 30 (20%) for OM + PCO. There were no significant differences in clinical or metabolic features among the groups, except for LH, total cholesterol, and HDL cholesterol. Conclusion: In this population defined by ESHRE criteria, 73% of the patients met the former NIH definition for PCOS. Different phenotypes of PCOS cases were clinically or biochemically similar. Whether these women have an increased risk of infertility or metabolic complications remains to be determine. (J Kor Endocrine Soc 22:326~331, 2007) 연구배경: PCOS는 가임기 여성에서 흔한 내분비 질환이나 병인이 확실하지 않고 증세가 다양하여 통일된 진단기준 마련이 쉽지 않다. NIH는 안드로겐 과다와 배란 장애가 있는 경우, ESHRE/ASRM은 안드로겐 과다, 희발월경, 다낭난소 중 2가지가 있는 경우를 PCOS의 진단기준으로 제시하였다. 본 연구에서는 ESHRE 진단기준에 따라 PCOS 환자를 분류하고 이들의 임상적, 대사적, 호르몬 특징을 관찰하여 PCOS의 임상적 표현형을 규명하고자 하였다.방법: 대상군은 고안드로겐혈증(HA), 희발월경(OM) 그리고 다낭난소(PCO)를 모두 가지고 있는 군(이하 HA + OM + PCO군), 고안드로겐혈증과 희발월경이 있으면서 다낭난소는 없는 군(이하 HA + OM군), 고안드로겐혈증과 다낭난소가 있으면서 희발월경이 없는 군(이하 HA + PCO군), 희발월경과 다낭난소가 있으면서 고안드로겐혈증이 없는 군(이하 OM + PCO군)의 4군으로 나누어, 대사인자와 호르몬을 측정하였다. 결과: PCOS 환자 151명 중 HA + OM + PCO군이 60명(40%), HA + OM군 50명(33%), HA + PCO군 11명(7%), OM + PCO군은 30명(20%)이었다. 각 군을 비교했을 때 황체호르몬, 총콜레스테롤, HDL-콜레스테롤이 유의한 차이를 보였으며, 그 외에는 통계적으로 의미 있는 임상적, 대사적 특징의 차이는 없었다.
한국인 다낭난소증후군 환자의 Calpain-10 유전자다형성
이혜진,변건우,변은경,오지영,오지영,홍영선,성연아,정혜원 대한내분비학회 2008 Endocrinology and metabolism Vol.23 No.5
Background: Polycystic ovary syndrome (PCOS) is characterized by chronic anovulation, hyperandrogenism and insulin resistance, and PCOS is known to be associated with an increased risk of type 2 diabetes mellitus (DM). PCOS has also been proposed to share a common genetic background with type 2 DM. The calpain 10 (CAPN10) gene is known to be associated with type 2 DM in several different population. We examined the association of CAPN10 gene polymorphisms and their influence on the metabolic abnormalities in Korean women who suffer with PCOS. Methods: One hundred sixty four women with PCOS and 325 control women were studied. The CAPN10 gene polymorphisms were genotyped by amplifying the genomic DNA. Anthropometric measures, a 75g oral glucose tolerance test and measurement of insulin sensitivity by the euglycemic hyperinsulinemic clamp technique were performed. Results: The frequencies of CAPN10 UCSNP-43, UCSNP-19, UCSNP-63 and the haplotype combinations were not different between the women with PCOS and the control subjects. In the women with PCOS and who had the UCSNP-43 GA genotype, the post-load 90 minute plasma glucose level was significantly greater and the HDL cholesterol and insulin mediated glucose uptake were significantly lower compared to the women with PCOS and who had the GG genotype. Conclusion: The CAPN10 UCSNP-43 genotype might be responsible for insulin resistance, yet further study is required to confirm the role of this genetic polymorphism in the development of PCOS and the presentation of its disease features. Background: Polycystic ovary syndrome (PCOS) is characterized by chronic anovulation, hyperandrogenism and insulin resistance, and PCOS is known to be associated with an increased risk of type 2 diabetes mellitus (DM). PCOS has also been proposed to share a common genetic background with type 2 DM. The calpain 10 (CAPN10) gene is known to be associated with type 2 DM in several different population. We examined the association of CAPN10 gene polymorphisms and their influence on the metabolic abnormalities in Korean women who suffer with PCOS. Methods: One hundred sixty four women with PCOS and 325 control women were studied. The CAPN10 gene polymorphisms were genotyped by amplifying the genomic DNA. Anthropometric measures, a 75g oral glucose tolerance test and measurement of insulin sensitivity by the euglycemic hyperinsulinemic clamp technique were performed. Results: The frequencies of CAPN10 UCSNP-43, UCSNP-19, UCSNP-63 and the haplotype combinations were not different between the women with PCOS and the control subjects. In the women with PCOS and who had the UCSNP-43 GA genotype, the post-load 90 minute plasma glucose level was significantly greater and the HDL cholesterol and insulin mediated glucose uptake were significantly lower compared to the women with PCOS and who had the GG genotype. Conclusion: The CAPN10 UCSNP-43 genotype might be responsible for insulin resistance, yet further study is required to confirm the role of this genetic polymorphism in the development of PCOS and the presentation of its disease features.
하창윤,정혜경,류정화,정해선,변건우,김도영,문일환,조민선 대한소화기내시경학회 2004 Clinical Endoscopy Vol.29 No.6
Inflammatory bowel disease has a potential risk of developing colorectal cancer. However, there is little causal relationship between intestinal tuberculosis and colon cancer because intestinal tuberculosis is curable disease and has relatively short disease course. But there were a few case reports of intestinal tuberculosis associated with colon cancer. Diffuse infiltrating colon cancer, characterized by tumor cells in the presence of inflammatory changes with much fibrosis, is very rare in the colon. We experienced a 49-year-old woman who had tuberculous colitis combined with diffuse infiltrative colon cancer. She visited our hospital because of chronic diarrhea and abdominal pain. Colonoscopy showed multiple geographic ulcers in the transverse colon and partial intestinal obstruction. Histological examination revealed non-caseating granuloma and Mycobacterium tuberculosis was cultured in biopsied tissue. She took an anti- tuberculosis drug for 2 weeks, but her symptoms were aggravated. Therefore, extended right hemicolectomy was performed and revealed mucin-secreting, diffuse infiltrating adenocarcinoma. Herein, we report a rare case of diffuse infiltrative colon cancer coexisting with colonic tuberculosis with a review of liferatures. 만성 염증성 장질환은 대장암의 전구 병변으로 잘 알려져 있으나 장결핵은 이환기간이 짧고 치유가 가능하여 대장암과의 인과관계가 뚜렷하지 않다. 그러나 대장결핵과 대장암이 동반되었다는 몇몇 증례가 보고된 바 있다. 대장에 발생하는 미만성 침윤암은 심한 섬유화와 염증 반응이 특징적이며 대부분 위, 유방, 전립선 등 대장외 장기에서 대장으로 전이되는 경우가 흔하고 원발성 미만성 침윤암은 극히 드물다. 저자들은 만성 설사와 복통으로 내원한 49세 여자 환자가 대장내시경 검사에서 지도상 궤양이 있고 조직검사에서 비건락성 육아종이 관찰되었으며 조직배양 검사에서 결핵균이 동정되어 결핵 치료 도중, 치료에 불응하여 수술 후 횡행결장 및 상행결장에 이르는 원발성 미만성 침윤암이 동반된 1예를 경험하였기에 문헌고찰과 함께 보고한다.