대한한방소아과학회지에 게재된 체계적 문헌고찰의 보고 질 및 방법론적 질 평가

심수보,이주아,이혜림 대한한방소아과학회 2020 대한한방소아과학회지 Vol.34 No.1

Objectives: The purpose of this study is to assess the reporting quality and methodological quality of systematic reviews from the Journal of Pediatrics of Korean Medicine. Methods: Systematic reviews were selected from the Journal of Pediatrics of Korean Medicine (JPKM) by utilizing Oriental Medicine Advanced Searching Integrated System (OASIS) and JPKM homepage. Two independent researchers assessed the reporting quality through Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline checklist, and assessed the methodological quality of systematic review through Assessment of Multiple Systematic Reviews (AMSTAR) 2 tool checklist. Results: Four systematic reviews were finally selected for the assessment. When assessed by PRISMA, three literatures were little insufficient, and one literature was sufficient. When assessed by AMSTAR 2, three literatures were moderate quality, and one literature was critically low quality. Also, all of the reviews had no information about ‘Protocol and registration’, ‘publication bias’, and ‘conflicts of interest’. Conclusions: Systematic review is important for Journal of Pediatrics of Korean Medicine and Korean Medicine Society. Efforts are needed to improve the reporting and methodological quality of the systematic reviews through PRISMA and AMSTAR 2. 목적: 본 연구의 목적은 대한한방소아과학회지에 발표된 체계적 문헌고찰들의 보고의 질과 방법론적 질을 평가하는 데 있다. 방법: 대한한방소아과학회지에 발표된 체계적 문헌고찰을 검색하기 위해 OASIS (Oriental Medicine Advanced Searching Integrated System) 전통의학정보포털과 대한한방소아과학회 홈페이지 학회지 검색 시스템을 사용했다. 2명의 독립된 연구자가 PRISMA 체크리스트를 활용하여 체계적 문헌고찰의 보고의 질을 평가했고, AMSTAR 2 도구를 활용하여 체계적 문헌고찰의 방법론적 질을 평가했다. 결과: 4건의 체계적 문헌고찰이 최종적으로 평가를 위해 선정되었고, PRISMA를 통해 평가해보았을 때, 3건의 논문은 약간 부족한 수준의 보고 질 (Little insufficient report)을 나타냈고, 1건의 논문은 충분한 수준의 보고 질 (Sufficient report)을 나타냈다. AMSTAR 2를 통해 평가해보았을 때, 3건의 논문은 중등도의 질 (Moderate quality)로 평가되었고, 1건의 논문은 매우 낮은 질 (Critically low quality)로 평가되었다. 모든 논문에서 프로토콜과 등록, 출판 비뚤림, 이해상충에 대한 항목을 누락했다. 결론: 체계적 문헌고찰은 대한한방소아과학회지 및 한의학계에 중요한 연구로, PRISMA와 AMSTAR 2를 통해 체계적 문헌고찰의 보고의 질과 방법론적 질을 재고하는 노력이 필요할 것으로 사료된다.

