A Comparative Study of the Olympic Games in East Asia: the nexus between politics and sports

권소영 경희대학교(국제캠퍼스) 국제지역연구원 2015 아태연구 Vol.22 No.1

East Asia has grown its importance in the field of international sports as host of series of significant mega-sports event, such as Olympic Games. These events are often blended with cultural and political dynamics of the Asia-Pacific region, exhibiting certain features specific to the region. A comparative study of Olympic Games in East Asia has demonstrated that they have been strongly state-centric and predominately attached to national identity and nationalism. Hosting of an Olympic Games often featured in the national agenda, and accompanied direct involvement of the state. Despite the vastly different aspirations and economic, political and social situations that the cities confronted when they bid for the Olympic Games, the case studies of the Seoul 1988 Olympic Games and the Beijing 2008 Olympic Games showed that the legacies tend to converge for the betterment of the host country and the society in general. Whereas the debut in the Olympic stage has been strongly state-centric in connection to national development, future Olympic Games in East Asia is likely to bring different vision, objectives, and expectation as the transnationalistic ideals and goals gain more importance in international sports movement.

대한적십자사 HLA 적합 혈소판 헌혈자 등록제도

권소영,이선아,임아현,조남선,정철호,양진혁,박경운 대한수혈학회 2015 大韓輸血學會誌 Vol.26 No.3

Background: Transfusion of HLA-matched platelets is required when development of platelet refractoriness occurs after repeated platelet transfusion. This study was conducted to establish a HLA-matched platelet donor registry to supply matched platelets to patients who develop platelet refractoriness. Methods: HLA-matched platelet donors were recruited among plateletpheresis donors. HLA-A and HLA-B antigen types of recruited donors were tested using a polymerase chain reaction-sequence specific oligonucleotide probe method. Results: A total of 1,029 plateletpheresis donors were recruited. HLA-A and HLA-B antigen frequencies of recruited donors were similar to those of previously reported HLA antigen frequencies of Koreans. During the study period, a patient with platelet refractoriness recovered after receiving six units of HLA-matched platelets. Conclusion: During this study 1,029 donors were registered as HLA-matched platelet donors and a patient with platelet refractoriness received HLA-matched platelets using this registry. Supply of HLA-matched platelets will be facilitated by continuous expansion of the number of registered HLA-matched platelet donors, development of a program for management and searching for HLA-matched donors, and establishment of a request-supply system between hospitals and the Korean Red Cross through further studies. 배경: 혈소판제제를 반복적으로 수혈받아 혈소판수혈불응증이 발생한 경우에는 HLA 적합혈소판제제를 수혈하여야 한다. 본 연구는 혈소판수혈불응증 환자에게 적합한 혈소판제제를 공급하기 위해 HLA 적합 혈소판 헌혈자 등록제도를 구축하기 위해 시행되었다. 방법: 성분채혈혈소판 헌혈자를 대상으로 HLA 적합 혈소판 등록 헌혈자를 모집하였다. 모집된헌혈자를 대상으로 HLA-A와 HLA-B 항원형을역보합반응(polymerase chain reaction-sequence specific oligonucleotide probe, PCR-SSO)법을 이용해서 검사하였다. 결과: 총 1,029명의 HLA 적합 혈소판 등록 헌혈자를 확보하였다. 등록된 헌혈자들의 HLA-A 와 HLA-B 항원형 결과는 기존의 한국인 빈도와유사하였다. 연구기간 중 혈소판수혈불응증 환자1명에게 6단위의 HLA 적합 혈소판제제를 수혈하여 혈소판 수치가 회복된 예를 경험하였다. 결론: 본 연구를 통해서 1,029명의 헌혈자를HLA 적합 혈소판 헌혈자로 등록시킬 수 있었으며 이를 통해 혈소판수혈불응증을 보이는 환자에게 HLA 적합 혈소판제제를 수혈할 수 있었다. 향후 연구를 통해서 HLA 적합 혈소판 등록 헌혈자수의 지속적인 확대, 이들 헌혈자의 관리와 적합한 HLA 항원형을 갖는 헌혈자를 선정하기 위한전산 프로그램의 개발 그리고 HLA 적합 혈소판제제의 요청과 공급을 위한 의료기관과 대한적십자간의 공급체계가 구축되면 HLA 적합 혈소판제제를 보다 원활하게 공급할 수 있을 것으로 기대된다.

