http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
문주영 부천대학 2001 論文集 Vol.22 No.-
본 논문에서는 폐암 단체 검진에 대비한 CT 이미지의 1차 스크리닝(Screening) 자동화 시스템(Computer Assisted Diagnosis system)의 개선방법을 제안한다. 2차원의 CT 이미지로부터 3차원적인 정보를 수집(detect)하여 종양으로 의심할 수 있는 이상영역을 추출(extract)하는 방법을 제안한다. 즉, 각 슬라이스에 대하여 2차원 CT 이미지의 상하 슬라이스의 관계를 규명함으로써 3차원의 CT 이미지의 정보를 수집하고, 정상영역에서 제외된 영역을 이상영역(abnormal area)으로 정의하는(extract) 방법이다. 2차원적인 처리 단계에서의 CT 이미지에서 종양영역을 찾아내기 위한 유일한 실마리는 CT값이라 할 수 있지만, 획일된 CT값의 Threshold만으로는 종양영역을 찾기가 매우 어렵고 정확하지 못하다. 그것은 혈관영역의 CT값이 종양영역과 거의 일치하기 때문이다. 더우기 CT값은 주변 물질에 의해 영향을 받기 때문에 각 슬라이스의 위치를 고려한 가변적(varaiable)이고 재귀적(recursive)인 방법으로 Threshold를 결정해야 한다. 이에 따라 본 논문에서는 CT 이미지의 1차 스크리닝(Screening) 자동화 시스템을 개선하기 위하여 재귀적으로 구한 Threshold를 적용시키는 방법을 제안한다. In this paper, we propose an improvement of the computer-assisted diagonosis system for the first screening of CT images, preparing for a mass health examination for the lung cancer. The essence of the improving method is to extract abnormal areas suspected as cancers, by detecting three-dimensional information from two-dimensional images, that is, we collect information of three-dimensional CT images by investigating the relation of connected slices of two-dimensional CT images for each slice and extract areas excluded from the normal area as abnormal ones. While the only clue to find out cancer areas at the stage of two-dimensional processing is the CT values, it is very difficult and inaccurate to find out the tumor area from the threshold of CT values alone, This is because the CT values of vessels are almost the same as those of cancers. Furthermore, since the CT values depend on surrounding matters we must determine the threshold in a variable and recursive way, considering the position of each slice. Accordingly, in order to improve the computer-assisted diagnosis system for the first screening of CT images, we propose an using the threshold detected by recursive method.
Recent Update of Renin-angiotensin-aldosterone System in the Pathogenesis of Hypertension
문주영 전해질고혈압연구회 2013 Electrolytes & Blood Pressure Vol.11 No.2
The activation of renin-angiotensin-aldosterine system(RAAS) is one of the main pathogenesis of hypertension. All the components of RAAS are present in the kidneys at higher concentrations compared to plasma levels, and intrarenal formation of angiotensin II (Ang II) is independent of the systemic RAAS. There are some unique features in intrarenal RAAS compared to systemic RAAS. Unlike JG cells where Ang II inhibits renin release via the AngII type 1 (AT1) receptor by negative feedback, in the collecting duct Ang II stimulates renin expression via the AT1 receptor. Upregulated renin produced in the distal nephron may be able to support continued intrarenal Ang II formation leading to amplification or maintenance of the hypertensive state.The recently discovered angiotensin-converting enzyme-related carboxypeptidase 2 (ACE2)-Angiotensin-(1-7) Ang-(1-7)]-Mas receptor axis has an opposing function to that of the ACE-Ang II-AT1 receptor axis.The ACE2 deficiency was associated with an increase in blood pressure, and ACE2 knockout mice have highlighted hypertensive response to Ang II infusion associated with exaggerated accumulationof Ang II in the kidney. Recently, several numbers of patients have been evaluated as the activators of ACE2-Ang-(1-7)-Mas receptor axis, which can be divided into two main classes: aimed to increase the activity of ACE2, and directed to stimulate the Ang-(1-7) receptor Mas. In order to investigate new targets for hypertension and kidney disease, further research on the function of the ACE-Ang-(1-7)-Mas receptor axis is required.