男女 여러 性格型의 Dermatoglyphics 上의 特徵

洪海淑,金貴淑 최신의학사 1980 最新醫學 Vol.23 No.1

BudR편입法과 ^3H-thymidine autoradiography에 의한 不活性 X-染色體의 判別

홍해숙,주강,강�형 慶北大學校 醫科大學 1988 慶北醫大誌 Vol.29 No.4

The mechanism of X-chromosome replication is not yet fully defined. One of the key question concerning the control of mammalian X-chromosome differentiation is whether the process in one of inactivating a previously active X, or of a activation a single X, leaving any other inactive. It is well established that facultatively heterochromatic and late replicating X is not present until a blastocyst stage in such mammalian species as have been investigated by Lyon, et al. Thus, identification of inactive and active X-chromosome is one of interesting subject in the human genetics. Inactive X-chromosome has been detected by means of BudR Incorporation and ^3H-thymidine autoradiography. The result obtained that the: ·percentage of Barr body appearance was 30∼40%. ·autoradiography was heavily labelled on inactive X-chromosome. ·R-band was lightly stained on inactive X-chromosome. Therefore, identification of inactive X-chromosome would be important to evalute the correlations of sex linked abnormalities.

Duchenne Muscular Dystrophy에 관한 세포유전학 및 분자유전학적 연구

홍해숙 기초간호학회 2005 Journal of korean biological nursing science Vol.7 No.1

Purpose ; 본 연구는 X-염색체와 관련된 장애 중에서 흔하고 심한 Duchenne Muscular Dystrophy(DMD)의 세포유전학 및 분자유전학적 특성을 설명하기 위해서 DMD에 영향을 받고 있는 두 가계의 13명을 대상으로 가계도 분석과 염색체 분석 및 DNA 분석을 하였다. Method ; DNA분석은 DNA probe을 이용한 Southern blotting method로써 RFLPs와 DMD유전자 부위의 exon소실 유무를 조사하여 아래와 같은 결과를 얻었다. Conclusion ; A. 염색체 분석 : 말초혈액과 양수를 표본으로 High-Resolution GTG염색에서 A가계의 염색체 분석에서 12명의 염색체는 정상 X-염색체였으나 B가계의 Ⅰ-2(DMD여성)에서 46, x, -x, +t(2x)(q 21.1 : p21.2)로 나타난다. B. DNA분석3 : 1) RFLPs의 분석 J66,XJ-1.1,754-11로써 B가계의 RELPs(Restriction Fragment Length Polymorphisms)에서 J66/Pst Ⅰ은 l.7hb(E), 1.6kb(e)을 보여 주었고 XJ-1.l/Taq Ⅰ은 3.6kb(F), 3.0kb(f), 754-11/EoR Ⅰ은. 4.2kb(G), 2.0kb(g)의 대립인자를 나타내었다. 이상의 결과를 바탕으로 영향을 받고 있는 남자 (Ⅱ-2_의 haplotype는 보인자인 어머니의 한쪽 인자를 받았으며 어머니와 딸은 보인자이고 임산부의 태아는 남아였고 태아의 인자들은 그의 할아버지로부터 물려받아 DMD에 영향을 받지 않은 것으로 진단되었다. 2) DMD 유전자의 exon 소실에 대한 분석 cDNA probe 8과 cDNA probe 2b-3으로써 소실에 대한 진단은 영향을 받은 남자(Ⅱ-2)는 cDNA probe 8에서 12, 7.3, 6.6, 4.2kb에 소실이 있고 cDNA 2b-3d은 l.7kb에 소실에 나타났다.

응급실로 내원한 청장년층 급성심근경색증 환자의 임상특성 연구

홍해숙,장유량,Hong, Hae-Sook,Jang, Yu-Ryang 대한수사과학회 2008 대한수사과학회지 Vol.3 No.1

The purpose of this study was to figure out clinical characteristics in young and adult acute myocardial infarction patients come to emergency room. One hundred fifty four acute myocardial infarction cases were collected and analized from January 2003 to April 2006, especially focused on below the age 50. The results of the study were summarized as follows. The results were proportion up disease occur to women disease rate as men after 50 age and acute myocardial infarction occur to spring and winter most of all. Research for this patients coronary artery condition in cardiac angiography room and coronary artery condition is left anterior descending portion was obstruction and stenosis most of all at that time in emergency room. HDL-cholesterol was not normal range of this patients. About 57.9% patients downward normal range but total cholesterol was very variant condition. Investigated chest X-ray of this patients and result in upward 75% patients was C-T ratio 50% upward condition. And it was shown result from this patients 94. 7% was obesity condition and family history showed mother or father got hypertension or diabete mellitus patients but 42. 7% patients not family history. This patients not going to direct emergency room after via local medical center result in badly condition up. Have got outcomes of youth and adults age patient of acute myocardial infarction come to emergency room. Government and administration have to support advertising this results about acute myocardial infarction condition of nation people. We need to preservation and preventing this disease but if this disease occurrence, to the utmost directly and speedly emergency room for fast therapy.

