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박선홍,오영달,김은정,권락범 에스케이텔레콤 (주) 2015 Telecommunications Review Vol.25 No.3
2012년 교통안전공단의 보고서에 따르면 안전운전불이행 유형중 졸음운전과 주의 분산(운전 중 휴대전화 사용)이 50% 이상을 차지하는 것으로 나타났다. 즉, 국내 교통사고를 줄이기 위해서는 교통사고 사망자수의 70%이상을 차지하는 안전운전불이행 유형에서 졸음운전과 주의분산 행위를 억제하는 것이 효과적이라고 말할 수 있다. 선행 연구에서는 영상과 생체신호기반의 졸음운전과 주의 분산 행위를 모니터링하여 운전자에게 경고를 주는 기술이 대부분을 차지하고 있다. 본 연구에서는 복합적인 요인으로부터 발생하는 교통사고를 방지하기 위해서는 통합 HVI(영상, 생체, 차량 거동정보)를 퍼지이론을 적용하여 운전자 위험상황을 판단하는 알고리즘에 대해 제안하였다. 입력변수로는 영상에서는 일정시간 동안 누감은 시간의 누적 비율을 나타내는 PERCLOS와 시선 추적을 통한 시선분산정보, 생체에서는 심박수, 그리고 차량정보에서는 전방차량과의 안전거리 및 차선이탈 정보를 활용하였다. 이러한 입력변수를 바탕으로 퍼지이론을 적용하여 위험상황 판단 모델을 구현하고 시뮬레이션을 통하여 검증하였다.
박선홍,노용훈,이도용,나한조,김용기,최봉남,도남용 朝鮮大學校 附設 醫學硏究所 1996 The Medical Journal of Chosun University Vol.21 No.1
We have usually experienced bone conduction impairment in chronic otitis media, but it is unclear that raised bone conduction threshold is due to the reflection of cochlear dam- age and / or Carhart effect ( an artificial elevation of bone conduction threshold due to conductive defect ) or both. The purpose of this study is to verify the influence of the artificial elevation of the bone conduction threshold in chronic otitis media and to estimate Carhart effect. A total of 336 cases of tympanoplasty with unilateral chronic otitis media without any other causes of sensorineural hearing loss was studied. The average threshold levels of the bone conduction in diseased ears ranged from 18.5dB at 4kHz to 12.1dB at 250Hz The longer duration of the disease, the larger perforation size, the more severe damage of the middle ear structure and the presence of the cholesteatoma made bone conduction threshold increased. The postoperative thresholds of bone conduction were Improved in 36 cases (40.4%) of the 89 cases that underwent operation with type I tympanoplasty technique without electrie drilling. The degree of the maximal improvement was 14.3dB at 2000Hz and the minimum was 8.8dB at 250Hz. but these result did differ from a statistically significant degree. The result suggest that the bone conduction threshold in chronic otitis media is elevated artificially by conductive defect and improved by successful reconstructive surgery.
Piperidylmethyloxychalcone improves immunemediated acute liver failure via inhibiting TAK1 activity
박선홍,곽정아,정상헌,안병우,조원제,윤청용,나창선,황방연,홍진태,한상배,김영수 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Mice deficient in the toll-like receptor (TLR) or the myeloid differentiation factor 88 (MyD88) are resistant to acute liver failure (ALF) with sudden death of hepatocytes. Chalcone derivatives from medicinal plants protect from hepatic damages including ALF, but their mechanisms remain to be clarified. Here, we focused on molecular basis of piperidylmethyloxychalcone (PMOC) in the treatment of TLR/MyD88-associated ALF. C57BL/6J mice were sensitized with D-galactosamine (GalN) and challenged with Escherichia coli lipopolysaccharide (LPS, TLR4 agonist) or oligodeoxynucleotide containing unmethylated CpG motif (CpG ODN, TLR9 agonist) for induction of ALF. Post treatment with PMOC sequentially ameliorated hepatic inflammation, apoptosis of hepatocytes, severe liver injury and shock-mediated death in ALF-induced mice. As a mechanism, PMOC inhibited the catalytic activity of TGF-β-activated kinase 1 (TAK1) in a competitive manner with respect to ATP, displaced fluorescent ATP probe from the complex with TAK1, and docked at the ATP-binding active site on the crystal structure of TAK1. Moreover, PMOC inhibited TAK1 auto-phosphorylation, which is an axis in the activating pathways of nuclear factor-κB (NF-κB) or activating protein 1 (AP1), in the liver with ALF in vivo or in primary liver cells stimulated with TLR agonists in vitro. PMOC consequently suppressed TAK1-inducible NF-κB or AP1 activity in the inflammatory injury, an early pathogenesis leading to ALF. The results suggested that PMOC could contribute to the treatment of TLR/MyD88-associated ALF with the ATP-binding site of TAK1 as a potential therapeutic target.
Effect of transportation method on preoperative anxiety in children: a randomized controlled trial
박선홍,박상희,이성헌,최정일,배홍범,유영욱,정성태 대한마취통증의학회 2020 Korean Journal of Anesthesiology Vol.73 No.1
Background: This study was performed to evaluate the effect of a wagon as a transport vehicle instead of the standard stretcher car to reduce children’s anxiety of separation from parents. The secondary goal was to evaluate whether this anxiolytic effect was related to age. Methods: We divided 80 children (age 2–7 years) into two groups. The stretcher group was transferred to the operating room on a conventional stretcher car, whereas the wagon group was transferred using a wagon. The level of anxiety was evaluated three times using the Modified Yale Preoperative Anxiety Scale (mYPAS): in the waiting area (T0), in the hallway to the operating room (T1), and before induction of anesthesia (T2). Results: The mYPAS score was significantly lower in the wagon group (36.7 [31.7, 51.7]) than in the stretcher group (51.7 [36.7, 83.3]) at T1 (P = 0.007). However, there was no difference in the mYPAS score between the two groups at T2 (46.7 [32.5, 54.2] vs. 51.7 [36.7, 75.0], respectively, P = 0.057). The baseline anxiety tended to be lower with increasing age (r = −0.248, P = 0.031). During transportation to the operating room, the increase in the mYPAS score (T1-T0) was greater as the age of children decreased in the stretcher group (r = −0.340, P = 0.034). However, no correlation was observed in the wagon group (r = −0.053, P = 0.756). Conclusions: The wagon method decreased preoperative anxiety, suggesting that it may be a good alternative for reducing preoperative anxiety in children.
Physiological Activity of Polyphenol and Chlorogenic Acid
박선홍,한상배,김영수 충북대학교 동물의학연구소 2011 Journal of Biomedical and Translational Research Vol.12 No.2
All living organisms through respiration may lead to oxidative stress, a state where increased formation of reactive oxygen species overwhelms host protection and subsequently induces DNA damage, lipid peroxidation, and protein denaturation. Chlorogenic acid, as a phenolic acid, occurs ubiquitously in food. It has been proved to have a number of biological effects in vitro and in vivo, such as antioxidant, anti-inflammatory, and anticarcinogenic properties. Chlorogenic acid can therefore promote human health to some extent, and be hopeful to provide new ways for treatment of chronic diseases. Recent studies are focused on the antioxidant properties of dietary polyphenols. The in vitro data often conflict with results obtained from in vivo studies on the antioxidant capacity of plasma or the resistance of plasma and lipoproteins to oxidation ex vivo after the consumption of polyphenols-rich foods by human subjects. These inconsistencies are likely explained by the limited bioavailability of dietary polyphenols and their extensive metabolism in humans. Polyphenols exert multifacet actions, and any clinical application using these substances should be based on the precise understanding of the physiologically relevant mechanisms.