소아의 범발성 복막염을 동반한 천공성 충수염에서 복강경하 충수절제술 후 대량 흔들기 세척법 및 배액술의 역할

김우연,정재희,Kim, Woo-Yeon,Chung, Jae-Hee 대한소아외과학회 2011 소아외과 Vol.17 No.1

Use of laparoscopic appendectomy (LA) for perforated appendicitis (PA) in children remains controversial because of the development of postoperative intra-abdominal abscess formation. We developed the irrigation method for the prevention of abscess formation after LA performed for PA in children with severe panperitonitis. We called it 'the shaking irrigation'. The object of this study was to analyze the efficacy of this irrigation method. All cases of PA with severe panperitonitis in children that underwent LA with massive shaking irrigation and drainage between June 2003 and December 2007 were studied retrospectively. We included only PA with panperitonitis and large amounts of purulent ascites throughout the abdomen as well as an inflamed small bowel with ileus. Thirty-four children were involved in this study. The mean patient age was eight years. The mean amount of irrigation fluid was 8.2 L (range: 4-15 L), The mean operative time was 89.5 min. The mean length of the hospital stay was 5.1 days. There were no postoperative intra-abdominal abscesses. There was no conversion to open surgery. In conclusion, Use of LA in PA with severe panperitonitis in children is safe and effective. Massive shaking irrigation and abdominal drainage appears to prevent intra-abdominal abscesses after LA for PA with panperitonitis.

건뇌(健腦)의 치법(治法), 치방(治方)에 대한 문헌적(文獻的) 고찰(考察)

김우연,김덕곤,Kim U-Yeon,Kim Deok-Gon 대한한방소아과학회 1993 대한한방소아과학회지 Vol.7 No.1

소아(小兒) 건뇌(健腦)에 관한 본초(本草) 및 식품(食品)의 문헌적(文獻的) 고찰(考察)

김우연,이진용,김덕곤,Kim U-Yeon,Lee Jin-Yong,Kim Deok-Gon 대한한방소아과학회 1993 대한한방소아과학회지 Vol.7 No.1

진경온담탕(鎭驚溫膽湯)의 항경련(抗痙攣) 작용(作用)에 관(關)한 실험적(實驗的) 연구(硏究)

김우연,김덕곤,Kim Woo-Yeoun,Kim Deog-Kon 대한한방소아과학회 1995 대한한방소아과학회지 Vol.9 No.1

In order to investigate the anticonvulsive effect of Jinkyungondamtang, the experiment were performed in mice. After solid exract of Jinkyungondamtang was orally administered to mice, four types of convulsion were induced in mice by electric shock, strychnine, picrotoxin, and caffeine. Each of the time to elicit the convulsion and to die was observed. Results were as follows: 1. In the case of convulsion induced by electric shock, the lapse of the time to elicit convulsion and the time to die were delayed by oral administration of Jinkyungondam-tang(P<0.05, P<0.025). 2. The solid extracts of Jinkyungondamtang were revealed rem- arkable effect in delaying the time to die induced by stry-chnine (P<0.05). 3. By oral administration of Jinkyungondamtang, the lapse of the time to elicit convulsion and to die were delayed significantly to elicit convulsion inducing by picrotoxin (P<0.05, P<0.05). 4. Considerable prolongation of the lapse of the time to elicit the convulsion was observed in convulsion induced caffeine due to the anticonvulsive effects of Jinkyungondamtang (P<0.05).

잣나무 잎 추출물의 항균 및 항산화 활성과 성분분석

김정은 ( Jung Eun Kim ),김우연 ( Woo Yeon Kim ),김지욱 ( Ji Wook Kim ),박현수 ( Hyun Soo Park ),이승훈 ( Seung Hoon Lee ),이순영 ( Soon Young Lee ),김민지 ( Min Ji Kim ),김아름 ( A Reum Kim ),박수남 ( Soo Nam Park ) 대한화장품학회 2010 대한화장품학회지 Vol.36 No.4