소아 야뇨의 한의학적 치료에 대한 국내외 임상연구 동향 - 2000년 이후 발표된 연구를 중심으로 -

이유빈,정아람 대한한방소아과학회 2020 대한한방소아과학회지 Vol.34 No.1

목적: 이 연구의 목적은 최근 발표된 야뇨의 한의학적 치료에 대한 임상연구들을 분석하여 연구 동향 및 한의학적 치료의 효과와 안정성을 살펴보기 위함이다. 방법: 국내외 데이터베이스인 OASIS, KISS, NDSL, RISS, Cochrane, CINAHL, Embase, Pubmed에서 검색하였고, 2000년 이후로 2019년 10월까지 출판된 임상연구만을 포함하였다. 선택된 연구들에 대한 출판 연도, 연구 유형, 야뇨의 유형, 인구통계학적 정보, 유병 기간, 치료 방법 및 내용, 추적 기간, 평가 지표 및 결과 그리고 부작용을 정리하여 분석하였다. 결과: 총 38편의 연구가 선정되었다. 선정된 연구 38편에서 야뇨증에 쓰인 한의학적 치료 방법으로는 침 치료가 가장 많았으며, 한약 치료, 전기 자극 치료, 뜸 치료, 혈위 지압 치료, 첩부 요법 순이었다. 침 치료에는 삼음교 (SP6)와 관원 (CV4)이 가장 많이 사용되었고, 한약 치료에선 축천환이 가장 많이 사용되었으며 약재는 익지인과 산약이 가장 높은 사용 빈도를 보였다. 치료 결과 대부분의 연구에서 한의학적 치료시 총유효율이 높은 것으로 나타났으며, 다른 평가 지표에서도 전반적으로 긍정적인 결과가 보고되었다. 한의학적 치료군에서 발생한 부작용은 모두 침 치료나 천자가 시행된 상황에서 발생한 것으로 조사되었다. 결론: 본 연구는 소아 야뇨증의 전반적인 한의학적 치료에 대한 국내외의 임상연구들을 분석함으로써 연구 동향을 파악하고, 한의학적 치료의 유효성과 안정성을 평가하였다. 하지만 소아 야뇨증에 대한 한의학적 치료의 유효성과 안정성이 입증되기 위해선 향후 더 많은 연구가 진행되어야 할 것으로 보인다. Objectives : The purpose of this study is to identify the research trends and to evaluate the effectiveness and safety of Korean medicine treatment by analyzing the recently published clinical studies of Korean medicine treatment on nocturnal enuresis in children. Methods: The literatures were searched from OASIS, KISS, NDSL, RISS, Cochrane, CINAHL, Embase, Pubmed, and only clinical studies published from 2000 to October 2019 were included. The publication year, study type, type of enuresis, demographic information of participants, duration of illness, intervention type and details, follow-up period, outcome measurements and adverse events of selected literatures were analyzed. Results: A total of 38 studies were selected. In the selected studies, acupuncture was the most frequently used treatment for nocturnal enuresis, followed by herbal medicine, electrical stimulation treatment, moxibustion, acupressure and plaster therapy. The most commonly used acupoints for acupuncture were SP6 and CV4, and the most used herbal medicine was Chukcheonwhan, while Alpiniae Fructus (益智仁) and Dioscoreae Rhizoma (山藥) were the most used herbal materials. Most of the studies showed that the total effective rate of Korean medicine treatment was high. All the adverse events occurred in the Korean medicine treatment group were caused by acupuncture or puncture. Conclusions : This study analyzed clinical studies of Korean medicine treatment on nocturnal enuresis in children, identified the research trends and evaluated the effectiveness and safety of the Korean medicine treatment.

소아(小兒) 병력에 대한 증례(證例) 1례(例)

장태규,김장현,김기봉,Chang, Tae-Gyu,Kim,, Jang-Hynn,Kim, Ki-Bong 대한한방소아과학회 2005 대한한방소아과학회지 Vol.19 No.1

만성적(慢性的)인 경부(頸部) 동통(疼痛) 및 종창(腫脹)을 호소하여 동국대학교(東國大學校) 익당한방병원(翁塘韓方病院) 한방소아과(韓方小兒科)에 내원(內院)한 소아(小兒) 병력환자 1례(例)에 대하여 초진(初診) 진료(診療) 후 탁리소독음(托裏消毒飮)을 사용한 약물치료(藥物治療)와 carbon 광선치료(光線治療)를 병행하여 78일간 치료(治療)한 결과 경부(頸部) 동통(疼痛) 및 종창(腫脹)이 완전 소실되어 유효한 결과를 얻었기에 이에 치료경과(治療經過)를 보고 하는 바이다. Objectives : The objective of this study is to assess the clinical effect of Taklisodok-${\breve{u}}m$(托裏消毒飮) and Ultraviolet B(UVB) on scrofula. Methods : This clinical study was carried out with one case(male) who visited the Department of Pediatrics, Dongguk University Bundang Oriental Hospital and it was diagnosed as scrofula. It is treated with herb medication for 78 days and UVB in 36 times. We checked the size and aspect of open wound. Results : The child's open wound improved, and the scrofula disappeared. Conclusion : Taklisodok-${\breve{u}}m$(擺裏消毒飮) and UVB are effective in the treatment of scrofula and improve the function of removing inflammation and regerminating the skin in the body.