B형 간염 표면항원 검사시약 성능평가를 위한 B형 간염 표면항원 저역가 표준패널 확립

권소영,하건우,조연정,윤경원,최경영,주현아,오덕자,조남선,이주헌,유숙원 대한수혈학회 2009 大韓輸血學會誌 Vol.20 No.2

Background: A range of well characterized materials are needed for validating the performance of hepatitis B surface antigen (HBsAg) immunoassays. These materials are purchased currently from overseas manufacturers at a high cost and with limited quantity. This study was conducted to establish an HBsAg low titer performance panel for use as a national standard for validation of HBsAg immunoassays in Korea. Methods: 476 plasma units reactive on blood donor screening were collected HBsAg was tested using 3 enzyme immunoassays (EIA) and 1 chemiluminescence immunoassay (CIA). Units reactive on the CIA assay or on 2 or more immunoassays were subjected to hepatitis B virus (HBV) DNA quantification, HBV genotyping and subtyping. Units reactive on HBV DNA quantification were confirmed for HBsAg by neutralization. Candidates for the panel were subjected to a collaborative study performed at 7 laboratories using 7 immunoassays. Results: Eleven HBsAg positive units were selected for the low titer performance panel based on HBsAg immunoassay, HBV DNA quantification, HBV genotyping and subtyping results. The range of the HBsAg concentration of the panel members was 0.05∼1.28 IU/mL. Two HBsAg negative units were also included as negative controls. Conclusion: As a result of this study, a low titer performance panel [KFDA standard (08/028); HBsAg low titer performance panel (BTRL HBV/LP)] for validation of HBsAg immunoassays has been established as a Korean national standard. Use of this panel will improve performance assessment of HBsAg immunoassays. Because the performance of immunoassays cannot be assessed properly with a limited number of panels, continuous efforts are needed to develop a range of performance panels. 배경: HBsAg 검사시약의 성능평가와 품질관리를 위해서는 특성이 잘 규명된 다양한 종류의 검체들이 필요하다. 현재 이들 물질들은 고가의 가격과 제한된 양으로 외국으로부터 구입되고 있다. 본 연구는 HBsAg 검사시약의 성능평가를 위한 HBsAg 저역가 패널을 제조하여 이를 국가표준품으로 확립하고 하였다. 방법: 헌혈자 선별검사에서 양상결과를 보인 476단위의 혈장을 수집하였다. 이들 혈장에 대해 3종의 효소면역검사(enzyme immunoassay, EIA) 시약과 1종의 화학발광면역검사(chemiluminescence immunoassay, CIA) 시약을 사용하여 HBsAg을 검사하였다. CIA에서 양성결과를 보이거나 2종 이상의 면역혈청 검사시약에서 양성결과를 보인 경우 B형 간염바이러스(hepatitis B virus, HBV) DNA 정량검사, HBV 유전자형과 아형 검사를 시행하였다. HBV DNA 정량검사에서 DNA가 검출된 혈장에 대해서는 HBsAg neutralization을 통해 HBsAg 진양성 여부를 확인하였다. HBsAg 저역가 패널을 위한 후보물질들에 대해 7개 검사기관에서 7종의 검사시약을 사용하여 공동연구를 수행하였다. 결과: HBsAg 면역혈청검사, HBV DNA 정량검사, HBV 유전자형과 아형 검사결과를 근거로 11개의 HBsAg 진양성 혈액을 HBsAg 저역가 패널 구성원으로 선정하였다. 이들 검체의 HBsAg 농도는 0.05∼1.28 IU/mL의 범위 내에 있었다. HBsAg 음성 혈액 2단위는 음성대조물질로 패널에 포함되었다. 결론: 본 연구의 결과로 HBsAg 검사시약 성능평가를 위한 저역가 패널[KFDA standard (08/ 028); HBsAg low titer performance panel (BTRL HBV/LP)]이 국가표준품으로 확립되었다. 본 패널의 사용으로 HBsAg 검사시약의 성능평가가 개선될 것으로 기대된다. 검사시약의 성능을 정확하게 평가하기 위해서는 다양한 특성을 갖는 패널이 필요하기 때문에 보다 많은 수의 표준품이 지속적으로 개발되어야 할 것이다.