본 연구에서는 잣나무 잎 추출물의 항균, 항산화 및 성분 분석에 관한 연구를 수행하였다. 피부 상재균에 대한 항균활성 측정결과, Propionibacterium acnes (P. acnes), Staphylococcus aureus (S. aureus), Pityrosporum ovale (P. ovale) 및 Escherichia coli (E. coli)에 대한 ethyl acetate 분획의 MIC는 각각 0.06 %, 0.25 %, 0.13 %, 0.50 %로 나타났으며, P. acnes, P. ovale 및 S. aureus에서 큰 항균활성을 나타내었다. 잣나무 잎 추출물의 free radical (1,1-diphenyl-2-picrylhydrazyl, DPPH) 소거활성(FSC₅₀)은 aglycone 분획에서 22.93 μg/mL으로 나타났다. Luminol-의존성 화학발광법을 이용한 Fe³⁺-EDTA/H₂O₂계에서 생성된 활성산소종(reactive oxygen species, ROS)에 대한 잣나무 잎 추출물의 총 항산화능(OSC₅₀)은 50 % ethanol extract 분획에서 0.70 μg/mL, ethyl acetate 분획 및 aglycone 분획이 각각 1.04 및 1.43 μg/mL으로 매우 큰 항산화능을 보였다. Rose-bengal로 증감된 사람 적혈구의 광용혈 실험에서 추출물의 세포보호효과를 측정하였다. 잣나무 잎 추출물 분획들은 농도 의존적(5 ~ 50 μg/mL)으로 세포보호효과를 나타내었다. 잣나무잎 추출물의 가수분해로 얻은 ethyl acetate 분획은 TLC (PK-4, PK-6)와 HPLC (peak 1, peak 2)에서 2개의 주성분으로 나타났다. 이 성분들은 LC/ESI-MS/MS를 통해서 PK-6는 kaempferol-3-O-glucoside (astragalin)로, PK-4는 kaempferol-3-O-arabinoside (juglanin)로 확인되었다. 이상의 결과들은 잣나무 잎 추출물이 ROS를 소광시키거나 소거함으로써, 그리고 ROS에 대항하여 세포막을 보호함으로써 생체계, 특히 태양 자외선에 노출된 피부에서 항산화제로서 작용할 수 있음을 가리키며, 잣나무 잎 성분 분석, 그리고 피부 상재균에 대한 항균작용으로부터 항산화, 항노화 및 항균성 화장품 소재로서의 응용 가능성이 있음을 확인하였다. In this study, the antibacterial, antioxidative effect and component analysis of Pinus koraiensis leaf extracts were investigated. MIC values of the ethyl acetate fraction from P. koraiensis leaf extracts on P. acnes, S. aureus, P. ovale, and E. coli were 0.06 %, 0.25 %, 0.13 % and 0.50 %, respectively. The results showed that the antibacterial activity of the ethyl acetate fraction on P. acnes, P. ovale. and S. aureus was more prominent. The aglycone fraction of P. koraiensis leaf extracts (22.93 μg/mL) showed more higher free radical (1,1-diphenyl-2-picrylhydrazyl, DPPH) scavenging activity (FSC₅₀). Reactive oxygen species (ROS) scavenging activity (OSC₅₀) of P. koraiensis leaf extracts on ROS generated in Fe³⁺-EDTA/H₂O₂ system was investigated using the luminol-dependent chemiluminescence assay. The 50 % ethanol extract (0.70 μg/mL) showed the most prominent ROS scavenging activity. Also the ethyl acetate (1.04 μg/mL) and the aglycone fraction (1.43 μg/mL) showed very high antoxidant activity. The protective effects of extract/fractions of P. koraiensis leaf extracts on the rose-bengal sensitized photohemolysis of human erythrocytes were investigated. The P. koraiensis leaf extracts showed cellular membrane protective effects in a concentration dependent manner (5 ~ 50 μg/mL). TLC and HPLC chromatogram of the ethyl acetate fraction obtained from hydrolysis of P. koraiensis leaf extracts revealed 2 main bands (PK-4, PK-6) and peaks (peak 1, peak 2), which were identified as kaempferol-3-O-glucoside (PK-6, peak 1) and kaempferol-3-O-arabinoside (PK-4, peak 2) by LC/ESI-MS/MS, respectively. These results indicate that extract/fractions of P. koraiensis can function as antioxidants in biological systems, particularly skin exposed to UV radiation by scavenging ROS, and protect cellular membrane against ROS. Extract/fractions of P. koraiensis can be applicable to new cosmeceuticals for antioxidant, antiaging, and antibacterial activity.

안전한 자바 코딩 규약에 기반한 취약성 분석기의 설계

김우연(Woo-Youn Kim),박지우(Ji-Woo Park),손윤식(Yun-Sik Son),이창환(Chang-hwan Yi),구현우(Hyun-Woo Koo),김영자,오세만(Se-Man Oh) 한국정보과학회 2009 한국정보과학회 학술발표논문집 Vol.36 No.1C

최근 소프트웨어 개발 방법론의 발전과 함께 소프트웨어의 취약성을 제거하기 위한 방법론이 중요한 이슈로 대두되고 있다. 취약성을 제거하는 것은 소프트웨어의 안전성과 질적 향상에 기여할 수 있다. 이미 완성 단계의 소프트웨어에 대한 취약성을 분석하고, 제거하는 것은 코딩 단계에서 취약성 검사를 수행하는 것에 비해 비효율적이다. 개발 초기 단계에서부터 취약성을 제거하기 위해서는 컴파일 단계에서 취약성 검사가 수행되어야 한다. 본 논문에서는 기존의 안전한 자바 코딩 규약을 분석하고, 코딩 규약명세서를 이용하여 소프트웨어의 취약성을 분석할 수 있는 취약성 분석기를 설계한다. 제안한 취약성 분석기는 정형화된 컴파일러 방법론을 적용하였기 때문에 향후 컴파일 단계에서 취약성을 분석할 수 있는 기반 자료로 활용할 수 있다. 향후에는 자바 코딩 규약을 보완하고, 취약성 분석을 컴파일 단계에서 수행할 수 있도록 통합하는 기술에 대한 연구가 진행되어야 한다.

