도심 자율주행 기술 검증을 위한 소형 테스트베드

배현철,이은재,이세인,한제협,안희진 한국ITS학회 2024 한국ITS학회 학술대회 Vol.2024 No.4

신장이식 수술로 치험한 신원거대감소증 3례

배현철,김병길,김유선,박기일,정현주,최인준 대한신장학회 1997 춘계학술대회 초록집 Vol.1997 No.-

Burkholderia cepacia G4를 이용한 기상의 TCE처리용 2단계 CSTR / TBF 시스템 개발

배현철,이은열 한국생명과학회 2002 한국생명과학회 심포지움 Vol.35 No.-

폐에서 발생한 경화성 혈관종 증례 1예

배현철,이광재,최병휘,박인원,허성호 대한결핵 및 호흡기학회 1995 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.81 No.-

지구정보시스템을 이용한 금수산일대의 암반사면 안정성 평가

배현철,문상기,이영훈 대한자원환경지질학회 2000 자원환경지질 Vol.33 No.1

The goal of this study is to assess the spatial distribution of natural slopes and cutting slopes under would-be development. For this goal, a quantitative slope stability analysis method using GIS integrated with a computer program was developed. Through field investigations, the discontinuity parameters were collected such as orientation of discontinuity, persistence, spacing, JRC, JCS, and water depth. The distributions were interpolated from the ordinary kriging method in ARC/INFO GIS after variogram analysis. The layers showing all parameters needed for limit equilibrium analysis were constructed. The final layer using GIS works composed of 162,352 polygons, that is, unit slopes. The rock slope stability analysis program was coded by C++ language. This program can calculate geometrical vectors related to rock block failures using input orientation data and direction and dimension of strength to occur failure. Also, this can calculate shear strength of joints through empirical equations and quantitative factors of safety. This methodology was applied to the study area which is located in Jaecheon city and Danyang-gun of the northeastern Keumsu is about 135㎢. As a result, the study area was entirely stable but unstable, that is, factor of safety less than 1.0dominantly at the slopes near Keumsil, Daejangri, Keumsungmyun and Sojugol, Mt. Dongsan, Juksongmyun by the natural slope stability analysis. Assuming the cutting slope showing the same direction immediate, and quantitative analysis of factors of safety for a regional area could be conducted through GIS integrated with a computer program of limit equilibrium.

수산화알루미늄으로부터 수열법을 이용한 활성 알루미나 제조에 관한 연구

배현철,이상진,Bae, Hyeon Cheol,Lee, Sang-Jin 한국세라믹학회 2013 한국세라믹학회지 Vol.50 No.6

Activated alumina was fabricated with aluminum hydroxide in this study. High-purity alumina gel and boehmite were prepared from aluminum hydroxide by a hydrothermal process and fired to activate alumina having a surface area of 380 ~ 480 $m^2/g$ with less loss of ignition. The aging and drying condition during the fabrication process affected the loss of ignition, the sedimentation time of the alumina suspension, as well as the surface area of the activated alumina. For pellet-type activated alumina, the pre-fired alumina gel and boehmite were press-formed and fired at $400^{\circ}C$ and $550^{\circ}C$ for 6 h, respectively. The fired pellets showed a low density of 2.0 ~ 2.2 $g/cm^3$ with 20% firing shrinkage and sufficient handling strength. In this study, a new fabrication process for high-quality activated alumina with aluminum hydroxide is introduced. The effects of the processing parameters on the activated alumina properties are also examined.

망막병증을 동반한 제2형 당뇨환자에서 vitamin E투여후 단핵구 manganese superoxide dismutase(Mn-SOD)의 활성도 변화

배현철,최성남,공병호,오연상,신순현 중앙대학교 의과대학 의과학연구소 1998 中央醫大誌 Vol.23 No.1

There are some evidences that oxidative stresses have some roles in initiation and progression of the diabetic complications. Superoxide dismutase (SOD) is an essential enzyme for the dismutation of superoxide(:O2^-) radicals, and the activity is changed in some pathologic conditions such as diabetes. The aim of this study was to evaluate the association of Mn-SOD activity and severity of diabetic retinopathy and to compare between before and aftertreatment with vitamin E. The Mn-SOD activities were measured in 75 patients with NIDDM(41 noretinopathy, 21 nonproliferative retinopathy, 13 proliferative retinopathy) by spectrophotometry. The Mn-SOD activity(U/mg protein) was significantly elevated in diabetes after vitamin E treatment. The severity of diabetic retinopathy appeared not be statistically significant. In diabetic patients, there were no correlation between the Mn/SOD activity and the various clinical and biochemical parameters.