한방소아과학에서 임상 실습 교육의 만족도와 유용성 조사

김빛나래 대한한방소아과학회 2020 대한한방소아과학회지 Vol.34 No.4

Objectives: The purpose of this study is to evaluate the satisfaction and utility of a clinical training in Pediatrics of Korean Medicine after conducting participatory practices in clinical training. Methods: A survey was conducted with 46 students who completed a clinical training in 2019. After completing Problem Based Learning (PBL), Objective Structured Clinical Examination (OSCE) and Clinical Performance Examination (CPX), they filled out the questionnaire composed of 15 questions. In addition, it was required to rank the preferences for clinical training items and describe what was good about, things that need to be improved or corrected, and other areas to be implemented as a part of the clinical training. Results: 1. Mean of the total satisfaction score was 4.26. Mean satisfaction score of the educational method was 4.25, and mean score of the utility of educational effectiveness was 4.27. 2. Among the questions that evaluate satisfaction of the education program, ‘I agree with OSCE as a part of the clinical training for juniors.’ showed the highest score. Among the questions that evaluate utility of educational effectiveness, ‘It will be helpful to treat patients as a Korean Medicine doctor in the future’ showed the highest score. On the other hand, ‘I actively participated in the clinical training’ showed the lowest score. Conclusions: A clinical training in Pediatrics of Korean Medicine can be highly valued from the viewpoint of the satisfaction and its utility.

영아 지루성(脂漏性) 피부염(皮膚炎)에 대한 증례(證例) 1례(例)

김장현,김기봉,Kim, Jang-Hyun,Kim, Ki-Bong 대한한방소아과학회 2006 대한한방소아과학회지 Vol.20 No.2

심한 두부(頭部) 발진(發疹), 소양(搔痒) 및 화농(化膿)을 호소하여 동국대학교(東國大學校) 분당한방병원(盆塘韓方病院) 한방소아과(韓方小兒科)에 내원(來院)한 영아 지루성(脂漏性) 피부염(皮膚炎) 환자(患者) 1예(例)에 대하여 초진(初診) 진료(診療) 후 Aroma Lotion과 Aroma oil을 혼합한 외용제(外用劑)를 사용한 도포치료(塗布治療)와 carbon 광선치료(光線治療)를 병행하여 37일간 치료(治療)한 결과 두부(頭部) 발진(發疹), 소양(搔痒) 및 화농(化膿)이 완전 소실되어 유효한 결과를 얻었기에 이에 치료경과(治療經過)를 보고하는 바이다. Objectives : The objective of this study is to assess the clinical effect of illinition and carbon-ray treatment on seborrheic dermatitis. Methods : This clinical study was carried out with one case(male) who visited the Department of Pediatrics, Dongguk University Bundang Oriental Hospital and it was diagnosed as seborrheic dermatitis. It is treated with illinition for 37 days and carbon-ray treatment in 12 times. We checked the aspect of wound. Results : The child's wound improved, and the seborrheic dermatitis disappeared. Conclusions : Illinition and carbon-ray treatment are effective in the treatment of seborrheic dermatitis and improve the function of removing inflammation and regerenating the skin in the body.