4차 산업 기술 발전에 따른 식품산업의 변화와 대응

권소영 한국산업식품공학회 2021 학술대회 및 심포지엄 Vol.2021 No.05

군발두통 환자에서 botulinum toxin type A 치료 -증례 보고-

권소영,문동언,김영훈,이승현,유건희 대한마취통증의학회 2012 Anesthesia and pain medicine Vol.7 No.1

Cluster headache is a severe pain syndrome with a piercing, tearing sensation, nicknamed the suicide headache. It is associated with an autonomic symptom. No effective therapy is available in approximately 4−15% of patients with cluster headache. One of the treatment methods is occipital nerve block. It is conventionally performed with local anaesthetics, and in this case we used the botulinum toxin type A. Botulinum toxin is an effective therapeutic agent for various disorders, and has recently been discovered to be an effective treatment for chronic migraine. The efficacy of Botulinum toxin in headache invokes possible neurogenic effects that may reduce or even prevent sensitization of both the peripheral and central nervous system. Therefore, we describe a case of a 45-year-old male with a cluster headache that could not be controlled with conventional therapy. We performed botulium toxin type A therapy. Cluster headache VAS showed improvement after occipital nerve block using the botulinum toxin A.

Ketamine reduces the induced spinal p38 MAPK and pro-inflammatory cytokines in a neuropathic rats

권소영,염제화,주진덕 대한마취통증의학회 2014 Korean Journal of Anesthesiology Vol.66 No.1

Background: Neuropathic rats created by spinal nerve ligation are known to show higher levels of p38, c-Jun NH2-terminal kinase, and extracellular signal-regulated kinase p44/42 (ERK 1/2) of the mitogen-activated protein kinases (MAPKs). The authors of this study aimed to understand the effect of ketamine on p38 MAPK and inflammatory responses, as well as its effect on the development of neuropathic pain. Methods: The neuropathic rats were prepared by Chung's method with Sprague-Dawley rats. The research was carried out on three groups, a sham-operated group, a neuropathic pain and normal saline (NP + NS) group, and a neuropathic pain and ketamine (NP + Keta) group. The normal saline or ketamine was infused into the neuropathic rats through a mini-osmotic pump implanted in the subcutaneous space. After a week, the quantities of phospho-p38, p38 MAPK and pro-inflammatory cytokines were measured and compared through western blots and reverse transcriptase-polymerase chain reaction. Results: In comparison to the control group, the NP + NS group showed a significant increase of phospho-p38 and p38 MAPK, as well as of the proinflammatory cytokines, tumor necrosis factor α (TNFα), and intercellular adhesion molecule 1 (ICAM1). However, in the NP + Keta group, phospho-p38, p38 MAPK and TNFα and, ICAM1 were reduced in comparison to the NP + NS group. The paw withdrawal threshold test also showed the trend of recovery from the mechanical allodynia in the NP + Keta group. Conclusions: In the development of neuropathic pain, p38 MAPK and inflammatory responses are significantly related, and the use of ketamine reduces p38 MAPK and proinflammatory cytokines. Thus, the adequate use of ketamine could be effective for the prevention and treatment of neuropathic pain following peripheral injury.