신장이식 수술로 치험한 Oligomeganephronia 3례

배현철,김지홍,김병길,김유선,박기일,정현주,최인준,Bae Hyun-Chul,Kim Ji-Hong,Kim Pyung-Kil,Kim Yoo-Seon,Park Ki-Il,Jeong Hyun-Ju,Choi In-Jun 대한소아신장학회 1997 Childhood kidney diseases Vol.1 No.2

Oligomeganephronia is a rare congenital form of bilateral renal hypoplasia histologically characterized by reduction in number and hypertrophy of nephrons. Clinically, this condition is presented in early infancy with vomiting, polyuria, polydipsia and dehydration. The problems are readily corrected, but slowly progressive renal failure follows accompanied by failure to thrive, short stature, and renal osteodystrophy. We experienced three cases of oligomeganephronia. Case 1. : A 3 2/12 years old female child was incidentally diagnosed as renal failure at age of 2 months when she was hospitalized due to pneumonia. She had open renal biopsy and was diagnosed as bilateral dysplastic kidney. On OPD follow-up, she progressed to end-stage renal failure (BUN/Cr 114/4.6 mg/dl) and had renal transplantation. The specimen was shrunk remarkably and light microscopy showed oligomeganephronia. Case 2. : A 14 8/12 years old female child with proteinuria was detected in an annual urine screening program for school children, she was diagnosed as renal failure (BUN/Cr 33.9/4.1 mg/dl), and had $5{\times}4{\times}3\;cm$ sized mass on abdominal CT scan. She had renal biopsy, and the specimen showed oligomeganephronia. She had hemodialysis for six months, and renal transplantation along with bilateral nephrectomy was performed. Case 3. : A 14 8/12 years old male child was diagnosed having chronic nephritis and chronic renal failure at 3 years old, progressed to end-stage renal failure (BUN/Cr 87/9.6 mg/dl) on OPD follow-up, and had a rephrectomy and renal transplantation. The biopsy specimen showed oligomeganephronic hypoplasia, secondary focal segmental glomerolosclerosis, and chronic interstitial nephritis. We report 3 cases of oligomeganephronia that progressed to end-stage renal failure and had successful renal transplantation with a brief review of related literatures.

$^{99m}Tc-DMSA$ 스캔에서 일측성으로 동위원소 섭취가 안되는 환아들에 대한 임상적 고찰

배현철,김현영,김병길,한상원,Bae Hyun-Chul,Kim Hyun-Young,Kim Pyung-Kil,Han Sang-Won 대한소아신장학회 1997 Childhood kidney diseases Vol.1 No.1