뇌성마비의 조기치료에 관한 문헌적 고찰 - 최근 중의 잡지 중심으로 -

곡수영,이승연,유선애,Gok, Su-Yeong,Lee, Seung-Yeon,Lyu, Sun-Ae 대한한방소아과학회 2008 대한한방소아과학회지 Vol.22 No.3

Objectives : This study has been carried out to look into the methods of early treatment of cerebral palsy and the treatment effect by ages. Methods : The fifteen theses dealing with treatment effects by ages were analyzed, which were selected from the 121 theses retrieved out of the wu-ruan(五軟), wu-chi(五遲), wu-ying(五硬), naotan(腦?), naoxing-tanhuan(腦性??), during the period between the January 2004 to August 2008 by using the China Academic Journal(CAJ) of China National Knowledge Infrastructure(CNKI). Results : 1. Among the study objects in the 15 theses, it was identified that there were 1.97 times more boys with cerebral palsy than that of girls, and it appeared that there was no significant relationship between gender and the treatment. 2. The early treatment referred to the treatment which was carried out based on the early diagnosis within 6 months to one year after the birth. This is the time when the adaptability and plasticity of the brain are high, and it was found out that the treatment effective as babies are young. 3. For the treatment of cerebral palsy, the combination of Traditional Chinese and Western Medicine Therapy was more frequently used than the exclusive Chinese medical treatment method, and it was more effective. Especially in the case, the Chinese medical treatment was focused on the acupuncture and the Tuina Massage. Conclusions : 1. For the treatment of cerebral palsy, when the age between one and two years old was established as the standard. The younger the babies were, the higher treatment effects were obtained. 2. It appeared that the early treatment of oriental medicine had relatively excellent effects on cerebral palsy, but it turned out that we needed more studies for accurate results.

수두증으로 오지증(五遲症)과 오연증(五軟症)이 발생한 환아 1례

박준범,김태용,오민규,하광수,신현수,Park, Jun-Beom,Kim, Tae-Yong,O, Min-Kyu,Ha, Kwang-Su,Shin, Hyun-Su 대한한방소아과학회 2006 대한한방소아과학회지 Vol.20 No.3

Objectives : The purpose of this study is to report a pediatric patient with five retardations and five flaccidities caused by hydrocephalus treated with oriental medicine. Methods : We performed an ambulatory treatment for him with herb medicine, acupuncture. And we measured grade of sitting, standing, walking, speaking. Results : The child's sitting, standing time increased from zero second to one-two minutes, and speaking improved. Conclusions : We report the good results of oriental medical treatment on this case. And this study requires further studies about five retardations and five flaccidities caused by hydrocephalus.

뇌성마비의 한약치료에 대한 임상연구 동향 -중의학 논문을 중심으로-

이보람,신혜진,이지홍,장규태 대한한방소아과학회 2017 대한한방소아과학회지 Vol.31 No.3

Objectives The purpose of this study is to provide clinical evidence of herbal medicine treatment for cerebral palsy by reviewing randomized controlled trials conducted in China. Methods We searched literatures dated up to 17 May, 2017 in China National Knowledge Infrastructure (CNKI), and evaluated methodological quality of those studies using ‘Risk of Bias’ tool. Results Sixteen studies were selected for analysis. These studies indicated that the total effective rate, motor function, self-care, muscle spasticity were significantly improved in the herbal medicine treatment group, as compared to the control group. The most-commonly-used herbs were Poria (茯苓), Astragali Radix (黃芪), Glycyrrhizae Radix (甘草), and Atractylodis Rhizoma Alba (白朮). There were no serious adverse events found that were associated with herbal medicine treatment. The methodological quality of included studies was generally unclear or low. Conclusions This study shows that the herbal medicine treatment can be effective and safe in treating cerebral palsy. Further well-designed clinical trials with high methodological quality and appropriate assessment tools need to be performed to solidify these findings.

가감보아탕(加減補兒湯)의 조혈(造血) 및 면역증진(免疫增進)에 관한 연구(硏究)