Cytochrome P4502E1유전자의 다양성과 알코올성 간질환 발생과의 관련성에 관한 연구

권소영,연종은,박영태,김진호,변관수,이창홍 大韓消化器病學會 1997 大韓消化器病學會誌 Vol.29 No.5

만성 B형 간염바이러스 보유자에서 C형 간염바이러스 중복 감염에 관한 연구

권소영,연종은,박영태,김진호,변관수,서동진,이창홍 大韓消化器病學會 1996 大韓消化器病學會誌 Vol.28 No.1

붓스트랩방법을 이용한 등분산 검정의 다중비교

권소영,박만식 한국자료분석학회 2017 Journal of the Korean Data Analysis Society Vol.19 No.5

Multiple comparison is a comparison of differences between groups used when the null hypothesis is rejected in the analysis of variance. Baek, Park (2013) proposed a multiple comparison that uses t-statistic, followed by a sequentially rejective method of Holm (1979) using the bootstrapping methods. In Baek, Park (2013), however, only the traditional homogeneity of variance test was used in the homogeneity of variance test before using t-statistic. In this paper, both the test of mean difference and the homogeneity of variance test are simultaneously taken into account by employing the bootstrapping method and the sequentially rejective method. In order to check the homogeneity of variances between groups, we propose a double bootstrapping method, where the second-stage bootstrap samples re-sampled from a certain first-stage bootstrap sample are utilized in terms of variance and, consequently, the results about the variances are considered to the final decision on the significance of mean differences. As a result of applying the proposed method through the case analysis, it is confirmed that there is a possibility of different decision making by the difference of the test sequence. 사후분석(post-hoc analysis) 혹은 다중비교(multiple comparison)는 분산분석(analysis of variance)에서 귀무가설(null hypothesis)을 기각시켰을 때 관심대상인 집단들 간의 개별적인 비교를 위한 절차이다. Baek, Park(2013)은 두 집단씩 짝을 지어 t-통계량을 구한 후 붓스트랩방법(bootstrapping method)을 사용하여 Holm(1979)의 순차적 기각방법(sequentially rejective method)을 근간으로 검정하는 다중비교방법을 제안하였는데 이 때, 등분산 여부를 검정하는데 있어 원 자료의 등분산 검정(homogeneity of variance test)을 고려하였다. 본 연구에서는 평균차이 검정(test for mean differences)을 등분산 검정과 연동해서 수행하기 위해 t-통계량을 통한 평균차이 검정을 적용하기 전에 분산의 동일성 여부를 붓스트랩방법과 순차적 기각방법으로 알아보고자 한다. 이를 통해 얻어진 주어진 표본의 분산의 동일성 여부로부터 최종적인 평균차이 검정을 수행하기 위하여 이중(double) 붓스트랩방법을 제안한다. 본 연구에서는 사례분석을 통해 제안한 방법을 적용하였다. 그 결과, 검정순서에서 차이가 발생하고 결과적으로 상이한 의사결정이 이루어질 수 있음을 확인하였다.

부사관의 군 인성과 조직몰입의 관계에서 공동체의식의 매개효과

권소영 한국청소년학회 2021 청소년학연구 Vol.28 No.3

부사관들이 지각한 자신의 군 인성과 조직몰입 및 공동체의식의 관계를 살펴보고 군 인성과 조직몰입의 관계에서 공동체의식이 매개역할을 하는지 알아보았다. 연구는 D시에 소재한 군부대 부사관 371명을 대상으로 실시되었다. SPSS / WIN 20.0을 사용하여 자료분석을 하였으며, 매개효과 검증을 위해 Baron과 Kenny(1986)의 매개효과 검증 및 Sobel 검증을 수행하였다. 첫째, 주요 변인들 간의 상관분석 결과, 군 인성은 조직몰입 및 공동체의식과 정적으로 유의한 상관관계에 있다. 또한 공동체의식과 조직몰입도 정적으로 유의한 상관관계가 있었다. 둘째, 군 인성과 조직몰입의 관계에서 공동체의식의 매개효과를 검증 결과, 군 인성과 조직몰입의 관계에서 공동체의식이 부분매개 하는 것으로 나타났다. 이것은 군 인성이 조직몰입에 직접적인 영향을 미치기도 하지만, 군 인성이 공동체의식을 향상시켜 조직몰입도를 증가시킨다는 것을 의미한다. 따라서 부사관들의 조직몰입을 향상시키기 위해서는 군대 내에서 군 인성을 함양시켜주는 동시에 공동체의식을 효과적으로 향상시키는 방법이 필요함을 시사한다. This study was conducted to investigate the mediating effect of noncommissioned officers' military character, sense of community and the relationship between military character, sense of community and organizational commitment. For this purpose, this study executed the following survey to 371 noncommissioned officers in City D in Gangwon-do, Korea. For basic statistical processing such as correlation analysis, SPSS / WIN 20.0 was used and to verify the mediators, the mediating effect verification and the Sobel verification of Baron and Kenny(1986) were conducted. First, the correlation between military character and organizational commitment, sense of community and organizational commitment, military character and sense of community all showed a significant positive correlation. Second, it showed that sense of community partially affected the relationship between noncommissioned officers' military character and organizational commitment. To help noncommissioned officers organizational commitment their military life, it needs to consistantly improve thier working environment so that soldieres can reach out to upper class to develop military character and sense of community.