http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
오늘 본 자료
최정일,김웅모,윤명하,이형곤 대한통증학회 2010 The Korean Journal of Pain Vol.23 No.3
Background:Tumor necrosis factor-alpha and other proinflammatory cytokines are becoming well recognized as key mediators in the pathogenesis of many types of neuropathic pain. Thalidomide has profound immunomodulatory actions in addition to their originally intended pharmacological actions. There has been debate on the analgesic efficacy of opioids in neuropathic pain. The aim of this study was to investigate the effect of thalidomide and morphine on a spinal nerve ligation model in rats. Methods:Male Sprague-Dawley rats weighing 100−120 g were used. Lumbar (L) 5 and 6 spinal nerve ligations were performed to induce neuropathic pain. For assessment of mechanical allodynia, mechanical stimulus using von Frey filament was applied to the paw to measure withdrawal threshold. The effects of intraperitoneal thalidomide (6.25, 12.5, 25 and 50 mg/kg, respectively) and morphine (3 and 10 mg/kg, respectively) were examined on a withdrawal threshold evoked by spinal nerve ligation. Results:After L5 and 6 spinal nerve ligation, paw withdrawal thresholds on the ipsilateral side were significantly decreased compared with pre-operative baseline and with those in the sham-operated group. Intraperitoneal thalidomide and morphine significantly increased the paw withdrawal threshold compared to controls and produced dose-responsiveness. Conclusions:Systemic thalidomide and morphine have antiallodynic effect on neuropathic pain induced by spinal nerve ligation in rat. These results suggest that morphine and thalidomide may be alternative therapeutic approaches for neuropathic pain. (Korean J Pain 2010; 23: 172-178)
개에서 심기능과 산소균형에 미치는 Dobutamine 과 Epinephrine 의 영향
최정일,유경연,임웅모,정성욱,정성태 대한마취과학회 2001 Korean Journal of Anesthesiology Vol.41 No.2
Effects of Dobutamine and Epinephrine on Myocardial Function and Oxygen Balance in Normal and Stunned Myocardium in Dogs Seongwook Jeong, M.D., Jeong Il Choi, M.D., Sung Tae Jeong, M.D. Kyung Yeon Yoo, M.D., and Woong Mo Im, M.D. Department of Anesthesiology, Chonnam University Hospital, Gwangju, Korea Background: Myocardial ischemia is known to depress systolic and diastolic functions for a prolonged period of time. Dobutamine and epinephrine are frequently administered to improve myocardial function during cardiac surgery. The vascular response to vasopressors might be altered by ischemia and reperfusion, since alterations in vascular control mechanisms have been demonstrated even after a short period of ischemia. The present study was aimed to investigate the effects of dobutamine and epinephrine of regional and global myocardial functions, coronary blood flow (CBF) and myocardial oxygen consumption (MVO_2) in normal and stunned myocardium in an open-chest canine model. Methods: Forty-eight dogs were acutelly instrumented under enflurane anesthesia to measure aortic and left ventricular pressures, and pulmonary (cardiac output) and left anterior descending (LAD) blood flows via a Doppler flowmeter, and a subendocardial segment length in the region supplied by the LAD. In series 1, increamental doses of dobutamine (1,2,5,10 ㎍/kg/min, n = 9 ) or epinephrine (0.02, 0.04, 0.1, 0.2 ㎍/kg/min, n = 10) were infused intravenously (IV) for 10 min before (normal) and after 15 min of LAD occlusion and subsequent 1 hr-reperfusion (stunned). In series 2, incremental doses of dobutamine (50, 125, 250, 375 ng/mL of LAD flow, n =14) or epinephrine (4. 10. 20. 30 ng/mL of LAD flow, n = 15) were infused directly into the LAD (IC) for 3-5 min before (normal) and after myocardial ischemia (stunned). Segment shortening (%SS), as an index of regional diastolic function, were evaluated. Simultaneous arterial and coronary venous contents of oxygen and lactate were measured to calculate MVO_2 and oxygen (EO_2) and lactate extraction (E??) ratios during IV or IC infusions of epinephrine or dobutamine. Effectiveness of metabolic vasodilation was determined from EO_2. Results: IV or IC infusions of dobutamine or epinephrine before ischemia resulted in dose-dependent increases in mechanical functions (%SS and dL/dt max) and MVO_2. These changes were accompanied by parallel increases in CBF resulting in unaltered EO_2. After the ischemia and reper-fusion, %SS and dL/dt max were depressed and E?? was reduced, but similar mechanical responses (%SS and dL/dt max) to both dobutamine & epinephrine were observed. Also, in the stunned myocardium, CBF increased in parallel with mechanical function and MVO_2 with either IC or IV dobutamine, resulting in an unaltered EO_2. However, IC but not IV epinephrine did not affect EO_2, suggesting abolishment of its direct vasodilating effect in stunned myocardium. IN addition, IC epinephrine infusion further decreased E??, while IC dobutamine did not affect it in stunned myocardium. During IV infusions, dobutamine caused a dose-dependent increase in the heart rate but epinephrine did not affect it, despite the comparable increase in cardiac index and mean aortic pressure. Conclusions: The results indicate that dobutamine and epinephrine exert similar positive inotropic and lusitropic effects in normal and stunned myocardium in dogs. However, epinephrine causes direct coronary vasodilation in normal myocardium, but it does not directly affect coronary vascular tone in stunned myocardium. IN addition, epinephrine infusion dose-dependently depresses E?? in stunned myo-cardium. IN contrast, dobutamine affects neither direct coronary vascular tone nor E?? regardless of ische-mia and reperfusion injury. (Korean J Anesthesiol 2001; 41: 207~221)
최정일,장예진 한국융합보안학회 2015 융합보안 논문지 Vol.15 No.3_2
본 연구에서는 종합주가지수와 코스닥지수 그리고 융합보안 관련기업인 에스원, 안랩, 슈프리마, 라온시큐어, 이글루시큐리티의 주가를 이용하였다. 지난 2010년 8월에서 2014년 7월까지 총 4년(208주) 동안 지수 및 주가 동향을 파악하였다. 또한 보안 관련주의 기초통계량과, 분산분석, 상관분석, 각 주별 상승률동향 등 다양한 실증 분석을 시도하였다. 본 연구의 목적은 보안관련 기업들과 종합주가지수, 코스닥지수와의 상관관계를 살펴보는데 있다. 또한 각 기업들 주가흐름의 특징들을 파악하면서 투자가치가 있는지 분석하는데 있다. 향후 지식융합보안 산업의 높은 성장 가능성을 보았을 때 보안 관련기업들의 투자 가능성과 투자 메리트에 기대를 걸어보았다. 향 후 성장 가능성이 높은 보안 관련기업에 대한 투자는 시장수익률 대비 높은 수익률을 보일 것으로 기대가 된다. In this research, we used KOSPI, KOSDAQ and a stock price of Information Security related Company - S1, Ahnlab, Suprema, Raonscure and Igloosecurity. From August 2010 to July 2014, that is during 208 weeks(4 years), we had grasped index and stock price trend. Also we had attempted various Empirical analysis – Basic statistics of Security related Stock, Analysis of variance, Correlation analysis and Weekly Rate of Rise trends. The first purpose of this research is to see correlation between Security related Company and KOSPI, KOSDAQ. The second purpose of this research is to analyze whether stock items have investment value or not while watching features of flow of stock price per item. We expect possibility and merit of investment when we suppose Security industry’s high potential to grow. It seems that Security related Company deserves to be invested. We expect investment for Security related Company that has high possibility of growing will create high yields compared to Market yields.