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박지상,최정현,김주,Jing Shian Yang,김진현,장현석,장용석 대한면역학회 2017 Immune Network Vol.17 No.6
Major histocompatibility complex (MHC) class II molecules, which are recognized for their primary function of presenting an antigen to the T cell receptor, are involved in various signaling pathways in B cell activation. We identified heterogeneous nuclear ribonucleoprotein (hnRNP) A2B1 as an MHC class II molecule-associated protein involved in MHC class II-mediated signal transduction in lipopolysaccharide (LPS)-stimulated 38B9 B cells. Although the function of hnRNP A2B1 in the nucleus is primarily known, the level of hnRNP A2B1 in the cytoplasm was increased in LPS-stimulated 38B9 cells, while it was not detected in the cytoplasm of non-treated 38B9 cells. The silencing of hnRNP A2B1 expression using siRNA disturbed B cell maturation by regulation of mitogen-activated protein kinase signaling, NF-κB activation, and protein kinase B activation. These results suggest that hnRNP A2B1 is associated with MHC class II molecules and is involved in B cell activation signaling pathways in LPS-stimulated 38B9 cells.
다중검출기 CT영상에서 Fitz-Hugh-Curtis 증후군과 유사한 간피막조영증강 소견의 분석
박지상,박성진,이혜경,이범하,홍현숙,차장규,임훈 대한영상의학회 2008 대한영상의학회지 Vol.58 No.3
목적: 복부 CT에서 간피막조영증강을 유발하는 질환군을 알아보고 조영증강양상과 연관질환 사이의 관계를 분석하고자 하였다. 대상과 방법: 복부 CT중 동맥기영상이 포함된 797개의 증례를 검토하여 이중 간피막조영증강을 보인 47예를 대상으로 하였다. 남녀 비는 13:34이었고 평균연령은 53세였다. 이들의 CT 영상과 최종 진단을 후향적으로 분석하여 연관질환을 규명하였으며 조영증강양상과의 관계를 비교하였다. 또한, 간피막조영증강이 문맥기영상까지 지속하는 경우를 재검토하여 증상기간과의 관계를 평가하였다. 결과: 이 연구에서 간피막조영증강의 빈도는 5.9%(47/797)로 FHC 증후군(Fitz-Hugh-Curtis 증후군)(6예)뿐만 아니라 다른 여러 질환에서도 나타났다. 염증질환이 20예, 악성질환이 13예가 있었으며 그 외 지방간, 외상, 간혈관종 등도 있었다. 간피막조영증강의 범위는 양성질환에서 광범위한 조영증강이 64.7%(22/34), 악성질환에서 46.2%(6/13)에서 보였다. 간피막조영증강이 문맥기까지 지속하는 경우는 68.1%(32/47)이었고, 양성질환에서 문맥기조영증강이 있었던 경우 평균증상기간은 19.8일이었으며, 그렇지 않은 경우는 3.8일이었다. 결론: 간피막조영증강은 동맥기 CT에서 드물게 발견되며 FHC 증후군뿐만 아니라 다른 여러 질환에서 보일 수 있다. CT는 간피막조영증강과 동반질환을 찾아내는데 매우 유용하였다.
박지상,홍현숙,이종세,김대호,이혜경,이범하,차장규,박성진,김시찬 대한영상의학회 2008 대한영상의학회지 Vol.59 No.2
Purpose: To evaluate the CT and MRI findings of the large endolymphatic duct or sac syndrome (LEDS) and its associated anomalies, with clinical features. Materials and Methods: We retrospectively reviewed the MR and CT images of 52 ears obtained from 26 patients with LEDS. We reviewed the clinical findings, audiology testing, and treatment results. The degree of hearing loss was classified from normal to profound, based on pure tone audiometry. The largest areas were measured at each endolymphatic duct and analyzed to determine whether a correlation exists with the degree of hearing loss. We also analyzed the differences in measurements between CT and MRI findings. Results: All 26 patients had some degree of sensorineural hearing loss, which resulted in 18 ears to undergo a cochlear implantation. One patient was diagnosed with Cornelia de Lange syndrome. Five patients had a sudden hearing loss onset. Ten ears had incomplete cochlear partitions, whereas 28 ears had enlarged vestibules. All patients had severe to profound hearing loss. We found no statistical correlation between the size of the largest area of the endolymphatic duct and the degree of hearing loss. The mean area of the endolymphatic ducts, as per an MRI examination, revealed slightly greater areas than the CT findings, although the differences were not significant. Conclusion: Enlarged vestibules and incomplete partitions of the cochlea were common anomalies associated with LEDS. We found no statistical correlation between the largest area of the endolymphatic duct or sac with the degree of hearing loss.