http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
곽미경,최덕현,이재혁,김혜정,박형규,서교일,유명희,변동원 대한골대사학회 2015 대한골대사학회지 Vol.22 No.1
Background: Recently, it has been suggested that decrease in serum sodium level is associated with osteoporosis. However, no study in Korea has reported the association of decrease in serum sodium level with osteoporosis. In this study, we investigated the relationship between the decrease in serum sodium level and severity of osteoporotic fracture in patients. Methods: We enrolled 290 subjects who were admitted and operated at Soonchunhyang University Hospital due to major fractures. For the control group, we enrolled 1,027 subjects who visited a health promotion center. We carried a 1:1 matching with age and sex from the case group. Results: In a total of 164 age- and sex-matched subjects, serum sodium level was significantly lower in the fracture group than in the non-fracture group (P=0.001). Serum sodium level was significantly lower in the severe osteoporosis group than that in the non- severe osteoporosis group (P=0.002). Old age and decrease in serum sodium level were independent risk factors of osteoporosis (odds ratio [OR]=1.088, P=0.008, confidence interval [CI]=[1.022-1.157]; OR= 0.840, P=0.037, CI=0.713-0.989). Conclusions: Serum sodium level was significantly lower in the fracture group than that in the non-fracture group and in the severe osteoporosis group than that in the non-severe osteoporosis group. Based on our results, the decrease in serum sodium level could be an independent risk factor for osteoporosis.
심바스타틴 간 손상 기왕력 환자에서 메티마졸 복용 후 발생한 급성 담즙정체성 간염 1예
곽미경,김소라,박정완,한수정,김민진,진소영,김혜정,장재영,변동원,박형규 순천향대학교 순천향의학연구소 2014 Journal of Soonchunhyang Medical Science Vol.20 No.2
Methimazole and prophylthiouracil are commonly prescribed for patients with hyperthyroidism. The serious side effect of toxic hepatitis caused by these two drugs is well known. According to recent Korean and American management guidelines for hyperthyroidism, mehimazole is recommended as the first-choice antithyroid drug for the treatment of hyperthyroidism. Toxic hepatitis rarely occurs in methimazole users. We report a rare case of a 52-year-old female with toxic hepatitis after methimazole use that had past medical history of simvastatin induced liver injury.
Protection against Amyloid Beta Cytotoxicity by Sulforaphane: Role of the Proteasome
곽미경,박현민,김정애 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.1
The 26S proteasome plays a major role in degradation of abnormal proteins within the cell. The indirect antioxidant including sulforaphane (SFN) protects cells from oxidative damage by increasing the expression of Nrf2-target genes. It has been observed that the expression of multiple subunits of the proteasome was up-regulated by indirect antioxidants through the Nrf2 pathway. In the current study, the role of SFN in amyloid β1-42 (Aβ1-42)-induced cytotoxicity has been investigated in murine neuroblastoma cells. Treatment with SFN protected cells from Aβ1-42-mediated cell death in Neuro2A and N1E 115 cells. Inhibition of proteasome activities by MG132 could abolish the protective effect of SFN against Aβ1-42. Neuro2A cells, which were stably overexpressing the catalytic subunit of the proteasome PSMB5, showed an elevated resistance toward Aβ1-42 toxicity compared to control cells. Furthermore, the in vitro assay demonstrated that the Aβ1-42 peptide is degraded by the proteasome fraction. These results suggest that proteasome-inducing indirect antioxidants may facilitate the removal of the Aβ1-42 peptide and lead to the amelioration of abnormal protein-associated etiologies.
곽미경,조성제 한국정보전자통신기술학회 2018 한국정보전자통신기술학회논문지 Vol.11 No.6
The purpose of this study is to identify the relationship between psychological wellbeing of social welfare facility workers and their organizational commitment. The subjects of this study were 230 social welfare facility workers in OO city, Gyeongsangbuk-do, Korea. Analysis was conducted using the SPSS program, including frequency analysis, reliability analysis and correlation analysis, and regression analysis on the causal relationship between variables. The results of the study showed that the psychological wellbeing of social welfare facility workers had a meaningful effect on their emotional commitment, continuous commitment and normative commitment. These results confirmed that the higher the psychological wellbeing of social welfare facility workers, the higher the sub-factors of organizational commitment, such as emotional, continuous, normative commitment, resulting in positive effects on the achievement of goals and values that are pursued by the welfare facilities. This study aims to become foundational data for the improvement of working conditions to improve psychological wellbeing of social welfare facility workers to increase organizational commitment.
복식호흡이 상·하지 수술 환자의 수술 전 불안과 혈압에 미치는 효과
곽미경,김윤경,홍해숙 기초간호학회 2011 Journal of korean biological nursing science Vol.13 No.1
수술을 앞둔 환자들은 활동의 제한, 사회경제적인 걱정들, 수술 후의 후유증이나 신체기능저하 등에 대한 두려움 등의 다양한 정서적 반응으로 인해 불안을 경험하게 된다. 수술 전 불안은 마취회복과 수술 후 환자 상태에 영향을 주고, 불안 감소는 수술 후 회복을 증진시키며 부작용도 감소시킨다고 하였다(Choi, 2006). 더구나 수술 전 불안 수준은 입원환자보다 높아 중재가 필요하며, 전인적인 관점에서 수술 전 불안을 관리할 수 있는 방안이 요구된다(Joe & Hong, 2001). 불안을 감소시키기 위하여 약물치료, 정신치료, 행동치료가 사용되어 왔으나 약물치료는 예기치 않은 합병증을 초래할 수 있고, 정신치료는 시간이 오래 걸린다는 단점이 있는 반면, 행동치료는 간호사가 손쉽게 임상에서 적용할 수 있다(Kim, Song, & Choi, 2000). 수술환자의 불안을 감소시키기 위해서 다양한 간호중재가 연구되어 왔는데 그 예로는 마사지 요법(Kim & Chang, 2000), 사전정보제공과 교육(Ju, 2002), 이완요법(Song & Kim, 2010), 심상요법(Lee, 2004), 지지적 간호중재(Joe & Hong, 2001), 음악요법(Lee & Hong, 2008) 등이 있다. 정보제공은 선행연구를 고찰해보면, 일관성이 없는 연구결과가 보고되고 있으며(Oh & Ahn, 1997), 수술과 관련된 정보를 많이 알려주는 것에 대해서 알고 싶어 하지 않는 성향을 가진 환자에게는 오히려 불안을 증가시킬 수 있다고 하였다(Kim et al., 2007).