강자성 재료에서의 전자기력 발생 지연 측정 방법

김우연(Woo-Yeon Kim),강민수(Min Soo Kang),이종민(Jong Min Lee),배용채(Yong-Chae Bae),김승종(Seung-Jong Kim) 한국소음진동공학회 2010 한국소음진동공학회 학술대회논문집 Vol.2010 No.4

디페닐렌비닐렌 치환기를 가진 카바졸계 청색발광 공중합체 합성

김우연(Woo Yeon Kim),윤근병(Keun Byoung Yoon) 한국고분자학회 2013 폴리머 Vol.37 No.6

공액구조 고분자의 밴드갭을 줄이기 위하여 청색의 디페닐렌비닐렌을 치환기를 갖는 카바졸 단량체와 용해도향상을 위해 옥틸기를 도입한 카바졸 공단량체를 합성하여 신규 공중합체를 제조하였다. Suzuki 커플링 중합으로공중합체를 제조하고, 공중합체의 열적, 분광학적, 전기광학적 특성을 조사하여 고분자 유기발광 다이오드(PLED)의발광층에의 사용가능성을 조사하였다. 용액상태에서 공중합체의 UV 최대 흡수 파장은 333~340 nm, PL 최대방출 파장은 409~464 nm를 보였으며, 상대양자효율은 최대 25.8%의 값을 보였다. 열중량분석 결과 350 oC까지 열안정성을보이고, 필름형성이 용이하였으며, 공중합체를 발광층으로 사용한 PLED 소자에서 4.0 V에서 청색광을 나타내었다. Novel carbazole based copolymers were synthesized by Suzuki coupling polymerization. (Diphenylene)vinylene and n-octyl was introduced to carbazole as pendants for reducing band gap and improving solubility, respectively. Thermal,photoluminescence and electro-luminescence of copolymers were studied for applying the emitting layer of polymer light emitting diode (PLED). Maximum UV-vis absorption and photoluminescence (PL) emission wavelength of copolymers showed 333~340 nm and 409~464 nm in solution state, respectively. The relative quantum yield using 9,10-diphenylanthracene as a reference was 25.8%. These copolymers exhibited high thermal stability (Td = 350 oC) and good film forming ability. Good luminance was obtained at voltages lower than 8 V and the onset voltage was observed at 4.0 V.

영역 구분을 통한 다시점 영상의 깊이맵 손상 복구 기법

김우연(Wooyeun Kim),신지태(Jitae Shin),오병태(Byung Tae Oh) 한국통신학회 2015 韓國通信學會論文誌 Vol.40 No.12

골반골 골절로 인한 동맥 파열로 동맥 색전술을 시행받은 환자에서의 생존 비교

김우연 ( Woo Youn Kim ),홍은석 ( Eun Seok Hong ),홍정석 ( Jung Seok Hong ),안력 ( Ryeok Ahn ),황재철 ( Jae Cheol Hwang ),김선휴 ( Sun Hyu Kim ) 대한외상학회 2008 大韓外傷學會誌 Vol.21 No.1

Purpose: This study was to evaluate the effect of arterial embolization on survival in patients with pelvic bone fractures and arterial bleeding. Methods: From January 2001 to December 2007, in all, 18 patients with pelvic bone fractures that had been treated with interventional arterial embolization were included in this retrospective study. The Injury Severity Score (ISS), the Revised Trauma Score (RTS), the initial hemodynamic status, the blood gas analysis, blood transfusion data, and mortality were the main outcome measurements. Results: Pelvic bone fractures were classified into lateral compression (LC), antero-posterior compression (APC), vertical shear (VS), and combined (CM) type according to the Young-Burgess classification. The Survivor group included 11 patients (61.1%), and the non-survivor group included 7 patients (38.9%). The mean ages for the survivor and the non-survivor groups were 40.0 and 45.6 years (p=0.517). The types of pelvic bone fractures were LC 11 (61.1%), APC 6 (33.3%), and VS 1 (5.6%): LC 7 (63.6%), and APC 4 (36.4%) in the survivor group and LC 4 (57.1%), APC 2 (28.6%), and VS 1 (14.3%) in the non-survivor group. The internal iliac artery was the predominant injured vessel among both the survivors (n = 5, 45.5%) and the non-survivors (n = 4, 57.1%). No differences in initial blood pressures, ISS, and RTS existed between the two groups, but the arterial pH was lower in the non-survivor group (pH 7.09 (±0.20) vs 7.30 (±0.08), p=0.018). The number of transfused 24-hour units of packed RBC was greater in the non-survivor group (24.1±12.5 vs 14.4±6.8, p=0.046). Conclusion: No differences in initial blood pressure and trauma scores existed between survivors and non-survivors with pelvic bone fractures, who had been treated with arterial embolization, but arterial pH was lower the in non-survivors.