목적 : DMSA스캔은 신장의 형태학적 질환의 진단에 유용한 방사선과적 검사이다. 본원에서 DMSA스캔을 시행한 환아중 일측성으로 동위원소 섭취가 안되는 환아를 대상으로 이들의 성별, 연령별 분포와 임상적 소견, 원인질환 및 동반질환을 분석하고 이에 대한 치료 및 예후를 알아보고자 하였다. 방법 : 1980년부터 1995년까지 16년간 본원에 내원하여 DMSA 스캔을 시행한 생후 1일부터 15세 환아중 일측성으로 신기능을 상실한 경우와 5% 이내로 매우 저하되어 있는 61명을 대상으로 이들의 성별, 연령별 분포와 내원하게 된 주소, 내원당시의 임상적 소견, 정맥내 신우조영술, 복부초음파, 배뇨성 방광요관조영술, 최종 진단명, 동반되어있는 반대편 신장 및 전신 질환, 내원당시의 혈액검사, 치료, 그리고 추적 관찰후의 결과 등에 대한 항목을 조사하고 상호 연관관계를 분석하였다. 결과 : 1) 대상 환아의 연령 분포는 평균 3.3세였으며, 특히 1세이하가 전체의 46%였고 성별 분포는 남녀 1.4:1의 비율로 남아가 많았다. 2) 내원하게된 주소는 산전초음파에서 신장 이상이 발견된 경우가 31.2%로 가장 많았으며, 다음으로 반복적 요로감염, 복부종괴 촉지, 육안적 혈뇨, 복통 순이였으며, 다른 질환의 평가중 우연히 신장 이상이 발견된 경우도 26.2%를 차지하였다. 3) 내원당시 임상적 소견은 발열, 농뇨 등의 요로감염 증상이 가장 많았고, 고혈압, 복부종괴 촉지, 육안적 혈뇨, 변비, 무증상, 현미경적 혈뇨 순이였다. 4) 비기능성 신장의 최종진단명은 다낭성 신이형성(multicystic dysplastic kidney)이 36.1%로 가장 많았고, 수신증, 신발육부전, 신형성부전 순이였다. 5) 비기능성 신장의 치료는 47.5%에서 수술적 치료를 시행받았고, 수술적 치료중 신적출술이 75.9%(전체의 36.1%)로 가장 많았으며 그외에는 근피적 방광루조성술, 요관방광문합술, 신적출 및 신이식 순이였고, 32.8%는 치료없이 추적관찰만 했던 환아들이였다. 6) 반대측 신장에 침범된 질환은 수신증이 90.5%로 가장 많았고 신형성부전, 신원거대감소증이 각각 1례였다. 7) 총 61명의 환아중 4명이 만성 신부전으로 이행하였는데 이들은 모두 반대편 신장에도 심한 병변이 동반되었던 경우였으며 그 외의 환아들은 비교적 예후가 좋았다. 결 론 : 신기능을 상실한 신장중 대부분은 선천적인 질환에 의한 경우였으며 양측성으로 침범된 경우 만성신부전으로 이행한 경우도 있었으나 편측으로 침범된 경우 예후가 좋은 편이였으며 양측성인 경우도 조기진단 후 수술 받은 경우 신기능이 잘 유지되었다. 본 연구를 통하여 주산기 신장 병변에 대한 평가는 중요하며, 출생후 민감도가 높은 검사방법으로 조기에 진단하고 처치하면 비교적 예후가 좋다는 것을 알 수 있었다. The DMSA scan is a useful radiologic study in diagnosis of morphologic and functional diseases of kidney. We evaluated the distribution of sex and age, clinical manifestations, diagnosis, combined diseases, treatment and prognosis of the 61 patients with non-functioning kidney(no isotope uptake or uptake below 5% in DMSA scan) who admitted in our hospital from 1980 to 1995. The proportion of patients under 1 year old age was 46%. Sex ratio was 1.4:1 with male predominance. Most diagnosis of non-functioning kidneys were congenital such as multicystic dysplastic kidney, hydronephrosis due to ureteropelvic junction obstruction, renal agenesis and renal hypoplasia. In order of frequency thirty one percent of them were previously detected on antenatal ultrasonogram. Treatment consisted of operation in 47.5%, mostly nephrectomy and 32.8% of patients were followed up at OPD base without definite treatment. The most common combined diseases was hydronephrosis, in 4patients who had both kidneys inveloved progressed to chronic renal failure, but the prognosis in most cases were good. It is important to evaluate renal diseases in perinatal periods, and we believe that highly sensitive diagnostic study contribute to early treatment plan and thus to good prognosis.

미생물 에폭사이드 가수분해효소 활성을 이용한 유기용매에서의 광학활성 para-Nitrostyrene Oxide 생산

배현철,김현숙,이수정,이은열,양승택,김희숙 한국생명과학회 2002 생명과학회지 Vol.12 No.4

방향족 에폭사이드 기질에 대한 입체선택적 가수분해 활성이 우수한 Aspergillus niger LK를 이용하여 광학활성 (S)-para-nitrostyrene oxide를 제조하였다. 수용액에서 기질 의 낮은 용해도를 극복하기 위하여 유기용매에서 광학분할 반응을 수행하였으며, 생촉매 활성 저하가 가장 적은 dodecane을 유기용매로 선정하였다. 반응온도 3$0^{\circ}C$ 및 최적 water content 2% (v/v)의 조건에서 약 10시간 정도의 반응을 통해 ee 값이 100 %인 광학적으로 순수한 (S)-para-nitrostyrene oxide를 37% 정도(이론수율 : 50 %)의 높은 수율로 얻을 수 있었다. Enantioselective resolution of racemic para-nitrostyrene oxide was investigated using epoxide hydrolase activity of Aspergillus niger LK for the production of optically pure (S)-para-nitrostyrene oxide. To overcome the poor solubility of the substrate, enantioselective hydrolysis in an organic solvent was attempted under optimized reaction conditions including reaction temperature and water content. (S)-para-Nitrostyrene oxide with high optical purity (> 99% ee) was obtained at 37% yield using fungal epoxide hydrolase-catalyzed enantioselective resolution.