김윤희,유동열,Kim Yun-Hee,Yoo Dong-Youl 대한한방소아과학회 2000 대한한방소아과학회지 Vol.14 No.1

The KGBT has been used to weak children with anorexia, fatigue, and growth retardation. This study was carried out to prove the effects of the hematopoiesis and the immune proliferation by KGBT. Previously, C57BL/6 mice was treated with cyclophosphamide(100mg/kg) for leukopenia, and then administered KGBT (concentration is 1.37 g/kg, 504 mg/kg, and 137 mg/kg) to the treated mice. The mice was analyzed expression of thrombopoietin(TPO), stem cell factor(SCF) and interleukin-3 from bone marrow cell, interleukin-10 (IL-10), and interferon-$ {\gamma}$(INF-${\gamma}$) from splenic cell, and NOSⅡ gene from macrophage using by RT-PCR. Also proliferation of immune cell was analyzed using 3H-thymidine uptake and flow cytometery in splenic cells. The results were obtained as follows ; 1. The total number of WBC, RBC and PLT was increased in the KGBT treated group than in the control group. 2. In vitro, the proliferation of splenic cells was increased in normal, control, and KGBT treated group. And Administration of KGBT was reduced the cytotoxicity by CTX. 3. In bone marrow cell, the gene expression of immune regulatory factor that associated with hematopoiesis, such as TPO, SCF, and IL-13 was increased in the KGBT treated group than control. 4 The titer of hemagglutinin and hemolysin was increased in the KGBT treated group than control. 5. In analysis of positive leucocytes from splenic cell of BALB/c mice, the subpopulation percent of CD4+, CD8+,and CD19+ was increased in the KGBT treated group than control. The KGBT has been used to weak children with anorexia, fatigue, and growth retardation. This study was carried out to prove the effects of the hematopoiesis and the immune proliferation by KGBT. Previously, C57BL/6 mice was treated with cyclophosphamide(100mg/kg) for leukopenia, and then administered KGBT (concentration is 1.37 g/kg, 504 mg/kg, and 137 mg/kg) to the treated mice. The mice was analyzed expression of thrombopoietin(TPO), stem cell factor(SCF) and interleukin-3 from bone marrow cell, interleukin-10 (IL-10), and interferon-$ {\gamma}$(INF-${\gamma}$) from splenic cell, and NOSⅡ gene from macrophage using by RT-PCR. Also proliferation of immune cell was analyzed using 3H-thymidine uptake and flow cytometery in splenic cells. The results were obtained as follows ; 1. The total number of WBC, RBC and PLT was increased in the KGBT treated group than in the control group. 2. In vitro, the proliferation of splenic cells was increased in normal, control, and KGBT treated group. And Administration of KGBT was reduced the cytotoxicity by CTX. 3. In bone marrow cell, the gene expression of immune regulatory factor that associated with hematopoiesis, such as TPO, SCF, and IL-13 was increased in the KGBT treated group than control. 4 The titer of hemagglutinin and hemolysin was increased in the KGBT treated group than control. 5. In analysis of positive leucocytes from splenic cell of BALB/c mice, the subpopulation percent of CD4+, CD8+,and CD19+ was increased in the KGBT treated group than control. 6. The expression of IL-10 gene was reduced in the KGBT treated group than control, whereas the expression of INF-${\gamma}$ was increased in the KGBT treated group. 7. In macrophage, the production of NO and gene expression of NOSH was increased in the KGBT treated group than control. 8. After infection of EMC virus, the survival time of infected mice was longer in the KGBT treated group than control.

설사를 동반한 장간막 림프절염 환아 증례 보고

정지호,오지은,이해자,박은정,Jung, Ji-Ho,Oh, Ji-Eun,Lee, Hai-Ja,Park, Eun-Jung 대한한방소아과학회 2008 대한한방소아과학회지 Vol.22 No.3

Objectives : The purpose of this study is to report a case of nine-year-old female pediatric patient who had diagnosed as mesenteric lymphadenitis with abdominal pain. Methods : The patient was treated by acupunture (acupoint: Hegu(LI4), Zusanli(S36), Zhongwan(CV12), Tianshu (S25)), indirect moxibustion and herb medicine (Koakhyangjeonggisan-kamibang, Jakyakgamchotang Ex) for one week. We observed clinical progress. Result and conclusions : After oriental medical treatment, symptoms of mesenteric lymphadenitis (day and night abdominal pain, diarrhea) were improved. This study showed that oriental medicine can be a meaningful treatment for mesenteric lymphadenitis. For more accurate studies, further treatment cases would be needed.