PDA를 이용한 가정호스피스정보시스템의 개발- 고령군 보건소를 대상으로 -

홍해숙,김화선 대한의료정보학회 2008 Healthcare Informatics Research Vol.14 No.1

Objective: This study focuses on the development of a systematic and efficient information system for effective management of patient data in home hospice care. It is easily implemented in the hospice environment and is based on wired and wireless communications along with mobile computing technology. Methods: The design of this portable home hospice information system was based on an analysis of the services provided by visiting nurses and on the opinions of users, in accordance with the Ministry of Health and Welfare’s Guidelines for Cancer Patient Management Program 2005. The system has eight main menus, each of which performs a different function. The system includes the home hospice information system (HHIS), a compact .NET framework, and the health center information system (HCIS). Results: A trial was conducted with three experienced visiting nurses, who each used a personal digital assistant (PDA) loaded with the new system to add patient information. The functions include registering a new patient, performing appropriate nursing service according to established guidelines, based on the patient’s condition, and searching data records. The system resulted in a saving of 8.5 minutes in nursing data recording time. Conclusion: The findings of this study are expected to help field workers in community nursing to decrease the nursing data recording time by using PDAs.

FISH법을 이용한 Tticho-Rhino-Phalangeal 증후군의 미세한 염색체이상

홍해숙,김태완 대한해부학회 1996 Anatomy & Cell Biology Vol.29 No.5

장루 관리를 위한 Web 기반 간호교육 프로그램 개발

홍해숙,Hong, Hae-Sook 한국가정간호학회 2003 가정간호학회지 Vol.10 No.2

The purpose of this study was to develop and apply a Web-based Nursing Education & Instruction Program to help the clinical nurses improving their knowledge and skills of ostomy care. This program was developed in three different steps: analysis. design. and development. The results of the study were as follows: The analysis step was designed to select the study contents for effective and easy educationthrough the analyses of specialized books. This surveyed and analyzed study contents were categorized into five different sections. Introduction. ostomy classification. ostomy management. elimination management. and life style. After that each section describes necessary information of each category. In the design step. the image files used in this program were created using Adobe Photoshop 6.0. and HTML files were designed and developed using Namo Editor 5.0. In the development step. the developed program was published into Web using FTP (File Transfer Protocol) and then finalized after trial operation for testing of real users. In addition. this Web-based Nursing Education & Instruction Program will be used as excellentand effective tool for continuous and lifelong education in nursingfield. In this study. computer-aided education program was developed for ostomy management and managed at the Web-Server (http://hshong.knu.ac.kr/ostomy) in order to help nurses real-time education in clinical field by this program.

염색체 채색법에 의한 사람과 Mouse의 잡종세포에서 사람염색체의 채색

홍해숙,황성운 대한해부학회 1995 Anatomy & Cell Biology Vol.28 No.1

간호교육에서의 유전학 교육과정 현황과 요구

홍해숙,변영순,나연경 대한기초간호자연과학회 2003 Journal of korean biological nursing science Vol.5 No.1

The purpose of this study was to investigate and analyse current educational requirements related to genetics curriculum(from June 2002 to September 2002) established at nursing institutions and to provide the basic data for the development of genetics science program at the undergraduate. Subjects of this study were comprised of twenty three colleges of nursing in 4-year baccalaureate and thirty colleges in 3-year diploma programs. The results of this study were as follows : 1) 32 colleges offer courses related to genetics. 29 among 32 colleges have that integrated. Three schools have established completely independent courses of genetics. 21 colleges do not have any courses dealing with genetics. 2) The contents of courses related to genetics include:Congenital abnormalities, chromosomal aberrations, congenital metabolic disease, prenatal diagnosis and genetic counseling, genes and chromosomes, immune genetics, blood type and genetics, rule of genetics, variation in gene expression, the map of the human gene, gene linkage genetics, interaction of genes, single inheritance in order and genetic biochemistry. 3) For course credit, 14colleges(48.3%) offered at most 1 credit per course. The grade of student who can take the course, 51.7% were in their second year while 37.9% were in their third year. The majors of nursing faculty who taught the course were nursing(51.7%) and basic nursing science(17.2%). 4) As far as the need of opening the courses related to genetics, 36 colleges(67.0%) have made a ‘need’, 12 schools(22.6%) state ‘dose not need’. The reason for need were the following:development of bio engineering, increase number of patients who are related to genetics, recognition of the need in clinical nursing. 7 schools(13.2%) agreed to offer independent course in genetics but 39 schools(73.6%) are in disagreement with that. When the school offers the course with other courses, 27 schools(50.0%) are opening basic nursing science and 14 schools(26.4%) are opening nursing as an integrated courses. If the name of course was either genetic nursing(34.0%) or genetics(28.3%), the credits for the course was one or 2 credits. 33 schools(62.3%) students were in the first or second years. 41 schools(84.9%), the majors of the faculty who had taught the course were either basic nursing science(35.8%), nursing(28.3%) or basic medicine(24.5%). The contents of the course should include in that order:Chromosome aberrations, prenatal diagnosis and genetic counseling, congenital metabolic disease, congenital abnormalities, genes and chromosomes, the rules of genetics, immune genetics, interaction of genes, variation in gene expression, etc. The results and discussions of the study indicate that the entire curriculums need to be investigated with respect to contents of education, nursing curriculums and name of courses because of the increasing need of knowledge related to genetics in the clinical practice.

Capsaicin을 투여한 성숙 흰쥐의 Intervibrissal Fur 부위의 말초 신경 손상에 관하여

홍해숙,나연경 기초간호학회 2006 Journal of korean biological nursing science Vol.8 No.1